Những bất thường cấu trúc não trong bệnh dystonia cổ

Springer Science and Business Media LLC - Tập 14 - Trang 1-14 - 2013
Tino Prell1, Thomas Peschel2, Bernadette Köhler3, Martin H Bokemeyer4, Reinhard Dengler3, Albrecht Günther1,5, Julian Grosskreutz1
1Hans Berger Department of Neurology, Jena University Hospital, Jena, Germany
2Department of Psychiatry and Psychotherapy, Medical School Hannover, Hannover, Germany
3Department of Neurology and Clinical Neurophysiology, Medical School Hannover, Hannover, Germany
4Department of Neuroradiology, Jena University Hospital, Jena, Germany
5Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany

Tóm tắt

Dystonia cổ nguyên phát được đặc trưng bởi các cơn co thắt, run rẩy hoặc giật không tự nguyện. Bệnh này không chỉ giới hạn ở rối loạn trong hệ thống ganglia nền, vì các phương pháp MRI morphometry dựa trên voxel (VBM) và hình ảnh tensor khuếch tán (DTI) đã phát hiện nhiều thay đổi khu vực trong não của các bệnh nhân. Trong nghiên cứu này, các hình ảnh quét của 24 bệnh nhân bị dystonia cổ và 24 đối chứng được ghép nối về tuổi tác và giới tính đã được phân tích bằng VBM, DTI và hình ảnh truyền từ tính (MTI) sử dụng phương pháp dựa trên voxel và phân tích khu vực quan tâm. Kết quả được đối chiếu với UDRS, TWSTRS và thời gian mắc bệnh. Chúng tôi phát hiện rằng có sự thay đổi cấu trúc ở ganglia nền; thalamus; vỏ vận động; vỏ tiền vận động; vỏ trán, vỏ thái dương và vỏ đỉnh; hệ thống thị giác; tiểu não và thân não của những bệnh nhân mắc dystonia. Dystonia cổ là một bệnh đa hệ thống liên quan đến nhiều mạng lưới như hệ vận động, cảm giác và thị giác.

Từ khóa

#dystonia cổ #bất thường cấu trúc não #MRI morphometry #hình ảnh tensor khuếch tán #bệnh đa hệ thống

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