The ToxCast Program for Prioritizing Toxicity Testing of Environmental Chemicals

2005, In vitro zonation and toxicity in a hepatocyte bioreactor, Toxicol. Sci., 84, 110, 10.1093/toxsci/kfi052

2004, NIH Molecular Libraries Initiative, Science, 306, 1138, 10.1126/science.1105511

2006, Characterization of compound mechanisms and secondary activities by BioMAP analysis, J. Pharmacol. Toxicol. Methods, 53, 67, 10.1016/j.vascn.2005.06.003

2005, Toxicity testing: Creating a revolution based on new technologies, Trends Biotechnol., 23, 299, 10.1016/j.tibtech.2005.04.006

2005, High-content screening assay for activators of the Wnt/Fzd pathway in primary human cells, Assay Drug Dev. Technol., 3, 133, 10.1089/adt.2005.3.133

2004, Chemogenomics: An emerging strategy for rapid target and drug discovery, Nat. Rev. Genet., 5, 262, 10.1038/nrg1317

2006, Metabolism: A bottleneck in in vitro toxicological test development. The report and recommendations of ECVAM workshop 54, Altern. Lab Anim., 34, 49, 10.1177/026119290603400113

2003, Generation and validation of rapid computational filters for cyp2d6 and cyp3a4, Drug Metab. Dispos., 31, 1077, 10.1124/dmd.31.9.1077

2005, Analysis of drug-induced effect patterns to link structure and side effects of medicines, Nat. Chem. Biol., 1, 389, 10.1038/nchembio747

2005, Biological spectra analysis: Linking biological activity profiles to molecular structure, Proc. Natl. Acad. Sci. USA., 102, 261, 10.1073/pnas.0407790101

2005, Biospectra analysis: Model proteome characterizations for linking molecular structures and biological response, J. Med. Chem., 48, 6918, 10.1021/jm050494g

2006, Capturing complex 3D tissue physiology in vitro, Nat. Rev. Mol. Cell Biol., 7, 211, 10.1038/nrm1858

2005, An alternative approach for the safety evaluation of new and existing chemicals, an exercise in integrated testing, Regul. Toxicol. Pharmacol., 42, 284, 10.1016/j.yrtph.2005.05.002

2006, A chemogenomic approach to discovering target-selective drugs, Chem. Biol. Drug Des., 67, 85, 10.1111/j.1747-0285.2005.00325.x

2006, In vivo hepatotoxicity study of rats in comparison with in vitro hepatotoxicity screening system, J. Toxicol. Sci., 31, 23, 10.2131/jts.31.23

2006, Using high-throughput screening data to discriminate compounds with single-target effects from those with side effects, J. Chem. Inf. Model, 46, 1549, 10.1021/ci050495h

2006, Critical review of the role of HTS in drug discovery, Drug Discov. Today, 11, 277, 10.1016/j.drudis.2006.02.001

2006, An efficient rapid system for profiling the cellular activities of molecular libraries, Proc. Natl. Acad. Sci. USA., 103, 3153, 10.1073/pnas.0511292103

2005, Greater than the sum of its parts: Combining models for useful ADMET prediction, J. Med. Chem., 48, 1287, 10.1021/jm049254b

2006, High concordance of drug-induced human hepatotoxicity with in vitro cytotoxicity measured in a novel cell-based model using high content screening, Arch. Toxicol, 80, 580, 10.1007/s00204-006-0091-3

2003, PASS biological activity spectrum predictions in the enhanced open NCI database browser, J. Chem. Inf. Comput. Sci., 43, 228, 10.1021/ci020048r

2006, Chemical structure indexing of toxicity data on the internet: moving towards a flat world, Curr. Opin. Drug Discov. Dev, 9, 314

2000, A gene expression database for the molecular pharmacology of cancer, Nat. Genet., 24, 236, 10.1038/73439

2004, Environmental genomics: A key to understanding biology, pathophysiology and disease, Hum. Mol. Genet., 13, R217, 10.1093/hmg/ddh228

2005, A microscale in vitro physiological model of the liver: Predictive screens for drug metabolism and enzyme induction, Curr. Drug Metab., 6, 569, 10.2174/138920005774832632

2005, Targeting inputs and optimising HTS for agrochemical discovery, Comb. Chem. High Throughput Screen., 8, 577, 10.2174/138620705774575346

2005, High throughput screening in agrochemical research, Comb. Chem. High Throughput Screen., 8, 589, 10.2174/138620705774575300

2005, Research perspectives for pre-screening alternatives to animal experimentation—On the relevance of cytotoxicity measurements, barrier passage determinations and high throughput screening in vitro to select potentially hazardous compounds in large sets of chemicals, Toxicol. Appl. Pharmacol., 207, 393, 10.1016/j.taap.2005.01.056

2005, Dynamic monitoring of cytotoxicity on microelectronic sensors, Chem. Res. Toxicol., 18, 154, 10.1021/tx049721s

2006, Development of a toxicogenomics in vitro assay for the efficient characterization of compounds, Pharmacogenomics, 7, 177, 10.2217/14622416.7.2.177

2006, The art of data mining the minefields of toxicity databases to link chemistry to biology, Curr. Comput. Aided Drug Des., 2, 1