The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized

Cancer Cell - Tập 10 Số 5 - Trang 389-399 - 2006
Mark F. van Delft1,2, Andrew H. Wei2, Kylie D. Mason1,2, Cassandra J. Vandenberg2, Lin Chen2, Peter E. Czabotar2, Simon N. Willis2, Clare L. Scott2, Catherine L. Day3, Suzanne Cory2, Jerry M. Adams2, Andrew W. Roberts2, David C.S. Huang2
1Department of Medical Biology, The University of Melbourne, Parkville, Victoria 3010, Australia
2The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
3Biochemistry Department, University of Otago, Dunedin 9001, New Zealand

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