The Identification and Characterization of the Marine Natural Product Scytonemin as a Novel Antiproliferative Pharmacophore

Journal of Pharmacology and Experimental Therapeutics - Tập 303 Số 2 - Trang 858-866 - 2002
Christopher S. Stevenson1, Elizabeth A. Capper, Amy Roshak, Brian L. Márquez, Chris Eichman, Jeffrey R. Jackson, Michael R. Mattern, William H. Gerwick, Robert S. Jacobs, Lisa A. Marshall
1Department of Ecology, Evolution and Marine Biology, University of California at Santa Barbara, Santa Barbara, CA 93106, USA

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Butler, 1988, Stimulation of human synovial fibroblast DNA synthesis by recombinant cytokines., J Rheumatol, 15, 1463

Carte, 1996, Biomedical potential of marine natural products., Bioscience, 46, 271, 10.2307/1312834

Coussens, 1986, Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signaling pathways., Science (Wash DC), 233, 859, 10.1126/science.3755548

Cragg, 1997, Natural products in drug discovery and development., J Nat Prod, 60, 52, 10.1021/np9604893

Desai, 1992, Activation of human cyclin-dependent kinases in vitro., Mol Biol Cell, 3, 571, 10.1091/mbc.3.5.571

Folkman, 1980, Angiogenesis in vitro., Science (Wash DC), 288, 551

Garcia-Echeverria, 2000, ATP site-directed competitive and irreversible inhibitors of protein kinases., Med Res Rev, 20, 28, 10.1002/(SICI)1098-1128(200001)20:1<28::AID-MED2>3.0.CO;2-2

Garcia-Pichel, 1998, Solar ultraviolet light and the evolutionary history of cyanobacteria., Origins Life Evol Biosph, 28, 321, 10.1023/A:1006545303412

Huang, 1995, GRB2 and SH-PTP2: potentially important endothelial signaling molecules downstream of the TEK/TIE2 receptor tyrosine kinase., Oncogene, 11, 2097

Jackson, 2000, An indolocarbazole inhibitor of human checkpoint kinase (Chk1) abrogates cell cycle arrest caused by DNA damage., Cancer Res, 60, 566

Kobayashi, 1994, Nostodione A, a novel mitotic spindle poison from a blue-green alga Nostoc commune., Z Naturforsch, 49, 464, 10.1515/znc-1994-7-812

Kumagai, 1996, Purification and molecular cloning of Plx1, a cdc25-regulatory kinase from Xenopus egg extracts., Science (Wash DC), 273, 1377, 10.1126/science.273.5280.1377

Lane, 1996, Antibody microinjection reveals an essential role for human polo-like kinase 1 (Plk1) in the functional maturation of mitotic centrosomes., J Cell Biol, 135, 1701, 10.1083/jcb.135.6.1701

Lee, 2000, Potent and selective nonpeptide inhibitors of caspases 3 and 7 inhibit apoptosis and maintain cell functionality., J Biol Chem, 275, 16007, 10.1074/jbc.275.21.16007

Marquez, 1998, Curacin D, an antimitotic agent from the marine cyanobacterium Lyngbya majuscula., Phytochemistry, 49, 2387, 10.1016/S0031-9422(98)00365-3

Marshall, 1993, Co-existence of two biochemically distinct phospholipase A2 activities in human platelet, monocyte and neutrophil., Biochem Cell Biol, 71, 331, 10.1139/o93-050

McConnell, 1994, The discovery of natural products with therapeutic potential., Biotechnology, 26, 109

Meijer, 2000, Inhibition of cyclin-dependent kinases, GSK-3β and CK1 by hymenialdisine, a marine sponge constituent., Chem Biol (Lond), 7, 1

Norbury, 1992, Animal cell cycles and their controls., Annu Rev Biochem, 61, 441, 10.1146/annurev.bi.61.070192.002301

Proteau, 1993, The structure of scytonemin, an ultraviolet sunscreen pigment from the sheaths of cyanobacteria., Experientia, 49, 825, 10.1007/BF01923559

Remmers, 1991, Platelet-derived growth factors and heparin-binding (fibroblast) growth factors in the synovial tissue pathology of rheumatoid arthritis., Semin Arthritis Rheum, 21, 191, 10.1016/0049-0172(91)90009-O

Roshak, 2000, The human polo-like kinase, PLK, regulates cdc2/cyclin B through phosphorylation and activation of the cdc25C phosphatase., Cell Signal, 12, 405, 10.1016/S0898-6568(00)00080-2

Rubin, 1988, Expression of platelet-derived growth factor receptors is induced on connective tissue cells during chronic synovial inflammation., Scand J Immunol, 27, 285, 10.1111/j.1365-3083.1988.tb02349.x

Stevenson, 2002, Scytonemin, a marine natural product inhibitor of kinases key in hyperproliferative inflammatory diseases., Inflamm Res, 51, 112, 10.1007/BF02684014

Sunkel, 1988, polo, a mitotic mutant of Drososphila displaying abnormal spindle poles., J Cell Sci, 89, 25, 10.1242/jcs.89.1.25

Varterasian, 1998, Phase I study of bryostatin 1 in patients with relapsed Non-Hodgkin’s lymphoma and acute lymphocytic leukemia., J Clin Oncol, 16, 56, 10.1200/JCO.1998.16.1.56

Wagner, 1999, In vitro pharmacology of cryptophycin 52 (LY355703) in human tumor cell lines., Cancer Chemother Pharmacol, 43, 115, 10.1007/s002800050871