Sphingosine-1-phosphate signaling and its role in disease

Trends in Cell Biology - Tập 22 Số 1 - Trang 50-60 - 2012
Michael Maceyka1, Kuzhuvelil B. Harikumar2, Sheldon Milstien2, Sarah Spiegel2
1Department of Biochemistry and Molecular Biology, Massey Cancer Center, Virginia Commonwealth University School of Medicine, 1101 E. Marshall Street, Richmond, VA 23298, USA.
2Department of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, 1101 E. Marshall Street, Richmond, VA 23298, USA.

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Olivera, 1993, Sphingosine-1-phosphate as a second messenger in cell proliferation induced by PDGF and FCS mitogens, Nature, 365, 557, 10.1038/365557a0

Cuvillier, 1996, Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate, Nature, 381, 800, 10.1038/381800a0

Spiegel, 2011, The outs and the ins of sphingosine-1-phosphate in immunity, Nat. Rev. Immunol., 11, 403, 10.1038/nri2974

Pitson, 2010, Regulation of sphingosine kinase and sphingolipid signaling, Trends Biochem. Sci., 36, 97, 10.1016/j.tibs.2010.08.001

Jarman, 2010, Translocation of sphingosine kinase 1 to the plasma membrane is mediated by calcium- and integrin-binding protein 1, J. Biol. Chem., 285, 483, 10.1074/jbc.M109.068395

Leclercq, 2011, Guanine nucleotides regulate sphingosine kinase 1 activation by eukaryotic elongation factor 1A and provide a mechanism for eEF1A-associated oncogenesis, Oncogene, 30, 372, 10.1038/onc.2010.420

Hait, 2009, Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate, Science, 325, 1254, 10.1126/science.1176709

Strub, 2011, Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration, FASEB J., 25, 600, 10.1096/fj.10-167502

Don, 2009, A lipid binding domain in sphingosine kinase 2, Biochem. Biophys. Res. Commun., 380, 87, 10.1016/j.bbrc.2009.01.075

Hait, 2007, Sphingosine kinase type 2 activation by ERK-mediated phosphorylation, J. Biol. Chem., 282, 12058, 10.1074/jbc.M609559200

Ding, 2007, Protein kinase D-mediated phosphorylation and nuclear export of sphingosine kinase 2, J. Biol. Chem., 282, 27493, 10.1074/jbc.M701641200

Schnitzer, 2009, Hypoxia enhances sphingosine kinase 2 activity and provokes sphingosine-1-phosphate-mediated chemoresistance in A549 lung cancer cells, Mol. Cancer Res., 7, 393, 10.1158/1541-7786.MCR-08-0156

Wacker, 2009, Hypoxic preconditioning-induced cerebral ischemic tolerance: role of microvascular sphingosine kinase 2, Stroke, 40, 3342, 10.1161/STROKEAHA.109.560714

Schwab, 2007, Finding a way out: lymphocyte egress from lymphoid organs, Nat. Immunol., 8, 1295, 10.1038/ni1545

Brinkmann, 2010, Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis, Nat. Rev. Drug Discov., 9, 883, 10.1038/nrd3248

Pham, 2008, S1P1 receptor signaling overrides retention mediated by G alpha i-coupled receptors to promote T cell egress, Immunity, 28, 122, 10.1016/j.immuni.2007.11.017

Cyster, 2010, B cell follicles and antigen encounters of the third kind, Nat. Immunol., 11, 989, 10.1038/ni.1946

Jenne, 2009, T-bet-dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow, J. Exp. Med., 206, 2469, 10.1084/jem.20090525

Allende, 2011, Sphingosine-1-phosphate lyase deficiency produces a pro-inflammatory response while impairing neutrophil trafficking, J. Biol. Chem., 286, 7348, 10.1074/jbc.M110.171819

Pitson, 2009, Regulation of stem cell pluripotency and neural differentiation by lysophospholipids, Neurosignals, 17, 242, 10.1159/000231891

Camerer, 2009, Sphingosine-1-phosphate in the plasma compartment regulates basal and inflammation-induced vascular leak in mice, J. Clin. Invest., 119, 1871

Scherer, 2010, Tumor necrosis factor-alpha enhances microvascular tone and reduces blood flow in the cochlea via enhanced sphingosine-1-phosphate signaling, Stroke, 41, 2618, 10.1161/STROKEAHA.110.593327

Kono, 2007, Deafness and stria vascularis defects in S1P2 receptor null mice, J. Biol. Chem., 282, 10690, 10.1074/jbc.M700370200

Maclennan, 2006, The S1P(2) sphingosine 1-phosphate receptor is essential for auditory and vestibular function, Hear. Res., 220, 38, 10.1016/j.heares.2006.06.016

Sato, 2007, Critical role of ABCA1 transporter in sphingosine 1-phosphate release from astrocytes, J. Neurochem., 103, 2610, 10.1111/j.1471-4159.2007.04958.x

Mitra, 2006, Role of ABCC1 in export of sphingosine-1-phosphate from mast cells, Proc. Natl. Acad. Sci. U.S.A., 103, 16394, 10.1073/pnas.0603734103

Takabe, 2010, Estradiol induces export of sphingosine 1-phosphate from breast cancer cells via ABCC1 and ABCG2, J. Biol. Chem., 285, 10477, 10.1074/jbc.M109.064162

Kawahara, 2009, The sphingolipid transporter spns2 functions in migration of zebrafish myocardial precursors, Science, 323, 524, 10.1126/science.1167449

Schwab, 2005, Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients, Science, 309, 1735, 10.1126/science.1113640

Berdyshev, 2011, Intracellular S1P generation is essential for S1P-induced motility of human lung endothelial cells: role of sphingosine kinase 1 and S1P lyase, PLoS ONE, 6, e16571, 10.1371/journal.pone.0016571

Siow, 2010, Intracellular localization of sphingosine kinase 1 alters access to substrate pools but does not affect the degradative fate of sphingosine-1-phosphate, J. Lipid Res., 51, 2546, 10.1194/jlr.M004374

Bagdanoff, 2010, J. Med. Chem., 53, 8650, 10.1021/jm101183p

Spiegel, 2003, Sphingosine-1-phosphate: an enigmatic signalling lipid, Nat. Rev. Mol. Cell Biol., 4, 397, 10.1038/nrm1103

Ghosh, 1990, Intracellular calcium release mediated by sphingosine derivatives generated in cells, Science, 248, 1653, 10.1126/science.2163543

Ghosh, 1994, Sphingosine 1-phosphate generated in the endoplasmic reticulum membrane activates release of stored calcium, J. Biol. Chem., 269, 22628, 10.1016/S0021-9258(17)31692-7

Mattie, 1994, Sphingosine-1-phosphate, a putative second messenger, mobilizes calcium from internal stores via an inositol trisphosphate-independent pathway, J. Biol. Chem., 269, 3181, 10.1016/S0021-9258(17)41846-1

Xia, 2002, Sphingosine kinase interacts with TRAF2 and dissects tumor necrosis factor-alpha signaling, J. Biol. Chem., 277, 7996, 10.1074/jbc.M111423200

Alvarez, 2010, Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2, Nature, 465, 1084, 10.1038/nature09128

Puneet, 2010, SphK1 regulates proinflammatory responses associated with endotoxin and polymicrobial sepsis, Science, 328, 1290, 10.1126/science.1188635

Artal-Sanz, 2009, Prohibitin and mitochondrial biology, Trends Endocrinol. Metab., 20, 394, 10.1016/j.tem.2009.04.004

Takasugi, 2011, BACE1 activity is modulated by cell-associated sphingosine-1-phosphate, J. Neurosci., 31, 6850, 10.1523/JNEUROSCI.6467-10.2011

Chi, 2011, Sphingosine-1-phosphate and immune regulation: trafficking and beyond, Trends Pharmacol. Sci., 32, 16, 10.1016/j.tips.2010.11.002

Pyne, 2010, Sphingosine 1-phosphate and cancer, Nat. Rev. Cancer, 10, 489, 10.1038/nrc2875

Guan, 2011, Sphingosine kinase 1 regulates the Akt/FOXO3a/Bim pathway and contributes to apoptosis resistance in glioma cells, PLoS ONE, 6, e19946, 10.1371/journal.pone.0019946

Salas, 2011, Sphingosine kinase-1 and sphingosine 1-phosphate receptor 2 mediate Bcr-Abl1 stability and drug resistance by modulation of protein phosphatase 2A, Blood, 117, 5941, 10.1182/blood-2010-08-300772

Kim, 2011, Sphingosine 1-phosphate regulates matrix metalloproteinase-9 expression and breast cell invasion through S1P3-G{alpha}q coupling, J. Cell Sci., 124, 2220, 10.1242/jcs.076794

Anelli, 2010, Role of sphingosine kinase-1 in paracrine/transcellular angiogenesis and lymphangiogenesis in vitro, FASEB J., 24, 2727, 10.1096/fj.09-150540

Lee, 2010, STAT3-induced S1PR1 expression is crucial for persistent STAT3 activation in tumors, Nat. Med., 16, 1421, 10.1038/nm.2250

Dickson, 2011, A phase I clinical trial of safingol in combination with cisplatin in advanced solid tumors, Clin. Cancer Res., 17, 2484, 10.1158/1078-0432.CCR-10-2323

Paugh, 2008, A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia, Blood, 112, 1382, 10.1182/blood-2008-02-138958

Kapitonov, 2009, Targeting sphingosine kinase 1 inhibits Akt signaling, induces apoptosis, and suppresses growth of human glioblastoma cells and xenografts, Cancer Res., 69, 6915, 10.1158/0008-5472.CAN-09-0664

Song, 2011, Sphingosine kinase-1 enhances resistance to apoptosis through activation of PI3K/Akt/NF-kappaB pathway in human non-small cell lung cancer, Clin. Cancer Res., 17, 1839, 10.1158/1078-0432.CCR-10-0720

Loveridge, 2010, The sphingosine kinase 1 inhibitor 2-(p-hydroxyanilino)-4-(p-chlorophenyl)thiazole induces proteasomal degradation of sphingosine kinase 1 in mammalian cells, J. Biol. Chem., 285, 38841, 10.1074/jbc.M110.127993

Antoon, 2011, Pharmacological inhibition of sphingosine kinase isoforms alters estrogen receptor signaling in human breast cancer, J. Mol. Endocrinol., 46, 205, 10.1530/JME-10-0116

Kennedy, 2011, Development of amidine-based sphingosine kinase 1 nanomolar inhibitors and reduction of sphingosine 1-phosphate in human leukemia cells, J. Med. Chem., 54, 3524, 10.1021/jm2001053

Van Brocklyn, 2005, Sphingosine kinase-1 expression correlates with poor survival of patients with glioblastoma multiforme: roles of sphingosine kinase isoforms in growth of glioblastoma cell lines, J. Neuropathol. Exp. Neurol., 64, 695, 10.1097/01.jnen.0000175329.59092.2c

Sankala, 2007, Involvement of sphingosine kinase 2 in p53-independent induction of p21 by the chemotherapeutic drug doxorubicin, Cancer Res., 67, 10466, 10.1158/0008-5472.CAN-07-2090

Weigert, 2009, Sphingosine kinase 2 deficient tumor xenografts show impaired growth and fail to polarize macrophages towards an anti-inflammatory phenotype, Int. J. Cancer., 125, 2114, 10.1002/ijc.24594

French, 2010, Pharmacology and antitumor activity of ABC294640, a selective inhibitor of sphingosine kinase-2, J. Pharmacol. Exp. Ther., 333, 129, 10.1124/jpet.109.163444

Antoon, 2010, Antiestrogenic effects of the novel sphingosine kinase-2 inhibitor ABC294640, Endocrinology, 151, 5124, 10.1210/en.2010-0420

Daum, 2009, Sphingosine 1-phosphate: a regulator of arterial lesions, Arterioscler. Thromb. Vasc. Biol., 29, 1439, 10.1161/ATVBAHA.108.175240

Sato, 2010, Role of sphingosine 1-phosphate in anti-atherogenic actions of high-density lipoprotein, World J. Biol. Chem., 1, 327, 10.4331/wjbc.v1.i11.327

Keul, 2011, Sphingosine-1-phosphate receptor 3 promotes recruitment of monocyte/macrophages in inflammation and atherosclerosis, Circ. Res., 108, 314, 10.1161/CIRCRESAHA.110.235028

Wang, 2010, Sphingosine-1-phosphate receptor-2 deficiency leads to inhibition of macrophage proinflammatory activities and atherosclerosis in apoE-deficient mice, J. Clin. Invest., 120, 3979, 10.1172/JCI42315

Skoura, 2011, Sphingosine-1-phosphate receptor-2 function in myeloid cells regulates vascular inflammation and atherosclerosis, Arterioscler. Thromb. Vasc. Biol., 31, 81, 10.1161/ATVBAHA.110.213496

Christoffersen, 2011, Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M, Proc. Natl. Acad. Sci. U.S.A., 108, 9613, 10.1073/pnas.1103187108

Nofer, 2007, FTY720, a synthetic sphingosine 1 phosphate analogue, inhibits development of atherosclerosis in low-density lipoprotein receptor-deficient mice, Circulation, 115, 501, 10.1161/CIRCULATIONAHA.106.641407

Keul, 2007, The sphingosine-1-phosphate analogue FTY720 reduces atherosclerosis in apolipoprotein E-deficient mice, Arterioscler. Thromb. Vasc. Biol., 27, 607, 10.1161/01.ATV.0000254679.42583.88

Blom, 2010, FTY720 stimulates 27-hydroxycholesterol production and confers atheroprotective effects in human primary macrophages, Circ. Res., 106, 720, 10.1161/CIRCRESAHA.109.204396

Summers, 2010, Sphingolipids and insulin resistance: the five Ws, Curr. Opin. Lipidol., 21, 128, 10.1097/MOL.0b013e3283373b66

Deevska, 2011, The twists and turns of sphingolipid pathway in glucose regulation, Biochimie, 93, 32, 10.1016/j.biochi.2010.05.016

Holland, 2011, Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice, J. Clin. Invest., 121, 1858, 10.1172/JCI43378

Holland, 2011, Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin, Nat. Med., 17, 55, 10.1038/nm.2277

Fox, 2011, Circulating sphingolipid biomarkers in models of type 1 diabetes, J. Lipid Res., 52, 509, 10.1194/jlr.M010595

Imasawa, 2010, Blockade of sphingosine 1-phosphate receptor 2 signaling attenuates streptozotocin-induced apoptosis of pancreatic beta-cells, Biochem. Biophys. Res. Commun., 392, 207, 10.1016/j.bbrc.2010.01.016

Raisz, 2005, Pathogenesis of osteoporosis: concepts, conflicts, and prospects, J. Clin. Invest., 115, 3318, 10.1172/JCI27071

Ryu, 2006, Sphingosine 1-phosphate as a regulator of osteoclast differentiation and osteoclast-osteoblast coupling, EMBO J., 25, 5840, 10.1038/sj.emboj.7601430

Pederson, 2008, Regulation of bone formation by osteoclasts involves Wnt/BMP signaling and the chemokine sphingosine-1-phosphate, Proc. Natl. Acad. Sci. U.S.A., 105, 20764, 10.1073/pnas.0805133106

Ishii, 2009, Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis, Nature, 458, 524, 10.1038/nature07713

Ishii, 2010, Chemorepulsion by blood S1P regulates osteoclast precursor mobilization and bone remodeling in vivo, J. Exp. Med., 207, 2793, 10.1084/jem.20101474

Baker, 2010, Genetic sphingosine kinase 1 deficiency significantly decreases synovial inflammation and joint erosions in murine TNF-alpha-induced arthritis, J. Immunol., 185, 2570, 10.4049/jimmunol.1000644

Reines, 2009, Topical application of sphingosine-1-phosphate and FTY720 attenuate allergic contact dermatitis reaction through inhibition of dendritic cell migration, J. Invest. Dermatol., 129, 1954, 10.1038/jid.2008.454

Tsunemi, 2010, Effects of the novel immunosuppressant FTY720 in a murine rheumatoid arthritis model, Clin. Immunol., 136, 197, 10.1016/j.clim.2010.03.428

Kurashima, 2007, Sphingosine 1-phosphate-mediated trafficking of pathogenic Th2 and mast cells for the control of food allergy, J. Immunol., 179, 1577, 10.4049/jimmunol.179.3.1577

Guillermet-Guibert, 2009, Targeting the sphingolipid metabolism to defeat pancreatic cancer cell resistance to the chemotherapeutic gemcitabine drug, Mol. Cancer Ther., 8, 809, 10.1158/1535-7163.MCT-08-1096

Ricci, 2009, In vitro anti-leukaemia activity of sphingosine kinase inhibitor, Br. J. Haematol., 144, 350, 10.1111/j.1365-2141.2008.07474.x

Nishiuma, 2008, Inhalation of sphingosine kinase inhibitor attenuates airway inflammation in asthmatic mouse model, Am. J. Physiol. Lung Cell. Mol. Physiol., 294, L1085, 10.1152/ajplung.00445.2007

Fitzpatrick, 2011, Attenuation of arthritis in rodents by a novel orally-available inhibitor of sphingosine kinase, Inflammopharmacology, 19, 75, 10.1007/s10787-010-0060-6

Chumanevich, 2010, Suppression of colitis-driven colon cancer in mice by a novel small molecule inhibitor of sphingosine kinase, Carcinogenesis, 31, 1787, 10.1093/carcin/bgq158

Beljanski, 2011, Combined anticancer effects of sphingosine kinase inhibitors and sorafenib, Invest. New Drugs, 29, 1132, 10.1007/s10637-010-9452-0

Chiba, 2010, SKI-II, an inhibitor of sphingosine kinase, ameliorates antigen-induced bronchial smooth muscle hyperresponsiveness, but not airway inflammation, in mice, J. Pharmacol. Sci., 114, 304, 10.1254/jphs.10202FP

Bandhuvula, 2011, S1P lyase: a novel therapeutic target for ischemia-reperfusion injury of the heart, Am. J. Physiol. Heart Circ. Physiol., 300, H1753, 10.1152/ajpheart.00946.2010

Zhao, 2011, Protection of LPS-induced murine acute lung injury by sphingosine-1-phosphate lyase suppression, Am. J. Respir. Cell Mol. Biol., 45, 426, 10.1165/rcmb.2010-0422OC

Awad, 2011, Chronic sphingosine 1-phosphate 1 receptor activation attenuates early-stage diabetic nephropathy independent of lymphocytes, Kidney Int., 79, 1090, 10.1038/ki.2010.544

Bajwa, 2010, Activation of sphingosine-1-phosphate 1 receptor in the proximal tubule protects against ischemia-reperfusion injury, J. Am. Soc. Nephrol., 21, 955, 10.1681/ASN.2009060662

Diab, 2010, Stimulation of sphingosine 1-phosphate signaling as an alveolar cell survival strategy in emphysema, Am. J. Respir. Crit. Care Med., 181, 344, 10.1164/rccm.200906-0826OC

Hasegawa, 2010, Activation of sphingosine 1-phosphate receptor-1 by FTY720 is neuroprotective after ischemic stroke in rats, Stroke, 41, 368, 10.1161/STROKEAHA.109.568899

Kim, 2009, Fingolimod and related compounds in a spontaneous autoimmune polyneuropathy, J. Neuroimmunol., 214, 93, 10.1016/j.jneuroim.2009.07.006

Marsolais, 2009, A critical role for the sphingosine analog AAL-R in dampening the cytokine response during influenza virus infection, Proc. Natl. Acad. Sci. U.S.A., 106, 1560, 10.1073/pnas.0812689106

Niessen, 2009, Endogenous EPCR/aPC-PAR1 signaling prevents inflammation-induced vascular leakage and lethality, Blood, 113, 2859, 10.1182/blood-2008-12-192385

Pan, 2006, A monoselective sphingosine-1-phosphate receptor-1 agonist prevents allograft rejection in a stringent rat heart transplantation model, Chem. Biol., 13, 1227, 10.1016/j.chembiol.2006.09.017

Zhang, 2009, AUY954, a selective S1P(1) modulator, prevents experimental autoimmune neuritis, J. Neuroimmunol., 216, 59, 10.1016/j.jneuroim.2009.09.010

Oskeritzian, 2010, Essential roles of sphingosine-1-phosphate receptor 2 in human mast cell activation, anaphylaxis, and pulmonary edema, J. Exp. Med., 207, 465, 10.1084/jem.20091513