Stages of the Pathologic Process in Alzheimer Disease: Age Categories From 1 to 100 Years

Journal of Neuropathology and Experimental Neurology - Tập 70 Số 11 - Trang 960-969 - 2011
Heiko Braak1,2, Dietmar Rudolf Thal1,2, Estifanos Ghebremedhin1,2, Kelly Del Tredici1,2
1Department of Anatomy and Developmental Biology (EG), School of Biomedical Sciences, University of Queensland, Brisbane, Australia.
2From Clinical Neuroanatomy, Department of Neurology (HB, KDT) and Laboratory for Neuropathology - Institute of Pathology (DT, EG), Center for Clinical Research, University of Ulm, Ulm, Germany

Tóm tắt

Từ khóa


Tài liệu tham khảo

10.1097/NEN.0b013e3181919a48

10.1007/BF00308809

10.1016/S0197-4580(97)00056-0

10.1007/s00401-006-0127-z

Thal, 2000, Sequence of Ab-protein deposition in the human medial temporal lobe, J Neuropathol Exp Neurol, 59, 733, 10.1093/jnen/59.8.733

10.1212/WNL.58.12.1791

Alafuzoff, 2008, Staging of neurofibrillary pathology in Alzheimer's disease: A study for the BrainNet Europe Consortium, Brain Pathol, 18, 484, 10.1111/j.1750-3639.2008.00147.x

10.1007/s00401-010-0789-4

10.1073/pnas.90.11.5066

Trojanowski, 2000, "Fatal attractions” of proteins, A comprehensive hypothetical mechanism underlying Alzheimer's disease and other neurodegenerative disorders. Ann N Y Acad Sci, 924, 62

10.1126/science.1132814

Goedert, 2006, Tau protein, the paired helical filament and Alzheimer's disease, J Alzheimers Dis, 9, 195, 10.3233/JAD-2006-9S323

Mattson MP . Molecular and cellular pathways towards and away from Alzheimer's disease. In: Jucker M Beyreuther K Haass C Nitsch R Christen Y , eds. Alzheimer: 100 Years and Beyond . Berlin, Germany: Springer, 2006:371–78

10.1111/j.1750-3639.2007.00053.x

10.1159/000283478

Dickson, 2009, Neuropathology of non-Alzheimer degenerative disorders, Int J Clin Exp Pathol, 25, 1

10.1016/0304-3940(87)90204-7

10.1093/brain/awm305

10.1016/S0072-9752(07)01251-1

10.1111/j.1750-3639.1991.tb00661.x

10.1016/S0197-4580(02)00065-9

10.1007/s00401-010-0664-3

10.1097/NEN.0b013e3181c6c13d

10.1016/0306-4522(87)90123-0

10.1016/0165-0173(89)90017-9

10.1002/1531-8249(200101)49:1<53::AID-ANA30>3.0.CO;2-Q

10.1111/j.1365-2990.2008.00997.x

10.1097/NEN.0b013e31816a1df3

10.1111/j.1365-2990.2009.01038.x

10.1002/ana.410240210

10.1016/S0197-4580(97)00035-3

10.1001/archneur.60.3.337

10.1146/annurev.neuro.28.061604.135709

10.1111/j.1440-1789.2006.00725.x

10.1016/j.neurobiolaging.2006.02.007

10.1159/000113716

10.2174/156720508784533286

10.1038/nrn2573

10.1016/0306-4522(83)90023-4

10.1016/S0006-8993(98)00441-7

10.1097/00005072-199902000-00008

10.1007/BF00293315

10.1146/annurev.pathmechdis.2.010506.092044

10.1038/nature08983

10.1523/JNEUROSCI.4521-10.2010

10.1007/s12035-010-8137-1

10.1111/j.1750-3639.2009.00326.x

Patten, 2010, Reactive oxygen species: Stuck in the middle of neurodegeneration, J Alzheimers Dis, 20, 357, 10.3233/JAD-2010-100498

10.1016/0197-4580(94)90031-0

10.1007/s00401-011-0826-y

10.1016/0306-4522(95)90397-P

10.1002/ana.21509

10.1006/nbdi.1996.0003

10.1006/exnr.1997.6777

Del, 2008, Neurofibrillary changes of the Alzheimer type in very elderly individuals: Neither inevitable nor benign, Commentary on “No disease in the brain of a 115-year-old woman.” Neurobiol Aging, 29, 1133

10.1007/s00401-007-0207-8

10.2174/156720508785132307

10.1007/s00401-009-0486-3

10.1007/s00401-010-0716-8

10.1083/jcb.200108057

10.1007/s004019900178

Hardy JA . The amyloid hypothesis: History and alternatives. In: Jucker M Beyreuther K Haass C , eds. Alzheimer: 100 Years and Beyond . Berlin, Germany: Springer, 2006:151–56

10.1126/science.1072994

10.1016/j.neurobiolaging.2003.12.015

10.1016/j.neurobiolaging.2003.09.009

10.1016/j.jalz.2007.11.008

10.1016/j.biocel.2008.12.015

10.1016/S1474-4422(09)70299-6

10.1126/science.1062097

10.1126/science.1058189

10.1016/j.neuron.2004.07.003

10.1371/journal.pone.0016648

10.1007/s00401-011-0825-z

10.1016/j.tins.2010.04.003

10.1074/jbc.M110.209296