TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells

Nature - Tập 554 Số 7693 - Trang 544-548 - 2018
Sanjeev Mariathasan1, Shannon J. Turley1, Dorothee Nickles1, Alessandra Castiglioni1, Kobe Yuen1, Yulei Wang1, Edward E. Kadel1, Hartmut Koeppen1, Jillian L. Astarita1, Rafael Cubas1, Suchit Jhunjhunwala1, Romain Banchereau1, Yagai Yang1, Yinghui Guan1, Cécile Chalouni1, James Ziai1, Yasin Şenbabaoğlu1, Stephen P. Santoro1, Daniel Sheinson1, Jeffrey Hung1, Jennifer M. Giltnane1, Andrew A. Pierce1, Kathryn Mesh1, Steve Lianoglou1, Johannes Riegler1, Richard A.D. Carano1, Pontus Eriksson2, Mattias Höglund2, Loan Somarriba3, Daniel L. Halligan3, Michiel S. van der Heijden4, Yohann Loriot5, Jonathan E. Rosenberg6, Lawrence Fong7, Ira Mellman1, Daniel S. Chen1, Marjorie Green1, Christina Louise Derleth1, Gregg Fine1, Priti S. Hegde1, Richard Bourgon1, Thomas Powles8
1Genentech, South San Francisco, California 94080, USA
2Division of Oncology and Pathology, Department of Clinical Sciences Lund, Lund University, Lund, 223 81, Skåne, Sweden
3Fios Genomics, Edinburgh, EH16 4UX, UK
4Netherlands Cancer Institute, Amsterdam 1066 CX, The Netherlands
5Department of Cancer Medicine, Institut Gustave Roussy, University of Paris Sud, Villejuif 94800, France
6Department of Medicine, Genitourinary Oncology Service, Memorial Sloan Kettering Cancer Center, New York, 10065, New York, USA
7University of California San Francisco, Helen Diller Family Comprehensive Cancer Center, San Francisco, 94158, California, USA
8Barts Experimental Cancer Medicine Centre, Barts Cancer Institute, Queen Mary University of London, London, EC1M 6BQ, UK

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