Synergistic neuroprotective therapies with hypothermia

Hagberg, 1996, The changing panorama of cerebral palsy – bilateral spastic forms in particular, Acta Paediatr, 416, 48, 10.1111/j.1651-2227.1996.tb14277.x

Gunn, 2000, Cerebral hypothermia for prevention of brain injury following perinatal asphyxia, Curr Opin Pediatr, 12, 111, 10.1097/00008480-200004000-00004

Kapetanakis, 2009, Therapeutic hypothermia for neonatal encephalopathy: a UK survey of opinion, practice and neuro-investigation at the end of 2007, Acta Paediatr, 98, 631, 10.1111/j.1651-2227.2008.01159.x

Azzopardi, 2009, Arch Dis Child Fetal Neonatal Ed, 94, F260, 10.1136/adc.2008.146977

Gluckman, 2005, Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomized trial, Lancet, 365, 663, 10.1016/S0140-6736(05)70932-6

Shankaran, 2005, Whole-body hypothermia for neonates with hypoxic–ischemic encephalopathy, N Engl J Med, 353, 1574, 10.1056/NEJMcps050929

Azzopardi, 2009, Moderate hypothermia to treat perinatal asphyxial encephalopathy, N Engl J Med, 361, 1349, 10.1056/NEJMoa0900854

Gunn, 2006, Hypothermic neuroprotection, NeuroRx, 3, 154, 10.1016/j.nurx.2006.01.007

Gunn, 2008, Therapeutic hypothermia changes the prognostic value of clinical evaluation of neonatal encephalopathy, J Pediatr, 152, 55, 10.1016/j.jpeds.2007.06.003

Shankaran, 2008, Outcomes of safety and effectiveness in a multicenter randomized, controlled trial of whole-body hypothermia for neonatal hypoxic-ischemic encephalopathy, Pediatrics, 122, 10.1542/peds.2008-0456

Wyatt, 2007, Pediatrics, 119, 912, 10.1542/peds.2006-2839

Roka, 2008, Elevated morphine concentrations in neonates treated with morphine and prolonged hypothermia for hypoxic ischemic encephalopathy, Pediatrics, 121, 10.1542/peds.2007-1987

Aicardi, 2008, Overview: neonatal seizures, 2283

Calabresi, 2003, Antiepileptic drugs as a possible neuroprotective strategy in brain ischemia, Ann Neurol, 53, 693, 10.1002/ana.10603

Liu, 2004, Topiramate extends the therapeutic window for hypothermia-mediated neuroprotection after stroke in neonatal rats, Stroke, 35, 1460, 10.1161/01.STR.0000128029.50221.fa

Zhang, 2000, Modulation of high-voltage-activated calcium channels in dentate granule cells by topiramate, Epilepsia, 41, 10.1111/j.1528-1157.2000.tb02173.x

White, 1997, Topiramate enhaces GABA-mediated chloride flux and GABA-evoked chloride currents in murine brain neurons and increases seizure threshold, Epilepsy Res, 28, 167, 10.1016/S0920-1211(97)00045-4

Zona, 1997, Topiramate attenuates voltage-gated sodium currents in rat cerebellar granule cells, Neurosci Lett, 231, 123, 10.1016/S0304-3940(97)00543-0

Herrero, 2002, The two new actions of topiramate: inhibition of depolarizing GABA (A)-mediated responses and activation of a potassium conductance, Neuropharmacology, 42, 210, 10.1016/S0028-3908(01)00171-X

Noh, 2006, Neuroprotective effect of topiramate on hypoxic ischemic injury in neonatal rats, Exp Neurol, 210, 470, 10.1016/j.expneurol.2006.04.038

Angehagen, 2005, Topiramate reduces AMPA-induced Ca(2+) transients and inhibits GluR1 subunit phosphorilation in astrocytes from primary cultures, J Neurochem, 94, 1124, 10.1111/j.1471-4159.2005.03259.x

Follet, 2004, Glutamate receptor-mediated oligodendrocyte toxicity in periventricular leukomalacia: a protective role for topiramate, J Neurosci, 24, 4412, 10.1523/JNEUROSCI.0477-04.2004

Schubert, 2005, Neuroprotective effects of topiramate after hypoxia-ischemia in newborn piglets, Brain Res, 1058, 129, 10.1016/j.brainres.2005.07.061

Filippi, 2009, Topiramate concentrations in neonates treated with prolonged whole body hypothermia for hypoxic-ischemic encephalopathy, Epilepsia, 50, 2355, 10.1111/j.1528-1167.2009.02302.x

Glauser, 1999, Topiramate pharmacokinetics in infants, Epilepsia, 40, 788, 10.1111/j.1528-1157.1999.tb00780.x

Kim, 2007, Antiepileptic drug-indiced neuronal cell death in the immature brain: effects of carbamazepine, topiramate, and levetiracetam as monotherapy versus polytherapy, J Pharmacol Exp Ther, 323, 165, 10.1124/jpet.107.126250

Lynch, 2004, The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam, Proc Natl Acad Sci U S A, 101, 9861, 10.1073/pnas.0308208101

Lee, 2009, Levetiracetam inhibits glutamate transmission through presynaptic P/Q-type calcium channels on the granule cells of the dentate gyrus, Br J Pharmacol, 158, 1753, 10.1111/j.1476-5381.2009.00463.x

Mazarati, 2004, Anticonvulsant effects of levetiracetam and levetiracetam–diazepam combinations in experimental status epilepticus, Epilepsy Res, 58, 167, 10.1016/j.eplepsyres.2004.02.002

Hanon, 2001, Neuroprotective properties of the novel antiepileptic drug levetiracetam in the rat middle cerebral artery occlusion model of focal cerebral ischemia, Seizure, 10, 287, 10.1053/seiz.2000.0511

Costa, 2006, Multiple mechanisms underlying the neuroprotective effects of antiepileptic drugs against in vitro ischemia, Stroke, 37, 1319, 10.1161/01.STR.0000217303.22856.38

Kim, 2007, Neurodevelopmental impact of antiepileptic drugs and seizures in the immature brain, Epilepsia, 48, 19, 10.1111/j.1528-1167.2007.01285.x

Shoemaker, 2007, Levetiracetam for the treatment of neonatal seizures, J Child Neurol, 22, 95, 10.1177/0883073807299973

Piña-Garza, 2009, Adjunctive levetiracetam in infants and young children with refractory partial-onset seizures, Epilepsia, 50, 1141, 10.1111/j.1528-1167.2008.01981.x

Dworschak M, 2008, Pharmacologic neuroprotection. Is xenon the light at the end of the tunnel?, Crit Care Med, 36, 2477, 10.1097/CCM.0b013e31818113d2

Istaphanous, 2009, General anesthetics and the developing brain, Curr Opin Anaesthesiol, 22, 368, 10.1097/ACO.0b013e3283294c9e

Dinse, 2005, Xenon reduces glutamate-, AMPA-, and kainate-induced membrane currents in cortical neurons, Br J Anaesth, 94, 479, 10.1093/bja/aei080

Gruss, 2004, Two-pore-domain K+ channels are novel target for the anesthetic gases xenon, nitrous oxyde, and cyclopropane, Mol Pharmacol, 65, 443, 10.1124/mol.65.2.443

Goto, 1999, Thermoregulatory threshold for vasoconstriction in patients anesthetized with various 1-minimum alveolar concentration combinations of xenon, nitrous oxide, and isoflurane, Anesthesiology, 91, 626, 10.1097/00000542-199909000-00011

David, 2008, Neuroprotective effects of xenon: a therapeutic window of opportunity in rats subjected to transient cerebral ischemia, FASEB J, 22, 1275, 10.1096/fj.07-9420com

Ma, 2005, Xenon and hypothermia combine to provide neuroprotection from neonatal asphyxia, Ann Neurol, 58, 182, 10.1002/ana.20547

Hobbs, 2008, Xenon and hypothermia combine additively, offering long-term functional and histopathologic neuroprotection after neonatal hypoxia/ischemia, Stroke, 39, 1307, 10.1161/STROKEAHA.107.499822

Thoresen, 2009, Cooling combined with immediate or delayed xenon inhalation provides equivalent long-term neuroprotection after neonatal hypoxia–ischemia, J Cereb Blood Flow Metab, 29, 704, 10.1038/jcbfm.2008.163

Khan, 2004, Administration of N-acetylcysteine after focal cerebral ischemia protects brain and reduces inflammation in a rat model of experimental stroke, J Neurosci Res, 76, 519, 10.1002/jnr.20087

Jatana, 2006, Combination of systemic hypothermia and N-acetylcysteine attenuates hypoxic–ischemic brain injury in neonatal rats, Pediatr Res, 59, 684, 10.1203/01.pdr.0000215045.91122.44

Cakir, 2003, Neuroprotective effect of N-acetylcysteine and hypothermia on the spinal cord ischemia–reperfusion injury, Cardiovasc Surg, 11, 375, 10.1016/S0967-2109(03)00077-2

Paintlia, 2004, N-Acetylcysteine prevents endotoxin-induced degeneration of oligodendrocyte progenitors and hypomyelination in developing rat brain, J Neurosci Res, 78, 347, 10.1002/jnr.20261

Ahola, 1999, Pharmacokinetics of intravenous N-acetylcysteine in pre-term new-born infants, Eur J Clin Pharmacol, 55, 645, 10.1007/s002280050687

Ahola, 2003, N-Acetylcysteine does not prevent bronchopulmonary dysplasia in immature infants: a randomized controlled trial, J Pediatr, 143, 713, 10.1067/S0022-3476(03)00419-0

Maier, 1994, The need of Epoetin Beta (recombinant human erythropoietin) on the need for transfusion in very-low-birth-weight infants, N Engl J Med, 330, 1173, 10.1056/NEJM199404283301701

Ohls, 2004, Neurodevelopmental outcome and growth at 18 and 22 months' corrected age in extremely low birth weight infants treated with early erythropoietin and iron, Pediatrics, 114, 1287, 10.1542/peds.2003-1129-L

Maiese, 2005, New avenues of explorations for erythropoietin, J Am Med Assoc, 293, 90, 10.1001/jama.293.1.90

Kellert, 2007, A comparison of high-dose recombinant erythropoietin treatment regimens in brain-injured neonatal rats, Pediatr Res, 61, 451, 10.1203/pdr.0b013e3180332cec

Gonzalez, 2007, Erythropoietin enhances long-term neuroprotection and neurogenesis in neonatal stroke, Dev Neurosci, 29, 321, 10.1159/000105473

Gonzalez, 2009, Erythropoietin sustains cognitive function and brain volume after neonatal stroke, Dev Neurosci, 31, 403, 10.1159/000232558

van der Kooij, 2009, Combination of deferoxamine and erythropoietin: therapy for hypoxia–ischemia-induced brain injury in the neonatal rat?, Neurosci Lett, 451, 109, 10.1016/j.neulet.2008.12.013

Zhu, 2009, Erythropoietin improved neurological outcomes in newborns with hypoxic–ischemic encephalopathy, Pediatrics, 124, e218, 10.1542/peds.2008-3553

Cariou, 2008, Early high dose erythropoietin therapy and hypothermia after out-of-hospital cardiac arrest: a matched control study, Resuscitation, 76, 397, 10.1016/j.resuscitation.2007.10.003

Ehrenreich, 2009, Recombinant human erythropoietin in the treatment of acute ischemic stroke, Stroke, 40, 10.1161/STROKEAHA.109.564872

Tan, 1993, Melatonin: a potent endogenous hydroxyl radical scavenger, Endocrine J, 1, 57

Ashrafi, 2009, Melatonin versus chloral hydrate for recording sleep EEG, Eur J Paediatr Neurol

Husson, 2002, Melatoninergic neuroprotection of the murine periventricular white matter against neonatal excitotoxic challenge, Ann Neurol, 51, 82, 10.1002/ana.10072

Bouslama, 2007, Melatonin prevents learning disorders in brain-lesioned newborn mice, Neuroscience, 150, 712, 10.1016/j.neuroscience.2007.09.030

Carloni, 2008, Melatonin protects from the long-term consequences of a neonatal hypoxic–ischemic brain injury in rats, J Pineal Res, 44, 157, 10.1111/j.1600-079X.2007.00503.x

Ronen, 2003, Drug-induced hypothermia reduces ischemic damage: effects of the cannabinoid HU-210, Stroke, 34, 2000, 10.1161/01.STR.0000079817.68944.1E

Letechipía-Vallejo, 2007, Long-term morphological and functional evaluation of the neuroprotective effects of post-ischemic treatment with melatonin in rats, J Pineal Res, 42, 139, 10.1111/j.1600-079X.2006.00395.x

Fernandez-Lopez, 2007, The cannabinoid agonist WIN55212 reduces brain damage in an in vivo model of hypoxic–ischemic encephalopathy in newborns rats, Pediatr Res, 62, 255, 10.1203/PDR.0b013e318123fbb8

Alvarez, 2008, Neuroprotective effects of the nonpsychoactive cannabinoid cannabidiol in hypoxic–ischemic newborn piglets, Pediatr Res, 64, 653, 10.1203/PDR.0b013e318186e5dd

Fried, 2001, A literature review of the consequences of prenatal marihuana exposure. An emergency theme of a deficiency in aspects of executive function, Neurotoxicol Teratol, 23, 1, 10.1016/S0892-0362(00)00119-7

Ronen, 1999, The epidemiology of clinical neonatal seizures in Newfoundland: a population-based study, J Pediatr, 134, 71, 10.1016/S0022-3476(99)70374-4

Painter, 1999, Phenobarbital compared with phenytoin for the treatment of neonatal seizures, N Engl J Med, 341, 485, 10.1056/NEJM199908123410704

Dzhala, 2005, NKCC1 Transporter facilitates seizures in the developing brain, Nat Med, 11, 1205, 10.1038/nm1301

Dzhala, 2008, Bumetanide enhances phenobarbital efficacy in a neonatal seizures model, Ann Neurol, 63, 222, 10.1002/ana.21229

Bittigau, 2003, Antiepileptic drugs and apoptosis in the developing brain, Ann NY Acad Sci, 993, 103, 10.1111/j.1749-6632.2003.tb07517.x

Olney, 2002, Drug-induced apoptotic neurodegeneration in the developing brain, Brain Pathol, 12, 488, 10.1111/j.1750-3639.2002.tb00467.x

Stefovska, 2008, Sedative and anticonvulsant drugs suppress postnatal neurogenesis, Ann Neurol, 64, 434, 10.1002/ana.21463