Tensional homeostasis and the malignant phenotype

Cancer Cell - Tập 8 Số 3 - Trang 241-254 - 2005
Matthew J. Paszek1,2, Nastaran Zahir1,2, Kandice R. Levental1,2, Johnathon N. Lakins2, Gabriela I. Rozenberg2, Amit Gefen3, Cynthia A. Reinhart‐King1, Susan S. Margulies1, Micah Dembo4, David Boettiger5, Daniel A. Hammer1, Valerie M. Weaver2
1Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104
2Department of Pathology and Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104
3Department of Biomedical Engineering, Tel Aviv University, Tel Aviv 69978, Israel
4‡Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02215
5Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104

Tóm tắt

Từ khóa


Tài liệu tham khảo

Akiri, 2003, Lysyl oxidase-related protein-1 promotes tumor fibrosis and tumor progression in vivo, Cancer Res., 63, 1657

Arias-Salgado, 2003, Src kinase activation by direct interaction with the integrin β cytoplasmic domain, Proc. Natl. Acad. Sci. USA, 100, 13298, 10.1073/pnas.2336149100

Azar, 2001, A deformable finite element model of the breast for predicting mechanical deformations under external perturbations, Acad. Radiol., 8, 965, 10.1016/S1076-6332(03)80640-2

Beil, 2003, Sphingosylphosphorylcholine regulates keratin network architecture and visco-elastic properties of human cancer cells, Nat. Cell Biol., 5, 803, 10.1038/ncb1037

Bershadsky, 2003, Adhesion-dependent cell mechanosensitivity, Annu. Rev. Cell Dev. Biol., 19, 677, 10.1146/annurev.cellbio.19.111301.153011

Burridge, 2004, Rho and Rac take center stage, Cell, 116, 167, 10.1016/S0092-8674(04)00003-0

Callister, 2000

Chrzanowska-Wodnicka, 1996, Rho-stimulated contractility drives the formation of stress fibers and focal adhesions, J. Cell Biol., 133, 1403, 10.1083/jcb.133.6.1403

Colpaert, 2001, The presence of a fibrotic focus is an independent predictor of early metastasis in lymph node-negative breast cancer patients, Am. J. Surg. Pathol., 25, 1557, 10.1097/00000478-200112000-00016

Croft, 2004, Conditional ROCK activation in vivo induces tumor cell dissemination and angiogenesis, Cancer Res., 64, 8994, 10.1158/0008-5472.CAN-04-2052

Debnath, 2003, Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures, Methods, 30, 256, 10.1016/S1046-2023(03)00032-X

Delcommenne, 1995, Control of integrin expression by extracellular matrix, J. Biol. Chem., 270, 26794, 10.1074/jbc.270.45.26794

Engler, 2004, Myotubes differentiate optimally on substrates with tissue-like stiffness: pathological implications for soft or stiff microenvironments, J. Cell Biol., 166, 877, 10.1083/jcb.200405004

Fritz, 1999, Rho GTPases are over-expressed in human tumors, Int. J. Cancer, 81, 682, 10.1002/(SICI)1097-0215(19990531)81:5<682::AID-IJC2>3.0.CO;2-B

Galbraith, 2002, The relationship between force and focal complex development, J. Cell Biol., 159, 695, 10.1083/jcb.200204153

Gefen, 2003, Age-dependent changes in material properties of the brain and braincase of the rat, J. Neurotrauma, 20, 1163, 10.1089/089771503770802853

Guo, 2004, Integrin signalling during tumour progression, Nat. Rev. Mol. Cell Biol., 5, 816, 10.1038/nrm1490

Huang, 2004, Cell mechanics and mechanotransduction: pathways, probes, and physiology, Am. J. Physiol. Cell Physiol., 287, 1, 10.1152/ajpcell.00559.2003

Keller, 2003, How we are shaped: the biomechanics of gastrulation, Differentiation, 71, 171, 10.1046/j.1432-0436.2003.710301.x

Khaled, 2004, Palpation imaging using a haptic system for virtual reality applications in medicine, Stud. Health Technol. Inform., 98, 147

Lark, A.L., Livasy, C.A., Dressler, L., Moore, D.T., Millikan, R.C., Geradts, J., Iacocca, M., Cowan, D., Little, D., Craven, R.J., and Cance, W. (2005). High focal adhesion kinase expression in invasive breast carcinomas is associated with an aggressive phenotype. Mod Pathol., in press. Published online April 29, 2005. 10.1038/modpathol.3800424.

Lee, 2004, Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways, Mol. Cells, 17, 188, 10.1016/S1016-8478(23)13026-3

Li, 2003, Activation of integrin αIIbβ3 by modulation of transmembrane helix associations, Science, 300, 795, 10.1126/science.1079441

Liu, 2004, Polarity and proliferation are controlled by distinct signaling pathways downstream of PI3-kinase in breast epithelial tumor cells, J. Cell Biol., 164, 603, 10.1083/jcb.200306090

Lo, 2000, Cell movement is guided by the rigidity of the substrate, Biophys. J., 79, 144, 10.1016/S0006-3495(00)76279-5

Luo, 2004, Locking the β3 integrin I-like domain into high and low affinity conformations with disulfides, J. Biol. Chem., 279, 10215, 10.1074/jbc.M312732200

Luo, 2005, Disrupting integrin transmembrane domain heterodimerization increases ligand binding affinity, not valency or clustering, Proc. Natl. Acad. Sci. USA, 102, 3679, 10.1073/pnas.0409440102

McLean, 2004, Specific deletion of focal adhesion kinase suppresses tumor formation and blocks malignant progression, Genes Dev., 18, 2998, 10.1101/gad.316304

Moore, 2002, Control of embryonic lung branching morphogenesis by the Rho activator, cytotoxic necrotizing factor 1, J. Surg. Res., 104, 95, 10.1006/jsre.2002.6418

Netti, 2000, Role of extracellular matrix assembly in interstitial transport in solid tumors, Cancer Res., 60, 2497

Nicolas, 2004, Cell mechanosensitivity controls the anisotropy of focal adhesions, Proc. Natl. Acad. Sci. USA, 101, 12520, 10.1073/pnas.0403539101

O’Brien, 2001, Rac1 orientates epithelial apical polarity through effects on basolateral laminin assembly, Nat. Cell Biol., 3, 831, 10.1038/ncb0901-831

O’Brien, 2002, Opinion: Building epithelial architecture: insights from three-dimensional culture models, Nat. Rev. Mol. Cell Biol., 3, 531, 10.1038/nrm859

Padera, 2004, Pathology: cancer cells compress intratumour vessels, Nature, 427, 695, 10.1038/427695a

Paszek, 2004, The tension mounts: mechanics meets morphogenesis and malignancy, J. Mammary Gland Biol. Neoplasia, 9, 325, 10.1007/s10911-004-1404-x

Reinhart-King, 2003, Endothelial cell traction forces on RGD-derivatized polyacrylamide substrata, Langmuir, 19, 1573, 10.1021/la026142j

Riveline, 2001, Focal contacts as mechanosensors: externally applied local mechanical force induces growth of focal contacts by an mDia1-dependent and ROCK-independent mechanism, J. Cell Biol., 153, 1175, 10.1083/jcb.153.6.1175

Roovers, 2003, Effects of rho kinase and actin stress fibers on sustained extracellular signal-regulated kinase activity and activation of G(1) phase cyclin-dependent kinases, Mol. Cell. Biol., 23, 4283, 10.1128/MCB.23.12.4283-4294.2003

Sahai, 2002, ROCK and Dia have opposing effects on adherens junctions downstream of Rho, Nat. Cell Biol., 4, 408, 10.1038/ncb796

Sahai, 2001, Cross-talk between Ras and Rho signalling pathways in transformation favours proliferation and increased motility, EMBO J., 20, 755, 10.1093/emboj/20.4.755

Shi, 2003, A novel mode for integrin-mediated signaling: tethering is required for phosphorylation of FAK Y397, Mol. Biol. Cell, 14, 4306, 10.1091/mbc.E03-01-0046

Tzima, 2001, Activation of integrins in endothelial cells by fluid shear stress mediates Rho-dependent cytoskeletal alignment, EMBO J., 20, 4639, 10.1093/emboj/20.17.4639

Vial, 2003, ERK-MAPK signaling coordinately regulates activity of Rac1 and RhoA for tumor cell motility, Cancer Cell, 4, 67, 10.1016/S1535-6108(03)00162-4

Wang, 1998, Reciprocal interactions between β1-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: a different perspective in epithelial biology, Proc. Natl. Acad. Sci. USA, 95, 14821, 10.1073/pnas.95.25.14821

Wang, 2000, Substrate flexibility regulates growth and apoptosis of normal but not transformed cells, Am. J. Physiol. Cell Physiol., 279, C1345, 10.1152/ajpcell.2000.279.5.C1345

Weaver, 2002, β4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium, Cancer Cell, 2, 205, 10.1016/S1535-6108(02)00125-3

White, 2004, Targeted disruption of β1-integrin in a transgenic mouse model of human breast cancer reveals an essential role in mammary tumor induction, Cancer Cell, 6, 159, 10.1016/j.ccr.2004.06.025

Wozniak, 2003, ROCK-generated contractility regulates breast epithelial cell differentiation in response to the physical properties of a three-dimensional collagen matrix, J. Cell Biol., 163, 583, 10.1083/jcb.200305010

Yeung, 2005, Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion, Cell Motil. Cytoskeleton, 60, 24, 10.1002/cm.20041

Zahir, 2003, Autocrine laminin-5 ligates α6β4 integrin and activates RAC and NFκB to mediate anchorage-independent survival of mammary tumors, J. Cell Biol., 163, 1397, 10.1083/jcb.200302023

Zajaczkowski, 2003, Cell-matrix adhesions on poly(vinyl alcohol) hydrogels, Tissue Eng., 9, 525, 10.1089/107632703322066705

Zhong, 1997, Rho-stimulated contractility contributes to the fibroblastic phenotype of Ras-transformed epithelial cells, Mol. Biol. Cell, 8, 2329, 10.1091/mbc.8.11.2329