Sindbis virus as a human pathogen-epidemiology, clinical picture and pathogenesis

Reviews in Medical Virology - Tập 26 Số 4 - Trang 221-241 - 2016
Samuel Adouchief1, Teemu Smura1, Jussi Sane2, Olli Vapalahti3,4,1, Satu Kurkela4,1
1Department of Virology, Faculty of Medicine, University of Helsinki, Helsinki, Finland
2National Institute for Health and Welfare (THL), Helsinki, Finland
3Department of Veterinary Biosciences, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland
4Department of Virology and Immunology, HUSLAB, Helsinki University Central Hospital, Helsinki, Finland

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Suhrbier, 2012, Arthritogenic alphaviruses-an overview, Nature Reviews. Rheumatology, 8, 420, 10.1038/nrrheum.2012.64

Jost, 2010, Isolation and phylogenetic analysis of Sindbis viruses from mosquitoes in Germany, Journal of Clinical Microbiology, 48, 1900, 10.1128/JCM.00037-10

Jost, 2011, Medical importance of Sindbis virus in south-west Germany, Journal of Clinical Virology, 52, 278, 10.1016/j.jcv.2011.08.002

Eiden, 2014, Isolation of sindbis virus from a hooded crow in Germany, Vector Borne and Zoonotic Diseases, 14, 220, 10.1089/vbz.2013.1354

Ahlm, 2014, Seroprevalence of Sindbis virus and associated risk factors in northern Sweden, Epidemiology and Infection, 142, 1559, 10.1017/S0950268813002239

Brummer-Korvenkontio, 2002, Epidemiology of Sindbis virus infections in Finland 1981-96: possible factors explaining a peculiar disease pattern, Epidemiology and Infection, 129, 335, 10.1017/S095026880200740

Kurkela, 2008, Arthritis and arthralgia three years after Sindbis virus infection: clinical follow-up of a cohort of 49 patients, Scandinavian Journal of Infectious Diseases, 40, 167, 10.1080/00365540701586996

Sane, 2012, Clinical Sindbis alphavirus infection is associated with HLA-DRB1*01 allele and production of autoantibodies, Clinical Infectious Diseases, 55, 358, 10.1093/cid/cis405

Vander Veen, 2012, Alphavirus replicon vaccines, Animal Health Research Reviews, 13, 1, 10.1017/S1466252312000011

Quetglas, 2010, Alphavirus vectors for cancer therapy, Virus Research, 153, 179, 10.1016/j.virusres.2010.07.027

Sherman, 1990, Pathogenesis of encephalitis induced in newborn mice by virulent and avirulent strains of Sindbis virus, Journal of Virology, 64, 2041, 10.1128/JVI.64.5.2041-2046.1990

9th Report of the International Committee on Taxonomy of Viruses (ICTV) http://ictvonline.org/virusTaxonomy.asp 2014

Weaver, 2012, Alphaviruses: population genetics and determinants of emergence, Antiviral Research, 94, 242, 10.1016/j.antiviral.2012.04.002

Forrester, 2012, Genome-scale phylogeny of the alphavirus genus suggests a marine origin, Journal of Virology, 86, 2729, 10.1128/JVI.05591-11

Calisher, 1988, Reevaluation of the western equine encephalitis antigenic complex of alphaviruses (family Togaviridae) as determined by neutralization tests, American Journal of Tropical Medicine and Hygiene, 38, 447, 10.4269/ajtmh.1988.38.447

Hahn, 1988, Western equine encephalitis virus is a recombinant virus, Proceedings of the National Academy of Sciences of the United States of America, 85, 5997, 10.1073/pnas.85.16.5997

Lundstrom, 2010, Phylogeographic structure and evolutionary history of Sindbis virus, Vector Borne and Zoonotic Diseases, 10, 889, 10.1089/vbz.2009.0069

Saleh, 2003, Complete genomic sequence of the Australian south-west genotype of Sindbis virus: comparisons with other Sindbis strains and identification of a unique deletion in the 3′-untranslated region, Virus Genes, 26, 317, 10.1023/A:1024407516352

Tamura, 2013, MEGA6: Molecular Evolutionary Genetics Analysis version 6.0, Molecular Biology and Evolution, 30, 2725, 10.1093/molbev/mst197

Drummond, 2012, Bayesian phylogenetics with BEAUti and the BEAST 1.7, Molecular Biology and Evolution, 29, 1969, 10.1093/molbev/mss075

Drummond, 2006, Relaxed phylogenetics and dating with confidence, PLoS Biology, 4, e88, 10.1371/journal.pbio.0040088

Rambaut A Suchard MA Xie D Drummond AJ Tracer. 1.6 http://beast.bio.ed.ac.uk/Tracer

Sane, 2012, Complete coding sequence and molecular epidemiological analysis of Sindbis virus isolates from mosquitoes and humans, Finland, Journal of General Virology, 93, 1984, 10.1099/vir.0.042853-0

Bergqvist, 2015, Detection and isolation of Sindbis virus from mosquitoes captured during an outbreak in Sweden, 2013, Vector Borne and Zoonotic Diseases, 15, 133, 10.1089/vbz.2014.1717

Sammels, 1999, Geographic distribution and evolution of Sindbis virus in Australia, Journal of General Virology, 80, 739, 10.1099/0022-1317-80-3-739

Norder, 1996, Genetic relatedness of Sindbis virus strains from Europe, Middle East, and Africa, Virology, 222, 440, 10.1006/viro.1996.0441

Storm, 2013, Phylogeny of Sindbis virus isolates from South Africa, Southern African Journal of Infectious Diseases, 28, 207, 10.1080/10158782.2013.11441552

Strauss, 1984, Complete nucleotide sequence of the genomic RNA of Sindbis virus, Virology, 133, 92, 10.1016/0042-6822(84)90428-8

Strauss, 1994, The alphaviruses: gene expression, replication, and evolution, Microbiological Reviews, 58, 491, 10.1128/MMBR.58.3.491-562.1994

Spuul, 2011, Assembly of alphavirus replication complexes from RNA and protein components in a novel trans-replication system in mammalian cells, Journal of Virology, 85, 4739, 10.1128/JVI.00085-11

Jose, 2009, A structural and functional perspective of alphavirus replication and assembly, Future Microbiology, 4, 837, 10.2217/fmb.09.59

Taylor, 1955, Sindbis virus: a newly recognized arthropod transmitted virus, American Journal of Tropical Medicine and Hygiene, 4, 844, 10.4269/ajtmh.1955.4.844

Haddow AJ Annual Report 1961/62

Malherbe, 1963, Sindbis virus infection in man. Report of a case with recovery of virus from skin lesions, South African Medical Journal, 37, 547

Ben-Porath, 1965, Occurrence of antibodies to Sindbis virus in children from a West Nile endemic area, Israel Journal of Medical Sciences, 1, 88

Balducci, 1967, Survey for antibodies against arthropod-borne viruses in man and animals in Italy. II. Serologic status of human beings in a northern Italian region (Gorizia province), American Journal of Tropical Medicine and Hygiene, 16, 211, 10.4269/ajtmh.1967.16.211

Saikku P. Occurrence of group A hemagglutination inhibiting activity in Finish serum material Proceedings of the Symposium held in Smolenice near Bratislava 1966

Saikku P Alphaviruses in Europe Etiology, epidemiology, diagnoses and prophylaxis of Karelian Fever-Pogosta disease Academy of Medical Sciences Petrozavodsk, USSR 1984

Kunz, 1963, Nachweis hämagglutinations-hemmender Antikörper gegen Arbo-Viren in der Bevölkerung Österreichs, Zentralbl Bakt Parasit Infekt I Abt Orig, 190, 174

Pavlatos, 1964, Antibodies to arthropod-borne viruses in Greece, Transactions of the Royal Society of Tropical Medicine and Hygiene, 58, 422, 10.1016/0035-9203(64)90089-6

Skogh M Westermark SE Augustiexanthem med arthralgier (August exanthema with arthralgia) 1973

Brummer-Korvenkontio, 1981, Onko Suomen länsiosa säästynyt ‘Pogostalta’?, Suomen Lääkärilehti, 32, 2606

National Infectious Disease Registry maintained by the National Institute for Health and Welfare https://sampo.thl.fi/sampo_prod/cgi-bin/cognos.cgi?b_action=powerPlayService&ui.action=run&TARGET=%2Fcontent%2Ffolder[%40name%3D%27amor_prod%27]%2Ffolder[%40name%3D%27ttr%27]%2Fpackage[%40name%3D%27amor_ttr_shp_1610_fi_prod%27] 2015

Lundstrom, 1991, Geographical and temporal distribution of Ockelbo disease in Sweden, Epidemiology and Infection, 106, 567, 10.1017/S0950268800067637

Storm, 2013, Human cases of Sindbis fever in South Africa, 2006-2010, Epidemiology and Infection, 142, 234, 10.1017/S0950268813000964

Doherty, 1969, Sindbis virus infection in Australia, Medical Journal of Australia, 2, 1016, 10.5694/j.1326-5377.1969.tb107563.x

Jupp, 1986, Sindbis and West Nile virus infections in the Witwatersrand-Pretoria region, South African Medical Journal, 70, 218

Kurkela, 2004, Causative agent of Pogosta disease isolated from blood and skin lesions, Emerging Infectious Diseases, 10, 889, 10.3201/eid1005.030689

Mcintosh, 1964, Illness caused by Sindbis and West Nile viruses in South Africa, South African Medical Journal, 38, 291

McIntosh, 1976, Epidemics of West Nile and Sindbis viruses in South Africa with Culex (Culex) univittatus Theobald as vector, South African Journal of Science, 72, 295

Findlay, 1968, Arbovirus exanthem from Sindbis and West Nile viruses, British Journal of Dermatology, 80, 67, 10.1111/j.1365-2133.1968.tb12262.x

Skogh, 1982, Ockelbo disease: epidemic arthritis-exanthema syndrome in Sweden caused by Sindbis-virus like agent, Lancet, 1, 795, 10.1016/S0140-6736(82)91834-7

L'vov, 1982, Etiology of Karelia fever-a new arbovirus infection, Voprosy Virusologii, 27, 690

Nir, 1967, Isolation of arboviruses from wild birds in Israel, American Journal of Epidemiology, 86, 372, 10.1093/oxfordjournals.aje.a120747

Berezin, 1967, On the problem of investigation of the role of migratory birds in arbovirus circulation, Voprosy Virusologii, 12, 336

Papapanagiotou, 1974, Haemagglutination-inhibiting antibodies to arboviruses in a human population in Greece, Zentralbl Bakteriol Orig A, 228, 443

Serter, 1980, Arboviruses in the Mediterranean Countries, 155

Draganescu, 1975, Investigations on the presence of antibodies to several alphaviruses in humans and domestic animals of a region with elevated epidemiological potential, Virologie, 26, 99

Tempera, 1980, Haemagglutination inhibition antibodies against Sindbis virus in human and bovine sera in Eastern Sicily, Acta Virologica, 24, 157

Vesenjak-Hirjan, 1980, Arboviruses in the Mediterranean Countries, 165

Kurkela, 2008, Sindbis virus infection in resident birds, migratory birds, and humans, Finland, Emerging Infectious Diseases, 14, 41, 10.3201/eid1401.070510

Sane, 2009, Epidemiological analysis of mosquito-borne Pogosta disease in Finland, Eurosurveillance, 2010, 15

Espmark, 1984, Ockelbo disease in Sweden: epidemiological, clinical, and virological data from the 1982 outbreak, American Journal of Tropical Medicine and Hygiene, 33, 1203, 10.4269/ajtmh.1984.33.1203

Hubalek, 2005, Mosquitoborne viruses, Czech Republic, 2002, Emerging Infectious Diseases, 11, 116, 10.3201/eid1101.040444

Buckley, 2003, Serological evidence of West Nile virus, Usutu virus and Sindbis virus infection of birds in the UK, Journal of General Virology, 84, 2807, 10.1099/vir.0.19341-0

Buckley, 2006, Detection of seroconversion to West Nile virus, Usutu virus and Sindbis virus in UK sentinel chickens, Virology Journal, 3, 71, 10.1186/1743-422X-3-71

Juricova, 2009, Serological examination of songbirds (Passeriformes) for mosquito-borne viruses Sindbis, Tahyna, and Batai in a south Moravian wetland (Czech Republic), Vector Borne and Zoonotic Diseases, 9, 295, 10.1089/vbz.2008.0128

Lvov, 1984, Isolation of Karelian fever agent from Aedes communis mosquitoes, Lancet, 2, 399, 10.1016/S0140-6736(84)90562-2

Zhou, 1999, Complete nucleotide sequence of the nonstructural gene of alphavirus YN87448 strain isolated in China and its relationship to other Sindbis viruses, Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi, 13, 314

Vershinskii, 1983, Karelian fever-a new nosological form of arbovirus etiology (togaviridae, alphavirus, Sindbis complex), Trudy Instituta Imeni Pastera, 60, 31

Jalava, 2013, Climatic, ecological and socioeconomic factors as predictors of Sindbis virus infections in Finland, Epidemiology and Infection, 141, 1857, 10.1017/S095026881200249X

Rautenbach, 2011, Mosquito-borne viral infections in Southern Africa: a public health perspective, CME, 29, 204

Sane, 2011, Epidemic sindbis virus infection in Finland: a population-based case-control study of risk factors, Journal of Infectious Diseases, 204, 459, 10.1093/infdis/jir267

Lundstrom, 1999, Mosquito-borne viruses in western Europe: a review, Journal of Vector Ecology, 24, 1

Hubalek, 2008, Mosquito-borne viruses in Europe, Parasitology Research, 103, 29, 10.1007/s00436-008-1064-7

Gresikova, 1978, Identification of a Sindbis virus strain isolated from Hyaloma marginatum ticks in Sicily, Acta Virologica, 22, 231

Kostiukov, 1981, Isolation of the Sindbis virus from Hyalomma anatolicum CL Kock 1844 ticks in Tadzhikistan, Med Parazitol (Mosk), 50, 34

Al-Khalifa, 2007, Man-threatening viruses isolated from ticks in Saudi Arabia, Saudi Medical Journal, 28, 1864

Kozuch, 1978, Isolation of sindbis virus from the frog Rana ridibunda, Acta Virologica, 22, 78

Gresikova, 1973, Internationales Arbeitskolloquium uber Naturherde von Infektions-krankheit in Zentraleuropa, 17-19 April 1973, Illmitz und Graz, 59

Lundstrom, 1992, Antibodies to Ockelbo virus in three orders of birds (Anseriformes, Galliformes and Passeriformes) in Sweden, Journal of Wildlife Diseases, 28, 144, 10.7589/0090-3558-28.1.144

Ernek, 1975, Virus neutralizing antibodies to arboviruses in birds of the order Anseriformes in Czechoslovakia, Acta Virologica, 19, 349

Hesson, 2014, The arbovirus vector Culex torrentium is more prevalent than Culex pipiens in northern and central Europe, Medical and Veterinary Entomology, 28, 179, 10.1111/mve.12024

Lundstrom, 1990, Effect of environmental temperature on the vector competence of Culex pipiens and Cx. torrentium for Ockelbo virus, American Journal of Tropical Medicine and Hygiene, 43, 534, 10.4269/ajtmh.1990.43.534

Hesson, 2015, Culex torrentium mosquito role as major enzootic vector defined by rate of Sindbis virus infection, Sweden, 2009, Emerging Infectious Diseases, 21, 875, 10.3201/eid2105.141577

Jupp, 1986, Experimental assessment of the vector competence of Culex (Culex) neavei Theobald with West Nile and Sindbis viruses in South Africa, Transactions of the Royal Society of Tropical Medicine and Hygiene, 80, 226, 10.1016/0035-9203(86)90019-2

Francy, 1989, Ecologic studies of mosquitoes and birds as hosts of Ockelbo virus in Sweden and isolation of Inkoo and Batai viruses from mosquitoes, American Journal of Tropical Medicine and Hygiene, 41, 355, 10.4269/ajtmh.1989.41.355

Turell, 1990, Transmission of Ockelbo virus by Aedes cinereus, Ae. communis, and Ae. excrucians (Diptera: Culicidae) collected in an enzootic area in central Sweden, Journal of Medical Entomology, 27, 266, 10.1093/jmedent/27.3.266

Uejio, 2012, Climatic controls on West Nile virus and Sindbis virus transmission and outbreaks in South Africa, Vector Borne and Zoonotic Diseases, 12, 117, 10.1089/vbz.2011.0655

Niklasson, 1984, Association of a Sindbis-like virus with Ockelbo disease in Sweden, American Journal of Tropical Medicine and Hygiene, 33, 1212, 10.4269/ajtmh.1984.33.1212

Reinert, 2000, New classification for the composite genus Aedes (Diptera: Culicidae: Aedini), elevation of subgenus Ochlerotatus to generic rank, reclassification of the other subgenera, and notes on certain subgenera and species, Journal of the American Mosquito Control Association, 16, 175

Farajollahi, 2011, “Bird biting” mosquitoes and human disease: a review of the role of Culex pipiens complex mosquitoes in epidemiology, Infection, genetics and evolution, 11, 1577, 10.1016/j.meegid.2011.08.013

Harbach, 1984, Culex (Culex) Molestus Forskål (Diptera: Culicidae): neotype designation, description, variation, and taxonomic status, Proceedings of the Entomological Society of Washington, 86, 521

Fonseca, 2004, Emerging vectors in the Culex pipiens complex, Science, 303, 1535, 10.1126/science.1094247

Jaenson, 1990, Vector roles of Fennoscandian mosquitoes attracted to mammals, birds and frogs, Medical and Veterinary Entomology, 4, 221, 10.1111/j.1365-2915.1990.tb00280.x

Lundstrom, 1990, Swedish Culex torrentium and Cx. pipiens (Diptera: Culicidae) as experimental vectors of Ockelbo virus, Journal of Medical Entomology, 27, 561, 10.1093/jmedent/27.4.561

McIntosh, 1979, Infections in sentinel pigeons by Sindbis and West Nile viruses in South Africa, with observations on Culex (Culex) univittatus (Diptera: Culicidae) attracted to these birds, Journal of Medical Entomology, 16, 234, 10.1093/jmedent/16.3.234

Lundstrom, 1993, Viremia in three orders of birds (Anseriformes, Galliformes and Passeriformes) inoculated with Ockelbo virus, Journal of Wildlife Diseases, 29, 189, 10.7589/0090-3558-29.2.189

Lundstrom, 2001, Prevalence of sindbis virus neutralizing antibodies among Swedish passerines indicates that thrushes are the main amplifying hosts, Journal of Medical Entomology, 38, 289, 10.1603/0022-2585-38.2.289

Medlock, 2007, Possible ecology and epidemiology of medically important mosquito-borne arboviruses in Great Britain, Epidemiology and Infection, 135, 466, 10.1017/S0950268806007047

Sane, 2012, Prolonged myalgia in Sindbis virus infection: case description and in vitro infection of myotubes and myoblasts, Journal of Infectious Diseases, 206, 407, 10.1093/infdis/jis358

Laine, 2000, Prolonged arthritis associated with sindbis-related (Pogosta) virus infection, Rheumatology, 39, 1272, 10.1093/rheumatology/39.11.1272

Kurkela, 2005, Clinical and laboratory manifestations of Sindbis virus infection: prospective study, Finland, 2002-2003, Journal of Infectious Diseases, 191, 1820, 10.1086/430007

Chow, 2011, Persistent arthralgia induced by Chikungunya virus infection is associated with interleukin-6 and granulocyte macrophage colony-stimulating factor, Journal of Infectious Diseases, 203, 149, 10.1093/infdis/jiq042

Manni, 2008, Diagnostics of Pogosta disease: antigenic properties and evaluation of Sindbis virus IgM and IgG enzyme immunoassays, Vector Borne and Zoonotic Diseases, 8, 303, 10.1089/vbz.2007.0623

Sane, 2012, Development and evaluation of a real-time RT-PCR assay for Sindbis virus detection, Journal of Virological Methods, 179, 185, 10.1016/j.jviromet.2011.10.021

Appassakij, 2013, Viremic profiles in asymptomatic and symptomatic chikungunya fever: a blood transfusion threat?, Transfusion, 53, 2567, 10.1111/j.1537-2995.2012.03960.x

Vene, 1994, Development of specific antibody patterns and clinical symptoms following Ockelbo virus infection, Archives of Virology, 134, 61, 10.1007/BF01379107

Niklasson, 1988, Occurrence of arthralgia and specific IgM antibodies three to four years after Ockelbo disease, Journal of Infectious Diseases, 157, 832, 10.1093/infdis/157.4.832

Guard, 1982, Haemorrhagic manifestations with Sindbis infection. Case report, Pathology, 14, 89, 10.3109/00313028209069049

Turunen, 1998, Pogosta disease: clinical observations during an outbreak in the province of North Karelia, Finland, British Journal of Rheumatology, 37, 1177, 10.1093/rheumatology/37.11.1177

Horling, 1993, Detection of Ockelbo virus RNA in skin biopsies by polymerase chain reaction, Journal of Clinical Microbiology, 31, 2004, 10.1128/JCM.31.8.2004-2009.1993

Harley, 2002, Ross River virus disease in tropical Queensland: evolution of rheumatic manifestations in an inception cohort followed for six months, Medical Journal of Australia, 177, 352, 10.5694/j.1326-5377.2002.tb04836.x

Chopra, 2012, Acute Chikungunya and persistent musculoskeletal pain following the 2006 Indian epidemic: a 2-year prospective rural community study, Epidemiology & Infection, 140, 842, 10.1017/S0950268811001300

Sissoko, 2009, Post-epidemic Chikungunya disease on Reunion Island: course of rheumatic manifestations and associated factors over a 15-month period, PLoS Neglected Tropical Diseases, 3, e389, 10.1371/journal.pntd.0000389

Borgherini, 2008, Persistent arthralgia associated with Chikungunya virus: a study of 88 adult patients on Reunion Island, Clinical Infectious Diseases, 47, 469, 10.1086/590003

Niklasson, 1986, Ockelbo disease: arthralgia 3-4 years after infection with a Sindbis virus related agent, Lancet, 1, 1039, 10.1016/S0140-6736(86)91315-2

Schilte, 2013, Chikungunya virus-associated long-term arthralgia: a 36-month prospective longitudinal study, PLoS Neglected Tropical Diseases, 7, e2137, 10.1371/journal.pntd.0002137

Laine, 2003, Prevalence of Sindbis-related (Pogosta) virus infections in patients with arthritis, Clinical and Experimental Rheumatology, 21, 213, 10.1186/ar503

Calisher, 1985, Sensitive enzyme immunoassay for detecting immunoglobulin M antibodies to Sindbis virus and further evidence that Pogosta disease is caused by a western equine encephalitis complex virus, Journal of Clinical Microbiology, 22, 566, 10.1128/JCM.22.4.566-571.1985

Calisher, 1986, Complex-specific immunoglobulin M antibody patterns in humans infected with alphaviruses, Journal of Clinical Microbiology, 23, 155, 10.1128/JCM.23.1.155-159.1986

Mackenzie, 1994, Human and animal arboviral diseases in Australia, Recent Advances in Microbiology, 2, 1

Assuncao-Miranda, 2013, Molecular mechanisms involved in the pathogenesis of alphavirus-induced arthritis, BioMed Research International, 2013, 973516, 10.1155/2013/973516

Jaffar-Bandjee, 2009, Chikungunya virus takes centre stage in virally induced arthritis: possible cellular and molecular mechanisms to pathogenesis, Microbes and Infection, 11, 1206, 10.1016/j.micinf.2009.10.001

Kielian, 2010, Alphavirus entry and membrane fusion, Viruses, 2, 796, 10.3390/v2040796

Vancini, 2015, Alphavirus entry into host cells, Progress in Molecular Biology and Translational Science, 129, 33, 10.1016/bs.pmbts.2014.10.002

Wang, 1992, High-affinity laminin receptor is a receptor for Sindbis virus in mammalian cells, Journal of Virology, 66, 4992, 10.1128/JVI.66.8.4992-5001.1992

Klimstra, 1998, Adaptation of Sindbis virus to BHK cells selects for use of heparan sulfate as an attachment receptor, Journal of Virology, 72, 7357, 10.1128/JVI.72.9.7357-7366.1998

Klimstra, 2003, DC-SIGN and L-SIGN can act as attachment receptors for alphaviruses and distinguish between mosquito cell- and mammalian cell-derived viruses, Journal of Virology, 77, 12022, 10.1128/JVI.77.22.12022-12032.2003

Rose, 2011, Natural resistance-associated macrophage protein is a cellular receptor for sindbis virus in both insect and mammalian hosts, Cell Host Microbe, 10, 97, 10.1016/j.chom.2011.06.009

Karpf, 1998, Comparison of Sindbis virus-induced pathology in mosquito and vertebrate cell cultures, Virology, 240, 193, 10.1006/viro.1997.8914

Levine, 1993, Conversion of lytic to persistent alphavirus infection by the bcl-2 cellular oncogene, Nature, 361, 739, 10.1038/361739a0

Assuncao-Miranda, 2010, Pro-inflammatory response resulting from sindbis virus infection of human macrophages: implications for the pathogenesis of viral arthritis, Journal of Medical Virology, 82, 164, 10.1002/jmv.21649

Autio, 1996, An eruption associated with alphavirus infection, British Journal of Dermatology, 135, 320, 10.1111/j.1365-2133.1996.tb01172.x

Trgovcich, 1996, Fatal Sindbis virus infection of neonatal mice in the absence of encephalitis, Virology, 224, 73, 10.1006/viro.1996.0508

Klimstra, 1999, Infection of neonatal mice with sindbis virus results in a systemic inflammatory response syndrome, Journal of Virology, 73, 10387, 10.1128/JVI.73.12.10387-10398.1999

Ozden, 2007, Human muscle satellite cells as targets of Chikungunya virus infection, PLoS ONE, 2, 527, 10.1371/journal.pone.0000527

Heise, 2000, Sindbis-group alphavirus replication in periosteum and endosteum of long bones in adult mice, Journal of Virology, 74, 9294, 10.1128/JVI.74.19.9294-9299.2000

Trgovcich, 1999, TNFalpha, interferon, and stress response induction as a function of age-related susceptibility to fatal Sindbis virus infection of mice, Virology, 263, 339, 10.1006/viro.1999.9913

Gardner, 2012, Interferon-alpha/beta deficiency greatly exacerbates arthritogenic disease in mice infected with wild-type chikungunya virus but not with the cell culture-adapted live-attenuated 181/25 vaccine candidate, Virology, 425, 103, 10.1016/j.virol.2011.12.020

Gardner, 2010, Chikungunya virus arthritis in adult wild-type mice, Journal of Virology, 84, 8021, 10.1128/JVI.02603-09

Couderc, 2008, A mouse model for Chikungunya: young age and inefficient type-I interferon signaling are risk factors for severe disease, PLoS Pathogens, 4, 29, 10.1371/journal.ppat.0040029

Lidbury, 2011, Identification and characterization of a ross river virus variant that grows persistently in macrophages, shows altered disease kinetics in a mouse model, and exhibits resistance to type I interferon, Journal of Virology, 85, 5651, 10.1128/JVI.01189-10

Wauquier, 2011, The acute phase of Chikungunya virus infection in humans is associated with strong innate immunity and T CD8 cell activation, Journal of Infectious Diseases, 204, 115, 10.1093/infdis/jiq006

Hoarau, 2010, Persistent chronic inflammation and infection by Chikungunya arthritogenic alphavirus in spite of a robust host immune response, Journal of Immunology, 184, 5914, 10.4049/jimmunol.0900255

Ryman, 2007, Non-pathogenic Sindbis virus causes hemorrhagic fever in the absence of alpha/beta and gamma interferons, Virology, 368, 273, 10.1016/j.virol.2007.06.039

Her, 2010, Active infection of human blood monocytes by Chikungunya virus triggers an innate immune response, Journal of Immunology, 184, 5903, 10.4049/jimmunol.0904181

Labadie, 2010, Chikungunya disease in nonhuman primates involves long-term viral persistence in macrophages, Journal of Clinical Investigation, 120, 894, 10.1172/JCI40104

Way, 2002, Persistent Ross River virus infection of murine macrophages: an in vitro model for the study of viral relapse and immune modulation during long-term infection, Virology, 301, 281, 10.1006/viro.2002.1587

Lidbury, 2008, Macrophage-derived proinflammatory factors contribute to the development of arthritis and myositis after infection with an arthrogenic alphavirus, Journal of Infectious Diseases, 197, 1585, 10.1086/587841

Rulli, 2011, Protection from arthritis and myositis in a mouse model of acute chikungunya virus disease by bindarit, an inhibitor of monocyte chemotactic protein-1 synthesis, Journal of Infectious Diseases, 204, 1026, 10.1093/infdis/jir470

Rulli, 2009, Amelioration of alphavirus-induced arthritis and myositis in a mouse model by treatment with bindarit, an inhibitor of monocyte chemotactic proteins, Arthritis and Rheumatism, 60, 2513, 10.1002/art.24682

Morrison, 2007, Complement contributes to inflammatory tissue destruction in a mouse model of Ross River virus-induced disease, Journal of Virology, 81, 5132, 10.1128/JVI.02799-06

Morrison, 2008, Complement receptor 3 promotes severe ross river virus-induced disease, Journal of Virology, 82, 11263, 10.1128/JVI.01352-08

Kam, 2012, Early appearance of neutralizing immunoglobulin G3 antibodies is associated with chikungunya virus clearance and long-term clinical protection, Journal of Infectious Diseases, 205, 1147, 10.1093/infdis/jis033

Lum, 2013, An essential role of antibodies in the control of Chikungunya virus infection, Journal of Immunology, 190, 6295, 10.4049/jimmunol.1300304

Pal, 2013, Development of a highly protective combination monoclonal antibody therapy against Chikungunya virus, PLoS Pathogens, 9, e1003312, 10.1371/journal.ppat.1003312

Couderc, 2009, Prophylaxis and therapy for Chikungunya virus infection, Journal of Infectious Diseases, 200, 516, 10.1086/600381

Morrison, 2006, Characterization of Ross River virus tropism and virus-induced inflammation in a mouse model of viral arthritis and myositis, Journal of Virology, 80, 737, 10.1128/JVI.80.2.737-749.2006

Teo, 2013, A pathogenic role for CD4+ T cells during Chikungunya virus infection in mice, Journal of Immunology, 190, 259, 10.4049/jimmunol.1202177

Collins, 2013, A temporal model of human IgE and IgG antibody function, Frontiers in Immunology, 4, 235, 10.3389/fimmu.2013.00235

Kapur, 2014, IgG-effector functions: “the good, the bad and the ugly”, Immunology Letters, 160, 139, 10.1016/j.imlet.2014.01.015

Bouquillard, 2009, Rheumatoid arthritis after Chikungunya fever: a prospective follow-up study of 21 cases, Annals of the Rheumatic Diseases, 68, 1505, 10.1136/ard.2008.097626

Nakaya, 2012, Gene profiling of Chikungunya virus arthritis in a mouse model reveals significant overlap with rheumatoid arthritis, Arthritis and Rheumatism, 64, 3553, 10.1002/art.34631

Fraser, 1980, Possible genetic determinants in epidemic polyarthritis caused by Ross River virus infection, Australian and New Zealand Journal of Medicine, 10, 597, 10.1111/j.1445-5994.1980.tb04238.x

Weyand, 1992, The influence of HLA-DRB1 genes on disease severity in rheumatoid arthritis, Annals of Internal Medicine, 117, 801, 10.7326/0003-4819-117-10-801

Kerr, 2002, Association of symptomatic acute human parvovirus B19 infection with human leukocyte antigen class I and II alleles, Journal of Infectious Diseases, 186, 447, 10.1086/341947