T cell responses in experimental viral retinitis: Mechanisms, peculiarities and implications for gene therapy with viral vectors
Tài liệu tham khảo
Abi-Hanna, 1988, HLA antigens in ocular tissues. I. In vivo expression in human eyes, Transplantation, 45, 610, 10.1097/00007890-198803000-00021
Aichele, 1995, T cell priming versus T cell tolerance induced by synthetic peptides, J. Exp. Med., 182, 261, 10.1084/jem.182.1.261
Atherton, 1991, Retinitis in euthymic mice following inoculation of murine cytomegalovirus (MCMV) via the supraciliary route, Curr. Eye Res., 10, 667, 10.3109/02713689109013858
Atherton, 1992, T cell depletion increases susceptibility to murine cytomegalovirus retinitis, Invest. Ophthalmol. Vis. Sci., 33, 3353
Bainbridge, 2008, Effect of gene therapy on visual function in Leber’s congenital amaurosis, N. Engl. J. Med., 358, 2231, 10.1056/NEJMoa0802268
Barker, 1967, The role of regional lymphatics in the skin homograft response, Transplantation, 5, 962, 10.1097/00007890-196707001-00026
Barton, 2000, Lymphocytic choriomeningitis virus: reemerging central nervous system pathogen, Pediatrics, 105, E35, 10.1542/peds.105.3.e35
Barton, 2001, Congenital lymphocytic choriomeningitis virus infection: decade of rediscovery, Clin. Infect. Dis., 33, 370, 10.1086/321897
Bevan, 1996, Investigation of murine cytomegalovirus latency and reactivation in mice using viral mutants and the polymerase chain reaction, J. Med. Virol., 48, 308, 10.1002/(SICI)1096-9071(199604)48:4<308::AID-JMV3>3.0.CO;2-B
Bigger, 1998, NK cell modulation of murine cytomegalovirus retinitis, J. Immunol., 160, 5826, 10.4049/jimmunol.160.12.5826
Buchmeier, 1980, The virology and immunobiology of lymphocytic choriomeningitis virus infection, Adv. Immunol., 30, 275, 10.1016/S0065-2776(08)60197-2
Camelo, 2006, Antigen from the anterior chamber of the eye travels in a soluble form to secondary lymphoid organs via lymphatic and vascular routes, Invest. Ophthalmol. Vis. Sci., 47, 1039, 10.1167/iovs.05-1041
Camelo, 2004, The distribution of antigen in lymphoid tissues following its injection into the anterior chamber of the rat eye, J. Immunol., 172, 5388, 10.4049/jimmunol.172.9.5388
Caspi, 2006, Ocular autoimmunity: the price of privilege?, Immunol. Rev., 213, 23, 10.1111/j.1600-065X.2006.00439.x
Chiba, 1998, FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. I. FTY720 selectively decreases the number of circulating mature lymphocytes by acceleration of lymphocyte homing, J. Immunol., 160, 5037, 10.4049/jimmunol.160.10.5037
Chirmule, 1999, Immune responses to adenovirus and adeno-associated virus in humans, Gene Ther., 6, 1574, 10.1038/sj.gt.3300994
Coats, 2000, Ophthalmologic findings in children with congenital cytomegalovirus infection, J. AAPOS, 4, 110
Collins, 1993, Detection of latent cytomegalovirus DNA in diverse organs of mice, J. Infect. Dis., 168, 725, 10.1093/infdis/168.3.725
Copland, 2007, Monoclonal antibody-mediated CD200 receptor signaling suppresses macrophage activation and tissue damage in experimental autoimmune uveoretinitis, Am. J. Pathol., 171, 580, 10.2353/ajpath.2007.070272
Cousins, 1991, Immune privilege and suppression of immunogenic inflammation in the anterior chamber of the eye, Curr. Eye Res., 10, 287, 10.3109/02713689108996334
Crawford, 1987, Effects of topical PGF2 alpha on aqueous humor dynamics in cynomolgus monkeys, Curr. Eye Res., 6, 1035, 10.3109/02713688709034874
Critchfield, 1994, T cell deletion in high antigen dose therapy of autoimmune encephalomyelitis, Science, 263, 1139, 10.1126/science.7509084
Culbertson, 1986, Varicella zoster virus is a cause of the acute retinal necrosis syndrome, Ophthalmology, 93, 559, 10.1016/S0161-6420(86)33701-1
Cunningham, 1998, Ocular manifestations of HIV infection, N. Engl. J. Med., 339, 236, 10.1056/NEJM199807233390406
Davies, 2006, Microglia and macrophages are increased in response to ischemia-induced retinopathy in the mouse retina, Mol. Vis., 12, 467
Duan, 1994, Dissemination and replication of MCMV after supraciliary inoculation in immunosuppressed BALB/c mice, Invest. Ophthalmol. Vis. Sci., 35, 1124
Dullforce, 2004, APCs in the anterior uveal tract do not migrate to draining lymph nodes, J. Immunol., 172, 6701, 10.4049/jimmunol.172.11.6701
Ecoiffier, 2010, Differential distribution of blood and lymphatic vessels in the murine cornea, Invest. Ophthalmol. Vis. Sci., 51, 2436, 10.1167/iovs.09-4505
Egan, 1996, Peptide-specific T cell clonal expansion in vivo following immunization in the eye, an immune-privileged site, J. Immunol., 157, 2262, 10.4049/jimmunol.157.6.2262
Erles, 1999, Update on the prevalence of serum antibodies (IgG and IgM) to adeno-associated virus (AAV), J. Med. Virol., 59, 406, 10.1002/(SICI)1096-9071(199911)59:3<406::AID-JMV22>3.0.CO;2-N
Fabriek, 2005
Faunce, 2002, NKT cell-derived RANTES recruits APCs and CD8+ T cells to the spleen during the generation of regulatory T cells in tolerance, J. Immunol., 169, 31, 10.4049/jimmunol.169.1.31
Ford, 1995, Normal adult ramified microglia separated from other central nervous system macrophages by flow cytometric sorting. Phenotypic differences defined and direct ex vivo antigen presentation to myelin basic protein-reactive CD4+ T cells compared, J. Immunol., 154, 4309, 10.4049/jimmunol.154.9.4309
Forrester, 2009, Privilege revisited: an evaluation of the eye’s defence mechanisms, Eye (Lond), 23, 756, 10.1038/eye.2008.259
Forrester, 1998, Marrow-derived activated macrophages are required during the effector phase of experimental autoimmune uveoretinitis in rats, Curr. Eye Res., 17, 426, 10.1080/02713689808951224
Forrester, 1993, Dendritic cells and "dendritic" macrophages in the uveal tract, Adv. Exp. Med. Biol., 329, 599, 10.1007/978-1-4615-2930-9_100
Forrester, 2010, Dendritic cell physiology and function in the eye, Immunol. Rev., 234, 282, 10.1111/j.0105-2896.2009.00873.x
Gabelt, 2005, Changes in aqueous humor dynamics with age and glaucoma, Prog. Retin. Eye Res., 24, 612, 10.1016/j.preteyeres.2004.10.003
Gallant, 1992, Incidence and natural history of cytomegalovirus disease in patients with advanced human immunodeficiency virus disease treated with zidovudine. The Zidovudine Epidemiology Study Group, J. Infect. Dis., 166, 1223, 10.1093/infdis/166.6.1223
Gallimore, 1998, Induction and exhaustion of lymphocytic choriomeningitis virus-specific cytotoxic T lymphocytes visualized using soluble tetrameric major histocompatibility complex class I-peptide complexes, J. Exp. Med., 187, 1383, 10.1084/jem.187.9.1383
Garg, 2005, Systemic and intraocular manifestations of West Nile virus infection, Surv. Ophthalmol., 50, 3, 10.1016/j.survophthal.2004.10.001
Grajewski, 2006, Endogenous IRBP can be dispensable for generation of natural CD4+CD25+ regulatory T cells that protect from IRBP-induced retinal autoimmunity, J. Exp. Med., 203, 851, 10.1084/jem.20050429
Gregerson, 2008, Evidence for extrathymic generation of regulatory T cells specific for a retinal antigen, Ophthalmic Res., 40, 154, 10.1159/000119868
Gregerson, 2006, RPE cells resist bystander killing by CTLs, but are highly susceptible to antigen-dependent CTL killing, Invest. Ophthalmol. Vis. Sci., 47, 5385, 10.1167/iovs.06-0636
Gregerson, 2003, CD45-positive cells of the retina and their responsiveness to in vivo and in vitro treatment with IFN-gamma or anti-CD40, Invest. Ophthalmol. Vis. Sci., 44, 3083, 10.1167/iovs.02-1014
Greter, 2005, Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis, Nat. Med., 11, 328, 10.1038/nm1197
Hickey, 1999, Leukocyte traffic in the central nervous system: the participants and their roles, Semin. Immunol., 11, 125, 10.1006/smim.1999.0168
Hoffman, 1997, Cell-mediated immune response and stability of intraocular transgene expression after adenovirus-mediated delivery, Invest. Ophthalmol. Vis. Sci., 38, 2224
Holtappels, 2008, Subdominant CD8 T-cell epitopes account for protection against cytomegalovirus independent of immunodomination, J. Virol., 82, 5781, 10.1128/JVI.00155-08
Hoover, 1996, Occurrence of cytomegalovirus retinitis after human immunodeficiency virus immunosuppression, Arch. Ophthalmol., 114, 821, 10.1001/archopht.1996.01100140035004
Jabs, 2010, Course of cytomegalovirus retinitis in the era of highly active antiretroviral therapy: five-year outcomes, Ophthalmology, 117, 10.1016/j.ophtha.2010.03.031
Jabs, 2010, "Mortality associated with resistant cytomegalovirus among patients with cytomegalovirus retinitis and AIDS.", Ophthalmology, 117, 128, 10.1016/j.ophtha.2009.06.016
Jabs, 2007, Longitudinal study of the ocular complications of AIDS: 1. Ocular diagnoses at enrollment, Ophthalmology, 114, 780, 10.1016/j.ophtha.2006.11.008
Jacobson, 2000, Natural history and outcome of new AIDS-related cytomegalovirus retinitis diagnosed in the era of highly active antiretroviral therapy, Clin. Infect. Dis., 30, 231, 10.1086/313612
Jamieson, 2006, Lymphocytic choriomeningitis virus: an emerging obstetric pathogen?, Am. J. Obstet. Gynecol., 194, 1532, 10.1016/j.ajog.2005.11.040
Jiang, 2006, Sialoadhesin promotes the inflammatory response in experimental autoimmune uveoretinitis, J. Immunol., 177, 2258, 10.4049/jimmunol.177.4.2258
Joly, 2009, Cooperative phagocytes: resident microglia and bone marrow immigrants remove dead photoreceptors in retinal lesions, Am. J. Pathol., 174, 2310, 10.2353/ajpath.2009.090023
Jooss, 2003, Immunity to adenovirus and adeno-associated viral vectors: implications for gene therapy, Gene Ther., 10, 955, 10.1038/sj.gt.3302037
Kallio-Kokko, 2006, Hantavirus and arenavirus antibody prevalence in rodents and humans in Trentino, Northern Italy, Epidemiol. Infect., 134, 830, 10.1017/S0950268805005431
Kercher, 2000, Immune transfer protects severely immunosuppressed mice from murine cytomegalovirus retinitis and reduces the viral load in ocular tissue, J. Infect. Dis., 182, 652, 10.1086/315781
Kerr, 2008, The dynamics of leukocyte infiltration in experimental autoimmune uveoretinitis, Prog. Retin. Eye Res., 27, 527, 10.1016/j.preteyeres.2008.07.001
Lassmann, 1993, Bone marrow derived elements and resident microglia in brain inflammation, Glia, 7, 19, 10.1002/glia.440070106
Lauterbach, 2006, Adoptive immunotherapy induces CNS dendritic cell recruitment and antigen presentation during clearance of a persistent viral infection, J. Exp. Med., 203, 1963, 10.1084/jem.20060039
Lee, 2008, Ex vivo dynamic imaging of retinal microglia using time-lapse confocal microscopy, Invest. Ophthalmol. Vis. Sci., 49, 4169, 10.1167/iovs.08-2076
Li, 2008, Intraocular route of AAV2 vector administration defines humoral immune response and therapeutic potential, Mol. Vis., 14, 1760
Lin, 2007, Recombinant adeno-associated virus vectors induce functionally impaired transgene product-specific CD8+ T cells in mice, J. Clin. Invest., 117, 3958
Lindsey, 2002, Identification of the mouse uveoscleral outflow pathway using fluorescent dextran, Invest. Ophthalmol. Vis. Sci., 43, 2201
Maguire, 2008, Safety and efficacy of gene transfer for Leber’s congenital amaurosis, N. Engl. J. Med., 358, 2240, 10.1056/NEJMoa0802315
Mahendradas, 2008, Ocular manifestations associated with chikungunya, Ophthalmology, 115, 287, 10.1016/j.ophtha.2007.03.085
Marrie, 1998, Seroprevalence of lymphocytic choriomeningitis virus in Nova Scotia, Am. J. Trop. Med. Hyg., 58, 47, 10.4269/ajtmh.1998.58.47
Masli, 2002, Expression of thrombospondin in TGFbeta-treated APCs and its relevance to their immune deviation-promoting properties, J. Immunol., 168, 2264, 10.4049/jimmunol.168.5.2264
McGavern, 2002, T cells in the central nervous system: the delicate balance between viral clearance and disease, J. Infect. Dis., 186, S145, 10.1086/344264
McMahon, 2005, Epitope spreading initiates in the CNS in two mouse models of multiple sclerosis, Nat. Med., 11, 335, 10.1038/nm1202
McMenamin, 1997, The distribution of immune cells in the uveal tract of the normal eye, Eye (Lond), 11, 183, 10.1038/eye.1997.49
McMenamin, 1994, Immunomorphologic studies of macrophages and MHC class II-positive dendritic cells in the iris and ciliary body of the rat, mouse, and human eye, Invest. Ophthalmol. Vis. Sci., 35, 3234
McMenamin, 2001
McMenamin, 1992, Class II major histocompatibility complex (Ia) antigenbearing dendritic cells within the iris and ciliary body of the rat eye: distribution, phenotype and relation to retinal microglia, Immunology, 77, 385
Medawar, 1948, Immunity to homologous grafted skin; the fate of skin homografts transplanted to the brain, to subcutaneous tissue, and to the anterior chamber of the eye, Br. J. Exp. Pathol., 29, 58
Mets, 2000, Lymphocytic choriomeningitis virus: an underdiagnosed cause of congenital chorioretinitis, Am. J. Ophthalmol., 130, 209, 10.1016/S0002-9394(00)00570-5
Michaels, 1998, Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection, N. Engl. J. Med., 339, 405, 10.1056/NEJM199808063390612
Mingozzi, 2007, CD8(+) T-cell responses to adeno-associated virus capsid in humans, Nat. Med., 13, 419, 10.1038/nm1549
Moskophidis, 1993, Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells, Nature, 362, 758, 10.1038/362758a0
Munks, 2006, Genome-wide analysis reveals a highly diverse CD8 T cell response to murine cytomegalovirus, J. Immunol., 176, 3760, 10.4049/jimmunol.176.6.3760
Nimmerjahn, 2005, Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo, Science, 308, 1314, 10.1126/science.1110647
Park, 1997, Subacute sclerosing panencephalitis manifesting as viral retinitis: clinical and histopathologic findings, Am. J. Ophthalmol., 123, 533, 10.1016/S0002-9394(14)70179-5
Peden, 2004, Circulating anti-wild-type adeno-associated virus type 2 (AAV2) antibodies inhibit recombinant AAV2 (rAAV2)-mediated, but not rAAV5-mediated, gene transfer in the brain, J. Virol., 78, 6344, 10.1128/JVI.78.12.6344-6359.2004
Prendergast, 1998, T cell traffic and the inflammatory response in experimental autoimmune uveoretinitis, Invest. Ophthalmol. Vis. Sci., 39, 754
Rao, 2003, Pathogenic role of retinal microglia in experimental uveoretinitis, Invest. Ophthalmol. Vis. Sci., 44, 22, 10.1167/iovs.02-0199
Raveney, 2008, Fingolimod (FTY720) as an acute rescue therapy for intraocular inflammatory disease, Arch. Ophthalmol., 126, 1390, 10.1001/archopht.126.10.1390
Raymond, 1987, Punctate outer retinitis in acute Epstein-Barr virus infection, Am. J. Ophthalmol., 104, 424, 10.1016/0002-9394(87)90236-4
Reichel, 1998, Immune responses limit adenovirally mediated gene expression in the adult mouse eye, Gene Ther., 5, 1038, 10.1038/sj.gt.3300691
Richards, 2010, Virus expanded regulatory T cells control disease severity in the Theiler’s virus mouse model of MS, J. Autoimmun., 36, 142, 10.1016/j.jaut.2010.12.005
Robbins, 1990, Retinopathy following intravitreal injection of mice with MHV strain JHM, Adv. Exp. Med. Biol., 276, 519, 10.1007/978-1-4684-5823-7_72
Skelsey, 2003, CD25+, interleukin-10-producing CD4+ T cells are required for suppressor cell production and immune privilege in the anterior chamber of the eye, Immunology, 110, 18, 10.1046/j.1365-2567.2003.01676.x
Staras, 2006, Seroprevalence of cytomegalovirus infection in the United States, 1988-1994, Clin. Infect. Dis., 43, 1143, 10.1086/508173
Steptoe, 1995, Functional studies of major histocompatibility class II-positive dendritic cells and resident tissue macrophages isolated from the rat iris, Immunology, 85, 630
Streilein, 1990, Anterior chamber associated immune deviation: the privilege of immunity in the eye, Surv. Ophthalmol., 35, 67, 10.1016/0039-6257(90)90048-Z
Streilein, 1999, Immunoregulatory mechanisms of the eye, Prog. Retin. Eye Res., 18, 357, 10.1016/S1350-9462(98)00022-6
Streilein, 2003, Ocular immune privilege: the eye takes a dim but practical view of immunity and inflammation, J. Leukoc. Biol., 74, 179, 10.1189/jlb.1102574
Streilein, 2002, The eye’s view of antigen presentation, Hum. Immunol., 63, 435, 10.1016/S0198-8859(02)00393-2
Streit, 2000, Microglial response to brain injury: a brief synopsis, Toxicol. Pathol., 28, 28, 10.1177/019262330002800104
Taylor-Wiedeman, 1991, Monocytes are a major site of persistence of human cytomegalovirus in peripheral blood mononuclear cells, J. Gen. Virol., 72, 2059, 10.1099/0022-1317-72-9-2059
Taylor, 2007, Ocular immunosuppressive microenvironment, Chem. Immunol. Allergy, 92, 71, 10.1159/000099255
Toris, 1987, Aqueous humor dynamics in experimental iridocyclitis, Invest. Ophthalmol. Vis. Sci., 28, 477
Vandenberghe, 2006, Heparin binding directs activation of T cells against adeno-associated virus serotype 2 capsid, Nat. Med., 12, 967, 10.1038/nm1445
Webb, 1990, Extrathymic tolerance of mature T cells: clonal elimination as a consequence of immunity, Cell, 63, 1249, 10.1016/0092-8674(90)90420-J
Weinreb, 2000, Uveoscleral outflow: the other outflow pathway, J. Glaucoma, 9, 343, 10.1097/00061198-200010000-00001
Weller, 1996, Lymphocyte targeting of the central nervous system: a review of afferent and efferent CNS-immune pathways, Brain Pathol., 6, 275, 10.1111/j.1750-3639.1996.tb00855.x
Wisniewski, 1991, Structural and functional aspects of the interaction of inflammatory cells with the blood-brain barrier in experimental brain inflammation, Brain Pathol., 1, 89, 10.1111/j.1750-3639.1991.tb00645.x
Wong, 2001, Anti-inflammatory antioxidants attenuate the expression of inducible nitric oxide synthase mediated by advanced glycation endproducts in murine microglia, Eur. J. Neurosci., 14, 1961, 10.1046/j.0953-816x.2001.01820.x
Xu, 2007, Turnover of resident retinal microglia in the normal adult mouse, Glia, 55, 1189, 10.1002/glia.20535
Xu, 2007, Identification of novel dendritic cell populations in normal mouse retina, Invest. Ophthalmol. Vis. Sci., 48, 1701, 10.1167/iovs.06-0697
Xu, 2003, Leukocyte trafficking in experimental autoimmune uveitis: breakdown of blood-retinal barrier and upregulation of cellular adhesion molecules, Invest. Ophthalmol. Vis. Sci., 44, 226, 10.1167/iovs.01-1202
Xu, 2004, Reduction in shear stress, activation of the endothelium, and leukocyte priming are all required for leukocyte passage across the blood–retina barrier, J. Leukoc. Biol., 75, 224, 10.1189/jlb.1002479
Xu, 2003, Requirements for passage of T lymphocytes across noninflamed retinal microvessels, J. Neuroimmunol, 142, 47, 10.1016/S0165-5728(03)00258-3
Xu, 2002, Gammadelta T cells in anterior chamber-induced tolerance in CD8(+) CTL responses, Invest. Ophthalmol. Vis. Sci., 43, 3473
Yoser, 1993, Systemic viral infections and their retinal and choroidal manifestations, Surv. Ophthalmol., 37, 313, 10.1016/0039-6257(93)90064-E
Yucel, 2009, Identification of lymphatics in the ciliary body of the human eye: a novel "uveolymphatic" outflow pathway, Exp. Eye Res., 89, 810, 10.1016/j.exer.2009.08.010
Zierhut, 1998, Mucosal immunology and the eye, Immunol. Today, 19, 148, 10.1016/S0167-5699(97)01229-2
Zinkernagel, 2009, Immunopathological basis of lymphocytic choriomeningitis virus-induced chorioretinitis and keratitis, J. Virol., 83, 159, 10.1128/JVI.01211-08
Zinkernagel, M.S., C. Petitjean, et al. Kinetics of ocular and systemic antigen-specific T cell responses elicited during murine cytomegalovirus retinitis. Immunol. Cell Biol., in press, doi:10.1038/icb.2011.43.
Zinkernagel, 1996, Immunology taught by viruses, Science, 271, 173, 10.1126/science.271.5246.173