Simple and efficient synthesis of chiral amino alcohols with an amino acid-based skeleton

Letters in Peptide Science - Tập 10 - Trang 79-82 - 2003
Paulina Juszczyk1, Regina Kasprzykowska1, Aleksandra S. Kołodziejczyk1
1Faculty of Chemistry, University of Gdańsk, Gdańsk, Poland

Tóm tắt

Sodium bis(2-methoxyethoxy)aluminum hydride, NaAlH2(OCH2CH2OCH3)2, commercially known as Vitride® or Red-Al®, enables rapid synthesis of pure optically active N-protected amino alcohols and peptide alcohols in very high yields. The method is very simple and attractive, as it does not require an additional step of N-protected amino acid derivatization and proceeds without the loss of enantiomeric homogeneity.

Tài liệu tham khảo

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Thông tin xuất bản

Letters in Peptide Science

Tập 10

79-82

Thông tin tác giả