Synergistic Effect of 1,3,6-Trihydroxy-4,5,7-Trichloroxanthone in Combination with Doxorubicin on B-Cell Lymphoma Cells and Its Mechanism of Action Through Molecular Docking

Roman, 2011, Epidemiology of lymphomas, Histopathology, 58, 4, 10.1111/j.1365-2559.2010.03696.x Teras, 2016, 2016 US lymphoid malignancy statistics by World Health Organization subtypes, CA Cancer J Clin, 66, 443, 10.3322/caac.21357 Clarke, 2011, Lymphoid malignancies in U.S. Asians: Incidence rate differences by birthplace and acculturation, Cancer Epidemiol Biomarkers Prev, 20, 1064, 10.1158/1055-9965.EPI-11-0038 Zha, 2014, Disulfiram targeting lymphoid malignant cell lines via ROS-JNK activation as well as Nrf2 and NF-kB pathway inhibition, J Transl Med, 12, 163, 10.1186/1479-5876-12-163 Wakharde, 2018, Synergistic Activation of Doxorubicin against Cancer: A Review OPEN ACCESS, Am J Clin Mic Antimicrob, 1, 1 Maxwell, 2009, 14-3-3ζ mediates resistance of diffuse large B cell lymphoma to an anthracycline-based chemotherapeutic regimen, J Biol Chem, 284, 22379, 10.1074/jbc.M109.022418 Pinto, 2010, 31) Combination Chemotherapy in Cancer : Principles, Evaluation and Drug Delivery Strategies, Curr Cancer Treat, 695 Kashif, 2015, In vitro discovery of promising anti-cancer drug combinations using iterative maximisation of a therapeutic index, Sci Rep, 5, 14118, 10.1038/srep14118 Chou, 2006, Theoretical Basis, Experimental Design, and Computerized Simulation of Synergism and Antagonism in Drug Combination Studies, Pharmacol Rev, 58, 621, 10.1124/pr.58.3.10 Davis, 2003, Raf-1 and Bcl-2 Induce Distinct and Common Pathways That Contribute to Breast Cancer Drug Resistance 1, Clin Cancer Res, 9, 1161 Katayama, 2014, Regulations of P-Glycoprotein/ABSB1/MDR1 in Human Cancer Cells, New J Sci, 2014, 10.1155/2014/476974 Yeung, 2001, Raf kinase inhibitor protein interacts with NFKB-inducing kinase and TAK1 and inhibits NF-K B activation, Mol Cell Biol, 21, 7207, 10.1128/MCB.21.21.7207-7217.2001 Lim, 2014, Pathogenetic Importance and Therapeutic Implications of NF-KB in Lymphoid Malignancies, Immunol Rev, 246, 359, 10.1111/j.1600-065X.2012.01105.x Tyner, 2012, Targeting survivin and p53 in pediatric acute lymphoblastic leukemia, Leukemia, 26, 623, 10.1038/leu.2011.249 Reeder, 2011, Novel therapeutic agents for B-cell lymphoma: Developing rational combinations, Blood, 117, 1453, 10.1182/blood-2010-06-255067 Xu, 2012, Genetic protein TmSm (T34A) enhances sensitivity of chemotherapy to breast cancer cell lines as a synergistic drug to doxorubicin, Biomed Pharmacother, 66, 368, 10.1016/j.biopha.2011.12.004 Roskoski, 2016, Ibrutinib inhibition of Bruton protein-tyrosine kinase (BTK) in the treatment of B cell neoplasms, Pharmacol Res, 113, 395, 10.1016/j.phrs.2016.09.011 Taylor, 2015, Cooperative Effects of Akt-1 and Raf-1 on the Induction of Cellular Senescence in Doxorubicin or Tamoxifen Treated Breast Cancer Cells, Oncotarget, 2, 610, 10.18632/oncotarget.315 Naci, 2012, α2β1 integrin promotes chemoresistance against doxorubicin in cancer cells through extracellular signal-regulated kinase (ERK), J Biol Chem, 287, 17065, 10.1074/jbc.M112.349365 Su, 2011, Anti-tumour effects of xanthone derivatives and the possible mechanisms of action, Invest New Drugs, 29, 1230, 10.1007/s10637-010-9468-5 Yuanita, 2016, Design of Hydroxy Xanthones Derivatives As Anticancer Using Quantitative Structure-Activity Relationship, Asian J Pharm Clin Res, 9, 3 Yuanita, 2019, Synthesis, Characterization and Molecular Docking of Chloro-substituted Hydroxyxanthone Derivatives, Chem J Mold, 14, 68, 10.19261/cjm.2018.520 Singh, 2017, Effect of dimethyl sulfoxide on in vitro proliferation of skin fibroblast cells, J Biotech Res, 8, 78 Mosmann, 1983, Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays, J Immunol Methods, 65, 55, 10.1016/0022-1759(83)90303-4 Prayong, 2008, Cytotoxic activity screening of some indigenous Thai plants, Fitoterapia, 79, 598, 10.1016/j.fitote.2008.06.007 Zhang, 2016, Synergistic combination of microtubule targeting anticancer fludelone with cytoprotective panaxytriol derived from panax ginseng against MX-1 cells in vitro: Experimental design and data analysis using the combination index method, Am J Cancer Res, 6, 97 Miladiyah, 2018, Biological activity, quantitative structure–activity relationship analysis, and molecular docking of xanthone derivatives as anticancer drugs, Drug Des Dev Ther, 12, 149, 10.2147/DDDT.S149973 Korb, 2009, Empirical scoring functions for advanced Protein-Ligand docking with PLANTS, J Chem Inf Model, 49, 84, 10.1021/ci800298z Huang, 2007, Efficient molecular docking of NMR structures : Application to HIV-1 protease, Protein Sci, 16, 43, 10.1110/ps.062501507 DeLano, 2005, Review: The case for open-source software in drug discovery, Drug Discov Today, 10, 213, 10.1016/S1359-6446(04)03363-X Fouche, 2008, In vitro anticancer screening of South African plants, J Ethnopharm, 119, 455, 10.1016/j.jep.2008.07.005 Miles, 2018, Synergistic Effect of Endogenous and Exogenous Aldehydes on Doxorubicin Toxicity in Yeast, Biomed Res Int, 2018, 10.1155/2018/4938189 Kuete, 2014, Cytotoxicity and modes of action of three naturally occurring xanthones (8-hydroxycudraxanthone G, morusignin I and cudraxanthone I) against sensitive and multidrug-resistant cancer cell lines, Phytomed, 21, 315, 10.1016/j.phymed.2013.08.018 Mohan, 2012, Involvement of NF-κB and Bcl2/Bax signaling pathways in the apoptosis of MCF7 cells induced by a xanthone compound Pyranocycloartobiloxanthone A, Phytomed, 19, 1007, 10.1016/j.phymed.2012.05.012 Cheng, 2011, Antioxidant xanthone derivatives induce cell cycle arrest and apoptosis and enhance cell death induced by cisplatin in NTUB1 cells associated with ROS, Eur J Med Chem, 46, 1222, 10.1016/j.ejmech.2011.01.043 Liu, 2013, Caspase-3-dependent apoptosis of citreamicin ε-induced heLa iells Is associated with reactive oxygen species generation, Chem Res Toxicol, 26, 1055, 10.1021/tx4000304 Jia, 2015, Recent Research on Bioactive Xanthones from Natural Medicine: Garcinia hanburyi, AAPS PharmSciTech, 16, 742, 10.1208/s12249-015-0339-4 Al-Salahi, 2014, Cytotoxicity Evaluation of a New Set of 2-Aminobenzo[de]iso-quinoline-1,3-diones, Int J Mol Sci, 15, 22483, 10.3390/ijms151222483 Ghanbari, 2016, Study of the Cytotoxicity Effect of Doxorubicin-loaded/Folic acid-Targeted Super Paramagnetic Iron Oxide Nanoparticles on AGS Cancer Cell Line, J Nanomed Nanotechnol, 7, 10.4172/2157-7439.1000368 Tsakalozou, 2012, Combination effects of docetaxel and doxorubicin in hormone-refractory prostate cancer cells, Biochem Res Intern, 2012, 10.1155/2012/832059 Chou, 2010, Drug combination studies and their synergy quantification using the chou-talalay method, Cancer Res, 70, 440, 10.1158/0008-5472.CAN-09-1947 McDonald, 2006, Aza-stilbenes as potent and selective c-RAF inhibitors, Bioorg Med Chem Lett, 16, 5378, 10.1016/j.bmcl.2006.07.063 Thaimattam, 2004, 3D-QSAR CoMFA, CoMSIA studies on substituted ureas as Raf-1 kinase inhibitors and its confirmation with structure-based studies, Bioorg Med Chem, 12, 6415, 10.1016/j.bmc.2004.09.029 Weinstein-oppenheimer, 2001, Role of the Raf Signal Transduction Cascade in the in Vitro Resistance to the Anticancer Drug Doxorubicin Role of the Raf Signal Transduction Cascade in the in Vitro Resistance to the Anticancer Drug Doxorubicin 1, Clin Cancer Res, 7, 2898 Richly, 2006, Results of a Phase I trial of sorafenib (BAY 43-9006) in combination with doxorubicin in patients with refractory solid tumors, Ann Oncol, 17, 866, 10.1093/annonc/mdl017 Wang, 2017, Design, synthesis and evaluation of derivatives based on pyrimidine scaffold as potent Pan-Raf inhibitors to overcome resistance, Eur J Med Chem, 130, 86, 10.1016/j.ejmech.2017.02.041 Schepetkin, 2015, Anti-Inflammatory Effects and Joint Protection in Collagen-Induced Arthritis after Treatment with IQ-1S, a Selective c-Jun N-Terminal Kinase Inhibitor, J Pharmacol Exp Ther, 353, 505, 10.1124/jpet.114.220251 Lee, 2014, Cytotoxic activity of 3,6-dihydroxyflavone in human cervical cancer cells and its therapeutic effect on c-Jun N-terminal kinase inhibition, Molecules, 19, 13200, 10.3390/molecules190913200 Kim, 2011, Tetrathiomolybdate induces doxorubicin sensitivity in resistant tumor cell lines, Gynecol Oncol, 122, 183, 10.1016/j.ygyno.2011.03.035 Ashenden, 2017, An In Vivo Functional Screen Identifies JNK Signaling As a Modulator of Chemotherapeutic Response in Breast Cancer, Mol Cancer Ther, 16, 1967, 10.1158/1535-7163.MCT-16-0731 Kurumbail, 1996, WCS. “Structural basis for selective inhibition of cyclooxigenase-2 by anti-inflammatory agents, Nature, 384, 400, 10.1038/384644a0 Meenambiga, 2015, In silico docking studies on the components of inonotus sp., a medicinal mushroom against cyclooxygenase-2 enzyme, Asian J Pharm Clin Res Res, 8, 142 Foti, 2009, In vitro inhibition of multiple cytochrome P450 isoforms by xanthone derivatives from mangosteen extract, Drug Metab Dispos, 37, 1848, 10.1124/dmd.109.028043