Strategies of antioxidant defense

FEBS Journal - Tập 215 Số 2 - Trang 213-219 - 1993
Helmut Sies1
1Institut für Physiologische Chemie I, Heinrich Heine Universität, Düsseldorf, Germany

Tóm tắt

Cellular protection against the deleterious effects of reactive oxidants generated in aerobic metabolism, called oxidative stress, is organized at multiple levels. Defense strategies include three levels of protection; prevention, interception, and repair. Regulation of the antioxidant capacity includes the maintenance of adequate levels of antioxidant and the localization of antioxidant compounds and enzymes. Short‐term and long‐term adaptation and cell specialisation in these functions are new areas of interest. Control over the activity of prooxidant enzymes, such as NADPH oxidase and NO synthases, is crucial. Synthetic antioxidants mimic biological strategies.

Từ khóa


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