THE MUTAGENIC ACTIVITY OF 61 AGENTS AS DETERMINED BY THE MICRONUCLEUS, SALMONELLA, AND SPERM ABNORMALITY ASSAYS

Canadian Science Publishing - Tập 21 Số 3 - Trang 319-333 - 1979
W. Robert Bruce, John A. Heddle

Tóm tắt

A comparison of two rapid and inexpensive in vivo mammalian assays and the Ames Salmonella assay is presented for 61 agents; Acetylsalicylic acid; Acriflavine; Actinomycin D; 2(2-furyl)-3-(5-nitro-2-furyl)acrylamide (AF-2); Aflatoxin B1; 2-aminofluorene; Aminopterin; Aroclor 1254; Ascorbic acid; Azathioprine; Benzo(a)pyrene; 5-Bromo-2'-deoxyuridine; Busulphan; Butylated hydroxytoluene; Cadmium chloride; Caffeine; Calcium cyclamate; Chloral hydrate; Chloromycetin succinate; Codeine phosphate; Colchicine; Cycloheximide; Cyclophosphamide; DDT; 2,4-Diaminoanisole; Dibutylnitrosamine; 9,10 Dimethyl-1,2-benzanthracene; 1,1 Dimethylhydrazine; Dimethylnitrosamine; Epinephrine; Ethyl methane sulphonate (EMS); 2-formylamino-4-(5-nitro-2-furyl)thiazole (FANFT); 2-(2-formylhydrazino)-4-(5-nitro-2-furyl)thiazole (FNT); Glucose; Griseofulvin; Hycanthone methane sulphonate; Hydroxyurea; 5-Iodo-2'-deoxyuridine; Lead acetate; Mechlorethamine; 3-Methylcholanthrene; Methyl mercury acetate; Methyl methane sulfonate (MMS); N-methyl-N-nitro-N'-nitrosoguanidine; Mitomycin C; Monosodium glutamate; 1-Naphthalamine; 2-Naphthalamine; Nitrofurazone; 4-Nitro-O-phenylene diamine; 4-Nitro-quinoline-1-oxide (4-NQO); Phenobarbitone; Procarbazine; Quinacrine dihydrochloride; Radiation (γ-rays); Sodium chloride; Triethylene thiophosphoramide; Trimethyl phosphate; Tris(2-methyl-1-arizidinyl) phosphine oxide; Urethan; Vinblastine. The results support the concept of multiple assays for mutagenicity and show that some combinations of assays are superior to others.

Từ khóa


Tài liệu tham khảo

Bder I. D., 1969, Mumangenetik, 7, 137

Ames B. N., 1975, Roc. Natl. Acad. Sci. U.S.A., 72, 2423, 10.1073/pnas.72.6.2423

Bmce W. R., 1974, Mutat. Wes., 23, 382

Clark J ., 1974, Aust. S. Biol. Sci., 27, 427, 10.1071/BI9740427

Clruk M., 1975, Mutat. Res., 28, 87, 10.1016/0027-5107(75)90318-8

Croft W. A., 1973, J. Natl. Cancer Inst., 91, 941, 10.1093/jnci/51.3.941

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Thông tin xuất bản

Canadian Science Publishing

Tập 21 Số 3

319-333

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