The NADH:ubiquinone oxidoreductase (complex I) of respiratory chains
Tóm tắt
The inner membranes of mitochondria contain three multi-subunit enzyme complexes that act successively to transfer electrons from NADH to oxygen, which is reduced to water (Fig. I). The first enzyme in the electron transfer chain, NADH:ubiquinone oxidoreductase (or complex I), is the subject of this review. It removes electrons from NADH and passes them via a series of enzyme-bound redox centres (FMN and Fe-S clusters) to the electron acceptor ubiquinone. For each pair of electrons transferred from NADH to ubiquinone it is usually considered that four protons are removed from the matrix (see section 4.1 for further discussion of this point).
Từ khóa
Tài liệu tham khảo
Yagi, 1991, Paracoccus denitrificans. Biol. Chem. Hoppe-Seyler, 372, 555
Walker J. E. , Arizmendi J. M. , Dupuis A. , Fearnley I. M. , Finel M. , Medd S. M. , Pilkington S. J. , Runswick M. J. & Skehel J. M. (1992). Sequences of twenty subunits of NADH:ubiquinone oxidoreductase from bovine heart mitochondria. Application of a novel strategy for sequencing proteins using the polymerase chain reaction. J. molec. Biol. (in the press).
Videira, 1990, Molecular cloning of subunits of complex I from Neurospora crassa Primary structure and in vitro expression of a 22 kDa polypeptide, J. biol. Chem., 265, 13060, 10.1016/S0021-9258(19)38267-5
Vercesi, 1978, Stoichiometry of H+ ejection and Ca2+ uptake coupled to electron transport in rat heart mitochondria, J. biol. Chem., 253, 6379, 10.1016/S0021-9258(19)46944-5
Van Belzen R. , De Jong A. M. P. & Albracht S. J. P. (1992). On the stoichiometry of the iron-sulphur clusters in mitochondrial NADH: Q oxidoreductase. Eur. J. Biochem. (submitted).
Yagi, 1990, Paracoccus denitrificans. Biochemistry, 29, 5515
Trumpower, 1990, The protonmotive Q cycle, J. biol. Chem., 265, 11409, 10.1016/S0021-9258(19)38410-8
Taylor, 1977, Amino acid sequence of dogfish muscle lactate dehydrogenase, J.biol. Chem., 252, 1799, 10.1016/S0021-9258(17)40621-1
Sumegi, 1984, Complex I binds several mitochondrial NADcoupled dehydrogenases, J. biol. Chem., 259, 15040, 10.1016/S0021-9258(17)42511-7
Singer, 1987, Biochemistry of the neurotoxic action of MPTP: or how a faulty batch of ‘designer drug’ led to parkinsonism in drug abusers, TIBS, 12, 266
Singer, 1992, Molecular Mechanisms in Bioenergetics
Simpson, 1987, Comparison of the maxicircle (mitochondrial) genomes of Leishmania tarentolae and Trypanosoma brucei at the level of nucleotide sequence, J. biol. Chem., 262, 6182, 10.1016/S0021-9258(18)45555-X
Yagi, 1988, Identification of the dicyclohexylcarbodiimide binding subunit of NADH-ubiquinone oxidoreductase (complex I), J. biol. Chem., 263, 16150, 10.1016/S0021-9258(18)37571-9
Rypniewski, 1991, Anabaena 7120. Biochemistry, 30, 4126
Rossman, 1975, The Enzymes, 61
Roe, 1985, The complete nucleotide sequence of the Xenopus laevis mitochondrial genome, J. biol. Chem., 260, 9759, 10.1016/S0021-9258(17)39303-1
Röhlen, 1991, Relationship between a subunit of NADH dehydrogenase (complex I) and a protein family including subunits of cytochrome reductase and processing protease from mitochondria, FEBS Lett., 278, 75, 10.1016/0014-5793(91)80087-J
Pozzan, 1979, H+/site, charge/site, and ATP/site ratios at coupling sites I and II in mitochondrial e−transport, J. biol. Chem., 254, 10200, 10.1016/S0021-9258(19)86693-0
Pollock, 1988, The processing peptidase of yeast mitochondria: the two cooperating components MPP and PEP are structurally related, EMBO J., 7, 3493, 10.1002/j.1460-2075.1988.tb03225.x
Di Virgilio, 1982, Activation of site I redox driven H+ pump by exogenous quinones in intact mitochondria, J. biol. Chem., 257, 4106, 10.1016/S0021-9258(18)34692-1
Okimoto, 1992, Caenorhabditis elegans and Ascaris suum. Genetics, 130, 471
Sawers, 1985, Differential expression of hydrogenase isoenzymes in Escherichi coli K12: evidence for a third isoenzyme, J. Bacteriol., 164, 1324, 10.1128/JB.164.3.1324-1331.1985
Finel M. , Skehel J. M. , Albracht S. P. J. , Fearnley I. M. & Walker J. E. (1992). Resolution of NADH:ubiquinone oxidoreductase from bovine heart mitochondria into two subcomplexes one of which contains the redox centres of the enzyme. Biochemistry (in the press).
Lemasters, 1984, Thermodynamic limits to the ATP/site stoichiometries of oxidative phosphorylation by rat liver mitochondria, j. biol. Client., 259, 3058
Chen, 1984, Identification of the NADH-NAD+ transhydrogenase peptide of the mitochondrial NADH-CoQ reductase (complex I). A photodependent labeling study utilizing arylazido-β-alanyl NAD+, J. biol. Chem., 259, 5124, 10.1016/S0021-9258(17)42965-6
Brown, 1992, Mitochondrial DNA complex I and II mutations associated with Leber's hereditary optic neuropathy, Genetics, 130, 163, 10.1093/genetics/130.1.163
Peck, 1957, Formic dehydrogenase and the hydrogenylase enzyme complex in coli-aerogenes bacteria, J. Bacteriol., 73, 706, 10.1128/JB.73.6.706-721.1957
Krishnamoorthy, 1988, Studies on the electron transfer pathway, topography of iron–sulphur centres, and site of coupling in NADH-Q oxidoreductase, J. biol. Chetn., 263, 17566, 10.1016/S0021-9258(19)77873-9
Correll, 1991, Flavins and Flavoproteins, 743
Shinozaki, 1986, The complete nucleotide sequence of the tobacco chloroplast genome: its gene organization and expression, EMBO J., 5, 2043, 10.1002/j.1460-2075.1986.tb04464.x
Fearnley, 1989, A homologue of the nuclear encoded 49 kD subunit of bovine mitochondrial NADH-unbiquinone reductase is coded in chloroplast DNA, EMBO J., 8, 665, 10.1002/j.1460-2075.1989.tb03424.x
Shuber, 1986, Methanobacterium formicicum. J. biol. Chem., 261, 12942, 10.1016/S0021-9258(18)69253-1
Beavis, 1987, Upper and lower limits of the charge translocation stoichiometry of mitochondrial electron transport, j. biol. Chem., 262, 6165, 10.1016/S0021-9258(18)45553-6
Orme-Johnson, 1974, Electron paramagnetic resonance detectable electron acceptors in beef heart mitochondria. Reduced diphosphopyridine nucleotide ubiquinone reductase segment of the electron transfer system, J. biol. Chem., 249, 1922, 10.1016/S0021-9258(19)42873-1
Schmitt, 1991, The petite phenotype resulting from a truncated copy of subunit 6 results from loss of assembly of the cytochrome bc1 complex and can be suppressed by overexpression of subunit 9, J. biol. Chem., 266, 14958, 10.1016/S0021-9258(18)98571-6
Boehnke, 1983, Two models for a maternal factor in the inheritance of Huntington's disease, Am. J. Hum. Genet., 35, 845
Chen, 1981, Studies on the interaction of arylazido-β alanyl NAD+ with the mitochondrial NADH dehydrogenase, J. biol. Chem., 256, 8318, 10.1016/S0021-9258(19)68846-0
Luu-The, 1989, Full length cDNA structure and deduced amino acid sequence of human 3β-hydroxy-5-ene steroid dehydrogenase, Molec. Endocrinol., 3, 1310, 10.1210/mend-3-8-1310
Suzuki, 1983, Evidence of an ubisemiquinone radical(s) from the NADH-ubiquinone reductase of the mitochondrial respiratory chain, J. biol. Chem., 258, 352, 10.1016/S0021-9258(18)33264-2
Benecke R. , Strümper P. & Weiss H. (1992). Electron transfer complex I defect in idiopathic dystonia. Ann. Neurol. (in the press).
Hwang, 1991, Acyl carrier protein derived sequence encoded by the chloroplast genome in the marine diatom Cylindrotheca sp. strain Ni, J. biol. Chem., 266, 13492, 10.1016/S0021-9258(18)92723-7
Ohnishi, 1985, EPR studies of iron–sulfur clusters in isolated subunits and subfractions of NADH-ubiquinone oxidoreductase, J. biol. Chem., 260, 2782, 10.1016/S0021-9258(18)89430-3
Breakefield, 1992, An Introduction to Molecular Neurobiology, 517
Towler, 1988, Myristoyl CoA:protein. N-myristoyltransferase activities from rat liver and yeast possess overlapping yet distinct peptide substrate specificies, J. biol. Chem., 263, 1784, 10.1016/S0021-9258(19)77945-9
Lim, 1986, Three-dimensional structure of the iron–sulfur flavoprotein trimethylamine dehydrogenase at 2.4 Å resolution, J. biol. Chem., 261, 15140, 10.1016/S0021-9258(18)66843-7
Brody, 1990, Plant Lipid Biochemistry, Structure and Utilization, 117
Cremona, 1964, Studies on the respiratory chain-linked reduced nicotinamide adenine dinucleotide dehydrogenase, J. biol. Chem., 239, 2328, 10.1016/S0021-9258(20)82237-6
Walker, 1986, Evolution of ATP synthase, Chemica Scripta, 26B, 263
Brusilow, 1989, Organization and sequence of the genes encoding the proton-translocating ATPase of Bacillus megaterium, J. biol. Chem., 264, 1528, 10.1016/S0021-9258(18)94219-5
Cantatore, 1989, The complete nucleotide sequence, gene organization and genetic code of the mitochondrial genome of Paracentrotus lividus, J. biol. Chem., 264, 10965, 10.1016/S0021-9258(18)60413-2
Garesse, 1988, Drosophila melanogaster mitochondrial DNA: gene organization and evolutionary considerations, Genetics, 118, 649, 10.1093/genetics/118.4.649
Høj, 1987, Identification of a chloroplast encoded 9 kDa polypeptide as a 2[4Fe-4S] protein carrying centers A and B of photosystem I, j. biol. Chem., 262, 12676, 10.1016/S0021-9258(18)45260-X
Lemasters, 1984, The ATP to oxygen stoichiometries of oxidative phosphorylation by rat liver mitochondria. An analysis of ADP-induced oxygen jumps by linear nonequilibrium thermodynamics, J. biol. Chetn., 259, 13123, 10.1016/S0021-9258(18)90666-6
Graham, 1991, Mutational analysis of the mitochondrial Rieske iron–sulfur protein of Saccharomyces cerevisiae. III Import, protease processing, and assembly into the cytochrome bci complex of iron–sulfur protein lacking the iron–sulfur cluster, J. biol. Chem., 266, 22485, 10.1016/S0021-9258(18)54598-1
Fearnley I. M. & Walker J. E. (1992). Conservation of sequences of subunits of mitochondrial complex I and their relationships with other proteins. Biochim. Biophys. Acta Bioenerget. Revs (in the press).
Mayhew, 1975, The Enzymes, 57
Fukushima, 1989, Substrate channeling of NADH and binding of dehydrogenases to complex I, J. biol. Chem., 264, 16483, 10.1016/S0021-9258(19)84731-2
Howell, 1991, Leber hereditary optic neuropathy: involvement of the mitochondrial NDi gene and evidence for an intragenic suppressor mutation, Am. J. Hum. Genet., 48, 935
Howell, 1992, Molecular genetic analysis of a sporadic case of Leber hereditary optic neuropathy, Am. J. Hum. Genet., 50, 443
Huoponen, 1991, A new mt DNA mutation associated with Leber hereditary optic neuropathy, Am.J. Hum. Genet., 48, 1147
Steinmetz, 1986, Protein PSIIG. An additional component of photosystem II identified through its plastic gene in maize, J. biol. Chem., 261, 2485, 10.1016/S0021-9258(17)35808-8
Ise, 1985, Mitochondrial translation of subunits of the rotenone-sensitive NADH:ubiquinone reductase in Neurospora crassa, EMBO J., 4, 2075, 10.1002/j.1460-2075.1985.tb03894.x
Katayama, 1991, Deleted mitochondrial DNA in the skeletal muscle of aged individuals, Biochem Inter., 25, 47
Majander, 1991, Electron transfer properties of NADH:ubiquinone reductase in the ND1/3460 and the ND4/11778 mutations of the Leber hereditary optic neuroretinopathy (LHON), FEBS Lett., 292, 289, 10.1016/0014-5793(91)80886-8
Yang, 1986, Purification of a three subunit ubiquinolcytochrome c oxidoreductase complex from Paracoccus denitrificans, J. biol. Chem., 261, 12282, 10.1016/S0021-9258(18)67236-9
Ohnishi, 1981, Iron–sulfur clusters studied in NADH-ubiquinone oxidoreductase and in soluble NADH dehydrogenase, J. biol. Chem., 256, 9216, 10.1016/S0021-9258(19)52531-5
Taketani, 1990, Molecular cloning, sequencing, and expression of mouse ferrochelatase, J. biol. Chem., 265, 19377, 10.1016/S0021-9258(17)45378-6
Meinhardt, 1990, Studies of the NADH-menaquinone oxidoreductase segment of the respiratory chain in Thermus thermophilus HB-8, J. biol. Chem., 265, 1360, 10.1016/S0021-9258(19)40022-7
Moras, 1975, Studies of asymmetry in the three-dimensional structure of lobster D-glyceraldehyde-3-phosphate dehydrogenase, J. biol. Chem., 290, 9137, 10.1016/S0021-9258(19)40703-5
Hatefi, 1962, Studies on the electron transfer system. XL. Preparation and properties of mitochondrial DPNH-coenzyme Q reductase, J. biol. Chem., 237, 1676, 10.1016/S0021-9258(19)83761-4
Hacobs, 1988, Nucleotide sequence and gene organization of sea urchin mitochondrial DNA, J. molec. Biol., 202, 185, 10.1016/0022-2836(88)90452-4
Singer, 1990, Mechanism of the neurotoxicity of MPTP, FEBS Lett., 274, 1, 10.1016/0014-5793(90)81315-F
Meinhardt, 1987, EPR characterization of the iron–sulfur clusters in the NADH: ubiquinone oxidoreductase segment of the respiratory chain in Paracoccus denitrificans, J. biol. Chem., 262, 9147, 10.1016/S0021-9258(18)48060-X
Nehls U. , Friedrich T. , Schmiede A. , Ohnishi T. & Weiss H. (1992). Characterization of assembly intermediates of NADH:ubiquinone oxidoreductase (complex I) accumulated in Neurospora mitochondria by gene disruption. J. molec. Biol. (in the press).
Cozens, 1986, A sixth subunit of ATP synthase, an F0 component, is encoded in the pea chloroplast genome, EMBO J., 5, 217, 10.1002/j.1460-2075.1986.tb04201.x
Nicholls, 1992, Bioenergetics, 2
Nixon, 1989, psbG is not a photosystem two gene but may be an ndh gene, J. biol. Chem., 264, 14129, 10.1016/S0021-9258(18)71652-9
Ohnishi, 1979, Membrane Proteins in Energy Transduction, 1
Müller-Hocker, 1989, Cytochrome c oxidase deficient cardiomyocytes in the human heart – an age-related phenomenon, Am. J. Pathol., 134, 1167