Synthesis, characterization and antitumour activity of 7,7-di-n-butyl-5,9-dioxo-6,8-dioxa-7-stanna-spiro[3,5]nonane, a di-n-butyltin(IV) analog of “paraplatin”, and of a series of di-n-butyltin(IV) derivatives of mono- and disubstltuted malonic acids

Paraplatin (carboplatin). Compendium of Recent Data, Bristol-Myers International Group, 345 Park Avenue, New York, New York 10154. Crowe, 1987, Drugs of the Future, 12, 255 Crowe, 1988, 1, 103 Aldridge, 1976, Organotin Compounds: New chemistry and Applications, 157, 186 Aldridge, 1978, 9 Kalinowski, 1984, 546 A. Meriem, M. Gielen and R. Willem, Synthesis, characterization and antitumour activity of a series ol diorganotin(IV) derivatives of bis(car☐ymethyl)amines,J. Organometal. Chem., in press. Gielen, 1968, Bull. Soc. Chim. Belg., 77, 5, 10.1002/bscb.19680770101 Boué, 1968, Bull. Soc. Chim. Belg., 77, 43, 10.1002/bscb.19680770105 Gielen, 1983, Organic Mass Spectrometry, 18, 224, 10.1002/oms.1210180510 Gielen, 1983, Organic Mass Spectrometry, 18, 451, 10.1002/oms.1210181010 Gielen, 1983, Organic Mass Spectrometry, 18, 453, 10.1002/oms.1210181011 Gielen, 1985, Bull. Soc. Chim. Belg., 94, 359, 10.1002/bscb.19850940508 Gielen, 1985, Bull. Soc. Chim. Belg., 94, 1075, 10.1002/bscb.19850941128 Gielen, 1987, Main Group Met. Chem., 10, 147 Singh, 1975, J.Org. Chem., 40, 2969, 10.1021/jo00908a030 Davies, 1983, J. Organomet. Chem., 258, 7, 10.1016/0022-328X(83)89502-3 Gielen, 1987, J. Organomet. Chem., 328, 61, 10.1016/S0022-328X(00)99767-5