T cell costimulation blockade promotes transplantation tolerance in combination with sirolimus and post-transplantation cyclophosphamide for haploidentical transplantation in children with severe aplastic anemia

Transplant Immunology - Tập 43-44 - Trang 54-59 - 2017
Sarita Rani Jaiswal1,2, Prakash Bhakuni1, Shamsuz Zaman1, Satish Bansal1, Priyanka Bharadwaj1, Sneh Bhargava1, Suparno Chakrabarti1,2
1Department of Blood and Marrow Transplantation, Dharamshila Narayana Superspeciality Hospital and Research Centre, New Delhi, India
2Manashi Chakrabarti Foundation, Kolkata, India

Tóm tắt

Từ khóa


Tài liệu tham khảo

Georges, 2016, Hematopoietic stem cell transplantation for acquired aplastic anemia, Curr.Opin.Hematol., 23, 495, 10.1097/MOH.0000000000000281

Clay, 2014, Nonmyeloablative peripheral blood haploidentical stem cell transplantation for refractory severe aplastic anemia, Biol. Blood Marrow Transplant., 20, 1711, 10.1016/j.bbmt.2014.06.028

Esteves, 2015, Haploidentical BMT and post-transplant Cy for severe aplastic anemia: a multicenter retrospective study, Bone Marrow Transplant., 50, 685, 10.1038/bmt.2015.20

Jaiswal, 2015, Pre-transplant sirolimus might improve the outcome of haploidentical peripheral blood stem cell transplantation with post-transplant cyclophosphamide for patients with severe aplastic anemia, Bone Marrow Transplant., 50, 873, 10.1038/bmt.2015.50

Jaiswal, 2015, Hemophagocytic syndrome following haploidentical peripheral blood stem cell transplantation with post-transplant cyclophosphamide, Int. J. Hematol., 103, 234, 10.1007/s12185-015-1905-y

Jaiswal, 2016, Haploidentical transplantation in children with unmanipulated peripheral blood stem cell graft: The need to look beyond post-transplantation cyclophosphamide in younger children, Pediatr. Transplant., 20, 675, 10.1111/petr.12724

Blazar, 1994, In vivo blockade of CD28/CTLA4: B7/BB1 interaction with CTLA4-Ig reduces lethal murine graft-versus-host disease across the major histocompatibility complex barrier in mice, Blood, 83, 3815, 10.1182/blood.V83.12.3815.3815

Guinan, 1999, Transplantation of anergic histoincompatible bone marrow allografts, N. Engl. J. Med., 340, 1704, 10.1056/NEJM199906033402202

Koura, 2013, In vivo T cell costimulation blockade with abatacept for acute graft-versus-host disease prevention: a first-in-disease trial, Biol. Blood Marrow Transplant., 19, 1638, 10.1016/j.bbmt.2013.09.003

Jaiswal, 2016, T cell costimulation blockade for hyperacute steroid refractory graft versus-host disease in children undergoing haploidentical transplantation, Transpl. Immunol., 39, 46, 10.1016/j.trim.2016.08.009

de Graav, 2016, Down-regulation of surface CD28 under belatacept treatment: an escape mechanism for antigen-reactive T-cells, PLoS One, 11, 10.1371/journal.pone.0148604

Kanakry, 2013, Aldehyde dehydrogenase expression drives human regulatory T cell resistance to posttransplantation cyclophosphamide, Sci. Transl. Med., 5, 211ra157, 10.1126/scitranslmed.3006960

Lo, 2013, Belatacept and sirolimus prolong nonhuman primate renal allograft survival without a requirement for memory T cell depletion, Am. J. Transplant., 13, 320, 10.1111/j.1600-6143.2012.04342.x

Jaiswal, 2017, Cytotherapy, 19, 531, 10.1016/j.jcyt.2016.12.006

Pilat, 2011, Costimulatory pathways in transplantation, Semin. Immunol., 23, 293, 10.1016/j.smim.2011.04.002

Snanoudj, 2006, Costimulation blockade and its possible future use in clinical transplantation, Transpl. Int., 19, 693, 10.1111/j.1432-2277.2006.00332.x

Yamada, 2002, The CD154-CD40 costimulatory pathway in transplantation, Transplantation, 73, S36, 10.1097/00007890-200201151-00012

Storb, 1999, Stable mixed hematopoietic chimerism in dogs given donor antigen, CTLA4Ig, and 100 cGy total body irradiation before and pharmacologic immunosuppression after marrow transplant, Blood, 94, 2523, 10.1182/blood.V94.7.2523.419k18_2523_2529

Jonker, 2002, Blocking the CD80 and CD86 costimulation molecules: lessons to be learned from animal models, Transplantation, 73, S23, 10.1097/00007890-200201151-00009

Wekerle, 2000, Allogeneic bone marrow transplantation with co-stimulatory blockade induces macrochimerism and tolerance without cytoreductive host treatment, Nat. Med., 6, 464, 10.1038/74731

Luznik, 2010, High-dose cyclophosphamide for graft-versus-host disease prevention, Curr. Opin. Hematol., 17, 493, 10.1097/MOH.0b013e32833eaf1b

Schuurhuis, 2006, Ins and outs of dendritic cells, Int. Arch. Allergy Immunol., 140, 53, 10.1159/000092002

Bonfim, 2017, Haploidentical bone marrow transplantation with post-transplant cyclophosphamide for children and adolescents with Fanconi anemia, Biol. Blood Marrow Transplant., 23, 310, 10.1016/j.bbmt.2016.11.006

Kitchens, 2012, Integrin antagonists prevent costimulatory blockade-resistant transplant rejection by CD8(+) memory T cells, Am. J. Transplant., 12, 69, 10.1111/j.1600-6143.2011.03762.x

Ramsey, 2013, Anti-LFA-1 or rapamycin overcome costimulation blockade-resistant rejection in sensitized bone marrow recipients, Transpl. Int., 26, 206, 10.1111/tri.12021

Davies, 2015, Donor-derived T cells can be rendered hyporesponsive to alloantigen without loss of pathogen or tumor immune responses, Blood, 110, 771, 10.1182/blood.V110.11.771.771

Pinelli, 2015, Rapamycin ameliorates the CTLA4-Ig-mediated defect in CD8(+) T cell immunity during gammaherpesvirus infection, Am. J. Transplant., 15, 2576, 10.1111/ajt.13326

Povoleri, 2013, Thymic versus induced regulatory T cells - who regulates the regulators?, Front. Immunol., 4, 169, 10.3389/fimmu.2013.00169

Riella, 2012, Deleterious effect of CTLA4-Ig on a Treg-dependent transplant model, Am. J. Transplant., 12, 846, 10.1111/j.1600-6143.2011.03929.x

Pilat, 2012, Belatacept and Tregs: friends or foes?, Immunotherapy, 4, 351, 10.2217/imt.12.13

Razmara, 2008, CTLA-4 x Ig converts naive CD4+, Int. Immunol., 20, 471, 10.1093/intimm/dxn007

Bestard, 2011, Costimulatory blockade with mTor inhibition abrogates effector T-cell responses allowing regulatory T-cell survival in renal transplantation, Transpl. Int., 24, 451, 10.1111/j.1432-2277.2011.01223.x

Pilat, 2015, Rapamycin and CTLA4Ig synergize to induce stable mixed chimerism without the need for CD40 blockade, Am. J. Transplant., 15, 1568, 10.1111/ajt.13154

Grohmann, 2002, CTLA-4-Ig regulates tryptophan catabolism in vivo, Nat. Immunol., 3, 1097, 10.1038/ni846

Vitale, 2005, NK-dependent DC maturation is mediated by TNFalpha and IFNgamma released upon engagement of the NKp30 triggering receptor, Blood, 106, 566, 10.1182/blood-2004-10-4035