THE GENETICS OF <i>CAENORHABDITIS ELEGANS</i>

Genetics - Tập 77 Số 1 - Trang 71-94 - 1974
Sydney Brenner1
1Medical Research Council Laboratory of Molecular Biology Hills Road, Cambridge CB2 2QH, England

Tóm tắt

ABSTRACT Methods are described for the isolation, complementation and mapping of mutants of Caenorhabditis elegans, a small free-living nematode worm. About 300 EMS-induced mutants affecting behavior and morphology have been characterized and about one hundred genes have been defined. Mutations in 77 of these alter the movement of the animal. Estimates of the induced mutation frequency of both the visible mutants and X chromosome lethals suggests that, just as in Drosophila, the genetic units in C.elegans are large.

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