Silyl Modification of Biologically Active Compounds. 8. Trimethylsilyl Ethers of Hydroxyl-containing Thiazole Derivatives

Chemistry of Heterocyclic Compounds - Tập 38 - Trang 859-866 - 2002
A. Zablotskaya1, I. Segal1, S Germane1, I. Shestakova1, I. Domracheva1, A. Nesterova1, A. Geronikaki2, E. Lukevics1
1Latvian Institute of Organic Synthesis, Riga
2Department of Pharmaceutical Chemistry, Aristotelian University of Thessaloniki, Greece

Tóm tắt

Trimethylsilyl ethers of various hydroxyl-containing thiazole derivatives have been synthesized. The psychotropic activity (in vivo) and the cytotoxicity (in vitro on tumor cell lines HT-1080 and MG-22A) of these ethers and of their unsilylated precursors have been studied. It was discovered that the obtained compounds possess a sedative action. A moderate cytotoxic effect was detected for piperidine-containing thiazoles, displayed most strongly in relation to MG-22A cells.

Tài liệu tham khảo

A. Zablotskaya, I. Segal, A. Kemme, S. Germane, J. Popelis, E. Lukevics, R. Berger, and H. Spies, Khim. Geterotsikl. Soedin., 543 (2002).

C. Dwivedi, T. K. Gupta, and S. S. Parmar, J. Med. Chem., 15, 553 (1972).

S. K. Chaudhari, M. Verma, A. K. Chaturvedi, and S. S. Parmar, J. Pharm. Sci., 64, 614 (1975).

S. A. H. El-Feky and Z. K. Abd El-Samii, Arch. Pharm. (Weinheim), 324, 381 (1991).

G. Trapani, A. Carotti, M. Franco, A. Latrofa, G. Genchi, and G. Liso, Eur. J. Med. Chem., 28, 13 (1993).

S. Tsutsumi, T. Okonogi, S. Shibahara, S. Ohuchi, E. Hatsushiba, A. A. Patchett, and B. G. Christensen, J. Med. Chem., 37, 3492 (1994).

N. Ergene and G. Capan, Farmaco, 49, 133 (1994).

J. B. Stenlake, N. C. Dhar, C. F. Henderson, R. B. Machr, J. Scharver, W. B. Wastila, and J. M. Midgley, Eur. J. Med. Chem., 28, 415 (1993).

A. Zablotskaya, S. Germane, I. Segal, and E. Lukevics, Latv. J. Chem., 79 (1993).

E. Lukevics, A. Zablotskaya, S. Germane, and I. Segal, Latv. J. Chem., 472 (1994).

E. Lukevics, I. Segal, A. Zablotskaya, and S. Germane, Khim. Geterotsikl. Soedin., 793 (1996).

E. Lukevics, I. Segal, A. Zablotskaya, and S. Germane, Molecules, 2, 180 (1997).

E. Lukevics, I. Segal, I. Birgele, and A. Zablotskaya, Khim. Geterotsikl. Soedin., 1253 (1998).

H. Spies, T. Fitts, A. Zablotskaya, S. Belyakov, and E. Lukevics, Khim. Geterotsikl. Soedin., 116 (1999).

A. Geronikaki and G. Theophilidis, Eur. J. Med. Chem., 27, 709 (1992).

R. Mgonzo, A. Geronikaki, and G. Theophilidis, Res. Commun. Pharmacol. Toxicol., 1, 136 (1996).

V. V. Prozorovskii, M. P. Prozorovskaya, and V. M. Demchenko, Pharmacology and Toxicology [in Russian], Khimiya, Moscow (1978), 497 p.

D. J. Fast, R. C. Lynch, and R. W. Leu, J. Leukocyte Biol., 52, 255 (1992).

P. J. Freshney, Culture of Animal Cells (A Manual of Basic Technique), Wiley-Liss, New York (1994), p. 296.

Thông tin
Thông tin xuất bản

Chemistry of Heterocyclic Compounds

Tập 38

859-866

Thông tin tác giả