Sleep and frailty risk: a systematic review and meta-analysis

Sleep and Breathing - Tập 24 - Trang 1187-1197 - 2020
Ali Pourmotabbed1, Behnoosh Boozari2, Atefeh Babaei1, Omid Asbaghi3, Marilyn S. Campbell4, Hamed Mohammadi2, Amir Hadi5, Sajjad Moradi2
1Department of Physiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
2Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
3Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran
4Department of Kinesiology and Health Promotion, University of Kentucky, Lexington, USA
5Halal Research Center of IRI, FDA, Tehran, Iran

Tóm tắt

Studies on the association between sleep and frailty risk have yielded contradictory outcomes. Therefore, a systematic review and meta-analysis were designed to examine the relationship between sleep and frailty risk. Relevant studies were identified by searching PubMed, Embase, and Scopus databases until 30 November 2019. Data were available from ten studies. Selected articles were published between 2009 and 2019. The odds ratios of 41,233 individuals were used for the meta-analysis. Pooled analysis demonstrated that when compared to the reference category of 6 to 8 hours nightly sleep duration, both the highest category (more than 8 hours, OR 1.21; 95% CI 1.10–1.32) and lowest category of sleep (under 6 hours, OR 1.13; 95% CI 1.08–1.18), were significantly correlated with increased risk of frailty. Furthermore, daytime drowsiness (OR 1.25; 95% CI 1.02–1.52), sleep disordered breathing (OR 1.28; 95% CI 1.03–1.58), and prolonged sleep latency (OR 1.18; 95% CI 1.06–1.31) enhanced the risk of frailty. Subgroup analyses by frailty status suggest that a shorter sleep duration was associated with risk of frailty but not pre-frailty. However, prolonged sleep time was significantly related with enhanced risk of pre-frailty and frailty. In addition, subgroup analyses via sex revealed that longer and shorter sleep durations increased risk of frailty in both men and women. The present study revealed that longer and shorter sleep durations are associated with increased risk of frailty.

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Sleep and Breathing

Tập 24

1187-1197

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