Sialic acid exerts anti-inflammatory effect through inhibiting MAPK-NF-κB/AP-1 pathway and apoptosis in ulcerative colitis

Abeln, 2019, Sialic acid is a critical fetal defense against maternal complement attack, Journal of Clinical Investigation, 129, 422, 10.1172/JCI99945 Arthur, 2013, Mitogen-activated protein kinases in innate immunity, Nature Reviews Immunology, 13, 679, 10.1038/nri3495 Chazaud, 2020, Inflammation and skeletal muscle regeneration: Leave it to the macrophages, Trends in Immunology, 41, 481, 10.1016/j.it.2020.04.006 Cheng, 2018, Serum amyloid A promotes LPS clearance and suppresses LPS-induced inflammation and tissue injury, EMBO reports, 19, 10.15252/embr.201745517 Cohen, 2017, Update on anti-tumor necrosis factor agents and other new drugs for inflammatory bowel disease, British Medical Journal, 357 Dai, 2021, A comprehensive review of edible bird’s nest, Food Research International, 140, 10.1016/j.foodres.2020.109875 de Souza, 2017, The IBD interactome: An integrated view of aetiology, pathogenesis and therapy, Nature Reviews Gastroenterology & Hepatology, 14, 739, 10.1038/nrgastro.2017.110 Friedrich, 2019, Cytokine networks in the pathophysiology of inflammatory bowel disease, Immunity, 50, 992, 10.1016/j.immuni.2019.03.017 Guo, 2006, Edible bird's nest extract inhibits influenza virus infection, Antiviral Research, 70, 140, 10.1016/j.antiviral.2006.02.005 Guo, 2016, Exogenous supplement of N-acetylneuraminic acid ameliorates atherosclerosis in apolipoprotein E-deficient mice, Atherosclerosis, 251, 183, 10.1016/j.atherosclerosis.2016.05.032 Guo, 2017, Octacosanol attenuates inflammation in both RAW264.7 macrophages and a mouse model of colitis, Journal of Agricultural and Food Chemistry, 65, 3647, 10.1021/acs.jafc.6b05465 Ji, 2019, Inflammatory regulatory network mediated by the joint action of NF-κB, STAT3, and AP-1 factors is involved in many human cancers, Proceedings of the National Academy of Sciences of the United States of America, 116, 9453, 10.1073/pnas.1821068116 Jin, 2019, EtOAc extract of H. attenuatum Choisy inhibits inflammation by suppressing the NF-κB and MAPK pathways and modulating the gut microbiota, Phytomedicine, 57, 292, 10.1016/j.phymed.2018.12.037 Kaplan, 2021, The four epidemiological stages in the global evolution of inflammatory bowel disease, Nature reviews Gastroenterology & hepatology, 18, 56, 10.1038/s41575-020-00360-x Kurashima, 2021, Pancreatic glycoprotein 2 is a first line of defense for mucosal protection in intestinal inflammation, Nature Communications, 12, 1067, 10.1038/s41467-021-21277-2 Li, 2023, Targeting NF-κB pathway by dietary lignans in inflammation: Expanding roles of gut microbiota and metabolites, Critical Reviews in Food Science and Nutrition Liang, 2020, The extracts of Morinda officinalis and its hairy roots attenuate dextran sodium sulfate-induced chronic ulcerative colitis in mice by regulating inflammation and lymphocyte apoptosis, Frontiers in Immunology, 11, 2092, 10.3389/fimmu.2020.02092 Liu, 2021, Atractylenolide inhibits apoptosis and oxidative stress of HTR-8/SVneo cells by activating MAPK/ERK signalling in preeclampsia, Phytomedicine, 93, 10.1016/j.phymed.2021.153773 Ma, 2021, Preventive and therapeutic spermidine treatment attenuates acute colitis in mice, Journal of Agricultural and Food Chemistry, 69, 1864, 10.1021/acs.jafc.0c07095 Nanini, 2018, Damage-associated molecular patterns in inflammatory bowel disease: From biomarkers to therapeutic targets, World Journal of Gastroenterology, 24, 4622, 10.3748/wjg.v24.i41.4622 Nunes, 2014, Cell death and inflammatory bowel diseases: Apoptosis, necrosis, and autophagy in the intestinal epithelium, BioMed Research International, 2014, 10.1155/2014/218493 Ow, 2008, Cytochrome c: Functions beyond respiration, Nature Reviews Molecular Cell Biology, 9, 532, 10.1038/nrm2434 Park, 2022, The protective effect of edible bird’s nest against the immune-senescence process of UVB-irradiated hairless mice, Photochemistry and Photobiology., 98, 949, 10.1111/php.13564 Rahimifard, 2017, Targeting the TLR4 signaling pathway by polyphenols: A novel therapeutic strategy for neuroinflammation, Ageing Research Reviews., 36, 11, 10.1016/j.arr.2017.02.004 Roh, 2012, Mechanisms of edible bird‘s nest extract-induced proliferation of human adipose-derived stem cells, Evidence-Based Complementary and Alternative Medicine, 2012, 10.1155/2012/797520 Schirmer, B., Bringmann, L., Seifert, R., & Neumann, D. (2018). In vivo evidence for partial activation of eosinophils via the histamine H4-receptor: Adoptive transfer experiments using eosinophils from H4R-/- and H4R+/+ mice. Frontiers in Immunology, 9, 2119. https://doi.org/10.3389/fimmu.2018.02119. Shen, 2019, Regulating effect of baicalin on IKK/IKB/NF-kB signaling pathway and apoptosis-related proteins in rats with ulcerative colitis, International Immunopharmacology, 73, 193, 10.1016/j.intimp.2019.04.052 Shi, 2017, Alliin, a garlic organosulfur compound, ameliorates gut inflammation through MAPK-NF-κB/AP-1/STAT-1 inactivation and PPARγ activation, Molecular Nutrition & Food Research, 61, 1601013, 10.1002/mnfr.201601013 Simion, V., Zhou, H.Y., Pierce, J.B., Yang, D.F., Haemmig, S., Tesmenitsky, Y., Sukhova, G., Stone, P.H., Libby, P., & Feinberg, M.W. (2020). LncRNA VINAS regulates atherosclerosis by modulating NF-κB and MAPK signaling. JCI Insight, 5(21), e140627. https://doi.org/10.1172/jci.insight.140627. Tambuwala, 2015, Targeted delivery of the hydroxylase inhibitor DMOG provides enhanced efficacy with reduced systemic exposure in a murine model of colitis, Journal of Controlled Release, 217, 221, 10.1016/j.jconrel.2015.09.022 Van Opdenbosch, 2019, Caspases in cell death, inflammation, and disease, Immunity, 50, 1352, 10.1016/j.immuni.2019.05.020 Vimala, 2012, Effects of edible bird’s nest on tumour necrosis factor-alpha secretion, nitric oxide production and cell viability of lipopolysaccharide-stimulated RAW 264.7 macrophages, Food and Agricultural Immunology, 23, 303, 10.1080/09540105.2011.625494 Wang, 2019, Chitosan ameliorates DSS-induced ulcerative colitis mice by enhancing intestinal barrier function and improving microflora, International Journal of Molecular Sciences, 20, 5751, 10.3390/ijms20225751 Wang, 2019, Maggot extracts alleviate inflammation and oxidative stress in acute experimental colitis via the activation of Nrf2, Oxidative Medicine and Cellular Longevity, 2019, 4703253, 10.1155/2019/4703253 Wei, 2021, Shaoyao decoction attenuates DSS-induced ulcerative colitis, macrophage and NLRP3 inflammasome activation through the MKP1/NF-κB pathway, Phytomedicine, 92, 10.1016/j.phymed.2021.153743 Xie, 2018, Effect of maternal administration of edible bird's nest on the learning and memory abilities of suckling offspring in mice, Neural Plasticity, 2018, 7697261, 10.1155/2018/7697261 Xu, 2019, Immune-checkpoint protein VISTA regulates antitumor immunity by controlling myeloid cell-mediated inflammation and immunosuppression, Cancer Immunology Research, 7, 1497, 10.1158/2326-6066.CIR-18-0489 Xu, 2020, DKK3 attenuates JNK and AP-1 induced inflammation via Kremen-1 and DVL-1 in mice following intracerebral hemorrhage, Journal of Neuroinflammation, 17, 130, 10.1186/s12974-020-01794-5 Yang, 2021, An overview and future prospects of sialic acids, Biotechnology Advances, 46, 10.1016/j.biotechadv.2020.107678 Yim, 2020, Sustainable nanosheet antioxidants for sepsis therapy via scavenging intracellular reactive oxygen and nitrogen species, ACS Nano, 14, 10324, 10.1021/acsnano.0c03807 Yue, 2020, Understanding MAPK signaling pathways in apoptosis, International Journal of Molecular Sciences, 21, 2346, 10.3390/ijms21072346 Zenz, 2008, Activator protein 1 (Fos/Jun) functions in inflammatory bone and skin disease, Arthritis Research & Therapy, 10, 201, 10.1186/ar2338 Zhang, 2015, High fat diet-induced inflammation and oxidative stress are attenuated by N-acetylneuraminic acid in rats, Journal of Biomedical Science, 22, 96, 10.1186/s12929-015-0211-6 Zhao, 2021, Inflammation and tumor progression: Signaling pathways and targeted intervention, Signal Transduction and Targeted Therapy, 6, 263, 10.1038/s41392-021-00658-5 Zhao, 2016, The improvement effects of edible bird’s nest on proliferation and activation of B lymphocyte and its antagonistic effects on immunosuppression induced by cyclophosphamid, Drug Design, Development and Therapy, 10, 371 Zhou, 2021, Mogroside V exerts anti-inflammatory effect via MAPK-NF-κB/AP-1 and AMPK-PI3K/Akt/mTOR pathways in ulcerative colitis, Journal of Functional Foods, 87, 10.1016/j.jff.2021.104807 Hu, T., Lin, Q.L., Guo, T., Yang, T., Zhou, W.H., Deng, X.F., Yan, J.K., Luo, Y., Ju, MM., & Luo, F.J. (2018). Polysaccharide isolated from Phellinus linteus mycelia exerts anti-inflammatory effects via MAPK and PPAR signaling pathways. Carbohydrate Polymers, 200, 487-497. https://doi.org/10.1016/j.carbpol.2018.08.021. Büll, C., Boltje, T.J., Balneger, N., Weischer, S.M., Wassink, M., van Gemst, J.J., Bloemendal, V,R., Boon, L., van der Vlag, J., Heise, T., den Brok, M.H., & Adema, G.J. (2018). Sialic acid blockade suppresses tumor growth by enhancing T-cell-mediated tumor immunity. Cancer Research, 78(13), 3574-3588. https://doi.org/10.1158/0008-5472.CAN-17-3376.