Techniques for the measurement of the local myocardial extraction efficiency for inert diffusible contrast agents such as gadopentate dimeglumine

Magnetic Resonance in Medicine - Tập 30 Số 3 - Trang 332-336 - 1993
Chun Tong1, Frank S. Prato2,1, Gerald Wisenberg3,2, Ting Y. Lee4, Edwin Carroll5, Daivid Sandler5, J. M. Wills2
1Department of Physics, Lawson Research Institute, St. Joseph's Health Centre, University of Western Ontario, London, Ontario, Canada
2Department of Nuclear Medicine and Magnetic Resonance, Lawson Research Institute, St. Joseph's Health Centre, University of Western Ontario, London, Ontario, Canada
3Department of Medicine, Lawson Research Institute, St. Joseph's Health Centre, University of Western Ontario, London, Ontario, Canada
4Department of Radiology, Lawson Research Institute, St. Joseph's Health Centre, University of Western Ontario, London, Ontario, Canada
5Department of Surgery, Lawson Research Institute, St. Joseph's Health Centre, University of Western Ontario, London, Ontario, Canada

Tóm tắt

AbstractWe have previously shown that the concentration of Gd‐DTPA as, a function of time ([Gd‐DTPA]t(t)) in the myocardium following an intravenous bolus injection of Gd‐DTPA can be moldered using the Modified Kety Equation. Fitting this model to measurements of [Gd‐DTPA]t(t) in a region of myocardium would allow the determination of myocardial distribution volume (λ) and the product of flow (F) and extraction efficiency (E), i.e., FE. Thus, to measure F,E must be known. We describe here techniques developed to measure local values of E in normal and diseased myocardium. These techniques are valid for any inert diffusible MR contrast agent.

Từ khóa


Tài liệu tham khảo

10.1002/mrm.1910230205

Kety S. S., 1951, Pharmacol. Rev., 3, 1

H. B. W.Larsson M.Stubgaard L.Søndergaard R.Wires‐tam P.Ring O.Henriksenand The Scandinavian Flow Group in “Proceedings 10th Annual Meeting Society of Magnetic Resonance in Medicine August 10–16 1991 San Francisco ” p.1145.

H. B. W.Larsson M.Stubgaard L.Sendergaard O.Henriksen in “Proceedings 11th Annual Meeting of the Society of Magnetic Resonance in Medicine August 8–14 1992 Berlin Germany” No. 1126.

10.1161/01.CIR.70.4.724

10.1161/01.RES.37.3.359

10.1161/01.RES.29.2.208

10.1161/01.CIR.63.6.1259

Tancredi R. G., 1975, Am. J Physiol., 229, 537, 10.1152/ajplegacy.1975.229.3.537

10.1113/jphysiol.1979.sp013043

10.1111/j.1748-1716.1963.tb02652.x

10.1111/j.1748-1716.1980.tb06549.x

Chinard F., 1955, Am. J. Physiol., 178, 197, 10.1152/ajplegacy.1954.178.2.197

Sorenson J. A., 1987, Physics in Nuclear Medicine

10.1002/mrm.1910300310

E. C. Y.Tong MSc. Thesis Physics University of Western Ontario July1991.

Chantler C., 1969, Clin. Sci., 37, 169

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Magnetic Resonance in Medicine

Tập 30 Số 3

332-336

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