Surgical margins in head and neck cancer: A contemporary review
Tóm tắt
Adequate resection margins are critical to the treatment decisions and prognosis of patients with head and neck squamous cell carcinoma (HNSCC). However, there are numerous controversies regarding reporting and interpretation of the status of resection margins. Fundamental issues relating to the basic definition of margin adequacy, uniform reporting standards for margins, optimal method of specimen dissection, and the role of intraoperative frozen section evaluation, all require further clarification and standardization. Future horizons for margin surveillance offer the possible use of novel methods such as “molecular margins” and contact microscopic endoscopy, However, the limitations of these approaches need to be understood. The goal of this review was to evaluate these issues to define a more rational, standardized approach for achieving resection margin adequacy for patients with HNSCC undergoing curative resection. © 2012 Wiley Periodicals, Inc. Head Neck, 2013
Từ khóa
Tài liệu tham khảo
Jäckel MC, 2007, Impact of re‐resection for inadequate margins on the prognosis of upper aerodigestive tract cancer treated by laser microsurgery, Laryngoscope, 117, 35, 10.1097/01.mlg.0000251165.48830.89
Weisberger EC, 2001, Intraoperative microwave processing of bone margins during resection of head and neck cancer, Arch Otolaryngol Head Neck Surg, 127, 790
Dedivitis RA, 2009, Contact endoscopy of the larynx as an auxiliary method to the surgical margins in frontolateral laryngectomy, Acta Otorhinolaryngol Ital, 29, 16
Anneroth G, 1984, A methodologic study of histologic classification and grading of malignancy in oral squamous cell carcinoma, Scand J Dent Res, 92, 448