The Clinically Used Iron Chelator Deferasirox Is an Inhibitor of Epigenetic JumonjiC Domain-Containing Histone Demethylases

ACS Chemical Biology - Tập 14 Số 8 - Trang 1737-1750 - 2019
Martin Roatsch1, Inga Hoffmann1, Martine I. Abboud2, Rebecca L. Hancock2, Hanna Tarhonskaya2, Kuo‐Feng Hsu2, Sarah E. Wilkins2, Tzu-Lan Yeh2, Kerstin Lippl2, Kerstin Serrer3, Isabelle Moneke4, Theresa D. Ahrens5, Dina Robaa6, Sandra Wenzler1, Nicolas Barthès1, Henriette Franz7, Wolfgang Sippl6, Silke Laßmann5, Sven Diederichs4,8, Erik Schleicher3, Christopher J. Schofield2, Akane Kawamura2, Roland Schüle7, Manfred Jung1
1Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universität Freiburg, Albertstraße 25, 79104 Freiburg i.Br., Germany
2Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, United Kingdom
3Institute of Physical Chemistry, Albert-Ludwigs-Universität Freiburg, Albertstraße 21, 79104 Freiburg i.Br., Germany
4Division of Cancer Research, Department of Thoracic Surgery, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, German Cancer Consortium (DKTK)-Partner Site Freiburg, Breisacher Straße 115, 79106 Freiburg i.Br., Germany
5Institute for Surgical Pathology, Medical Center and Faculty of Medicine, University of Freiburg, Breisacher Straße 115a, 79106 Freiburg i.Br., Germany
6Institute of Pharmacy, Martin-Luther-University Halle-Wittenberg, Wolfgang-Langenbeck-Straße 4, 06120 Halle (Saale), Germany
7Central Clinical Research, Medical Center and Faculty of Medicine, University of Freiburg, Breisacher Straße 66, 79106 Freiburg i.Br., Germany
8Division of RNA Biology & Cancer, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany

Tóm tắt

Từ khóa


Tài liệu tham khảo

10.1038/nrd3674

10.1016/j.cell.2007.02.005

10.1038/nature04433

10.1016/j.cell.2006.03.028

10.4161/15592294.2014.983381

10.1016/j.ejmech.2018.10.040

10.3892/ijo.2012.1618

Patani N., 2011, Anticancer Res., 31, 4115

10.1016/j.bbrc.2007.05.179

10.1016/j.canlet.2013.04.009

10.1002/jcb.24009

10.1016/j.celrep.2012.09.033

10.1002/mc.20758

10.1016/j.cancergen.2014.11.001

10.1126/science.aaw1026

10.1002/cmdc.200900301

10.1016/j.pharmthera.2015.01.002

10.2217/epi.12.3

10.1016/j.molonc.2012.07.004

10.2217/epi.13.79

10.1002/cmdc.201500335

10.4155/fmc.15.188

10.1002/cmdc.201600218

10.1021/jm800936s

10.1002/cmdc.201800377

10.1371/journal.pone.0015535

10.1021/jm4012802

10.1038/nature11262

10.1016/j.bmcl.2012.07.091

10.1021/ja201597b

10.1021/jm1003655

10.1080/15592294.2016.1249089

10.1038/ncomms3035

10.1021/acs.jcim.8b00539

10.1016/j.bmcl.2019.03.028

10.1021/acs.jmedchem.5b01758

10.1016/j.bmc.2011.01.046

10.1101/cshperspect.a026484

Hauser A.-T., 2015, Epigenetic Technological Applications, 397, 10.1016/B978-0-12-801080-8.00018-1

Højrup C., 2019, Epigenetic Drug Discovery, 265

10.1021/acs.jmedchem.8b01219

10.1002/anie.201810179

10.1098/rstb.2017.0071

10.1111/bjh.14376

10.4084/mjhid.2018.066

10.1039/C6CC09882G

10.1038/s41598-019-39214-1

10.1039/b916357c

10.1074/jbc.M009458200

10.1021/cr9900275

10.1021/bi4010914

Patil, R. S., Charugundla, K., Neela, P. K., Pradhan, N. S., and Valgeirsson, J. (2009) Substantially pure Deferasirox and process for the preparation thereof. Patent WO 2009/147529.

10.1002/ejic.200400363

10.1016/j.ica.2012.06.011

10.1002/chem.200304820

10.1016/j.ejphar.2016.04.026

10.1021/acs.orglett.6b00277

10.1039/C8CC00387D

10.1002/anie.201612185

10.1002/jcb.24423

10.1111/bph.12045

10.3892/ijo.2013.1855

10.1016/j.exphem.2013.02.004

10.1186/s12957-016-0829-1

10.2217/cer.15.20

10.1016/j.blre.2018.03.002

10.1111/bph.12093

10.1002/jcph.113

10.1124/mol.112.081893

10.1023/A:1013302231549

10.1038/nature04853

Thông tin
Thông tin xuất bản

ACS Chemical Biology

Tập 14 Số 8

1737-1750

Thông tin tác giả