TNFR1 and TNFR2 in the Control of the Life and Death Balance of Macrophages

Annibaldi, 2018, Checkpoints in TNF-induced cell death: implications in inflammation and cancer., Trends Mol. Med., 24, 49, 10.1016/j.molmed.2017.11.002

Balcewicz-Sablinska, 1999, Interleukin 10 produced by macrophages inoculated with Mycobacterium avium attenuates mycobacteria-induced apoptosis by reduction of TNF-alpha activity., J. Infect. Dis., 180, 1230, 10.1086/315011

Balcewicz-Sablinska, 1998, Pathogenic Mycobacterium tuberculosis evades apoptosis of host macrophages by release of TNF-R2, resulting in inactivation of TNF-alpha., J. Immunol., 161, 2636, 10.4049/jimmunol.161.5.2636

Banner, 1993, Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation., Cell, 73, 431, 10.1016/0092-8674(93)90132-a

Basu, 2007, Execution of macrophage apoptosis by PE_PGRS33 of Mycobacterium tuberculosis is mediated by Toll-like receptor 2-dependent release of tumor necrosis factor-alpha., J. Biol. Chem., 282, 1039, 10.1074/jbc.M604379200

Bermudez, 1999, Apoptosis of Mycobacterium avium-infected macrophages is mediated by both tumour necrosis factor (TNF) and Fas, and involves the activation of caspases., Clin. Exp. Immunol., 116, 94, 10.1046/j.1365-2249.1999.00852.x

Bhattacharyya, 2003, Execution of macrophage apoptosis by Mycobacterium avium through apoptosis signal-regulating kinase 1/p38 mitogen-activated protein kinase signaling and caspase 8 activation., J. Biol. Chem., 278, 26517, 10.1074/jbc.M300852200

Bodmer, 2002, The molecular architecture of the TNF superfamily., Trends Biochem. Sci., 27, 19, 10.1016/S0968-0004(01)01995-8

Borghi, 2018, The E3 ubiquitin ligases HOIP and cIAP1 are recruited to the TNFR2 signaling complex and mediate TNFR2-induced canonical NF-kappaB signaling., Biochem. Pharmacol., 153, 292, 10.1016/j.bcp.2018.01.039

Brenner, 2015, Regulation of tumour necrosis factor signalling: live or let die., Nat. Rev. Immunol., 15, 362, 10.1038/nri3834

Brown, 2004, Calcium and ROS-mediated activation of transcription factors and TNF-alpha cytokine gene expression in macrophages exposed to ultrafine particles., Am. J. Physiol. Lung Cell. Mol. Physiol., 286, L344, 10.1152/ajplung.00139.2003

Buchrieser, 2018, RIPK1 is a critical modulator of both tonic and TLR-responsive inflammatory and cell death pathways in human macrophage differentiation., Cell Death Dis., 9, 10.1038/s41419-018-1053-4

Centola, 2000, The gene for familial Mediterranean fever, MEFV, is expressed in early leukocyte development and is regulated in response to inflammatory mediators., Blood, 95, 3223, 10.1182/blood.V95.10.3223

Chan, 2000, A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling., Science, 288, 2351, 10.1126/science.288.5475.2351

Chanana, 2006, Tumour necrosis factor alpha mediated apoptosis in murine macrophages by Salmonella enterica serovar Typhi under oxidative stress., FEMS Immunol. Med. Microbiol., 47, 278, 10.1111/j.1574-695X.2006.00090.x

Chanana, 2007, Involvement of caspase-3, lipid peroxidation and TNF-alpha in causing apoptosis of macrophages by coordinately expressed Salmonella phenotype under stress conditions., Mol. Immunol., 44, 1551, 10.1016/j.molimm.2006.08.022

Chandel, 2000, Role of oxidants in NF-kappa B activation and TNF-alpha gene transcription induced by hypoxia and endotoxin., J. Immunol., 165, 1013, 10.4049/jimmunol.165.2.1013

Chauhan, 2018, BAX/BAK-induced apoptosis results in caspase-8-dependent IL-1beta maturation in macrophages., Cell Rep., 25, 2354, 10.1016/j.celrep.2018.10.087

Davies, 2005, TRAF6 is required for TRAF2-dependent CD40 signal transduction in nonhemopoietic cells., Mol. Cell. Biol., 25, 9806, 10.1128/mcb.25.22.9806-9819.2005

Devin, 2001, The alpha and beta subunits of IkappaB kinase (IKK) mediate TRAF2-dependent IKK recruitment to tumor necrosis factor (TNF) receptor 1 in response to TNF., Mol. Cell. Biol., 21, 3986, 10.1128/mcb.21.12.3986-3994.2001

Dondelinger, 2017, MK2 phosphorylation of RIPK1 regulates TNF-mediated cell death., Nat. Cell Biol., 19, 1237, 10.1038/ncb3608

Dondelinger, 2015, NF-kappaB-independent role of IKKalpha/IKKbeta in preventing RIPK1 kinase-dependent apoptotic and necroptotic cell death during TNF signaling., Mol. Cell, 60, 63, 10.1016/j.molcel.2015.07.032

Duckett, 1997, CD30-dependent degradation of TRAF2: implications for negative regulation of TRAF signaling and the control of cell survival., Genes Dev., 11, 2810, 10.1101/gad.11.21.2810

Dufour, 2011, The ribonucleotide reductase R1 subunits of herpes simplex virus types 1 and 2 protect cells against TNFalpha- and FasL-induced apoptosis by interacting with caspase-8., Apoptosis, 16, 256, 10.1007/s10495-010-0560-2

Ermolaeva, 2008, Function of TRADD in tumor necrosis factor receptor 1 signaling and in TRIF-dependent inflammatory responses., Nat. Immunol., 9, 1037, 10.1038/ni.1638

Fotin-Mleczek, 2002, Apoptotic crosstalk of TNF receptors: TNF-R2-induces depletion of TRAF2 and IAP proteins and accelerates TNF-R1-dependent activation of caspase-8., J. Cell Sci., 115, 2757, 10.1242/jcs.115.13.2757

Frank, 2019, Pyroptosis versus necroptosis: similarities, differences, and crosstalk., Cell Death Differ., 26, 99, 10.1038/s41418-018-0212-6

Fritsch, 2017, Role of ubiquitination and proteolysis in the regulation of pro- and anti-apoptotic TNF-R1 signaling., Biochim. Biophys. Acta Mol. Cell Res., 1864, 2138, 10.1016/j.bbamcr.2017.07.017

Fulda, 2016, Regulation of necroptosis signaling and cell death by reactive oxygen species., Biol. Chem., 397, 657, 10.1515/hsz-2016-0102

Fulda, 2001, Sensitization for death receptor- or drug-induced apoptosis by re-expression of caspase-8 through demethylation or gene transfer., Oncogene, 20, 5865, 10.1038/sj.onc.1204750

Fullsack, 2019, Redundant and receptor-specific activities of TRADD, RIPK1 and FADD in death receptor signaling., Cell Death Dis., 10, 10.1038/s41419-019-1396-5

Galve-de Rochemonteix, 1996, Tumor necrosis factor soluble receptor 75: the principal receptor form released by human alveolar macrophages and monocytes in the presence of interferon gamma., Am. J. Respir. Cell Mol. Biol., 14, 279, 10.1165/ajrcmb.14.3.8845179

Gehr, 1992, Both tumor necrosis factor receptor types mediate proliferative signals in human mononuclear cell activation., J. Immunol., 149, 911, 10.4049/jimmunol.149.3.911

Geng, 2017, Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis., Nat. Commun., 8, 10.1038/s41467-017-00406-w

Gossart, 1996, Reactive oxygen intermediates as regulators of TNF-alpha production in rat lung inflammation induced by silica., J. Immunol., 156, 1540, 10.4049/jimmunol.156.4.1540

Gregory, 2012, TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis., Nature, 488, 508, 10.1038/nature11307

Grotzer, 2000, Resistance to TRAIL-induced apoptosis in primitive neuroectodermal brain tumor cells correlates with a loss of caspase-8 expression., Oncogene, 19, 4604, 10.1038/sj.onc.1203816

He, 2017, Bacterial nucleotidyl cyclase inhibits the host innate immune response by suppressing TAK1 activation., Infect. Immun., 85, 10.1128/iai.00239-17

He, 2011, Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3-mediated pathway., Proc. Natl. Acad. Sci. U.S.A., 108, 20054, 10.1073/pnas.1116302108

Hopkins-Donaldson, 2003, Silencing of death receptor and caspase-8 expression in small cell lung carcinoma cell lines and tumors by DNA methylation., Cell Death Differ., 10, 356, 10.1038/sj.cdd.4401157

Ikushima, 2013, The IRF family transcription factors at the interface of innate and adaptive immune responses., Cold Spring Harb. Symp. Quant. Biol., 78, 105, 10.1101/sqb.2013.78.020321

Jaco, 2017, MK2 phosphorylates RIPK1 to prevent TNF-induced cell death., Mol. Cell, 66, 698, 10.1016/j.molcel.2017.05.003

Jamilloux, 2018, The pyrin inflammasome: from sensing RhoA GTPases-inhibiting toxins to triggering autoinflammatory syndromes., Pathog. Dis., 76, 10.1093/femspd/fty020

Jin, 2006, Distinct signaling pathways in TRAIL- versus tumor necrosis factor-induced apoptosis., Mol. Cell. Biol., 26, 8136, 10.1128/mcb.00257-06

Kaiser, 2013, Toll-like receptor 3-mediated necrosis via TRIF, RIP3, and MLKL., J. Biol. Chem., 288, 31268, 10.1074/jbc.M113.462341

Keane, 1997, Infection by Mycobacterium tuberculosis promotes human alveolar macrophage apoptosis., Infect. Immun., 65, 298, 10.1128/IAI.65.1.298-304.1997

Kearney, 2017, An inflammatory perspective on necroptosis., Mol. Cell, 65, 965, 10.1016/j.molcel.2017.02.024

Kono, 2000, NADPH oxidase-derived free radicals are key oxidants in alcohol-induced liver disease., J. Clin. Invest., 106, 867, 10.1172/jci9020

Kundu, 2009, A TNF- and c-Cbl-dependent FLIP(S)-degradation pathway and its function in Mycobacterium tuberculosis-induced macrophage apoptosis., Nat. Immunol., 10, 918, 10.1038/ni.1754

Lainez, 2004, Identification and characterization of a novel spliced variant that encodes human soluble tumor necrosis factor receptor 2., Int. Immunol., 16, 169, 10.1093/intimm/dxh014

Lawlor, 2017, XIAP loss triggers RIPK3- and caspase-8-driven IL-1beta activation and cell death as a consequence of TLR-MyD88-induced cIAP1-TRAF2 degradation., Cell Rep., 20, 668, 10.1016/j.celrep.2017.06.073

Lawlor, 2015, RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL., Nat. Commun., 6, 10.1038/ncomms7282

Legarda, 2016, CYLD proteolysis protects macrophages from TNF-mediated auto-necroptosis induced by LPS and licensed by type I IFN., Cell Rep., 15, 2449, 10.1016/j.celrep.2016.05.032

Lei, 2014, Enterovirus 71 3C inhibits cytokine expression through cleavage of the TAK1/TAB1/TAB2/TAB3 complex., J. Virol., 88, 9830, 10.1128/jvi.01425-14

Li, 2012, The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis., Cell, 150, 339, 10.1016/j.cell.2012.06.019

Li, 2002, TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2., Nature, 416, 345, 10.1038/416345a

Li, 2002, Ureaplasma urealyticum induces apoptosis in human lung epithelial cells and macrophages., Biol. Neonate, 82, 166, 10.1159/000063616

Li, 2018, Type I IFN operates pyroptosis and necroptosis during multidrug-resistant A. baumannii infection., Cell Death Differ., 25, 1304, 10.1038/s41418-017-0041-z

Locksley, 2001, The TNF and TNF receptor superfamilies: integrating mammalian biology., Cell, 104, 487, 10.1016/S0092-8674(01)00237-9

Man, 2017, Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases., Immunol. Rev., 277, 61, 10.1111/imr.12534

McComb, 2014, Type-I interferon signaling through ISGF3 complex is required for sustained Rip3 activation and necroptosis in macrophages., Proc. Natl. Acad. Sci. U.S.A., 111, E3206, 10.1073/pnas.1407068111

McComb, 2012, cIAP1 and cIAP2 limit macrophage necroptosis by inhibiting Rip1 and Rip3 activation., Cell Death Differ., 19, 1791, 10.1038/cdd.2012.59

McCormick, 2008, Control of apoptosis by human cytomegalovirus., Curr. Top. Microbiol. Immunol., 325, 281, 10.1007/978-3-540-77349-8_16

Medler, 2019, Tumor necrosis factor receptor-2 (TNFR2): an overview of an emerging drug target., Expert Opin. Ther. Targets, 23, 295, 10.1080/14728222.2019.1586886

Medvedev, 1996, Distinct roles of the two tumor necrosis factor (TNF) receptors in modulating TNF and lymphotoxin alpha effects., J. Biol. Chem., 271, 9778, 10.1074/jbc.271.16.9778

Menon, 2017, p38(MAPK)/MK2-dependent phosphorylation controls cytotoxic RIPK1 signalling in inflammation and infection., Nat. Cell Biol., 19, 1248, 10.1038/ncb3614

Mukai, 2010, Solution of the structure of the TNF-TNFR2 complex., Sci. Signal., 3, 10.1126/scisignal.2000954

Orning, 2018, Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death., Science, 362, 1064, 10.1126/science.aau2818

Pajuelo, 2018, NAD(+) depletion triggers macrophage necroptosis, a cell death pathway exploited by Mycobacterium tuberculosis., Cell Rep., 24, 429, 10.1016/j.celrep.2018.06.042

Pan, 2002, Etk/Bmx as a tumor necrosis factor receptor type 2-specific kinase: role in endothelial cell migration and angiogenesis., Mol. Cell. Biol., 22, 7512, 10.1074/jbc.M310678200

Park, 2007, The death domain superfamily in intracellular signaling of apoptosis and inflammation., Annu. Rev. Immunol., 25, 561, 10.1146/annurev.immunol.25.022106.141656

Park, 2000, A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction., Cell, 101, 777, 10.1016/S0092-8674(00)80889-2

Pathak, 2013, Helicobacter pylori protein JHP0290 binds to multiple cell types and induces macrophage apoptosis via tumor necrosis factor (TNF)-dependent and independent pathways., PLoS One, 8, 10.1371/journal.pone.0077872

Pauli, 1994, Control of tumor necrosis factor gene expression., Crit. Rev. Eukaryot. Gene Expr., 4, 323, 10.1615/critreveukargeneexpr.v4.i2-3.20

Peterson, 2016, Cell-extrinsic TNF collaborates with TRIF signaling to promote Yersinia-induced apoptosis., J. Immunol., 197, 4110, 10.4049/jimmunol.1601294

Philip, 2012, Cell death programs in Yersinia immunity and pathogenesis., Front. Cell. Infect. Microbiol., 2, 10.3389/fcimb.2012.00149

Philippe, 1993, Membrane expression and shedding of tumour necrosis factor receptors during activation of human blood monocytes: regulation by desferrioxamine., Immunology, 80, 300

Platnich, 2018, Shiga toxin/lipopolysaccharide activates caspase-4 and gasdermin D to trigger mitochondrial reactive oxygen species upstream of the NLRP3 inflammasome., Cell Rep., 25, 1525, 10.1016/j.celrep.2018.09.071

Pobezinskaya, 2008, The function of TRADD in signaling through tumor necrosis factor receptor 1 and TRIF-dependent Toll-like receptors., Nat. Immunol., 9, 1047, 10.1038/ni.1639

Rauert, 2010, Membrane tumor necrosis factor (TNF) induces p100 processing via TNF receptor-2 (TNFR2)., J. Biol. Chem., 285, 7394, 10.1074/jbc.M109.037341

Ray, 1992, Viral inhibition of inflammation: cowpox virus encodes an inhibitor of the interleukin-1 beta converting enzyme., Cell, 69, 597, 10.1016/0092-8674(92)90223-y

Roca, 2013, TNF dually mediates resistance and susceptibility to mycobacteria via mitochondrial reactive oxygen species., Cell, 153, 521, 10.1016/j.cell.2013.03.022

Rodrigues, 2013, Tumour necrosis factor receptors and apoptosis of alveolar macrophages during early infection with attenuated and virulent Mycobacterium bovis., Immunology, 139, 503, 10.1111/imm.12097

Rojas, 1999, TNF-alpha and IL-10 modulate the induction of apoptosis by virulent Mycobacterium tuberculosis in murine macrophages., J. Immunol., 162, 6122, 10.4049/jimmunol.162.10.6122

Rui, 2017, Disruption of MDA5-mediated innate immune responses by the 3C proteins of coxsackievirus A16, coxsackievirus A6, and enterovirus D68., J. Virol., 91, 10.1128/jvi.00546-17

Ruspi, 2014, TNFR2 increases the sensitivity of ligand-induced activation of the p38 MAPK and NF-kappaB pathways and signals TRAF2 protein degradation in macrophages., Cell. Signal., 26, 683, 10.1016/j.cellsig.2013.12.009

Saini, 2016, Mce4A protein of Mycobacterium tuberculosis induces pro inflammatory cytokine response leading to macrophage apoptosis in a TNF-alpha dependent manner., Microb. Pathog., 100, 43, 10.1016/j.micpath.2016.08.038

Saleh, 2017, Kinase activities of RIPK1 and RIPK3 can direct IFN-beta synthesis induced by lipopolysaccharide., J. Immunol., 198, 4435, 10.4049/jimmunol.1601717

Sarhan, 2018, Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection., Proc. Natl. Acad. Sci. U.S.A., 115, E10888, 10.1073/pnas.1809548115

Sharma, 2019, TNF/TNFR axis promotes pyrin inflammasome activation and distinctly modulates pyrin inflammasomopathy., J. Clin. Invest., 129, 150, 10.1172/jci121372

Shivapurkar, 2002, Differential inactivation of caspase-8 in lung cancers., Cancer Biol. Ther., 1, 65, 10.4161/cbt.1.1.45

Siegmund, 2016, Activation of TNFR2 sensitizes macrophages for TNFR1-mediated necroptosis., Cell Death Dis., 7, 10.1038/cddis.2016.285

So, 2013, Regulation of PI-3-kinase and akt signaling in T lymphocytes and other cells by TNFR family molecules., Front. Immunol., 4, 10.3389/fimmu.2013.00139

Sun, 2017, The non-canonical NF-kappaB pathway in immunity and inflammation., Nat. Rev. Immunol., 17, 545, 10.1038/nri.2017.52

Tartaglia, 1993, A novel domain within the 55 kd TNF receptor signals cell death., Cell, 74, 845, 10.1016/0092-8674(93)90464-2

Taylor, 1994, Interleukin-4 (IL-4) induces down-modulation and shedding of the p55 tumour necrosis factor receptor and inhibits TNF alpha’s effect on rheumatoid synovial fibroblasts., Rheumatol. Int., 14, 21, 10.1007/bf00302667

Teitz, 2000, Caspase 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN., Nat. Med., 6, 529, 10.1038/75007

Thapa, 2013, Interferon-induced RIP1/RIP3-mediated necrosis requires PKR and is licensed by FADD and caspases., Proc. Natl. Acad. Sci. U.S.A., 110, E3109, 10.1073/pnas.1301218110

Thoma, 1990, Identification of a 60-kD tumor necrosis factor (TNF) receptor as the major signal transducing component in TNF responses., J. Exp. Med., 172, 1019, 10.1084/jem.172.4.1019

Tschopp, 2010, NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production?, Nat. Rev. Immunol., 10, 210, 10.1038/nri2725

Vince, 2018, The mitochondrial apoptotic effectors BAX/BAK activate caspase-3 and -7 to trigger NLRP3 inflammasome and caspase-8 driven IL-1beta activation., Cell Rep., 25, 2339, 10.1016/j.celrep.2018.10.103

Wajant, 2003, Tumor necrosis factor signaling., Cell Death Differ., 10, 45, 10.1038/sj.cdd.4401189

Wajant, 2011, TNFR1-induced activation of the classical NF-kappaB pathway., FEBS J., 278, 862, 10.1111/j.1742-4658.2011.08015.x

Weng, 2014, Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death., Proc. Natl. Acad. Sci. U.S.A., 111, 7391, 10.1073/pnas.1403477111

Wicovsky, 2009, Tumor necrosis factor receptor-associated factor-1 enhances proinflammatory TNF receptor-2 signaling and modifies TNFR1-TNFR2 cooperation., Oncogene, 28, 1769, 10.1038/onc.2009.29

Wong, 2014, cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1- and RIPK3-dependent manner., Blood, 123, 2562, 10.1182/blood-2013-06-510743

Xaus, 2000, LPS induces apoptosis in macrophages mostly through the autocrine production of TNF-alpha., Blood, 95, 3823, 10.1182/blood.V95.12.3823.012k07_3823_3831

Xie, 2013, TRAF molecules in cell signaling and in human diseases., J. Mol. Signal., 8, 10.1186/1750-2187-8-7

Xu, 2001, Covalent inhibition revealed by the crystal structure of the caspase-8/p35 complex., Nature, 410, 494, 10.1038/35068604

Yabal, 2014, XIAP restricts TNF- and RIP3-dependent cell death and inflammasome activation., Cell Rep., 7, 1796, 10.1016/j.celrep.2014.05.008

Yarilina, 2008, TNF activates an IRF1-dependent autocrine loop leading to sustained expression of chemokines and STAT1-dependent type I interferon-response genes., Nat. Immunol., 9, 378, 10.1038/ni1576

Zheng, 2006, Competitive control of independent programs of tumor necrosis factor receptor-induced cell death by TRADD and RIP1., Mol. Cell. Biol., 26, 3505, 10.1128/mcb.26.9.3505-3513.2006

Zhou, 1997, Target protease specificity of the viral serpin CrmA. Analysis of five caspases., J. Biol. Chem., 272, 7797, 10.1074/jbc.272.12.7797

Zhou, 2013, A Vibrio parahaemolyticus T3SS effector mediates pathogenesis by independently enabling intestinal colonization and inhibiting TAK1 activation., Cell Rep., 3, 1690, 10.1016/j.celrep.2013.03.039

Zhu, 2016, Protein kinase D2 contributes to TNF-alpha-induced epithelial mesenchymal transition and invasion via the PI3K/GSK-3beta/beta-catenin pathway in hepatocellular carcinoma., Oncotarget, 7, 5327, 10.18632/oncotarget.6633