Structural Requirements for Factor Xa Inhibition by 3-Oxybenzamides with Neutral P1 Substituents: Combining X-ray Crystallography, 3D-QSAR, and Tailored Scoring Functions

Journal of Medicinal Chemistry - Tập 48 Số 9 - Trang 3290-3312 - 2005
Hans Matter1, David W. Will2, Marc Nazaré2, Herman Schreuder2, Volker Laux2, Volkmar Wehner2
1DI and A Chemistry, Aventis Pharma Deutschland GmbH, A Company of the Sanofi-Aventis Group, Building G 878, D-65926 Frankfurt am Main, Germany. [email protected]
2DI&A Chemistry, Aventis Pharma Deutschland GmbH, A Company of the Sanofi-Aventis Group, Building G 878, D-65926 Frankfurt am Main, Germany

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