The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages

Bunn, 1996, Oxygen sensing and molecular adaptation to hypoxia, Physiol Rev, 76, 839, 10.1152/physrev.1996.76.3.839

Hockel, 1998, Tumor hypoxia in pelvic recurrences of cervical cancer, Int J Cancer, 79, 365, 10.1002/(SICI)1097-0215(19980821)79:4<365::AID-IJC10>3.0.CO;2-4

Stadler, 1999, Influence of the hypoxic subvolume on the survival of patients with head and neck cancer, Int J Radiat Oncol Biol Phys, 44, 749, 10.1016/S0360-3016(99)00115-7

Maxwell, 1993, Inducible operation of the erythropoietin-3′ enhancer in multiple cell-lines: evidence for a widespread oxygen-sensing mechanism, Proc Natl Acad Sci USA, 90, 2423, 10.1073/pnas.90.6.2423

Ratcliffe, 1997, Oxygen regulated gene expression: erythropoietin as a model system, Kidney Int, 51, 514, 10.1038/ki.1997.72

Wang, 1995, Hypoxia-inducible factor-1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O-2 tension, Proc Natl Acad Sci USA, 92, 5510, 10.1073/pnas.92.12.5510

Crews, 1998, Control of cell lineage-specific development and transcription by bHLH-PAS proteins, Genes Dev, 12, 607, 10.1101/gad.12.5.607

Iyer, 1998, Cellular and developmental control of O-2 homeostasis by hypoxia-inducible factor 1 alpha, Genes Dev, 12, 149, 10.1101/gad.12.2.149

Tian, 1998, The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development, Genes Dev, 12, 3320, 10.1101/gad.12.21.3320

Tian, 1997, Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells, Genes Dev, 11, 72, 10.1101/gad.11.1.72

Ema, 1997, A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1 alpha regulates the VEGF expression and is potentially involved in lung and vascular development, Proc Natl Acad Sci USA, 94, 4273, 10.1073/pnas.94.9.4273

Flamme, 1997, HRF, a putative basic helix-loop-helix-PAS-domain transcription factor is closely related to hypoxia-inducible factor-1 alpha and developmentally expressed in blood vessels, Mech Dev, 63, 51, 10.1016/S0925-4773(97)00674-6

Gu, 1998, Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3 alpha, Gene Expr, 7, 205

Dachs, 1997, Targeting gene expression to hypoxic tumor cells, Nat Med, 3, 515, 10.1038/nm0597-515

Maxwell, 1997, Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth, Proc Natl Acad Sci USA, 94, 8104, 10.1073/pnas.94.15.8104

Ryan, 1998, HIF-1 alpha is required for solid tumor formation and embryonic vascularization, EMBO J, 17, 3005, 10.1093/emboj/17.11.3005

Carmeliet, 1998, Role of HIF-1 alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis, Nature, 394, 485, 10.1038/28867

Maxwell, 1999, The tumour suppressor protein VHL targets hypoxia inducible factors for oxygen dependent proteolysis, Nature, 399, 271, 10.1038/20459

Wiesener, 1998, Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1 alpha, Blood, 92, 2260, 10.1182/blood.V92.7.2260

Huang, 1996, Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit, J Biol Chem, 271, 32253, 10.1074/jbc.271.50.32253

Huang, 1998, Regulation of hypoxia-inducible factor 1 alpha is mediated by an O-2-dependent degradation domain via the ubiquitin-proteasome pathway, Proc Natl Acad Sci USA, 95, 7987, 10.1073/pnas.95.14.7987

Salceda, 1997, Hypoxia-inducible factor 1 alpha (HIF-1 alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions - its stabilization by hypoxia depends on redox-induced changes, J Biol Chem, 272, 22642, 10.1074/jbc.272.36.22642

Wenger, 1997, Oxygen(es) and the hypoxia-inducible factor-1, Biol Chem, 378, 609

Wiener, 1996, In vivo expression of mRNAs encoding hypoxia-inducible factor 1, Biochem Biophys Res Commun, 225, 485, 10.1006/bbrc.1996.1199

Yu, 1998, Temporal, spatial, and oxygen-regulated expression of hypoxia- inducible factor-1 in the lung, Am J Physiol, 275, L818

Ozaki, 1999, Hypoxia inducible factor-1 alpha is increased in ischemic retina: temporal and spatial correlation with VEGF expression, Invest Ophthalmol Vis Sci, 40, 182

Zhang, 1995, Enhancement of tumor-growth and vascular density by transfection of vascular endothelial-cell growth-factor into Mcf-7 human breast-carcinoma cells, J Natl Cancer Inst, 87, 213, 10.1093/jnci/87.3.213

Brown, 1995, Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in breast cancer, Hum Pathol, 26, 86, 10.1016/0046-8177(95)90119-1

Helmlinger, 1997, Interstitial pH and pO(2) gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlation, Nat Med, 3, 177, 10.1038/nm0297-177

Gatenby, 1996, A reaction-diffusion model of cancer invasion, Cancer Res, 56, 5745

Jiang, 1997, V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: involvement of HIF-1 in tumor progression, Cancer Res, 57, 5328

Punglia, 1997, Regulation of vascular endothelial growth factor expression by insulin-like growth factor I, Diabetes, 46, 1619, 10.2337/diacare.46.10.1619

Feldser, 1999, Reciprocal positive regulation of hypoxia-inducible factor 1 alpha and insulin-like growth factor 2, Cancer Res, 59, 3915

Conrad, 1999, EPAS1 trans-activation during hypoxia requires p42/p44 MAPK, J Biol Chem, 274, 33709, 10.1074/jbc.274.47.33709

Richard, 1999, p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1 alpha (HIF-1 alpha) and enhance the transcriptional activity of HIF-1, J Biol Chem, 274, 32631, 10.1074/jbc.274.46.32631

Zhong, 1999, Overexpression of hypoxia-inducible factor 1 alpha in common human cancers and their metastases, Cancer Res, 59, 5830

Fukumura, 1998, Tumor induction of VEGF promoter activity in stromal cells, Cell, 94, 715, 10.1016/S0092-8674(00)81731-6

Leek, 1996, Association of macrophage infiltration with angiogenesis and prognosis in invasive breast carcinoma, Cancer Res, 56, 4625

Cipolleschi, 1993, The role of hypoxia in the maintenance of hematopoietic stem-cells, Blood, 82, 2031, 10.1182/blood.V82.7.2031.2031

Li, 2000, PR39, a peptide regulator of angiogenesis, Nat Med, 6, 49, 10.1038/71527

Falini, 1993, Pg-M1: a new monoclonal-antibody directed against a fixative-resistant epitope on the macrophage-restricted form of the Cd68 molecule, Am J Pathol, 142, 1359

Master, 1989, Diagnostic application of monoclonal-antibody Kb90 (Cd11c) in acute myeloid-leukemia, Blut, 59, 221, 10.1007/BF00320851