Serum levels of insulin-like growth factor I and its binding proteins in health and disease

Growth Hormone & IGF Research - Tập 13 Số 4 - Trang 113-170 - 2003
Anders Juul1
1Department of Growth and Reproduction, University of Copenhagen, Blegdamsvej 9 Rigshopitalet, Section 5064, Copenhagen 2100, Denmark.

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Hall, 1972, Human somatomedin. Determination, occurrence, biological activity and purification, Acta Endocrinol. Suppl. (Copenh.), 163, 1052

Zapf, 1978, Nonsuppressible insulin-like activity (NSILA) from human serum: recent accomplishments and their physiologic implications, Metabolism, 27, 1803, 10.1016/0026-0495(78)90267-6

Daughaday, 1972, Somatomedin: proposed designation for sulphation factor, Nature, 235, 107, 10.1038/235107a0

Rinderknecht, 1978, The amino acid sequence of human insulin-like growth factor I and its structural homology with proinsulin, J. Biol. Chem., 253, 2769, 10.1016/S0021-9258(17)40889-1

D’Ercole, 1980, Evidence that somatomedin is synthesized by multiple tissues in the fetus, Dev. Biol., 75, 315, 10.1016/0012-1606(80)90166-9

Isaksson, 1982, Growth hormone stimulates longitudinal bone growth directly, Science, 216, 1237, 10.1126/science.7079756

Azcona, 1999, Growth response to rhIGF-I 80 microg/kg twice daily in children with growth hormone insensitivity syndrome: relationship to severity of clinical phenotype, Clin. Endocrinol. (Oxf.), 51, 787, 10.1046/j.1365-2265.1999.00887.x

Ranke, 1999, Long-term treatment of growth hormone insensitivity syndrome with IGF-I. Results of the European Multicentre Study. The Working Group on Growth Hormone Insensitivity Syndromes, Horm. Res., 51, 128, 10.1159/000023345

Camacho-Hubner, 1999, Effects of recombinant human insulin-like growth factor I (IGF-I) therapy on the growth hormone-IGF system of a patient with a partial IGF-I gene deletion, J. Clin. Endocrinol. Metab., 84, 1611, 10.1210/jc.84.5.1611

Sjogren, 1999, Liver-derived insulin-like growth factor I (IGF-I) is the principal source of IGF-I in blood but is not required for postnatal body growth in mice, Proc. Natl. Acad. Sci. USA, 96, 7088, 10.1073/pnas.96.12.7088

Yakar, 1999, Normal growth and development in the absence of hepatic insulin-like growth factor I, Proc. Natl. Acad. Sci. USA, 96, 7324, 10.1073/pnas.96.13.7324

Le Roith, 2001, What is the role of circulating IGF-I, Trends Endocrinol. Metab., 12, 48, 10.1016/S1043-2760(00)00349-0

Yakar, 2001, Liver-specific igf-1 gene deletion leads to muscle insulin insensitivity, Diabetes, 50, 1110, 10.2337/diabetes.50.5.1110

LeRoith, 1995, Molecular and cellular aspects of the insulin-like growth factor I receptor, Endocr. Rev., 16, 143, 10.1210/edrv-16-2-143

Siebler, 1995, Insulin-like growth factor I receptor expression and function in fibroblasts from two patients with deletion of the distal long arm of chromosome 15, J. Clin. Endocrinol. Metab., 80, 3447, 10.1210/jc.80.12.3447

Hattori, 1996, Decreased insulin-like growth factor I receptor expression and function in immortalized African Pygmy T cells, J. Clin. Endocrinol. Metab., 81, 2257, 10.1210/jc.81.6.2257

Nielsen, 1992, The molecular and cellular biology of insulin-like growth factor II, Prog. Growth Factor Res., 4, 257, 10.1016/0955-2235(92)90023-B

Steele-Perkins, 1988, Expression and characterization of a functional human insulin-like growth factor I receptor, J. Biol. Chem, 263, 11486, 10.1016/S0021-9258(18)37983-3

Baxter, 1998, Recommendations for nomenclature of the insulin-like growth factor binding protein superfamily, J. Clin. Endocrinol. Metab., 83, 3213, 10.1210/jc.83.9.3213

Baxter, 1990, Circulating levels and molecular distribution of the acid-labile (α) subunit of the high molecular weight insulin-like growth factor-binding protein complex, J. Clin. Endocrinol. Metab., 70, 1347, 10.1210/jcem-70-5-1347

Arany, 1994, Differential cellular synthesis of insulin-like growth factor binding protein-1 (IGFBP-1) and IGFBP-3 within human liver, J. Clin. Endocrinol. Metab., 79, 1871, 10.1210/jc.79.6.1871

Chin, 1994, Cellular localization and regulation of gene expression for components of the insulin-like growth factor ternary binding protein complex, Endocrinology, 134, 2498, 10.1210/en.134.6.2498

Juul, 1995, Serum levels of insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) in healthy infants, children, and adolescents: the relation to IGF-I, IGF-II, IGFBP-1, IGFBP-2, age, sex, body mass index, and pubertal maturation, J. Clin. Endocrinol. Metab., 80, 2534, 10.1210/jc.80.8.2534

Holman, 1996, Insulin-like growth factor binding protein-3: factors affecting binary and ternary complex formation, Growth Regul., 6, 42

Baxter, 1990, Glycosaminoglycans inhibit formation of the 140kDa insulin-like growth factor-binding protein complex, Biochem. J., 271, 773, 10.1042/bj2710773

Rajaram, 1997, Insulin-like growth factor-binding proteins in serum and other biological fluids: regulation and functions, Endocr. Rev., 18, 801, 10.1210/er.18.6.801

Povoa, 1984, Isolation and characterization of a somatomedin-binding protein from mid-term human amniotic fluid, Eur. J. Biochem., 144, 199, 10.1111/j.1432-1033.1984.tb08449.x

Koistinen, 1986, Placental protein 12 is a decidual protein that binds somatomedin and has an identical N-terminal amino acid sequence with somatomedin-binding protein from human amniotic fluid, Endocrinology, 118, 1375, 10.1210/endo-118-4-1375

Drop, 1979, Partial purification and characterization of a binding protein for insulin-like activity (ILAs) in human amniotic fluid: a possible inhibitor of insulin-like activity, Acta Endocrinol. (Copenh.), 90, 505, 10.1530/acta.0.0900505

Brismar, 1994, Effect of insulin on the hepatic production of insulin-like growth factor-binding protein-1 (IGFBP-1), IGFBP-3, and IGF-I in insulin-dependent diabetes, J. Clin. Endocrinol. Metab., 79, 872, 10.1210/jc.79.3.872

Yeoh, 1988, Metabolic regulation of the growth hormone independent insulin-like growth factor binding protein in human plasma, Acta Endocrinol. (Copenh.), 119, 465, 10.1530/acta.0.1190465

Frystyk, 1997, The effect of oral glucose on serum free insulin-like growth factor-I and -II in health adults, J. Clin. Endocrinol. Metab., 82, 3124, 10.1210/jc.82.9.3124

Westwood, 1994, The phosphorylation pattern of insulin-like growth factor-binding protein-1 in normal plasma is different from that in amniotic fluid and changes during pregnancy, J. Clin. Endocrinol. Metab., 79, 1735, 10.1210/jc.79.6.1735

Blum, 1993, Clinical studies of IGFBP-2 by radioimmunoassay, Growth Regul., 3, 100

Hwa, 1999, The insulin-like growth factor-binding protein (IGFBP) superfamily, Endocr. Rev., 20, 761, 10.1210/er.20.6.761

Lassarre, 1994, Insulin-like growth factor binding protein-3 is functionally altered in pregnancy plasma, Endocrinology, 134, 1254, 10.1210/en.134.3.1254

Gargosky, 1992, Measurement and characterization of insulin-like growth factor binding protein-3 in human biological fluids: discrepancies between radioimmunoassay and ligand blotting, Endocrinology, 131, 3051, 10.1210/en.131.6.3051

Lalou, 1993, Evidence that limited proteolysis of insulin-like growth factor binding protein-3 (IGFBP-3) occurs in the normal state outside of the bloodstream, Regul. Pept., 48, 179, 10.1016/0167-0115(93)90346-A

Bang, 1994, Decreased ternary complex formation and predominance of a 29kDa IGFBP-3 fragment in human fetal serum, Growth Regul., 4, 68

Juul, 1996, Serum concentrations of free and total insulin-like growth factor-I, IGF binding proteins -1 and -3 and IGFBP-3 protease activity in boys with normal or precocious puberty, Clin. Endocrinol. (Oxf.), 44, 515, 10.1046/j.1365-2265.1996.711531.x

Giudice, 1990, Insulin-like growth factor binding proteins in maternal serum throughout gestation and in the puerperium: effects of a pregnancy-associated serum protease activity, J. Clin. Endocrinol. Metab., 71, 806, 10.1210/jcem-71-4-806

Hossenlopp, 1990, Evidence of enzymatic degradation of insulin-like growth factor-binding proteins in the 150 K complex during pregnancy, J. Clin. Endocrinol. Metab., 71, 797, 10.1210/jcem-71-4-797

Langford, 1995, Serum insulin-like growth factor-binding protein-3 (IGFBP-3) levels and IGFBP-3 protease activity in normal, abnormal, and multiple human pregnancy, J. Clin. Endocrinol. Metab., 80, 21, 10.1210/jc.80.1.21

Skjaerbaek, 1998, Differential changes in free and total insulin-like growth factor I after major, elective abdominal surgery: the possible role of insulin-like growth factor-binding protein-3 proteolysis, J. Clin. Endocrinol. Metab., 83, 2445, 10.1210/jc.83.7.2445

Bang, 1998, Postoperative induction of insulin-like growth factor binding protein-3 proteolytic activity: relation to insulin and insulin sensitivity, J. Clin. Endocrinol. Metab., 83, 2509, 10.1210/jc.83.7.2509

Cwyfan, 1992, The induction of specific proteases for insulin-like growth factor-binding proteins following major heart surgery, J. Endocrinol., 135, 135, 10.1677/joe.0.1350135

Davenport, 1992, Insulin-like growth factor-binding protein-3 proteolysis is induced after elective surgery, J. Clin. Endocrinol. Metab., 75, 590, 10.1210/jc.75.2.590

Davies, 1991, The induction of a specific protease for insulin-like growth factor binding protein-3 in the circulation during severe illness, J. Endocrinol., 130, 469, 10.1677/joe.0.1300469

Stoving, 1999, Low serum levels of free and total insulin-like growth factor I (IGF-I) in patients with anorexia nervosa are not associated with increased IGF-binding protein-3 proteolysis, J. Clin. Endocrinol. Metab., 84, 1346, 10.1210/jc.84.4.1346

Pucilowska, 1993, The effect of dietary protein supplementation on insulin-like growth factors (IGFs) and IGF-binding proteins in children with shigellosis, J. Clin. Endocrinol. Metab., 77, 1516, 10.1210/jc.77.6.1516

Tillmann, 1998, Serum insulin-like growth factor-I, IGF binding protein-3 and IGFBP-3 protease activity after cranial irradiation, Horm. Res., 50, 71, 10.1159/000023237

Bereket, 1995, Effect of insulin on the insulin-like growth factor system in children with new-onset insulin-dependent diabetes mellitus, J. Clin. Endocrinol. Metab., 80, 1312, 10.1210/jc.80.4.1312

Bang, 1994, J. Clin. Endocrinol. Metab., 78, 1119, 10.1210/jc.78.5.1119

Fielder, 1992, Expression of serum insulin-like growth factors, insulin-like growth factor-binding proteins, and the growth hormone-binding protein in heterozygote relatives of Ecuadorian growth hormone receptor deficient patients, J. Clin. Endocrinol. Metab., 74, 743, 10.1210/jc.74.4.743

Skjaerbaek, 1998, No effect of growth hormone on serum insulin-like growth factor binding protein-3 proteolysis, J. Clin. Endocrinol. Metab., 83, 1206, 10.1210/jc.83.4.1206

Heding, 1996, Biosensor measurement of the binding of insulin-like growth factors I and II and their analogues to the insulin-like growth factor-binding protein-3, J. Biol. Chem, 271, 13948, 10.1074/jbc.271.24.13948

Drakenberg, 1990, Circulating forms and biological activity of intact and truncated insulin-like growth factor I in adult and neonatal rats, Acta Endocrinol. (Copenh.), 123, 43, 10.1530/acta.0.1230043

Giacobini, 1990, Truncated IGF-1 exerts trophic effects on fetal brain tissue grafts, Exp. Neurol., 108, 33, 10.1016/0014-4886(90)90004-C

Sara, 1989, Identification of Gly–Pro–Glu (GPE), the aminoterminal tripeptide of insulin-like growth factor 1 which is truncated in brain, as a novel neuroactive peptide, Biochem. Biophys. Res. Commun., 165, 766, 10.1016/S0006-291X(89)80032-4

Sara, 1993, The biological role of truncated insulin-like growth factor-1 and the tripeptide GPE in the central nervous system, Ann. N.Y. Acad. Sci., 692, 183, 10.1111/j.1749-6632.1993.tb26216.x

Nilsson-Hakansson, 1993, Effects of IGF-1, truncated IGF-1 and the tripeptide Gly–Pro–Glu on acetylcholine release from parietal cortex of rat brain, Neuroreport, 4, 1111

Yamamoto, 1994, Generation of des-(1–3) insulin-like growth factor-I in serum by an acid protease, Endocrinology, 135, 2432, 10.1210/en.135.6.2432

Yamamoto, 1995, N-terminal truncated insulin-like growth factor-I in human urine, J. Clin. Endocrinol. Metab., 80, 1179, 10.1210/jc.80.4.1179

Ryan, 1992, A normal population study of human salivary insulin-like growth factor 1 (IGF 1) concentrations from birth through puberty, J. Clin. Endocrinol. Metab., 74, 774, 10.1210/jc.74.4.774

Yokoya, 1988, Age-related changes in IGF I/SmC levels in plasma and urine – glomerular filtration of the unbound form, Acta Paediatr. Jpn., 30 Suppl, 50

Hizuka, 1991, Measurement of free form of insulin-like growth factor I in human plasma, Growth Regul., 1, 51

Takada, 1994, Measurement of free insulin-like growth factor-I using immunoradiometric assay, J. Immunoassay, 15, 263, 10.1080/15321819408009577

Frystyk, 1994, Free insulin-like growth factors (IGF-I and IGF-II) in human serum, FEBS Lett., 348, 185, 10.1016/0014-5793(94)00602-4

Frystyk, 2001, Determination of free insulin-like growth factor-I in human serum: comparison of ultrafiltration and direct immunoradiometric assay, Growth Horm. IGF. Res., 11, 117, 10.1054/ghir.2001.0197

Juul, 1997, Free insulin-like growth factor I serum levels in 1430 healthy children and adults, and its diagnostic value in patients suspected of growth hormone deficiency, J. Clin. Endocrinol. Metab., 82, 2497, 10.1210/jc.82.8.2497

Nyomba, 1997, Free insulin-like growth factor I (IGF-I) in healthy subjects: relationship with IGF-binding proteins and insulin sensitivity, J. Clin. Endocrinol. Metab., 82, 2177, 10.1210/jc.82.7.2177

Frystyk, 1997, Serum free IGF-I during a hyperinsulinemic clamp following 3 days of administration of IGF-I vs. saline, Am. J. Physiol., 273, E507

Bereket, 1996, Effect of short-term fasting on free/dissociable insulin-like growth factor I concentrations in normal human serum, J. Clin. Endocrinol. Metab., 81, 4379, 10.1210/jc.81.12.4379

Chapman, 1998, Recovery of growth hormone release from suppression by exogenous insulin-like growth factor I (IGF-I): evidence for a suppressive action of free rather than bound IGF-I, J. Clin. Endocrinol. Metab., 83, 2836, 10.1210/jc.83.8.2836

Kawai, 1999, Serum free insulin-like growth factor I (IGF-I), total IGF-I, and IGF-binding protein-3 concentrations in normal children and children with growth hormone deficiency, J. Clin. Endocrinol. Metab., 84, 82, 10.1210/jc.84.1.82

Guler, 1989, Insulin-like growth factors I and II in healthy man. Estimations of half-lives and production rates, Acta Endocrinol. (Copenh.), 121, 753, 10.1530/acta.0.1210753

Wilton, 1991, Pharmacokinetic profile of recombinant human insulin-like growth factor I given subcutaneously in normal subjects, Acta Paediatr. Scand. Suppl., 377, 111, 10.1111/apa.1991.80.s377.111

Fouque, 1995, Pharmacokinetics of recombinant human insulin-like growth factor-1 in dialysis patients, Kidney Int., 47, 869, 10.1038/ki.1995.130

Rabkin, 1996, Pharmacokinetics of insulin-like growth factor-1 in advanced chronic renal failure, Kidney Int., 49, 1134, 10.1038/ki.1996.164

Blum, 1991, Growth hormone resistance and inhibition of somatomedin activity by excess of insulin-like growth factor binding protein in uraemia, Pediatr. Nephrol., 5, 539, 10.1007/BF01453697

Boroujerdi, 1994, A compartmental model for simulation of IGF-I kinetics and metabolism, Methods Inf. Med., 33, 514, 10.1055/s-0038-1635049

Juul, 1998, The acid-labile subunit of human ternary insulin-like growth factor binding protein complex in serum: hepatosplanchnic release, diurnal variation, circulating concentrations in healthy subjects, and diagnostic use in patients with growth hormone deficiency, J. Clin. Endocrinol. Metab., 83, 4408, 10.1210/jc.83.12.4408

Dahn, 1988, Insulinlike growth factor 1 production is inhibited in human sepsis, Arch. Surg., 123, 1409, 10.1001/archsurg.1988.01400350123019

Fernqvist-Forbes, 1999, Splanchnic exchange of insulin-like growth factor binding protein-1 (IGFBP-1), IGF-I and acid-labile subunit (ALS) during normo- and hyper-insulinaemia in healthy subjects, Clin. Endocrinol. (Oxf.), 51, 327, 10.1046/j.1365-2265.1999.00775.x

Jesionowska, 1990, Determination of insulin and insulin-like growth factors in the ovarian circulation, Fertil. Steril., 53, 88, 10.1016/S0015-0282(16)53221-X

Moller, 1995, Concentrations, release, and disposal of insulin-like growth factor (IGF)-binding proteins (IGFBP), IGF-I, and growth hormone in different vascular beds in patients with cirrhosis, J. Clin. Endocrinol. Metab., 80, 1148, 10.1210/jc.80.4.1148

Brahm, 1997, Net fluxes over working thigh of hormones, growth factors and biomarkers of bone metabolism during short lasting dynamic exercise, Calcif. Tissue Int., 60, 175, 10.1007/s002239900210

Blethen, 1982, Kinetics of the somatomedin C/insulin-like growth factor I: response to exogenous growth hormone (GH) in GH-deficient children, J. Clin. Endocrinol. Metab., 54, 986, 10.1210/jcem-54-5-986

Copeland, 1980, Induction of immunoreactive somatomedin C human serum by growth hormone: dose–response relationships and effect on chromatographic profiles, J. Clin. Endocrinol. Metab., 50, 690, 10.1210/jcem-50-4-690

Tonshoff, 1995, Quantification of urinary insulin-like growth factors (IGFs) and IGF binding protein 3 in healthy volunteers before and after stimulation with recombinant human growth hormone, Eur. J. Endocrinol., 132, 433, 10.1530/eje.0.1320433

Mizuno, 2001, Kinetic analysis of the disposition of insulin-like growth factor 1 in healthy volunteers, Pharm. Res., 18, 1203, 10.1023/A:1010991313633

Frystyk, 1999, The pharmacokinetics of free insulin-like growth factor-I in healthy subjects, Growth Horm. IGF. Res., 9, 150, 10.1054/ghir.1999.0100

Grahnen, 1993, Pharmacokinetics of recombinant human insulin-like growth factor I given subcutaneously to healthy volunteers and to patients with growth hormone receptor deficiency, Acta Paediatr. Suppl., 82, 9, 10.1111/j.1651-2227.1993.tb12918.x

Daughaday, 1987, Serum somatomedin binding proteins: physiologic significance and interference in radioligand assay, J. Lab. Clin. Med., 109, 355

Breier, 1991, Radioimmunoassay for insulin-like growth factor-I: solutions to some potential problems and pitfalls, J. Endocrinol., 128, 347, 10.1677/joe.0.1280347

Mohan, 1995, Development of a simple valid method for the complete removal of insulin-like growth factor (IGF)-binding proteins from IGFs in human serum and other biological fluids: comparison with acid-ethanol treatment and C18 Sep-Pak separation, J. Clin. Endocrinol. Metab., 80, 637, 10.1210/jc.80.2.637

Bang, 1991, Comparison of acid ethanol extraction and acid gel filtration prior to IGF-I and IGF-II radioimmunoassays: improvement of determinations in acid ethanol extracts by the use of truncated IGF-I as radioligand, Acta Endocrinol. (Copenh.), 124, 620, 10.1530/acta.0.1240620

Schaffer, 1993, Characterization of the three 125I-iodination isomers of human insulin-like growth factor I (IGF1), Biochim. Biophys. Acta, 1203, 205, 10.1016/0167-4838(93)90084-5

Juul, 1994, Serum insulin-like growth factor-I in 1030 healthy children, adolescents, and adults: relation to age, sex, stage of puberty, testicular size, and body mass index, J. Clin. Endocrinol. Metab., 78, 744, 10.1210/jc.78.3.744

Baxter, 1993, Altered ligand specificity of proteolysed insulin-like growth factor binding protein-3, Biochem. Biophys. Res. Commun., 196, 1267, 10.1006/bbrc.1993.2389

Blum, 1988, A specific radioimmunoassay for insulin-like growth factor II: the interference of IGF binding proteins can be blocked by excess IGF-I, Acta Endocrinol. (Copenh.), 118, 374, 10.1530/acta.0.1180374

Quarmby, 1998, How much insulin-like growth factor I (IGF-I) circulates? Impact of standardization on IGF-I assay accuracy, J. Clin. Endocrinol. Metab., 83, 1211, 10.1210/jc.83.4.1211

Bang, 1994, Valid measurements of total IGF concentrations in biological fluids. Recommendations from the 3rd International Symposium on Insulin-like Growth Factors, J. Endocrinol., 143, C1, 10.1677/joe.0.143C001

Blum, 1993, Serum levels of insulin-like growth factor I (IGF-I) and IGF binding protein 3 reflect spontaneous growth hormone secretion, J. Clin. Endocrinol. Metab., 76, 1610, 10.1210/jc.76.6.1610

Aimaretti, 1998, Usefulness of IGF-I assay for the diagnosis of GH deficiency in adults, J. Endocrinol. Invest., 21, 506, 10.1007/BF03347336

Blum, 1990, A specific radioimmunoassay for the growth hormone (GH)-dependent somatomedin-binding protein: its use for diagnosis of GH deficiency, J. Clin. Endocrinol. Metab., 70, 1292, 10.1210/jcem-70-5-1292

Baxter, 1986, Radioimmunoassay of growth hormone-dependent insulinlike growth factor binding protein in human plasma, J. Clin. Invest., 78, 1504, 10.1172/JCI112742

Khosravi, 1997, Acid-labile subunit of human insulin-like growth factor-binding protein complex: measurement, molecular, and clinical evaluation, J. Clin. Endocrinol. Metab., 82, 3944, 10.1210/jc.82.12.3944

Baxter, 2000, Measurement of the acid-labile subunit of the insulin-like growth factor binding protein complex in human serum: a comparison of four immunoassays, J. Endocrinol., 165, 271, 10.1677/joe.0.1650271

Khosravi, 1999, The high molecular weight insulin-like growth factor-binding protein complex: epitope mapping, immunoassay, and preliminary clinical evaluation, J. Clin. Endocrinol. Metab., 84, 2826, 10.1210/jc.84.8.2826

Rose, 1988, The advantage of measuring stimulated as compared with spontaneous growth hormone levels in the diagnosis of growth hormone deficiency, N. Engl. J. Med., 319, 201, 10.1056/NEJM198807283190403

K. Albertsson-Wikland, S. Rosberg, K. Hall, Spontaneous secretion of growth hormone and serum levels of insulin-like growth factor I and somatomedin binding protein in children of different growth rates, in: O. Isaksson, C. Binder, K. Hall, et al. (Eds.), Growth Hormone-basic and Clinical Aspects. Elsevier, Amsterdam (Biomedical Division), 1987, pp. 163–175

Saggese, 1991, Relationship between plasma somatomedin C levels and 24-h spontaneous growth hormone secretion in short children, J. Pediatr. Endocrinol. Metab., 4, 159, 10.1515/JPEM.1991.4.3.159

Achermann, 1999, Peak and trough growth hormone (GH) concentrations influence growth and serum insulin like growth factor-1 (IGF-1) concentrations in short children, Clin. Endocrinol. (Oxf.), 50, 301, 10.1111/j.1365-2265.1999.tb03945.x

Achermann, 1998, The relationship between the growth hormone and insulin-like growth factor axis in long-term survivors of childhood brain tumours, Clin. Endocrinol. (Oxf.), 49, 639, 10.1046/j.1365-2265.1998.00585.x

Phillip, 1993, Plasma IGFBP-3 and its relationship with quantitative growth hormone secretion in short children, Clin. Endocrinol. (Oxf.), 39, 427, 10.1111/j.1365-2265.1993.tb02389.x

Nunez, 1996, Insulin-like growth factor I (IGF-I) and IGF-binding protein-3 concentrations compared to stimulated and night growth hormone in the evaluation of short children – a clinical research center study, J. Clin. Endocrinol. Metab., 81, 1927, 10.1210/jc.81.5.1927

Rudman, 1981, Impaired growth hormone secretion in the adult population: relation to age and adiposity, J. Clin. Invest., 67, 1361, 10.1172/JCI110164

Vahl, 1996, Abdominal adiposity and physical fitness are major determinants of the age associated decline in stimulated GH secretion in healthy adults, J. Clin. Endocrinol. Metab., 81, 2209, 10.1210/jc.81.6.2209

Baum, 1996, Assessment of growth hormone (GH) secretion in men with adult-onset GH deficiency compared with that in normal men – a clinical research center study, J. Clin. Endocrinol. Metab., 81, 84, 10.1210/jc.81.1.84

Corpas, 1992, Serum IGF-binding protein-3 is related to IGF-I, but not to spontaneous GH release, in healthy old men, Horm. Metab. Res., 24, 543, 10.1055/s-2007-1003385

Reutens, 1995, Evaluation and application of a highly sensitive assay for serum growth hormone (GH) in the study of adult GH deficiency, J. Clin. Endocrinol. Metab., 80, 480, 10.1210/jc.80.2.480

Baxter, 1987, Diurnal rhythm of growth hormone-independent binding protein for insulin-like growth factors in human plasma, J. Clin. Endocrinol. Metab., 65, 432, 10.1210/jcem-65-3-432

Buzzelli, 1993, Circulating growth hormone and insulin-like growth factor-I in nonalcoholic liver cirrhosis with or without superimposed hepatocarcinoma: evidence of an altered circadian rhythm, Am. J. Gastroenterol., 88, 1744

Oscarsson, 1997, Diurnal variation in serum insulin-like growth factor (IGF)-I and IGF binding protein-3 concentrations during daily subcutaneous injections of recombinant human growth hormone in GH-deficient adults, Clin. Endocrinol. (Oxf.), 46, 63, 10.1046/j.1365-2265.1997.d01-1740.x

Melarvie, 1995, Pulsatile nature of growth hormone levels in critically ill trauma victims, Surgery, 117, 402, 10.1016/S0039-6060(05)80060-1

Franklin, 1978, Serum NSILA-S: absence of diurnal variation or effect of food ingestion, Horm. Metab. Res., 10, 169, 10.1055/s-0028-1095820

Florini, 1985, Somatomedin-C levels in healthy young and old men: relationship to peak and 24-h integrated levels of growth hormone, J. Gerontol., 40, 2, 10.1093/geronj/40.1.2

Vermeulen, 1987, Nyctohemeral growth hormone profiles in young and aged men: correlation with somatomedin-C levels, J. Clin. Endocrinol. Metab., 64, 884, 10.1210/jcem-64-5-884

Taylor, 1990, The growth hormone independent insulin-like growth factor-I binding protein BP-28 is associated with serum insulin-like growth factor-I inhibitory bioactivity in adolescent insulin-dependent diabetics, Clin. Endocrinol. (Oxf.), 32, 229, 10.1111/j.1365-2265.1990.tb00859.x

Hamilton-Fairley, 1995, Diurnal variation of sex hormone binding globulin and insulin-like growth factor binding protein-1 in women with polycystic ovary syndrome, Clin. Endocrinol. (Oxf.), 43, 159, 10.1111/j.1365-2265.1995.tb01910.x

Prelevic, 1992, Twenty-four-hour serum growth hormone, insulin, C-peptide and blood glucose profiles and serum insulin-like growth factor-I concentrations in women with polycystic ovaries, Horm. Res., 37, 125, 10.1159/000182296

Jorgensen, 1990, Evening versus morning injections of growth hormone (GH) in GH-deficient patients: effects on 24-h patterns of circulating hormones and metabolites, J. Clin. Endocrinol. Metab., 70, 207, 10.1210/jcem-70-1-207

Skjaerbaek, 2000, Circadian variation in serum free and total insulin-like growth factor (IGF)-I and IGF-II in untreated and treated acromegaly and growth hormone deficiency, Clin. Endocrinol. (Oxf.), 52, 25, 10.1046/j.1365-2265.2000.00876.x

Batch, 1991, Abnormal regulation of insulin-like growth factor binding proteins in adolescents with insulin-dependent diabetes, J. Clin. Endocrinol. Metab., 73, 964, 10.1210/jcem-73-5-964

Cotterill, 1988, Regulation of the growth hormone-independent growth factor-binding protein in children, J. Clin. Endocrinol. Metab., 67, 882, 10.1210/jcem-67-5-882

Heuck, 1999, Circadian variation in serum free ultrafiltrable insulin-like growth factor I concentrations in healthy children, Pediatr. Res., 45, 733, 10.1203/00006450-199905010-00021

Jorgensen, 1990, Circadian patterns of serum insulin-like growth factor (IGF) II and IGF binding protein 3 in growth hormone-deficient patients and age- and sex-matched normal subjects, Acta Endocrinol. (Copenh.), 123, 257, 10.1530/acta.0.1230257

Storm, 1998, Calcium supplementation prevents seasonal bone loss and changes in biochemical markers of bone turnover in elderly New England women: a randomized placebo-controlled trial, J. Clin. Endocrinol. Metab., 83, 3817, 10.1210/jc.83.11.3817

Goodman-Gruen, 1997, Epidemiology of insulin-like growth factor-I in elderly men and women. The Rancho Bernardo Study, Am. J. Epidemiol., 145, 970, 10.1093/oxfordjournals.aje.a009065

Holdaway, 1997, Seasonal variation in the secretion of mammotrophic hormones in normal women and women with previous breast cancer, Breast Cancer Res. Treat, 42, 15, 10.1023/A:1005743626105

Juul, 2002, Low serum insulin-like growth factor I is associated with increased risk of ischemic heart disease. A population-based case-control study, Circulation, 106, 939, 10.1161/01.CIR.0000027563.44593.CC

Gelander, 1999, Monthly measurements of insulin-like growth factor I (IGF-I) and IGF-binding protein-3 in healthy prepubertal children: characterization and relationship with growth: the 1-year growth study, Pediatr. Res., 45, 377, 10.1203/00006450-199903000-00015

Bennett, 1997, Hypothalamic-pituitary-insulin-like growth factor-I axis dysfunction in patients with fibromyalgia, J. Rheumatol., 24, 1384

Verhaeghe, 1996, C-peptide, insulin-like growth factors I and II, and insulin-like growth factor binding protein-1 in cord serum of twins: genetic versus environmental regulation, Am. J. Obstet. Gynecol., 175, 1180, 10.1016/S0002-9378(96)70025-X

Kao, 1994, Insulin-like growth factor-I comparisons in healthy twin children, J. Clin. Endocrinol. Metab., 78, 310, 10.1210/jc.78.2.310

Harrela, 1996, Genetic and environmental components of interindividual variation in circulating levels of IGF-I, IGF-II, IGFBP-1, and IGFBP-3, J. Clin. Invest., 98, 2612, 10.1172/JCI119081

Hong, 1996, Quantitative genetic analyses of insulin-like growth factor I (IGF-I), IGF-binding protein-1, and insulin levels in middle-aged and elderly twins, J. Clin. Endocrinol. Metab., 81, 1791, 10.1210/jc.81.5.1791

Wong, 1999, Serum concentrations of insulin, insulin-like growth factor-I and insulin-like growth factor binding proteins are different between white and African American girls, J. Pediatr., 135, 296, 10.1016/S0022-3476(99)70123-X

Wilson, 1991, Insulin-like growth factor-I as a reflection of body composition, nutrition, and puberty in sixth and seventh grade girls, J. Clin. Endocrinol. Metab., 73, 907, 10.1210/jcem-73-4-907

Shibata, 2002, Concentrations of estrogens and IGFs in umbilical cord blood plasma: a comparison among caucasian, hispanic, and Asian-American females, J. Clin. Endocrinol. Metab., 87, 810, 10.1210/jc.87.2.810

Platz, 1999, Racial variation in insulin-like growth factor-1 and binding protein-3 concentrations in middle-aged men, Cancer Epidemiol. Biomarkers Prev., 8, 1107

Wright, 1996, Demonstration of a lack of racial difference in secretion of growth hormone despite a racial difference in bone mineral density in premenopausal women – a Clinical Research Center Study, J. Clin. Endocrinol. Metab., 81, 1023, 10.1210/jc.81.3.1023

Hopkins, 1996, Ethnicity affects IGFBP-3 and IGF-II in normal healthy young adult subjects, Clin. Endocrinol. (Oxf.), 45, 327, 10.1046/j.1365-2265.1996.00815.x

Schneid, 1990, Insulin-like growth factor-I gene analysis in subjects with constitutionally variant stature, Pediatr. Res., 27, 488, 10.1203/00006450-199005000-00014

Mullis, 1991, Constitutionally short stature: analysis of the insulin-like growth factor-I gene and the human growth hormone gene cluster, Pediatr. Res., 29, 412, 10.1203/00006450-199104000-00017

Bowcock, 1990, Polymorphism and mapping of the IGF1 gene, and absence of association with stature among African Pygmies, Hum. Genet., 85, 349, 10.1007/BF00206760

Johnston, 1999, The insulin-like growth factor-I (IGF-I) gene in individuals born small for gestational age (SGA), Clin. Endocrinol. (Oxf.), 51, 423, 10.1046/j.1365-2265.1999.00803.x

Rasmussen, 2000, Studies of the variability of the genes encoding the insulin-like growth factor I receptor and its ligand in relation to type 2 diabetes mellitus, J. Clin. Endocrinol. Metab., 85, 1606, 10.1210/jc.85.4.1606

Rosen, 1998, Association between serum insulin growth factor-I (IGF-I) and a simple sequence repeat in IGF-I gene: implications for genetic studies of bone mineral density, J. Clin. Endocrinol. Metab., 83, 2286, 10.1210/jc.83.7.2286

Vaessen, 2002, Association between genetic variation in the gene for insulin-like growth factor-I and low birthweight, Lancet, 359, 1036, 10.1016/S0140-6736(02)08067-4

Frayling, 2002, A putative functional polymorphism in the IGF-I gene. Association studies with type 2 diabetes, adult height, glucose tolerance, and fetal growth in U.K. populations, Diabetes, 51, 2313, 10.2337/diabetes.51.7.2313

Arends, 2002, Polymorphism in the IGF-I gene: Clinical relevance for short children born small for gestational age (SGA), J. Clin. Endocrinol. Metab., 87, 2720, 10.1210/jc.87.6.2720

Meulenbelt, 1998, A genetic association study of the IGF-1 gene and radiological osteoarthritis in a population-based cohort study (the Rotterdam Study), Ann. Rheum. Dis., 57, 371, 10.1136/ard.57.6.371

Miyao, 1998, Polymorphism of insulin-like growth factor I gene and bone mineral density, Calcif. Tissue Int., 63, 306, 10.1007/s002239900532

Takacs, 1999, Sibling pair linkage and association studies between bone mineral density and the insulin-like growth factor I gene locus, J. Clin. Endocrinol. Metab., 84, 4467, 10.1210/jc.84.12.4467

Vaessen, 2001, A polymorphism in the gene for IGF-I: functional properties and risk for type 2 diabetes and myocardial infarction, Diabetes, 50, 637, 10.2337/diabetes.50.3.637

Jernstrom, 2001, Genetic factors related to racial variation in plasma levels of insulin-like growth factor-1: implications for premenopausal breast cancer risk, Mol. Genet. Metab., 72, 144, 10.1006/mgme.2000.3130

Missmer, 2002, A sequence repeat in the insulin-like growth factor-1 gene and risk of breast cancer, Int. J. Cancer, 100, 332, 10.1002/ijc.10473

Kim, 2002, The relationship among serum insulin-like growth factor-I, insulin-like growth factor-I gene polymorphism, and bone mineral density in postmenopausal women in Korea, Am. J. Obstet. Gynecol., 186, 345, 10.1067/mob.2002.120483

DeLellis, 2003, IGF1 genotype, mean plasma level and breast cancer risk in the Hawaii/Los Angeles multiethnic cohort, Br. J. Cancer, 88, 277, 10.1038/sj.bjc.6600728

Allen, 2002, Serum insulin-like growth factor I (IGF-I) concentration in men is not associated with the cytosine-adenosine repeat polymorphism of the IGF-I gene, Cancer Epidemiol. Biomarkers. Prev., 11, 319

Deal, 2001, Novel promoter polymorphism in insulin-like growth factor-binding protein-3: correlation with serum levels and interaction with known regulators, J. Clin. Endocrinol. Metab., 86, 1274, 10.1210/jc.86.3.1274

Paolini, 2001, Placental transport of leucine, phenylalanine, glycine, and proline in intrauterine growth-restricted pregnancies, J. Clin. Endocrinol. Metab., 86, 5427, 10.1210/jc.86.11.5427

Powell-Braxton, 1993, IGF-I is required for normal embryonic growth in mice, Genes Dev., 7, 2609, 10.1101/gad.7.12b.2609

Liu, 1993, Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r), Cell, 75, 59

Liu, 1998, Insulin-like growth factor-I affects perinatal lethality and postnatal development in a gene dosage-dependent manner: manipulation using the Cre/loxP system in transgenic mice, Mol. Endocrinol., 12, 1452, 10.1210/me.12.9.1452

Powell-Braxton, 1993, Inactivation of the IGF-I gene in mice results in perinatal lethality, Ann. N. Y. Acad. Sci., 692, 300, 10.1111/j.1749-6632.1993.tb26240.x

Liu, 1999, Insulin-like growth factor I is essential for postnatal growth in response to growth hormone, Endocrinology, 140, 5178, 10.1210/en.140.11.5178

Woods, 1996, Intrauterine growth retardation and postnatal growth failure associated with deletion of the insulin-like growth factor I gene, N. Engl. J. Med., 335, 1363, 10.1056/NEJM199610313351805

Langford, 1998, Maternal and fetal insulin-like growth factors and their binding proteins in the second and third trimesters of human pregnancy, Hum. Reprod., 13, 1389, 10.1093/humrep/13.5.1389

Leger, 1996, Growth factors and intrauterine growth retardation. I. Serum growth hormone, insulin-like growth factor (IGF)-I, IGF-II, and IGF binding protein 3 levels in normally grown and growth-retarded human fetuses during the second half of gestation, Pediatr. Res., 40, 94, 10.1203/00006450-199607000-00017

Bang, 1994, Ontogeny of insulin-like growth factor-binding protein-1, -2, and -3: quantitative measurements by radioimmunoassay in human fetal serum, Pediatr. Res., 36, 528, 10.1203/00006450-199410000-00020

Bocconi, 1998, Insulinlike growth factor 1 in controls and growth-retarded fetuses, Fetal Diagn. Ther., 13, 192, 10.1159/000020837

Pirazzoli, 1997, Developmental pattern of fetal growth hormone, insulin-like growth factor I, growth hormone binding protein and insulin-like growth factor binding protein-3, Arch. Dis. Child Fetal Neonatal. Ed., 77, F100, 10.1136/fn.77.2.F100

Ostlund, 1997, Insulin-like growth factor I in fetal serum obtained by cordocentesis is correlated with intrauterine growth retardation, Hum. Reprod., 12, 840, 10.1093/humrep/12.4.840

Yang, 2000, Relationship of insulin-like growth factor-I, insulin-like growth factor binding protein-3, insulin, growth hormone in cord blood and maternal factors with birth height and birthweight, Pediatr. Int., 42, 31, 10.1046/j.1442-200x.2000.01167.x

Rajaram, 1995, Insulin-like growth factor (IGF)-I and IGF-binding protein 3 during the first year in term and preterm infants, Pediatr. Res., 37, 581, 10.1203/00006450-199505000-00004

Ong, 2000, J. Clin. Endocrinol. Metab., 85, 4266, 10.1210/jc.85.11.4266

Osorio, 1996, Insulin-like growth factors (IGFs) and IGF binding proteins-1, -2, and -3 in newborn serum: relationships to fetoplacental growth at term, Early Hum. Dev., 46, 15, 10.1016/0378-3782(96)01737-9

Fant, 1993, Circulating levels of IGFs and IGF binding proteins in human cord serum: relationships to intrauterine growth, Regul. Pept., 48, 29, 10.1016/0167-0115(93)90333-4

Giudice, 1995, Insulin-like growth factors and their binding proteins in the term and preterm human fetus and neonate with normal and extremes of intrauterine growth, J. Clin. Endocrinol. Metab., 80, 1548, 10.1210/jc.80.5.1548

Lo, 2002, Relation of cord serum levels of growth hormone, insulin-like growth factors, insulin-like growth factor binding proteins, leptin, and interleukin-6 with birth weight, birth length, and head circumference interm and preterm neonates, Nutrition, 18, 604, 10.1016/S0899-9007(01)00811-5

Christou, 2001, Cord blood leptin and insulin-like growth factor levels are independent predictors of fetal growth, J. Clin. Endocrinol. Metab., 86, 935, 10.1210/jc.86.2.935

Cianfarani, 1998, Intrauterine growth retardation: evidence for the activation of the insulin-like growth factor (IGF)-related growth-promoting machinery and the presence of a cation-independent IGF binding protein-3 proteolytic activity by two months of life, Pediatr. Res., 44, 374, 10.1203/00006450-199809000-00018

Wiznitzer, 1998, Insulin-like growth factors, their binding proteins, and fetal macrosomia in offspring of nondiabetic pregnant women, Am. J. Perinatol., 15, 23, 10.1055/s-2007-993893

Simmons, 1995, Interrelation between umbilical cord serum sex hormones, sex hormone-binding globulin, insulin-like growth factor I, and insulin in neonates from normal pregnancies and pregnancies complicated by diabetes, J. Clin. Endocrinol. Metab., 80, 2217, 10.1210/jc.80.7.2217

Bhaumick, 1986, Insulin-like growth factors (IGF) I and II in diabetic pregnancy: suppression of normal pregnancy-induced rise of IGF-I, Diabetologia, 29, 792, 10.1007/BF00873218

Vatten, 2002, Relationship of insulin-like growth factor-I and insulin-like growth factor binding proteins in umbilical cord plasma to preeclampsia and infant birth weight, Obstet. Gynecol., 99, 85, 10.1016/S0029-7844(01)01651-9

Halhali, 2000, Preeclampsia is associated with low circulating levels of insulin-like growth factor I and 1,25-dihydroxyvitamin D in maternal and umbilical cord compartments, J. Clin. Endocrinol. Metab., 85, 1828, 10.1210/jc.85.5.1828

Kajantie, 2001, Markers of type I and type III collagen turnover, insulin-like growth factors, and their binding proteins in cord plasma of small premature infants: relationships with fetal growth, gestational age, preeclampsia, and antenatal glucocorticoid treatment, Pediatr.Res., 49, 481, 10.1203/00006450-200104000-00008

Beratis, 1994, Prolactin, growth hormone and insulin-like growth factor-I in newborn children of smoking mothers, Clin. Endocrinol. (Oxf.), 40, 179, 10.1111/j.1365-2265.1994.tb02465.x

Bajoria, 2001, Placental regulation of insulin-like growth factor axis in monochorionic twins with chronic twin-twin transfusion syndrome, J. Clin. Endocrinol. Metab., 86, 3150, 10.1210/jc.86.7.3150

Westwood, 2001, Genes or placenta as modulator of fetal growth: evidence from the insulin-like growth factor axis in twins with discordant growth, Mol. Hum. Reprod., 7, 387, 10.1093/molehr/7.4.387

Bernardini, 1992, Plasma levels of insulin-like growth factor binding protein-1, and growth hormone binding protein activity from birth to the third month of life, Acta Endocrinol. (Copenh.), 127, 313, 10.1530/acta.0.1270313

Kaplowitz, 1982, Plasma somatomedin-C during the first year of life, J. Pediatr., 100, 932, 10.1016/S0022-3476(82)80519-2

Low, 2001, Onset of significant GH dependence of serum IGF-I and IGF-binding protein 3 concentrations in early life, Pediatr. Res., 50, 737, 10.1203/00006450-200112000-00018

Kajantie, 2002, IGF-I, IGF binding protein (IGFBP)-3, phosphoisoforms of IGFBP-1, and postnatal growth in very low birth weight infants, J. Clin. Endocrinol. Metab., 87, 2171, 10.1210/jc.87.5.2171

Cance-Rouzaud, 1998, Growth hormone, insulin-like growth factor-I and insulin-like growth factor binding protein-3 are regulated differently in small-for-gestational-age and appropriate-for-gestational-age neonates, Biol. Neonate, 73, 347, 10.1159/000013996

Leger, 1996, Pediatr. Res., 40, 101, 10.1203/00006450-199607000-00018

Ozkan, 1999, Associations of IGF-I, IGFBP-1 and IGFBP-3 on intrauterine growth and early catch-up growth, Biol. Neonate, 76, 274, 10.1159/000014169

de Waal, 1994, Endogenous and stimulated GH secretion, urinary GH excretion, and plasma IGF-I and IGF-II levels in prepubertal children with short stature after intrauterine growth retardation. The Dutch Working Group on Growth Hormone, Clin. Endocrinol. (Oxf.), 41, 621, 10.1111/j.1365-2265.1994.tb01828.x

Cutfield, 2002, IGFs and binding proteins in short children with intrauterine growth retardation, J. Clin. Endocrinol. Metab., 87, 235, 10.1210/jc.87.1.235

Fall, 1995, Size at birth and plasma insulin-like growth factor-1 concentrations, Arch. Dis. Child., 73, 287, 10.1136/adc.73.4.287

Jernstrom, 1998, Insulin-like growth factor-1 in relation to adult weight and birth weight in healthy nulliparous women, Int. J. Gynaecol. Obstet., 62, 11

Jaruratanasirikul, 1999, Serum insulin-like growth factor-1 (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP-3) in healthy Thai children and adolescents: relation to height, weight, and body mass index, J. Med. Assoc. Thai., 82, 984

Eliakim, 2001, Fitness, training, and the growth hormone–>insulin-like growth factor i axis in prepubertal girls, J. Clin. Endocrinol. Metab., 86, 2797, 10.1210/jc.86.6.2797

Yanovski, 2000, Insulin-like growth factors and bone mineral density in African American and White girls, J. Pediatr., 137, 826, 10.1067/mpd.2000.109151

Moreira-Andres, 1995, Correlations between bone mineral density, insulin-like growth factor I and auxological variables, Eur. J. Endocrinol., 132, 573, 10.1530/eje.0.1320573

Silbergeld, 1986, Insulin-like growth factor I (IGF-I) in healthy children, adolescents and adults as determined by a radioimmunoassay specific for the synthetic 53–70 peptide region, Clin. Endocrinol. (Oxf.), 25, 67, 10.1111/j.1365-2265.1986.tb03596.x

Smith, 1989, Relationship between insulin, insulin-like growth factor I, and dehydroepiandrosterone sulfate concentrations during childhood, puberty, and adult life, J. Clin. Endocrinol. Metab., 68, 932, 10.1210/jcem-68-5-932

Rayner, 1988, Growth hormone deficiency and the measurement of somatomedin C/IGF-I: the influence of sexual maturation, Clin. Endocrinol. (Oxf.), 28, 361, 10.1111/j.1365-2265.1988.tb03667.x

Giwercman, 1987, Age- and sex-related variations in the serum concentration of somatomedin C in normal children and adults, Ugeskr. Laeger, 149, 1320

Andrade, 1995, Serum insulin-like growth factor (IGF) binding protein-3 and IGF-I levels during childhood and adolescence. A cross-sectional study, Pediatr. Res., 38, 149, 10.1203/00006450-199508000-00003

Suwa, 1988, Serum insulin-like growth factor I (somatomedin-C) level in normal subjects from infancy to adulthood, pituitary dwarfs and normal variant short children, Endocrinol. Jpn., 35, 857, 10.1507/endocrj1954.35.857

Cara, 1987, A longitudinal study of the relationship of plasma somatomedin-C concentration to the pubertal growth spurt, Am. J. Dis. Child, 141, 562

Rosenfield, 1983, Relationship of somatomedin-C concentrations to pubertal changes, J. Pediatr., 103, 723, 10.1016/S0022-3476(83)80465-X

Cook, 1993, Effects of maturational stage on insulin sensitivity during puberty, J. Clin. Endocrinol. Metab., 77, 725, 10.1210/jc.77.3.725

Luna, 1983, Somatomedins in adolescence: a cross-sectional study of the effect of puberty on plasma insulin-like growth factor I and II levels, J. Clin. Endocrinol. Metab., 57, 268, 10.1210/jcem-57-2-268

Argente, 1993, Normative data for insulin-like growth factors (IGFs), IGF-binding proteins, and growth hormone-binding protein in a healthy Spanish pediatric population: age- and sex-related changes, J. Clin. Endocrinol. Metab., 77, 1522, 10.1210/jc.77.6.1522

Blumsohn, 1994, Biochemical markers of bone turnover in girls during puberty, Clin. Endocrinol. (Oxf.), 40, 663, 10.1111/j.1365-2265.1994.tb03019.x

Lofqvist, 2001, Reference values for IGF-I throughout childhood and adolescence: a model that accounts simultaneously for the effect of gender, age, and puberty, J. Clin. Endocrinol. Metab., 86, 5870, 10.1210/jc.86.12.5870

Wilson, 1992, Insulin-like growth factor binding protein-3 in normal pubertal girls, Acta Endocrinol. (Copenh.), 126, 381, 10.1530/acta.0.1260381

Juul, 1995, J. Clin. Endocrinol. Metab., 80, 3059, 10.1210/jc.80.10.3059

Nimura, 2000, Acid-labile subunit (ALS) measurements in children, Endocr. J., 47, S111, 10.1507/endocrj.47.SupplMarch_S111

Barrios, 2000, Normative data for total and free acid-labile subunit of the human insulin-like growth factor-binding protein complex in pre- and full-term newborns and healthy boys and girls throughout postnatal development, Horm. Res., 53, 148, 10.1159/000023554

Rose, 1991, Spontaneous growth hormone secretion increases during puberty in normal girls and boys, J. Clin. Endocrinol. Metab., 73, 428, 10.1210/jcem-73-2-428

Albertsson-Wikland, 1988, Analyses of 24-h growth hormone profiles in children: relation to growth, J. Clin. Endocrinol. Metab., 67, 493, 10.1210/jcem-67-3-493

Martha, 1996, A longitudinal assessment of hormonal and physical alterations during normal puberty in boys. III. The neuroendocrine growth hormone axis during late prepuberty, J. Clin. Endocrinol. Metab., 81, 4068, 10.1210/jc.81.11.4068

Metzger, 1993, Androgen receptor blockade with flutamide enhances growth hormone secretion in late pubertal males: evidence for independent actions of estrogen and androgen, J. Clin. Endocrinol. Metab., 76, 1147, 10.1210/jc.76.5.1147

Metzger, 1994, Estrogen receptor blockade with tamoxifen diminishes growth hormone secretion in boys: evidence for a stimulatory role of endogenous estrogens during male adolescence, J. Clin. Endocrinol. Metab., 79, 513, 10.1210/jc.79.2.513

Mauras, 2000, Estrogen suppression in males: metabolic effects, J. Clin. Endocrinol. Metab., 85, 2370, 10.1210/jc.85.7.2370

Ross, 1983, A preliminary study of the effect of estrogen dose on growth in Turner’s syndrome, N. Engl. J. Med., 309, 1104, 10.1056/NEJM198311033091806

Cuttler, 1985, Somatomedin-C levels in children and adolescents with gonadal dysgenesis: differences from age-matched normal females and effect of chronic estrogen replacement therapy, J. Clin. Endocrinol. Metab., 60, 1087, 10.1210/jcem-60-6-1087

Rosenfield, 1985, Physiologic testosterone or estradiol induction of puberty increases plasma somatomedin-C, J. Pediatr., 107, 415, 10.1016/S0022-3476(85)80522-9

Copeland, 1988, Effects of acute high dose and chronic low dose estrogen on plasma somatomedin-C and growth in patients with Turner’s syndrome, J. Clin. Endocrinol. Metab., 66, 1278, 10.1210/jcem-66-6-1278

Parker, 1984, Effect of testosterone on somatomedin-C concentrations in prepubertal boys, J. Clin. Endocrinol. Metab., 58, 87, 10.1210/jcem-58-1-87

Hobbs, 1993, Testosterone administration increases insulin-like growth factor-I levels in normal men, J. Clin. Endocrinol. Metab., 77, 776, 10.1210/jc.77.3.776

Jasper, 1985, Somatomedin response to testosterone stimulation in children with male pseudohermaphroditism, cryptorchidism, anorchia, or micropenis, J. Clin. Endocrinol. Metab., 60, 910, 10.1210/jcem-60-5-910

Hagenfeldt, 1992, Testosterone increases serum 1,25-dihydroxyvitamin D and insulin-like growth factor-I in hypogonadal men, Int. J. Androl., 15, 93, 10.1111/j.1365-2605.1992.tb01118.x

Keenan, 1993, Androgen-stimulated pubertal growth: the effects of testosterone and dihydrotestosterone on growth hormone and insulin-like growth factor-I in the treatment of short stature and delayed puberty, J. Clin. Endocrinol. Metab., 76, 996, 10.1210/jc.76.4.996

Rikken, 1998, Plasma levels of insulin-like growth factor (IGF)-I, IGF-II and IGF-binding protein-3 in the evaluation of childhood growth hormone deficiency, Horm. Res., 50, 166, 10.1159/000023268

Rasat, 1996, IGF-1 and IGFBP-3 screening for disorders of growth hormone secretion, N. Z. Med. J., 109, 156

Ranke, 2000, Significance of basal IGF-I, IGFBP-3 and IGFBP-2 measurements in the diagnostics of short stature in children, Horm. Res., 54, 60, 10.1159/000053233

Hall, 1999, Relationship between serum and urinary insulin-like growth factor-I through childhood and adolescence: their use in the assessment of disordered growth, Clin. Endocrinol. (Oxf.), 50, 611, 10.1046/j.1365-2265.1999.00699.x

Mitchell, 1999, Failure of IGF-I and IGFBP-3 to diagnose growth hormone insufficiency, Arch. Dis. Child, 80, 443, 10.1136/adc.80.5.443

Rosenfeld, 1986, Insulin-like growth factors I and II in evaluation of growth retardation, J. Pediatr., 109, 428, 10.1016/S0022-3476(86)80112-3

Rappaport, 1987, Somatomedin-C and growth in children with precocious puberty: a study of the effect of the level of growth hormone secretion, J. Clin. Endocrinol. Metab., 65, 1112, 10.1210/jcem-65-6-1112

Murata, 1994, Sustained high insulin-like growth factor-binding protein 3 levels after suppression of gonadal steroids in central precocious puberty, Clin. Pediatr. Endocrinol., 3, 183, 10.1297/cpe.3.Supple4_183

Antoniazzi, 1995, Bone mineral metabolism in girls with precocious puberty during gonadotrophin-releasing hormone agonist treatment, Eur. J. Endocrinol., 133, 412, 10.1530/eje.0.1330412

Pescovitz, 1985, Somatomedin-C in accelerated growth of children with precocious puberty, J. Pediatr., 107, 20, 10.1016/S0022-3476(85)80607-7

Mansfield, 1988, Changes in growth and serum growth hormone and plasma somatomedin-C levels during suppression of gonadal sex steroid secretion in girls with central precocious puberty, J. Clin. Endocrinol. Metab., 66, 3, 10.1210/jcem-66-1-3

Brauner, 1991, Idiopathic central precocious puberty in girls as a model of the effect of plasma estradiol level on growth, skeletal maturation and plasma insulin-like growth factor I, Horm. Res., 36, 116, 10.1159/000182143

Feuillan, 1995, Growth hormone hypersecretion in a girl with McCune-Albright syndrome: comparison with controls and response to a dose of long-acting somatostatin analog, J. Clin. Endocrinol. Metab., 80, 1357, 10.1210/jc.80.4.1357

Dimartino-Nardi, 1991, The effect of long-acting analog of luteinizing hormone-releasing hormone on growth hormone secretory dynamics in children with precocious puberty, J. Clin. Endocrinol. Metab., 73, 902, 10.1210/jcem-73-4-902

Kamp, 1991, Low growth hormone levels are related to increased body mass index and do not reflect impaired growth in luteinizing hormone-releasing hormone agonist-treated children with precocious puberty, J. Clin. Endocrinol. Metab., 72, 301, 10.1210/jcem-72-2-301

Cara, 1989, Growth hormone deficiency impedes the rise in plasma insulin-like growth factor I levels associated with precocious puberty, J. Pediatr., 115, 64, 10.1016/S0022-3476(89)80330-0

Attie, 1990, The pubertal growth spurt in eight patients with true precocious puberty and growth hormone deficiency: evidence for a direct role of sex steroids, J. Clin. Endocrinol. Metab., 71, 975, 10.1210/jcem-71-4-975

Yamada, 1998, Increase in free insulin-like growth factor-I levels in precocious and normal puberty, Endocr. J., 45, 407, 10.1507/endocrj.45.407

Hasegawa, 1995, Proteolytic activity of IGFBP-3 in various clinical conditions during childhood studied by means of western immunoblotting, Endocr. J., 42, 569, 10.1507/endocrj.42.569

Fontoura, 1989, Precocious puberty in girls: early diagnosis of a slowly progressing variant, Arch. Dis. Child, 64, 1170, 10.1136/adc.64.8.1170

Harris, 1985, Somatomedin-C in normal puberty and in true precocious puberty before and after treatment with a potent luteinizing hormone-releasing hormone agonist, J. Clin. Endocrinol. Metab., 61, 152, 10.1210/jcem-61-1-152

Kanety, 1996, Insulin-like growth factor-I and IGF binding protein-3 remain high after GnRH analogue therapy in girls with central precocious puberty, Clin. Endocrinol. (Oxf.), 45, 7, 10.1111/j.1365-2265.1996.tb02053.x

Sklar, 1991, Suppression of the pituitary-gonadal axis in children with central precocious puberty: effects on growth, growth hormone, insulin-like growth factor-I, and prolactin secretion, J. Clin. Endocrinol. Metab., 73, 734, 10.1210/jcem-73-4-734

Belgorosky, 1998, Irreversible increase of serum IGF-1 and IGFBP-3 levels in GnRH-dependent precocious puberty of different etiologies: implications for the onset of puberty, Horm. Res., 49, 226, 10.1159/000023176

Ibanez, 1997, Hyperinsulinemia and decreased insulin-like growth factor-binding protein-1 are common features in prepubertal and pubertal girls with a history of premature pubarche, J. Clin. Endocrinol. Metab., 82, 2283, 10.1210/jc.82.7.2283

Silfen, 2002, Elevated free IGF-I levels in prepubertal Hispanic girls with premature adrenarche: relationship with hyperandrogenism and insulin sensitivity, J. Clin. Endocrinol. Metab., 87, 398, 10.1210/jc.87.1.398

Miller, 1999, The molecular basis of premature adrenarche: an hypothesis, Acta Paediatr. Suppl., 88, 60, 10.1111/j.1651-2227.1999.tb14405.x

l’Allemand, 2002, Associations between body mass, leptin, IGF-I and circulating adrenal androgens in children with obesity and premature adrenarche, Eur. J. Endocrinol., 146, 537, 10.1530/eje.0.1460537

Ibanez, 2000, Premature adrenarche–normal variant or forerunner of adult disease, Endocr. Rev., 21, 671, 10.1210/er.21.6.671

Massa, 1992, Serum growth hormone (GH)-binding protein and insulin-like growth factor-I levels in Turner’s syndrome before and during treatment with recombinant human GH and ethinyl estradiol, J. Clin. Endocrinol. Metab., 75, 1298, 10.1210/jc.75.5.1298

Haeusler, 1995, Treatment of patients with Ullrich-Turner syndrome with conventional doses of growth hormone and the combination with testosterone or oxandrolone: effect on growth, IGF-I and IGFBP-3 concentrations, Eur. J. Pediatr., 154, 437, 10.1007/BF02029351

Saggese, 1995, Plasma growth hormone-binding protein activity, insulin-like growth factor I, and its binding protein levels in patients with Turner’s syndrome: effect of short- and long-term recombinant human growth hormone administration, Pediatr. Res., 37, 106, 10.1203/00006450-199501000-00020

Blum, 1990, Use of insulin-like growth factor-binding protein 3 for the evaluation of growth disorders, Horm. Res., 33, 31, 10.1159/000181581

Holl, 1993, The somatotropin-somatomedin axis in adult patients with Turner syndrome measurement of stimulated GH, GH-BP, IGF-I, IGF-II and IGFBP-3 in 25 patients, Horm. Res., 39, 30, 10.1159/000182691

Gravholt, 1997, Body composition and physical fitness are major determinants of the growth hormone-insulin-like growth factor axis aberrations in adult Turner’s syndrome, with important modulations by treatment with 17 beta-estradiol, J. Clin. Endocrinol. Metab., 82, 2570, 10.1210/jc.82.8.2570

Gravholt, 2001, Reduced free IGF-I and increased IGFBP-3 proteolysis in Turner syndrome: modulation by female sex steroids, Am. J. Physiol. Endocrinol. Metab., 280, E308, 10.1152/ajpendo.2001.280.2.E308

Juul, 1994, The ratio between serum levels of insulin-like growth factor (IGF)-I and the IGF binding proteins (IGFBP-1, 2 and 3) decreases with age in healthy adults and is increased in acromegalic patients, Clin. Endocrinol. (Oxf.), 41, 85, 10.1111/j.1365-2265.1994.tb03788.x

O’Connor, 1998, Serum levels of insulin-like growth factor-I are related to age and not to body composition in healthy women and men, J. Gerontol. A. Biol. Sci. Med Sci., 53, M176, 10.1093/gerona/53A.3.M176

Seck, 1998, Positive association between circulating free thyroxine and insulin-like growth factor l concentrations in euthyroid elderly individuals, Clin. Endocrinol. (Oxf.), 48, 361, 10.1046/j.1365-2265.1998.00415.x

Janssen, 1998, Serum free IGF-I, total IGF-I, IGFBP-1 and IGFBP-3 levels in an elderly population: relation to age and sex steroid levels, Clin. Endocrinol. (Oxf.), 48, 471, 10.1046/j.1365-2265.1998.00300.x

Sugimoto, 1998, Age-dependent changes in body composition in postmenopausal Japanese women: relationship to growth hormone secretion as well as serum levels of insulin-like growth factor (IGF)-I and IGF-binding protein-3, Eur. J. Endocrinol., 138, 633, 10.1530/eje.0.1380633

Paolisso, 1997, Serum levels of insulin-like growth factor-I (IGF-I) and IGF-binding protein-3 in healthy centenarians: relationship with plasma leptin and lipid concentrations, insulin action, and cognitive function, J. Clin. Endocrinol. Metab., 82, 2204, 10.1210/jc.82.7.2204

Pfeilschifter, 1996, Relationship between circulating insulin-like growth factor components and sex hormones in a population-based sample of 50- to 80-year-old men and women, J. Clin. Endocrinol. Metab., 81, 2534, 10.1210/jc.81.7.2534

Harris, 1997, Association of insulin-like growth factor-I with body composition, weight history, and past health behaviors in the very old: the Framingham Heart Study, J. Am. Geriatr. Soc., 45, 133, 10.1111/j.1532-5415.1997.tb04497.x

Kaklamani, 1999, Age, sex, and smoking are predictors of circulating insulin-like growth factor 1 and insulin-like growth factor-binding protein 3, J. Clin. Oncol., 17, 813, 10.1200/JCO.1999.17.3.813

Landin-Wilhelmsen, 1994, Clin. Endocrinol. (Oxf.), 41, 351, 10.1111/j.1365-2265.1994.tb02556.x

Nystrom, 1997, Population-based reference values for IGF-I and IGF-binding protein-1: relations with metabolic and anthropometric variables, Eur. J. Endocrinol., 136, 165, 10.1530/eje.0.1360165

Hilding, 1999, Serum levels of insulin-like growth factor I in 152 patients with growth hormone deficiency, aged 19–82 years, in relation to those in healthy subjects, J. Clin. Endocrinol. Metab., 84, 2013, 10.1210/jc.84.6.2013

Chapman, 1997, Effect of aging on the sensitivity of growth hormone secretion to insulin-like growth factor-I negative feedback, J. Clin. Endocrinol. Metab., 82, 2996, 10.1210/jc.82.9.2996

Schoen, 2002, Lack of association between adipose tissue distribution and IGF-I and IGFBP-3 in men and women, Cancer Epidemiol. Biomarkers. Prev., 11, 581

Signorello, 2000, Lifestyle factors and insulin-like growth factor1 levels among elderly men, Eur. J. Cancer Prev., 9, 173, 10.1097/00008469-200006000-00004

Copeland, 1990, The relationship between insulin-like growth factor-I, adiposity, and aging, Metabolism, 39, 584, 10.1016/0026-0495(90)90022-5

Rasmussen, 1994, The impact of obesity, fat distribution, and energy restriction on insulin-like growth factor-1 (IGF-1), IGF-binding protein-3, insulin, and growth hormone, Metabolism, 43, 315, 10.1016/0026-0495(94)90099-X

Poehlman, 1990, Influence of physical activity on insulin-like growth factor-I in healthy younger and older men, J. Clin. Endocrinol. Metab., 71, 1468, 10.1210/jcem-71-6-1468

Benbassat, 1997, Circulating levels of insulin-like growth factor (IGF) binding protein-1 and -3 in aging men: relationships to insulin, glucose, IGF, and dehydroepiandrosterone sulfate levels and anthropometric measures, J. Clin. Endocrinol. Metab., 82, 1484, 10.1210/jc.82.5.1484

O’Connor, 1999, Interrelationships of spontaneous growth hormone axis activity, body fat, and serum lipids in healthy elderly women and men, Metabolism, 48, 1424, 10.1016/S0026-0495(99)90154-3

Cruickshank, 2001, Epidemiology of the insulin-like growth factor system in three ethnic groups, Am. J. Epidemiol., 154, 504, 10.1093/aje/154.6.504

Lukanova, 2001, A cross-sectional study of IGF-I determinants in women, Eur. J. Cancer Prev., 10, 443, 10.1097/00008469-200110000-00008

Teramukai, 2002, Anthropometric and behavioral correlates of Unsulin-like growth factor I and insulin-like growth factor binding protein 3 in middle-aged Japanese men, Am. J. Epidemiol., 156, 344, 10.1093/aje/kwf069

Seck, 1998, Concentration of insulin-like growth factor (IGF)-I and -II in iliac crest bone matrix from pre- and postmenopausal women: relationship to age, menopause, bone turnover, bone volume, and circulating IGFs, J. Clin. Endocrinol. Metab., 83, 2331, 10.1210/jc.83.7.2331

Nasu, 1997, Effect of natural menopause on serum levels of IGF-I and IGF-binding proteins: relationship with bone mineral density and lipid metabolism in perimenopausal women, Eur. J. Endocrinol., 136, 608, 10.1530/eje.0.1360608

Romagnoli, 1993, Effect of estrogen deficiency on IGF-I plasma levels: relationship with bone mineral density in perimenopausal women, Calcif. Tissue Int., 53, 1, 10.1007/BF01352006

Seck, 2001, Low serum concentrations of insulin-like growth factor I are associated with femoral bone loss in a population-based sample of postmenopausal women, Clin. Endocrinol. (Oxf.), 55, 101, 10.1046/j.1365-2265.2001.01278.x

Langlois, 1998, Association between insulin-like growth factor I and bone mineral density in older women and men: the Framingham Heart Study, J. Clin. Endocrinol. Metab., 83, 4257, 10.1210/jc.83.12.4257

Janssen, 1998, Gender-specific relationship between serum free and total IGF-I and bone mineral density in elderly men and women, Eur. J. Endocrinol., 138, 627, 10.1530/eje.0.1380627

Johansson, 1994, Growth hormone-dependent insulin-like growth factor binding protein is a major determinant of bone mineral density in healthy men, J. Bone Miner. Res., 9, 915, 10.1002/jbmr.5650090617

Boonen, 1997, Age-associated decline in human femoral neck cortical and trabecular content of insulin-like growth factor I: potential implications for age-related (type II) osteoporotic fracture occurrence, Calcif. Tissue Int., 61, 173, 10.1007/s002239900318

Nicolas, 1994, Age-related decreases in insulin-like growth factor-I and transforming growth factor-beta in femoral cortical bone from both men and women: implications for bone loss with aging, J. Clin. Endocrinol. Metab., 78, 1011, 10.1210/jc.78.5.1011

Cappola, 2001, Association of IGF-I levels with muscle strength and mobility in older women, J. Clin. Endocrinol. Metab., 86, 4139, 10.1210/jc.86.9.4139

Papadakis, 1995, Insulin-like growth factor 1 and functional status in healthy older men, J. Am. Geriatr. Soc., 43, 1350, 10.1111/j.1532-5415.1995.tb06613.x

Boonen, 1996, Relationship between baseline insulin-like growth factor-I (IGF-I) and femoral bone density in women aged over 70 years: potential implications for the prevention of age-related bone loss, J. Am. Geriatr. Soc., 44, 1301, 10.1111/j.1532-5415.1996.tb01399.x

Kiel, 1998, Lack of an association between insulin-like growth factor-I and body composition, muscle strength, physical performance or self-reported mobility among older persons with functional limitations, J. Am. Geriatr. Soc., 46, 822, 10.1111/j.1532-5415.1998.tb02714.x

Kaklamani, 1999, Dietary fat and carbohydrates are independently associated with circulating insulin-like growth factor1 and insulin-like growth factor-binding protein 3 concentrations in healthy adults, J. Clin. Oncol., 17, 3291, 10.1200/JCO.1999.17.10.3291

Allen, 2000, Hormones and diet: low insulin-like growth factor-I but normal bioavailable androgens in vegan men, Br. J.Cancer, 83, 95, 10.1054/bjoc.2000.1152

Ma, 2001, Milk intake, circulating levels of insulin-like growth factor-i, and risk of colorectal cancer in men, J. Natl. Cancer Inst., 93, 1330, 10.1093/jnci/93.17.1330

Heaney, 1999, Dietary changes favorably affect bone remodeling in older adults, J. Am. Diet. Assoc., 99, 1228, 10.1016/S0002-8223(99)00302-8

Ninh, 1996, Zinc supplementation increases growth and circulating insulin-like growth factor I (IGF-I) in growth-retarded Vietnamese children, Am. J. Clin. Nutr., 63, 514, 10.1093/ajcn/63.4.514

Devine, 1998, Effects of zinc and other nutritional factors on insulin-like growth factor I and insulin-like growth factor binding proteins in postmenopausal women, Am. J. Clin. Nutr., 68, 200, 10.1093/ajcn/68.1.200

Hershkovitz, 1999, Zinc supplementation increases the level of serum insulin-like growth factor-I but does not promote growth in infants with nonorganic failure to thrive, Horm. Res., 52, 200, 10.1159/000023461

Nakamura, 1993, Mild to moderate zinc deficiency in short children: effect of zinc supplementation on linear growth velocity, J. Pediatr., 123, 65, 10.1016/S0022-3476(05)81538-0

Janssen, 1998, Serum total IGF-I, free IGF-I, and IGFB-1 levels in an elderly population: relation to cardiovascular risk factors and disease, Arterioscler. Thromb. Vasc. Biol., 18, 277, 10.1161/01.ATV.18.2.277

Yu, 1999, Plasma levels of insulin-like growth factor-I and lung cancer risk: a case-control analysis, J. Natl. Cancer Inst., 91, 151, 10.1093/jnci/91.2.151

Lukanova, 2001, A prospective study of insulin-like growth factor-I, IGF-binding proteins-1, -2 and -3 and lung cancer risk in women, Int. J. Cancer, 92, 888, 10.1002/ijc.1265

Rojdmark, 2000, Insulin-like growth factor (IGF)-1 and IGF-binding protein-1 concentrations in serum of normal subjects after alcohol ingestion: evidence for decreased IGF-1 bioavailability, Clin. Endocrinol. (Oxf.), 52, 313, 10.1046/j.1365-2265.2000.00908.x

Passilta, 1999, Glucose metabolism, insulin-like growth factor-I, and insulin-like growth factor-binding protein-1 after alcohol withdrawal, Alcohol Clin. Exp. Res., 23, 471, 10.1111/j.1530-0277.1999.tb04139.x

Paassilta, 1998, Alcohol withdrawal-induced change in lipoprotein(a): association with the growth hormone/insulin-like growth factor-I (IGF-I)/IGF-binding protein-1 (IGFBP-1) axis, Arterioscler. Thromb. Vasc. Biol., 18, 650, 10.1161/01.ATV.18.4.650

Ma, 1999, Prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF)-I and IGF-binding protein-3, J. Natl. Cancer Inst., 91, 620, 10.1093/jnci/91.7.620

Eliakim, 1996, Physical fitness, endurance training, and the growth hormone-insulin-like growth factor I system in adolescent females, J. Clin. Endocrinol. Metab., 81, 3986, 10.1210/jc.81.11.3986

Ambrosio, 1996, Function of the GH/IGF-1 axis in healthy middle-aged male runners, Neuroendocrinology, 63, 498, 10.1159/000127078

Kelly, 1990, Somatomedin-C, physical fitness, and bone density, J. Clin. Endocrinol. Metab., 70, 718, 10.1210/jcem-70-3-718

Jorgensen, 1998, Determinants of serum insulin-like growth factor I in growth hormone deficient adults as compared to healthy subjects, Clin. Endocrinol. (Oxf.), 48, 479, 10.1046/j.1365-2265.1998.00424.x

Eliakim, 1998, Peak oxygen uptake, muscle volume, and the growth hormone-insulin-like growth factor-I axis in adolescent males, Med. Sci. Sports Exerc., 30, 512, 10.1097/00005768-199804000-00007

Deuschle, 1998, Endurance training and its effect upon the activity of the GH-IGFs system in the elderly, Int. J. Sports Med., 19, 250, 10.1055/s-2007-971913

Abbasi, 1993, Low circulating levels of insulin-like growth factors and testosterone in chronically institutionalized elderly men, J. Am. Geriatr. Soc., 41, 975, 10.1111/j.1532-5415.1993.tb06764.x

Rudman, 1986, Hyposomatomedinemia in the nursing home patient, J. Am. Geriatr. Soc., 34, 427, 10.1111/j.1532-5415.1986.tb03409.x

Rao, 1993, Prevalence of low plasma IGF-I in poliomyelitis survivors, J. Am. Geriatr. Soc., 41, 697, 10.1111/j.1532-5415.1993.tb07456.x

Shetty, 1993, Hyposomatomedinemia in quadriplegic men, Am. J. Med. Sci., 305, 95, 10.1097/00000441-199302000-00006

Eliakim, 1998, Increased physical activity and the growth hormone-IGF-I axis in adolescent males, Am. J. Physiol., 275, R308

Smith, 1987, The effect of exercise on plasma somatomedin-C/insulinlike growth factor I concentrations, Metabolism, 36, 533, 10.1016/0026-0495(87)90162-4

Vitiello, 1997, Successful 6-month endurance training does not alter insulin-like growth factor-I in healthy older men and women, J. Gerontol. A, 52, M149, 10.1093/gerona/52A.3.M149

Pyka, 1994, Effect of a sustained program of resistance training on the acute growth hormone response to resistance exercise in older adults, Horm. Metab. Res., 26, 330, 10.1055/s-2007-1001697

Poehlman, 1994, The influence of endurance training on insulin-like growth factor-1 in older individuals, Metabolism, 43, 1401, 10.1016/0026-0495(94)90035-3

Roelen, 1997, Plasma insulin-like growth factor-I and high affinity growth hormone-binding protein levels increase after two weeks of strenuous physical training, Int. J. Sports Med., 18, 238, 10.1055/s-2007-972626

Dohm, 1990, IGF-I – stimulated glucose transport in human skeletal muscle and IGF-I resistance in obesity and NIDDM, Diabetes, 39, 1028, 10.2337/diabetes.39.9.1028

Bang, 1990, Exercise-induced changes in insulin-like growth factors and their low molecular weight binding protein in healthy subjects and patients with growth hormone deficiency, Eur. J. Clin. Invest., 20, 285, 10.1111/j.1365-2362.1990.tb01857.x

Berg, 1997, Net fluxes of IGF-I, IGFBP-1, insulin, GH and energy substrates over contracting muscle during prolonged exercise in healthy men, Endocrinol. Metab., 4, 313

Dall, 2001, No evidence of insulin-like growth factor-binding protein 3 proteolysis during a maximal exercise test in elite athletes, J. Clin. Endocrinol. Metab., 86, 669, 10.1210/jc.86.2.669

Cappon, 1994, Effect of brief exercise on circulating insulin-like growth factor I, J. Appl. Physiol., 76, 2490, 10.1152/jappl.1994.76.6.2490

Donath, 1996, Cardiovascular and metabolic effects of insulin-like growth factor I at rest and during exercise in humans, J. Clin. Endocrinol. Metab., 81, 4089, 10.1210/jc.81.11.4089

Hornum, 1997, Exercise-induced changes in circulating growth factors with cyclic variation in plasma estradiol in women, J. Appl. Physiol., 82, 1946, 10.1152/jappl.1997.82.6.1946

Schwarz, 1996, Acute effect of brief low- and high-intensity exercise on circulating insulin-like growth factor (IGF) I, II, and IGF-binding protein-3 and its proteolysis in young healthy men, J. Clin. Endocrinol. Metab., 81, 3492, 10.1210/jc.81.10.3492

Wallace, 1999, Responses of the growth hormone (GH) and insulin-like growth factor axis to exercise, GH administration, and GH withdrawal in trained adult males: a potential test for GH abuse in sport, J. Clin. Endocrinol. Metab., 84, 3591, 10.1210/jc.84.10.3591

Schmidt, 1995, Effects of exercise during normoxia and hypoxia on the growth hormone-insulin-like growth factor I axis, Eur. J. Appl. Physiol. Occup. Physiol., 71, 424, 10.1007/BF00635876

Kraemer, 1992, Growth hormone, IGF-I, and testosterone responses to resistive exercise, Med. Sci. Sports Exerc., 24, 1346, 10.1249/00005768-199212000-00007

Hopkins, 1994, Changes in circulating insulin-like growth factor-binding protein-1 (IGFBP-1) during prolonged exercise: effect of carbohydrate feeding, J. Clin. Endocrinol. Metab., 79, 1887, 10.1210/jc.79.6.1887

Jahreis, 1991, Influence of intensive exercise on insulin-like growth factor I, thyroid and steroid hormones in female gymnasts, Growth Regul., 1, 95

Kraemer, 1995, Responses of IGF-I to endogenous increases in growth hormone after heavy-resistance exercise, J. Appl. Physiol., 79, 1310, 10.1152/jappl.1995.79.4.1310

Suikkari, 1989, Prolonged exercise increases serum insulin-like growth factor-binding protein concentrations, J. Clin. Endocrinol. Metab., 68, 141, 10.1210/jcem-68-1-141

Koistinen, 1996, Effect of marathon run on serum IGF-I and IGF-binding protein 1 and 3 levels, J. Appl. Physiol., 80, 760, 10.1152/jappl.1996.80.3.760

Bermon, 1999, Responses of total and free insulin-like growth factor-I and insulin-like growth factor binding protein-3 after resistance exercise and training in elderly subjects, Acta Physiol. Scand., 165, 51, 10.1046/j.1365-201x.1999.00471.x

Ghigo, 1999, Dose-response study of GH effects on circulating IGF-I and IGFBP-3 levels in healthy young men and women, Am. J. Physiol., 276, E1009

Birkeland, 1997, Blood sampling in doping control. First experiences from regular testing in athletics, Int. J. Sports Med., 18, 8, 10.1055/s-2007-972587

Kicman, 1997, Serum IGF-I and IGF binding proteins 2 and 3 as potential markers of doping with human GH, Clin. Endocrinol. (Oxf.), 47, 43, 10.1046/j.1365-2265.1997.2111036.x

Karila, 1998, Growth hormone induced increase in serum IGFBP-3 level is reversed by anabolic steroids in substance abusing power athletes, Clin. Endocrinol. (Oxf.), 49, 459, 10.1046/j.1365-2265.1998.00556.x

Dall, 2000, The effect of four weeks of supraphysiological growth hormone administration on the insulin-like growth factor axis in women and men. GH-2000 Study Group, J. Clin. Endocrinol. Metab., 85, 4193, 10.1210/jc.85.11.4193

Giudice, 1992, Insulin-like growth factors and ovarian follicular development, Endocr. Rev., 13, 641

Rabinovici, 1990, Insulin-like growth factor I (IGF-I) levels in follicular fluid from human preovulatory follicles: correlation with serum IGF-I levels, Fertil. Steril., 54, 428, 10.1016/S0015-0282(16)53756-X

Juul, 1997, Changes in serum concentrations of growth hormone, insulin, insulin-like growth factor and insulin-like growth factor-binding proteins 1 and 3 and urinary growth hormone excretion during the menstrual cycle, Hum. Reprod., 12, 2123, 10.1093/humrep/12.10.2123

Caufriez, 1986, Modulation of immunoreactive somatomedin-C levels by sex steroids, Acta Endocrinol. (Copenh.), 112, 284, 10.1530/acta.0.1120284

Evans, 1984, Effects of human pancreatic growth hormone-releasing factor-40 on serum growth hormone, prolactin, luteinizing hormone, follicle-stimulating hormone, and somatomedin-C concentrations in normal women throughout the menstrual cycle, J. Clin. Endocrinol. Metab., 59, 1006, 10.1210/jcem-59-5-1006

Guidoux, 1986, Effect of the variations of female sex hormones during the menstrual cycle upon serum somatomedin and growth-promoting activity, Horm. Res., 23, 31, 10.1159/000180285

Blake, 1997, Relationships between insulin-like growth hormone factor-I and estradiol in reproductive aging, Fertil. Steril., 67, 697, 10.1016/S0015-0282(97)81369-6

Thierry, 1996, Serum and follicular fluid levels of insulin-like growth factor I (IGF-I), IGF-II, and IGF-binding protein-1 and -3 during the normal menstrual cycle, J. Clin. Endocrinol. Metab., 81, 1224, 10.1210/jc.81.3.1224

Wang, 1995, Serum levels of insulin-like growth factor I and insulin-like growth factor-binding protein-1 and -3 in women with regular menstrual cycles, Fertil. Steril., 63, 1204, 10.1016/S0015-0282(16)57598-0

Helle, 1998, Alterations in the insulin-like growth factor system during the menstrual cycle in normal women, Maturitas, 28, 259, 10.1016/S0378-5122(97)00088-1

Nikolic, 1998, Alterations in serum insulin-like growth factor (IGF-I) levels during the menstrual cycle, Jugoslav Med. Biochem., 17, 15

Wang, 2000, Cyclic changes in serum levels of insulin-like growth factor binding protein-1 in women treated with clomiphene citrate and tamoxifen, Gynecol. Endocrinol., 14, 236, 10.3109/09513590009167687

Westwood, 1999, Modification of plasma insulin-like growth factors and binding proteins during oral contraceptive use and the normal menstrual cycle, Am. J. Obstet. Gynecol., 180, 530, 10.1016/S0002-9378(99)70249-8

Kazer, 1990, An abnormality of the growth hormone/insulin-like growth factor-I axis in women with polycystic ovary syndrome, J. Clin. Endocrinol. Metab., 71, 958, 10.1210/jcem-71-4-958

Piaditis, 1995, Dysfunction of the growth hormone/insulin-like growth factor-I axis in women with polycystic ovarian syndrome, Clin. Endocrinol. (Oxf.), 42, 635, 10.1111/j.1365-2265.1995.tb02691.x

Carmina, 1995, Altered regulation of insulin-like growth factor binding protein-1 in patients with polycystic ovary syndrome, J. Soc. Gynecol. Investig., 2, 743, 10.1016/1071-5576(95)94690-V

Thierry, 1999, Elevated serum levels of free insulin-like growth factor I in polycystic ovary syndrome, J. Clin. Endocrinol. Metab., 84, 3030, 10.1210/jc.84.9.3030

Slowinska-Srzednicka, 1992, An abnormality of the growth hormone/insulin-like growth factor-I axis in women with polycystic ovary syndrome due to coexistent obesity, J. Clin. Endocrinol. Metab., 74, 1432, 10.1210/jc.74.6.1432

Aizawa, 1995, Elevated serum insulin-like growth factor-1 (IGF-1) levels in women with postadolescent acne, J. Dermatol., 22, 249, 10.1111/j.1346-8138.1995.tb03381.x

Butzow, 1995, Clomiphene citrate reduces serum insulin-like growth factor I and increases sex hormone-binding globulin levels in women with polycystic ovary syndrome, Fertil. Steril., 63, 1200, 10.1016/S0015-0282(16)57597-9

Morris, 1995, Alterations in the sensitivity of serum insulin-like growth factor 1 and insulin-like growth factor binding protein-3 to octreotide in polycystic ovary syndrome, Fertil. Steril., 63, 742, 10.1016/S0015-0282(16)57475-5

De, 2000, Effect of metformin on insulin-like growth factor (IGF) I and IGF-binding protein I in polycystic ovary syndrome, J. Clin. Endocrinol. Metab., 85, 1598, 10.1210/jc.85.4.1598

Hills, 1996, Circulating levels of IGF-I and IGF-binding protein-1 throughout pregnancy: relation to birthweight and maternal weight, J. Endocrinol., 148, 303, 10.1677/joe.0.1480303

Luthman, 1991, Serum levels and molecular sizes of growth hormone during pregnancy in relation to levels of lactogens, insulin-like growth factor I and insulin-like growth factor binding protein-1, Gynecol. Obstet. Invest., 31, 67, 10.1159/000293105

Hall, 1984, Somatomedin levels in pregnancy: longitudinal study in healthy subjects and patients with growth hormone deficiency, J. Clin. Endocrinol. Metab., 59, 587, 10.1210/jcem-59-4-587

Holmes, 1998, A prospective study of maternal serum insulin-like growth factor-I in pregnancies with appropriately grown or growth restricted fetuses, Br. J. Obstet. Gynaecol., 105, 1273, 10.1111/j.1471-0528.1998.tb10005.x

Wilson, 1982, Somatomedins in pregnancy: a cross-sectional study of insulin-like growth factors I and II and somatomedin peptide content in normal human pregnancies, J. Clin. Endocrinol. Metab., 55, 858, 10.1210/jcem-55-5-858

Holmes, 1997, Fetal and maternal plasma insulin-like growth factors and binding proteins in pregnancies with appropriate or retarded fetal growth, Early Hum. Dev., 49, 7, 10.1016/S0378-3782(97)01867-7

Caufriez, 1990, Placental growth hormone as a potential regulator of maternal IGF-I during human pregnancy, Am. J. Physiol., 258, E1014

Wang, 1995, Effects of labor on serum levels of insulin and insulin-like growth factor-binding proteins at the time of delivery, Acta Obstet. Gynecol. Scand., 74, 186, 10.3109/00016349509008936

Wang, 1993, Levels of insulin-like growth factor-I and insulin-like growth factor-binding protein-1 in pregnancy with preterm delivery, Br. J. Obstet. Gynaecol., 100, 472, 10.1111/j.1471-0528.1993.tb15275.x

Wang, 1995, Serum levels of insulin-like growth factor-binding protein-3 in normal pregnancy, Eur. J. Obstet. Gynecol. Reprod. Biol., 61, 157, 10.1016/0301-2115(95)02120-V

Suikkari, 1992, Insulin-like growth factor-binding protein-3 is functionally normal in pregnancy serum, J. Clin. Endocrinol. Metab., 74, 177, 10.1210/jc.74.1.177

Hasegawa, 1998, Insulin-like growth factors - insulin-like growth factor binding protein axis and diabetic control in insulin-dependent diabetes mellitus, Endocr. J., 45 Suppl., S129, 10.1507/endocrj.45.Suppl_S129

Verhaeghe, 2000, Placental growth hormone and IGF-I in a pregnant woman with Pit-1 deficiency, Clin. Endocrinol. (Oxf.), 53, 645, 10.1046/j.1365-2265.2000.01044.x

Merimee, 1982, Insulin-like growth factor in pregnancy: studies in a growth hormone-deficient dwarf, J. Clin. Endocrinol. Metab., 54, 1101, 10.1210/jcem-54-6-1101

Wang, 1996, Insulin-like growth factor-binding protein 1 and insulin-like growth factor-binding protein 3 in pre-eclampsia, Br. J. Obstet. Gynaecol., 103, 654, 10.1111/j.1471-0528.1996.tb09833.x

Varma, 1993, Evaluation of plasma insulin-like growth factor-binding protein-3 as a potential predictor of preeclampsia, Am. J. Obstet. Gynecol., 169, 995, 10.1016/0002-9378(93)90042-H

Hall, 1986, Serum levels of somatomedins and somatomedin-binding protein in pregnant women with type I or gestational diabetes and their infants, J. Clin. Endocrinol. Metab., 63, 1300, 10.1210/jcem-63-6-1300

Lauszus, 2001, Macrosomia associated with maternal serum insulin-like growth factor-I and -II in diabetic pregnancy, Obstet. Gynecol., 97, 734, 10.1016/S0029-7844(01)01189-9

Whittaker, 1990, Insulin-like growth factor 1 and its binding protein 1 during normal and diabetic pregnancies, Obstet. Gynecol., 76, 223

Caufriez, 1993, Regulation of maternal IGF-I by placental GH in normal and abnormal human pregnancies, Am. J. Physiol., 265, E572

Chu, 1998, Insulin-like growth factor binding protein-3 in the detection of fetal down syndrome pregnancies, Obstet. Gynecol., 91, 192, 10.1016/S0029-7844(97)00662-5

Moghadam, 1998, Maternal serum placental growth hormone and insulinlike growth factor binding proteins 1 and 3 in pregnancies affected by fetal aneuploidy and other abnormalities: implications for prenatal diagnosis of trisomy 21, Fetal Diagn. Ther., 13, 291, 10.1159/000020856

Martini, 2001, Influence of insulin-like growth factor-1 and leptin on bone mass in healthy postmenopausal women, Bone, 28, 113, 10.1016/S8756-3282(00)00408-7

Romagnoli, 1994, Circulating levels of insulin-like growth factor binding protein 3 (IGFBP-3) and insulin-like growth factor I (IGF-I) in perimenopausal women, Osteoporos. Int., 4, 305, 10.1007/BF01622187

Yamamoto, 1991, Effects of aging and sex on plasma insulin-like growth factor I (IGF-I) levels in normal adults, Acta Endocrinol. (Copenh.), 124, 497, 10.1530/acta.0.1240497

Ravn, 1995, Insulin-like growth factors I and II in healthy women with and without established osteoporosis, Eur. J. Endocrinol., 132, 313, 10.1530/eje.0.1320313

Poehlman, 1997, Menopause-associated changes in plasma lipids, insulin-like growth factor I and blood pressure: a longitudinal study, Eur. J. Clin. Invest., 27, 322, 10.1046/j.1365-2362.1997.1160662.x

Goodman-Gruen, 1996, Effect of replacement estrogen on insulin-like growth factor-I in postmenopausal women: the Rancho Bernardo Study, J. Clin. Endocrinol. Metab., 81, 4268, 10.1210/jc.81.12.4268

Cano, 1999, Effect of menopause and different combined estradiol-progestin regimens on basal and growth hormone-releasing hormone-stimulated serum growth hormone, insulin-like growth factor-1, insulin-like growth factor binding protein (IGFBP)-1, and IGFBP-3 levels, Fertil. Steril., 71, 261, 10.1016/S0015-0282(98)00432-4

Campagnoli, 1993, Differential effects of oral conjugated estrogens and transdermal estradiol on insulin-like growth factor 1, growth hormone and sex hormone binding globulin serum levels, Gynecol. Endocrinol., 7, 251, 10.3109/09513599309152509

Heald, 2000, Progestins abrogate estrogen-induced changes in the insulin-like growth factor axis, Am. J. Obstet. Gynecol., 183, 593, 10.1067/mob.2000.106994

Raudaskoski, 1998, Plasma insulin-like growth factor-I and its binding proteins 1 and 3 during continuous nonoral and oral combined hormone replacement therapy, Menopause, 5, 217, 10.1097/00042192-199805040-00006

Kam, 2000, Estrogens exert route- and dose-dependent effects on insulin-like growth factor (IGF)-binding protein-3 and the acid-labile subunit of the IGF ternary complex, J. Clin. Endocrinol. Metab., 85, 1918, 10.1210/jc.85.5.1918

Vestergaard, 1999, Effect of sex hormone replacement on the insulin-like growth factor system and bone mineral: a cross-sectional and longitudinal study in 595 perimenopausal women participating in the Danish Osteoporosis Prevention Study, J. Clin. Endocrinol. Metab., 84, 2286, 10.1210/jc.84.7.2286

Garnero, 1999, Effects of intranasal 17beta-estradiol on bone turnover and serum insulin-like growth factor I in postmenopausal women, J. Clin. Endocrinol. Metab., 84, 2390, 10.1210/jc.84.7.2390

Weissberger, 1991, Contrasting effects of oral and transdermal routes of estrogen replacement therapy on 24-h growth hormone (GH) secretion, insulin-like growth factor I, and GH-binding protein in postmenopausal women, J. Clin. Endocrinol. Metab., 72, 374, 10.1210/jcem-72-2-374

Dall’Aglio, 1994, Lack of effect of transdermal estrogen on the growth hormone-insulin-like growth factor axis, Horm. Metab. Res., 26, 211, 10.1055/s-2007-1000814

Cardim, 2001, The insulin-like growth factor-I system and hormone replacement therapy, Fertil. Steril., 75, 282, 10.1016/S0015-0282(00)01691-5

Hopkins, 1995, Insulin-like growth factor (IGF)-I levels in postmenopausal women receiving tibolone, Horm. Metab. Res., 27, 387, 10.1055/s-2007-979985

Bellantoni, 1991, Effects of progestin-opposed transdermal estrogen administration on growth hormone and insulin-like growth factor-I in postmenopausal women of different ages, J. Clin. Endocrinol. Metab., 72, 172, 10.1210/jcem-72-1-172

Campagnoli, 1998, Insulin-like growth factor-I and risk of breast cancer, Lancet, 352, 488, 10.1016/S0140-6736(05)79226-6

Posaci, 2001, Effects of HRT on serum levels of IGF-I in postmenopausal women, Maturitas, 40, 69, 10.1016/S0378-5122(01)00230-4

Decensi, 1999, Effect of tamoxifen on lipoprotein (a) and insulin-like growth factor-I (IGF-I) in healthy women, Eur. J. Cancer, 35, 596, 10.1016/S0959-8049(98)00428-6

Thissen, 1994, Nutritional regulation of the insulin-like growth factors, Endocr. Rev., 15, 80

Davenport, 1988, Serum concentrations of insulin-like growth factor II are not changed by short-term fasting and refeeding, J. Clin. Endocrinol. Metab., 67, 1231, 10.1210/jcem-67-6-1231

Clemmons, 1981, Reduction of plasma immunoreactive somatomedin C during fasting in humans, J. Clin. Endocrinol. Metab., 53, 1247, 10.1210/jcem-53-6-1247

Smith, 1995, Effects of caloric or protein restriction on insulin-like growth factor-I (IGF-I) and IGF-binding proteins in children and adults, J. Clin. Endocrinol. Metab., 80, 443, 10.1210/jc.80.2.443

Isley, 1983, Dietary components that regulate serum somatomedin-C concentrations in humans, J. Clin. Invest., 71, 175, 10.1172/JCI110757

Isley, 1984, Changes in plasma somatomedin-C in response to ingestion of diets with variable protein and energy content, JPEN. J. Parenter. Enteral. Nutr, 8, 407, 10.1177/0148607184008004407

Clemmons, 1985, Supplemental essential amino acids augment the somatomedin-C/insulin-like growth factor I response to refeeding after fasting, Metabolism, 34, 391, 10.1016/0026-0495(85)90230-6

Snyder, 1988, Treatment of obese, diet-restricted subjects with growth hormone for 11 weeks: effects on anabolism, lipolysis, and body composition, J. Clin. Endocrinol. Metab., 67, 54, 10.1210/jcem-67-1-54

Bang, 1994, Fasting affects serum insulin-like growth factors (IGFs) and IGF-binding proteins differently in patients with noninsulin-dependent diabetes mellitus versus healthy nonobese and obese subjects, J. Clin. Endocrinol. Metab., 78, 960, 10.1210/jc.78.4.960

Gama, 1990, The effect of synthetic very low calorie diets on the GH-IGF-1 axis in obese subjects, Clin. Chim. Acta, 188, 31, 10.1016/0009-8981(90)90143-G

Rasmussen, 1995, Lack of stimulation of 24-h growth hormone release by hypocaloric diet in obesity, J. Clin. Endocrinol. Metab., 80, 796, 10.1210/jc.80.3.796

Ho, 1988, Fasting enhances growth hormone secretion and amplifies the complex rhythms of growth hormone secretion in man, J. Clin. Invest., 81, 968, 10.1172/JCI113450

Beaune, 1997, Serum insulin-like growth factor I and physical performance in prepubertal Bolivian girls of a high and low socio-economic status, Eur. J. Appl. Physiol. Occup. Physiol., 76, 98, 10.1007/s004210050219

Martinez de Icaya, 2000, IGF-1 and its binding proteins, Ann. Nutr. Metab., 44, 139, 10.1159/000012836

Hintz, 1978, Plasma somatomedin and growth hormone values in children with protein-calorie malnutrition, J. Pediatr., 92, 153, 10.1016/S0022-3476(78)80099-7

Smith, 1981, Blood plasma levels of cortisol, insulin, growth hormone and somatomedin in children with marasmus, kwashiorkor, and intermediate forms of protein-energy malnutrition, Proc. Soc. Exp. Biol. Med., 167, 607, 10.3181/00379727-167-41222

Mohan, 1979, Plasma somatomedin activity in protein calorie malnutrition, Arch. Dis. Child, 54, 62, 10.1136/adc.54.1.62

Bouhaddioui, 1989, Immunoreactive somatomedin C in children from Morocco: a biological marker of nutritional growth retardation?, Biomed. Pharmacother., 43, 59, 10.1016/0753-3322(89)90192-3

Zamboni, 1996, Growth hormone-binding proteins and insulin-like growth factor-binding proteins in protein-energy malnutrition, before and after nutritional rehabilitation, Pediatr. Res., 39, 410, 10.1203/00006450-199603000-00006

Smith, 1989, Plasma somatomedin-C in Nigerian malnourished children fed a vegetable protein rehabilitation diet, Eur. J. Clin. Nutr., 43, 705

Unterman, 1985, Nutrition and somatomedin. XIII. Usefulness of somatomedin-C in nutritional assessment, Am. J. Med., 78, 228, 10.1016/0002-9343(85)90431-0

Bhutta, 1999, Insulin-like growth factor I response during nutritional rehabilitation of persistent diarrhoea, Arch. Dis. Child, 80, 438, 10.1136/adc.80.5.438

Kabir, 1992, Effects of a protein-rich diet during convalescence from shigellosis on catch-up growth, serum proteins, and insulin-like growth factor-I, Pediatr. Res., 32, 689, 10.1203/00006450-199212000-00014

Ascher, 1993, Different features of coeliac disease in two neighbouring countries, Arch. Dis. Child, 69, 375, 10.1136/adc.69.3.375

Locuratolo, 1999, The circulating insulin-like growth factor system in children with coeliac disease: an additional marker for disease activity, Diabetes Metab. Res. Rev., 15, 254, 10.1002/(SICI)1520-7560(199907/08)15:4<254::AID-DMRR47>3.0.CO;2-F

Eichler, 1991, Growth failure and insulin-like growth factor (IGF-I) in childhood celiac disease, Klin. Wochenschr., 69, 825, 10.1007/BF01649453

Weile, 1994, Insulin-like growth factor-I in celiac disease, J. Pediatr. Gastroenterol. Nutr., 19, 391, 10.1097/00005176-199411000-00004

Jansson, 2001, The decrease of IGF-I, IGF-binding protein-3 and bone alkaline phosphatase isoforms during gluten challenge correlates with small intestinal inflammation in children with coeliac disease, Eur. J. Endocrinol., 144, 417, 10.1530/eje.0.1440417

Federico, 1997, Effect of celiac disease and gluten-free diet on growth hormone-binding protein, insulin-like growth factor-i, and insulin-like growth factor-binding proteins, Horm. Res., 48, 108, 10.1159/000185499

Kirschner, 1986, Somatomedin-C levels in growth-impaired children and adolescents with chronic inflammatory bowel disease, Gastroenterology, 91, 830, 10.1016/0016-5085(86)90683-9

Valdimarsson, 1999, Low circulating insulin-like growth factor I in coeliac disease and its relation to bone mineral density, Scand. J. Gastroenterol., 34, 904, 10.1080/003655299750025381

Thomas, 1993, Insulin like growth factor-I, insulin like growth factor binding protein-1, and insulin in childhood Crohn’s disease, Gut, 34, 944, 10.1136/gut.34.7.944

Beattie, 1998, Responsiveness of IGF-I and IGFBP-3 to therapeutic intervention in children and adolescents with Crohn’s disease, Clin. Endocrinol. (Oxf.), 49, 483, 10.1046/j.1365-2265.1998.00562.x

Katsanos, 2001, Reduced serum insulin-like growth factor-1 (IGF-1) and IGF-binding protein-3 levels in adults with inflammatory bowel disease, Growth Horm. IGF Res., 11, 364, 10.1054/ghir.2001.0248

Waters, 1996, Recombinant human growth hormone, insulin-like growth factor 1, and combination therapy in AIDS-associated wasting. A randomized, double-blind, placebo-controlled trial, Ann. Intern. Med., 125, 865, 10.7326/0003-4819-125-11-199612010-00001

Lieberman, 1994, Anabolic effects of recombinant insulin-like growth factor-I in cachectic patients with the acquired immunodeficiency syndrome, J. Clin. Endocrinol. Metab., 78, 404, 10.1210/jc.78.2.404

Ellis, 1996, Changes in body composition of human immunodeficiency virus-infected males receiving insulin-like growth factor I and growth hormone, J. Clin. Endocrinol. Metab., 81, 3033, 10.1210/jc.81.8.3033

Campillo, 2000, Serum levels of insulin-like growth factor-1 in the three months following surgery for a hip fracture in elderly: relationship with nutritional status and inflammatory reaction, Clin. Nutr., 19, 349, 10.1054/clnu.2000.0124

Donahue, 1989, Response of IGF-1 to nutritional support in malnourished hospital patients: a possible indicator of short-term changes in nutritional status, Am. J. Clin. Nutr., 50, 962, 10.1093/ajcn/50.5.962

Smith, 1997, Use of insulin-like growth factor I (IGF-I) and IGF-binding protein measurements to monitor feeding of premature infants, J. Clin. Endocrinol. Metab., 82, 3982, 10.1210/jc.82.12.3982

Argente, 1997, Disturbances in the growth hormone-insulin-like growth factor axis in children and adolescents with different eating disorders, Horm. Res., 48, 16, 10.1159/000191306

Counts, 1992, The effect of anorexia nervosa and refeeding on growth hormone-binding protein, the insulin-like growth factors (IGFs), and the IGF-binding proteins, J. Clin. Endocrinol. Metab., 75, 762, 10.1210/jc.75.3.762

Argente, 1997, Multiple endocrine abnormalities of the growth hormone and insulin-like growth factor axis in patients with anorexia nervosa: effect of short- and long-term weight recuperation, J. Clin. Endocrinol. Metab., 82, 2084, 10.1210/jc.82.7.2084

Forbes, 1989, Hormonal response to overfeeding, Am. J. Clin. Nutr., 49, 608, 10.1093/ajcn/49.4.608

Hochberg, 1992, The distal axis of growth hormone (GH) in nutritional disorders: GH-binding protein, insulin-like growth factor-I (IGF-I), and IGF-I receptors in obesity and anorexia nervosa, Metabolism, 41, 106, 10.1016/0026-0495(92)90198-J

Rasmussen, 1995, Massive weight loss restores 24-h growth hormone release profiles and serum insulin-like growth factor-I levels in obese subjects, J. Clin. Endocrinol. Metab., 80, 1407, 10.1210/jc.80.4.1407

Frystyk, 1995, Free insulin-like growth factors in human obesity, Metabolism, 44, 37, 10.1016/0026-0495(95)90219-8

Jorgensen, 1995, Serum concentrations of insulin-like growth factors (IGFs), IGF binding proteins 1 and 3 and growth hormone binding protein in obese women and the effects of growth hormone administration: a double-blind, placebo-controlled study, Eur. J. Endocrinol., 133, 65, 10.1530/eje.0.1330065

Frystyk, 1999, Circulating levels of free insulin-like growth factors in obese subjects: the impact of type 2 diabetes, Diabetes Metab. Res. Rev., 15, 314, 10.1002/(SICI)1520-7560(199909/10)15:5<314::AID-DMRR56>3.0.CO;2-E

Cordido, 1991, Study of insulin-like growth factor I in human obesity, Horm. Res., 36, 187, 10.1159/000182158

Nam, 1997, Effect of obesity on total and free insulin-like growth factor (IGF)-1, and their relationship to IGF-binding protein (BP)-1, IGFBP-2, IGFBP-3, insulin, and growth hormone, Int. J. Obes. Relat. Metab. Disord., 21, 355, 10.1038/sj.ijo.0800412

Argente, 1997, Multiple endocrine abnormalities of the growth hormone and insulin-like growth factor axis in prepubertal children with exogenous obesity: effect of short- and long-term weight reduction, J. Clin. Endocrinol. Metab., 82, 2076, 10.1210/jc.82.7.2076

Minuto, 1988, Spontaneous growth hormone and somatomedin-C/insulin-like growth factor-I secretion in obese subjects during puberty, J. Endocrinol. Invest., 11, 489, 10.1007/BF03350166

Loche, 1987, Reduced growth hormone response to growth hormone-releasing hormone in children with simple obesity: evidence for somatomedin-C mediated inhibition, Clin. Endocrinol. (Oxf.), 27, 145, 10.1111/j.1365-2265.1987.tb01139.x

Saitoh, 1998, Serum concentrations of insulin, insulin-like growth factor(IGF)-I, IGF binding protein (IGFBP)-1 and -3 and growth hormone binding protein in obese children: fasting IGFBP-1 is suppressed in normoinsulinaemic obese children, Clin. Endocrinol. (Oxf.), 48, 487, 10.1046/j.1365-2265.1998.00476.x

Falorni, 1997, Serum levels of type I procollagen C-terminal propeptide, insulin-like growth factor-I (IGF-I), and IGF binding protein-3 in obese children and adolescents: relationship to gender, pubertal development, growth, insulin, and nutritional status, Metabolism, 46, 862, 10.1016/S0026-0495(97)90071-8

Kamoda, 1999, The phosphorylation status of insulin-like growth factor-binding protein-1 in prepubertal obese children, Eur. J. Endocrinol., 141, 585, 10.1530/eje.0.1410585

Wabitsch, 1996, Insulin-like growth factors and their binding proteins before and after weight loss and their associations with hormonal and metabolic parameters in obese adolescent girls, Int. J. Obes. Relat. Metab. Disord., 20, 1073

Yasunaga, 1998, Nutrition related hormonal changes in obese children, Endocr. J., 45, 221, 10.1507/endocrj.45.221

Timmins, 1996, Critical illness is associated with low circulating concentrations of insulin-like growth factors-I and -II, alterations in insulin-like growth factor binding proteins, and induction of an insulin-like growth factor binding protein 3 protease, Crit. Care Med., 24, 1460, 10.1097/00003246-199609000-00006

Baxter, 1998, Thirty-day monitoring of insulin-like growth factors and their binding proteins in intensive care unit patients, Growth Horm. IGF Res., 8, 455, 10.1016/S1096-6374(98)80298-0

Hawker, 1987, Relationship of somatomedin-C/insulin-like growth factor I levels to conventional nutritional indices in critically ill patients, Crit. Care Med., 15, 732, 10.1097/00003246-198708000-00004

Yarwood, 1997, Administration of human recombinant insulin-like growth factor-I in critically ill patients, Crit. Care Med., 25, 1352, 10.1097/00003246-199708000-00023

Takala, 1999, Increased mortality associated with growth hormone treatment in critically ill adults, N. Engl. J. Med., 341, 785, 10.1056/NEJM199909093411102

Clark, 1996, Sequential changes in insulin-like growth factor 1, plasma proteins, and total body protein in severe sepsis and multiple injury, JPEN. J. Parenter. Enteral. Nutr., 20, 363, 10.1177/0148607196020005363

de Groof, 2002, Acute stress response in children with meningococcal sepsis: important differences in the growth hormone/insulin-like growth factor I axis between nonsurvivors and survivors, J. Clin. Endocrinol. Metab., 87, 3118, 10.1210/jc.87.7.3118

Van den Berghe, 1998, Neuroendocrinology of prolonged critical illness: effects of exogenous thyrotropin-releasing hormone and its combination with growth hormone secretagogues, J. Clin. Endocrinol. Metab., 83, 309, 10.1210/jc.83.2.309

Balcells, 2001, Growth hormone/insulin-like growth factors axis in children undergoing cardiac surgery, Crit. Care Med., 29, 1234, 10.1097/00003246-200106000-00031

Van den Berghe, 2000, A paradoxical gender dissociation within the growth hormone/insulin-like growth factor I axis during protracted critical illness, J. Clin. Endocrinol. Metab., 85, 183, 10.1210/jc.85.1.183

Cotterill, 1996, The differential regulation of the circulating levels of the insulin-like growth factors and their binding proteins (IGFBP) 1, 2 and 3 after elective abdominal surgery, Clin. Endocrinol. (Oxf.), 44, 91, 10.1046/j.1365-2265.1996.649471.x

Price, 2001, Relation between serum insulinlike growth factor-1, insulinlike growth factor binding protein-2, and insulinlike growth factor binding protein-3 and nutritional intake in premature infants with bronchopulmonary dysplasia, J. Pediatr. Gastroenterol. Nutr., 32, 542, 10.1097/00005176-200105000-00010

Skinner, 1997, Growth and growth factors in premature infants receiving dexamethasone for bronchopulmonary dysplasia, Am. J. Perinatol., 14, 539, 10.1055/s-2007-994330

Wolthers, 1994, The insulin-like growth factor axis and collagen turnover during prednisolone treatment, Arch. Dis. Child, 71, 409, 10.1136/adc.71.5.409

Wolthers, 1995, The insulin-like growth factor axis and collagen turnover in asthmatic children treated with inhaled budesonide, Acta Paediatr., 84, 393, 10.1111/j.1651-2227.1995.tb13657.x

Wolthers, 1997, Knemometry, urine cortisol excretion, and measures of the insulin-like growth factor axis and collagen turnover in children treated with inhaled glucocorticosteroids, Pediatr. Res., 41, 44, 10.1203/00006450-199701000-00007

Burdet, 1997, Administration of growth hormone to underweight patients with chronic obstructive pulmonary disease. A prospective, randomized, controlled study, Am. J. Respir. Crit. Care Med., 156, 1800, 10.1164/ajrccm.156.6.9704142

Laursen, 1995, Diminished concentrations of insulin-like growth factor I in cystic fibrosis, Arch. Dis. Child, 72, 494, 10.1136/adc.72.6.494

Lebl, 2001, Insulin-like growth factor-I and insulin-like growth factor-binding protein-3 in cystic fibrosis: a positive effect of antibiotic therapy and hyperalimentation, Acta Paediatr., 90, 868, 10.1111/j.1651-2227.2001.tb02447.x

Tirakitsoontorn, 2001, Fitness, acute exercise, and anabolic and catabolic mediators in cystic fibrosis, Am. J. Respir. Crit. Care Med., 164, 1432, 10.1164/ajrccm.164.8.2102045

Taylor, 1999, The relationship between insulin, IGF-I and weight gain in cystic fibrosis, Clin. Endocrinol. (Oxf.), 51, 659, 10.1046/j.1365-2265.1999.00858.x

Hassan, 1991, Circulating growth hormone, insulin-like growth factor I, cortisol and free thyroxine in children with schistosomiasis with and without hepatic fibrosis, J. Trop. Pediatr., 37, 25, 10.1093/tropej/37.1.25

Holt, 1996, Sequential changes in insulin-like growth factor I (IGF-I) and IGF-binding proteins in children with end-stage liver disease before and after successful orthotopic liver transplantation, J. Clin. Endocrinol. Metab., 81, 160, 10.1210/jc.81.1.160

Buzi, 1998, Growth, insulin-like growth factor I (IGF-I), and IGF-binding proteins 1 and 3 in children with severe liver disease before and after liver transplantation: a longitudinal and cross-sectional study, Pediatr. Res., 43, 478, 10.1203/00006450-199804000-00007

Bucuvalas, 1996, Growth hormone insensitivity in children with biliary atresia, J. Pediatr. Gastroenterol. Nutr., 23, 135, 10.1097/00005176-199608000-00007

Maghnie, 1998, Failure to increase insulin-like growth factor-I synthesis is involved in the mechanisms of growth retardation of children with inherited liver disorders, Clin. Endocrinol. (Oxf.), 48, 747, 10.1046/j.1365-2265.1998.00425.x

Sheppard, 1987, Insulin-like growth factors (IGF) in liver disease: differential changes of IGF-I and IGF-II, Clin. Invest. Med., 10, 49

Moller, 1993, Urinary growth hormone (U-GH) excretion and serum insulin-like growth factor 1 (IGF-1) in patients with alcoholic cirrhosis, J. Hepatol., 17, 315, 10.1016/S0168-8278(05)80211-9

Kratzsch, 1995, Regulation of growth hormone (GH), insulin-like growth factor (IGF)I, IGF binding proteins -1, -2, -3 and GH binding protein during progression of liver cirrhosis, Exp. Clin. Endocrinol. Diabetes, 103, 285, 10.1055/s-0029-1211366

Shaarawy, 1998, Insulin-like growth factor binding protein-3: a novel biomarker for the assessment of the synthetic capacity of hepatocytes in liver cirrhosis, J. Clin. Endocrinol. Metab., 83, 3316, 10.1210/jc.83.9.3316

Moller, 1996, Prognostic value of insulinlike growth factor I and its binding protein in patients with alcohol-induced liver disease. EMALD group, Hepatology, 23, 1073, 10.1002/hep.510230521

Caregaro, 1997, Nutritional and prognostic significance of insulin-like growth factor 1 in patients with liver cirrhosis, Nutrition, 13, 185, 10.1016/S0899-9007(96)00399-1

Lee, 1989, IGF binding proteins in growth-retarded children with chronic renal failure, Pediatr. Res., 26, 308, 10.1203/00006450-198910000-00005

Hokken-Koelega, 1990, Twenty-four-hour plasma growth hormone (GH) profiles, urinary GH excretion, and plasma insulin-like growth factor-I and -II levels in prepubertal children with chronic renal insufficiency and severe growth retardation, J. Clin. Endocrinol. Metab., 71, 688, 10.1210/jcem-71-3-688

Blum, 1991, Growth hormone resistance and inhibition of somatomedin activity by excess of insulin-like growth factor binding protein in uraemia, Pediatr. Nephrol., 5, 539, 10.1007/BF01453697

Tonshoff, 1995, J. Clin. Endocrinol. Metab., 80, 2684, 10.1210/jc.80.9.2684

Zhou, 2001, IGFs and IGF-binding proteins in short children with steroid-dependent nephrotic syndrome on chronic glucocorticoids: changes with 1 year exogenous GH, Eur. J. Endocrinol., 144, 237, 10.1530/eje.0.1440237

Hokken-Koelega, 1993, Levels of growth hormone, insulin-like growth factor-I (IGF-I) and -II, IGF-binding protein-1 and -3, and cortisol in prednisone-treated children with growth retardation after renal transplantation, J. Clin. Endocrinol. Metab., 77, 932, 10.1210/jc.77.4.932

Powell, 1997, Insulin-like growth factor-binding protein-6 levels are elevated in serum of children with chronic renal failure: a report of the Southwest Pediatric Nephrology Study Group, J. Clin. Endocrinol. Metab., 82, 2978, 10.1210/jc.82.9.2978

Bereket, 1997, Growth hormone treatment in growth retarded children with end stage renal failure: effect on free/dissociable IGF-I levels, J. Pediatr. Endocrinol. Metab., 10, 197, 10.1515/JPEM.1997.10.2.197

Frystyk, 1999, Serum-free insulin-like growth factor I correlates with clearance in patients with chronic renal failure, Kidney Int., 56, 2076, 10.1046/j.1523-1755.1999.00798.x

Hokken-Koelega, 1996, Growth hormone treatment in children before and after renal transplantation, J. Pediatr. Endocrinol. Metab., 9, 359

Hokken-Koelega, 1996, A placebo-controlled, double-blind trial of growth hormone treatment in prepubertal children after renal transplant, Kidney Int. Suppl., 53, S128

Hokken-Koelega, 1994, Double blind trial comparing the effects of two doses of growth hormone in prepubertal patients with chronic renal insufficiency, J. Clin. Endocrinol. Metab., 79, 1185, 10.1210/jc.79.4.1185

Aleman, 1999, Insulin-like growth factor-I and cognitive function in healthy older men, J. Clin. Endocrinol. Metab., 84, 471, 10.1210/jc.84.2.471

Aleman, 2000, Age-sensitive cognitive function, growth hormone and insulin-like growth factor 1 plasma levels in healthy older men, Neuropsychobiology, 41, 73, 10.1159/000026636

Ryu, 2000, Modulation of neuroendocrinological function by psychosomatic training: acute effect of ChunDoSunBup Qi-training on growth hormone, insulin-like growth factor (IGF)-I, and insulin-like growth factor binding protein (IGFBP)-3 in men, Psychoneuroendocrinology, 25, 439, 10.1016/S0306-4530(99)00069-4

Franz, 1999, Insulin-like growth factor 1 and growth hormone binding protein in depression: a preliminary communication, J. Psychiatr. Res., 33, 121, 10.1016/S0022-3956(98)00066-1

Sara, 1982, Somatomedins in aging and dementia disorders of the Alzheimer type, Neurobiol. Aging, 3, 117, 10.1016/0197-4580(82)90006-9

Busiguina, 2000, Neurodegeneration is associated to changes in serum insulin-like growth factors, Neurobiol. Dis., 7, 657, 10.1006/nbdi.2000.0311

Torres-Aleman, 1998, The peripheral insulin-like growth factor system in amyotrophic lateral sclerosis and in multiple sclerosis, Neurology, 50, 772, 10.1212/WNL.50.3.772

Wilczak, 1998, Insulin-like growth factor system in serum and cerebrospinal fluid in patients with multiple sclerosis, Neurosci. Lett., 257, 168, 10.1016/S0304-3940(98)00829-5

Rothe, 1988, Plasma somatomedin-C levels in systemic sclerosis, Br. J. Dermatol., 119, 639, 10.1111/j.1365-2133.1988.tb03476.x

Schwab, 1997, Plasma insulin-like growth factor I and IGF binding protein 3 levels in patients with acute cerebral ischemic injury, Stroke, 28, 1744, 10.1161/01.STR.28.9.1744

Hussain, 1996, Insulin-like growth factor I alters peripheral thyroid hormone metabolism in humans: comparison with growth hormone, Eur. J. Endocrinol., 134, 563, 10.1530/eje.0.1340563

Jorgensen, 1994, Growth hormone administration stimulates energy expenditure and extrathyroidal conversion of thyroxine to triiodothyronine in a dose-dependent manner and suppresses circadian thyrotrophin levels: studies in GH-deficient adults, Clin. Endocrinol. (Oxf.), 41, 609, 10.1111/j.1365-2265.1994.tb01826.x

Mitchell, 1989, The relationship of insulin-like growth factor-I to total thyroxine in normal and low birth weight infants, Pediatr. Res., 25, 336, 10.1203/00006450-198904000-00004

Zamboni, 2000, Insulin-like growth factor binding protein-3 proteolysis and growth of athyreotic infants in the first weeks of life, Acta Paediatr., 89, 1050, 10.1111/j.1651-2227.2000.tb03349.x

Miell, 1993, Effects of hypothyroidism and hyperthyroidism on insulin-like growth factors (IGFs) and growth hormone- and IGF-binding proteins, J. Clin. Endocrinol. Metab., 76, 950, 10.1210/jc.76.4.950

Cavaliere, 1987, Effect of thyroid hormone therapy on plasma insulin-like growth factor I levels in normal subjects, hypothyroid patients and endemic cretins, Horm. Res., 25, 132, 10.1159/000180644

Valcavi, 1987, Effect of thyroxine replacement therapy on plasma insulin-like growth factor 1 levels and growth hormone responses to growth hormone releasing factor in hypothyroid patients, Clin. Endocrinol. (Oxf.), 27, 85, 10.1111/j.1365-2265.1987.tb00842.x

Chernausek, 1989, Attenuation of spontaneous, nocturnal growth hormone secretion in children with hypothyroidism and its correlation with plasma insulin-like growth factor I concentrations, J. Pediatr., 114, 968, 10.1016/S0022-3476(89)80439-1

Hoogerbrugge-vd, 1989, Relationship between insulin-like growth factor-I and low-density lipoprotein cholesterol levels in primary hypothyroidism in women, J. Endocrinol., 123, 341, 10.1677/joe.0.1230341

Wan, 1998, Insulin-like growth factor-binding protein-3 (IGFBP-3) but not insulin-like growth factor-I (IGF-I) remains elevated in euthyroid TSH-suppressed Graves’ disease, Horm. Metab. Res., 30, 213, 10.1055/s-2007-978868

Tada, 1994, Change in serum concentration of insulin-like growth factor II (IGF-II) in patients with thyroid disease, Endocr. J., 41, 541, 10.1507/endocrj.41.541

Teale, 1986, The measurement of insulin-like growth factor I: clinical applications and significance, Ann. Clin. Biochem., 23, 413, 10.1177/000456328602300406

Valimaki, 1990, Concentrations of somatomedin-C and triiodothyronine in patients with thyroid dysfunction and nonthyroidal illnesses, J. Endocrinol. Invest., 13, 155, 10.1007/BF03349528

Westermark, 1988, Growth factors and the thyroid: effects of treatment for hyper- and hypothyroidism on serum IGF-I and urinary epidermal growth factor concentrations, Acta Endocrinol. (Copenh.), 118, 415, 10.1530/acta.0.1180415

Miell, 1994, Reversible effects of cessation and recommencement of thyroxine treatment on insulin-like growth factors (IGFs) and IGF-binding proteins in patients with total thyroidectomy, J. Clin. Endocrinol. Metab., 79, 1507, 10.1210/jc.79.5.1507

Valcavi, 1993, Influence of hyperthyroidism on growth hormone secretion, Clin. Endocrinol. (Oxf.), 38, 515, 10.1111/j.1365-2265.1993.tb00348.x

Foldes, 1997, Decreased serum IGF-I and dehydroepiandrosterone sulphate may be risk factors for the development of reduced bone mass in postmenopausal women with endogenous subclinical hyperthyroidism, Eur. J. Endocrinol., 136, 277, 10.1530/eje.0.1360277

Ramos-Dias, 1995, Low circulating IGF-I levels in hyperthyroidism are associated with decreased GH response to GH-releasing hormone, Clin. Endocrinol. (Oxf.), 43, 583, 10.1111/j.1365-2265.1995.tb02923.x

Hansson, 1986, Somatomedin C in pathogenesis of malignant exophthalmos of endocrine origin, Lancet, 1, 218, 10.1016/S0140-6736(86)90698-7

Miell, 1993, The effects of dexamethasone treatment on immunoreactive and bioactive insulin-like growth factors (IGFs) and IGF-binding proteins in normal male volunteers, J. Endocrinol., 136, 525, 10.1677/joe.0.1360525

Bang, 1993, Insulin-like growth factor (IGF) I and II and IGF binding protein (IGFBP) 1, 2 and 3 in serum from patients with Cushing’s syndrome, Acta Endocrinol. (Copenh.), 128, 397, 10.1530/acta.0.1280397

Gourmelen, 1982, Serum somatomedin/insulin-like growth factor (IGF) and IGF carrier levels in patients with Cushing’s syndrome or receiving glucocorticoid therapy, J. Clin. Endocrinol. Metab., 54, 885, 10.1210/jcem-54-5-885

Thoren, 1981, Somatomedin A levels in patients with Cushing’s disease, Acta Endocrinol. (Copenh.), 97, 12, 10.1530/acta.0.0970012

Knip, 1995, Insulin-like growth factor binding proteins in prepubertal children with insulin-dependent diabetes mellitus, Eur. J. Endocrinol., 133, 440, 10.1530/eje.0.1330440

Dills, 1995, Insulin-like growth factor-I is related to glycemic control in children and adolescents with newly diagnosed insulin-dependent diabetes, J. Clin. Endocrinol. Metab., 80, 2139, 10.1210/jc.80.7.2139

Strasser-Vogel, 1995, Insulin-like growth factor (IGF)-I and -II and IGF-binding proteins-1, -2, and -3 in children and adolescents with diabetes mellitus: correlation with metabolic control and height attainment, J. Clin. Endocrinol. Metab., 80, 1207, 10.1210/jc.80.4.1207

Munoz, 1996, Insulin-like growth factor I, its binding proteins 1 and 3, and growth hormone-binding protein in children and adolescents with insulin-dependent diabetes mellitus: clinical implications, Pediatr. Res., 39, 992, 10.1203/00006450-199606000-00011

Radetti, 1997, Growth hormone-binding proteins, IGF-I and IGF-binding proteins in children and adolescents with type 1 diabetes mellitus, Horm. Res., 47, 110, 10.1159/000185444

Zachrisson, 2000, Increased 24h mean insulin-like growth factor binding protein-3 proteolytic activity in pubertal type 1 diabetic boys, Growth Horm. IGF Res., 10, 324, 10.1054/ghir.2000.0170

Cianfarani, 2000, J. Clin. Endocrinol. Metab., 85, 4162, 10.1210/jc.85.11.4162

Bereket, 1996, Insulin treatment normalizes reduced free insulin-like growth factor-I concentrations in diabetic children, Clin. Endocrinol. (Oxf.), 45, 321, 10.1046/j.1365-2265.1996.7760786.x

Jehle, 1998, Serum levels of insulin-like growth factor system components and relationship to bone metabolism in Type 1 and Type 2 diabetes mellitus patients, J. Endocrinol., 159, 297, 10.1677/joe.0.1590297

Elias, 1996, Relationship between prorenin, IGF-I, IGF-binding proteins and retinopathy in diabetic patients, Gen. Pharmacol., 27, 329, 10.1016/0306-3623(95)02033-0

Janssen, 1997, Free and total insulin-like growth factor I (IGF-I), IGF-binding protein-1 (IGFBP-1), and IGFBP-3 and their relationships to the presence of diabetic retinopathy and glomerular hyperfiltration in insulin-dependent diabetes mellitus, J. Clin. Endocrinol. Metab., 82, 2809, 10.1210/jc.82.9.2809

Moller, 2000, Growth hormone, IGF-I and diabetic angiopathy revisited, Clin. Endocrinol. (Oxf.), 52, 11, 10.1046/j.1365-2265.2000.00925.x

Clauson, 1998, Insulin-like growth factor-I and insulin-like growth factor binding protein-1 in a representative population of type 2 diabetic patients in Sweden, Scand. J. Clin. Lab. Invest., 58, 353, 10.1080/00365519850186544

Sandhu, 2002, Circulating concentrations of insulin-like growth factor-I and development of glucose intolerance: a prospective observational study, Lancet, 359, 1740, 10.1016/S0140-6736(02)08655-5

Johansson, 1992, The bone mineral density in acquired growth hormone deficiency correlates with circulating levels of insulin-like growth factor I, J. Intern. Med., 232, 447, 10.1111/j.1365-2796.1992.tb00613.x

Rosen, 1997, Increased fracture frequency in adult patients with hypopituitarism and GH deficiency, Eur. J. Endocrinol., 137, 240, 10.1530/eje.0.1370240

Johansson, 1997, Reduced serum levels of the growth hormone-dependent insulin-like growth factor binding protein and a negative bone balance at the level of individual remodeling units in idiopathic osteoporosis in men, J. Clin. Endocrinol. Metab., 82, 2795, 10.1210/jc.82.9.2795

Kassem, 1994, No evidence for reduced spontaneous or growth-hormone-stimulated serum levels of insulin-like growth factor (IGF)-I, IGF-II or IGF binding protein 3 in women with spinal osteoporosis, Eur. J. Endocrinol., 131, 150, 10.1530/eje.0.1310150

Kurland, 1997, Insulin-like growth factor-I in men with idiopathic osteoporosis, J. Clin. Endocrinol. Metab., 82, 2799, 10.1210/jc.82.9.2799

Ponzer, 1999, Nutritional status, insulin-like growth factor-1 and quality of life in elderly women with hip fractures, Clin. Nutr., 18, 241, 10.1016/S0261-5614(99)80076-4

Celiker, 2000, Comparison of serum insulin-like growth factor-1 and growth hormone levels in osteoporotic and non-osteoporotic postmenopausal women, Rheumatol. Int., 19, 205, 10.1007/s002960000058

Kim, 1999, The relationship among circulating insulin-like growth factor components, biochemical markers of bone turnover and bone mineral density in postmenopausal women under the age of 60, Clin. Endocrinol. (Oxf.), 51, 301, 10.1046/j.1365-2265.1999.00769.x

Sugimoto, 1997, Serum levels of insulin-like growth factor (IGF) I, IGF-binding protein (IGFBP)-2, and IGFBP-3 in osteoporotic patients with and without spinal fractures, J. Bone Miner. Res., 12, 1272, 10.1359/jbmr.1997.12.8.1272

Schurch, 1998, Protein supplements increase serum insulin-like growth factor-I levels and attenuate proximal femur bone loss in patients with recent hip fracture. A randomized, double-blind, placebo-controlled trial, Ann. Intern. Med., 128, 801, 10.7326/0003-4819-128-10-199805150-00002

Garnero, 2000, Low serum IGF-1 and occurrence of osteoporotic fractures in postmenopausal women, Lancet, 355, 898, 10.1016/S0140-6736(99)05463-X

Nicolai, 1999, Serum insulin-like growth factors IGF-I and IGFBP-3 in children with slipped capital femoral epiphysis, J. Pediatr. Orthop. B, 8, 103, 10.1097/00009957-199904000-00008

Lund, 1998, Collagen-derived markers of bone metabolism in osteogenesis imperfecta, Acta Paediatr., 87, 1131, 10.1111/j.1651-2227.1998.tb00920.x

Neidel, 1992, Low plasma levels of insulin-like growth factor I in Perthes’ disease. A controlled study of 59 consecutive children, Acta Orthop. Scand., 63, 393, 10.3109/17453679209154752

Cimaz, 1997, A multicenter study on insulin-like growth factor-I serum levels in children with chronic inflammatory diseases, Clin. Exp. Rheumatol., 15, 691

Aitman, 1989, Serum IGF-I levels and growth failure in juvenile chronic arthritis, Clin. Exp. Rheumatol., 7, 557

Touati, 1998, Beneficial effects of one-year growth hormone administration to children with juvenile chronic arthritis on chronic steroid therapy. I. Effects on growth velocity and body composition, J. Clin. Endocrinol. Metab., 83, 403, 10.1210/jc.83.2.403

Bechtold, 2001, GH therapy in juvenile chronic arthritis: results of a two-year controlled study on growth and bone, J. Clin. Endocrinol. Metab., 86, 5737, 10.1210/jc.86.12.5737

Davies, 1997, Juvenile rheumatoid arthritis. Effects of disease activity and recombinant human growth hormone on insulin-like growth factor 1, insulin-like growth factor binding proteins 1 and 3, and osteocalcin, Arthritis Rheum., 40, 332, 10.1002/art.1780400218

Allen, 1991, Insulin-like growth factor and growth hormone secretion in juvenile chronic arthritis, Ann. Rheum. Dis., 50, 602, 10.1136/ard.50.9.602

Bennett, 1988, Insulin-like growth factors I and II in children with systemic onset juvenile arthritis, J. Rheumatol., 15, 655

Lemmey, 2001, Association between insulin-like growth factor status and physical activity levels in rheumatoid arthritis, J. Rheumatol., 28, 29

Neidel, 2001, Changes in systemic levels of insulin-like growth factors and their binding proteins in patients with rheumatoid arthritis, Clin. Exp. Rheumatol., 19, 81

Schouten, 1993, Insulin-like growth factor-1: a prognostic factor of knee osteoarthritis, Br. J. Rheumatol., 32, 274, 10.1093/rheumatology/32.4.274

Toussirot, 1998, Insulin-like growth factor-I and insulin-like growth factor binding protein-3 serum levels in ankylosing spondylitis, Br. J. Rheumatol., 37, 1172, 10.1093/rheumatology/37.11.1172

Denko, 2001, Growth hormone, insulin, and insulin-like growth factor-1 in hypermobility syndrome, J. Rheumatol., 28, 1666

Bennett, 1992, Low levels of somatomedin C in patients with the fibromyalgia syndrome. A possible link between sleep and muscle pain, Arthritis Rheum., 35, 1113, 10.1002/art.1780351002

Jacobsen, 1995, A controlled study on serum insulin-like growth factor-I and urinary excretion of growth hormone in fibromyalgia, J. Rheumatol., 22, 1138

Buchwald, 1996, Insulin-like growth factor-I (somatomedin C) levels in chronic fatigue syndrome and fibromyalgia, J. Rheumatol., 23, 739

Bagge, 1998, Low growth hormone secretion in patients with fibromyalgia – a preliminary report on 10 patients and 10 controls, J. Rheumatol., 25, 145

Rosen, 1990, Premature mortality due to cardiovascular disease in hypopituitarism, Lancet, 336, 285, 10.1016/0140-6736(90)91812-O

Bulow, 1997, Increased cerebrovascular mortality in patients with hypopituitarism, Clin. Endocrinol. (Oxf.), 46, 75, 10.1046/j.1365-2265.1997.d01-1749.x

Bates, 1999, Life expectancy following surgery for pituitary tumours, Clin. Endocrinol. (Oxf.), 50, 315, 10.1046/j.1365-2265.1999.00650.x

Spallarossa, 1996, Insulin-like growth factor-I and angiographically documented coronary artery disease, Am. J. Cardiol., 77, 200, 10.1016/S0002-9149(96)90600-1

Goodman-Gruen, 2000, IGF-1 and ischemic heart disease in older people, J. Am. Geriatr. Soc., 48, 860, 10.1111/j.1532-5415.2000.tb04774.x

Lee, 1999, Changes of the insulin-like growth factor I system during acute myocardial infarction: implications on left ventricular remodeling, J. Clin. Endocrinol. Metab., 84, 1575, 10.1210/jc.84.5.1575

Botker, 1997, Insulin-like growth factor-I, insulin, and angina pectoris secondary to coronary atherosclerosis, vasospasm, and syndrome X, Am. J. Cardiol., 79, 961, 10.1016/S0002-9149(97)00021-0

Conti, 2001, Markedly reduced insulin-like growth factor-1 in the acute phase of myocardial infarction, J. Am. Coll. Cardiol., 38, 26, 10.1016/S0735-1097(01)01367-5

Corbalan, 1998, Enalapril restores depressed circulating insulin-like growth factor 1 in patients with chronic heart failure, J. Card. Fail, 4, 115, 10.1016/S1071-9164(98)90251-2

Niebauer, 1998, Deficient insulin-like growth factor I in chronic heart failure predicts altered body composition, anabolic deficiency, cytokine and neurohormonal activation, J. Am. Coll. Cardiol., 32, 393, 10.1016/S0735-1097(98)00226-5

Osterziel, 2000, The somatotrophic system in patients with dilated cardiomyopathy: relation of insulin-like growth factor-1 and its alterations during growth hormone therapy to cardiac function, Clin. Endocrinol. (Oxf.), 53, 61, 10.1046/j.1365-2265.2000.01029.x

Osterziel, 1998, Randomised, double-blind, placebo-controlled trial of human recombinant growth hormone in patients with chronic heart failure due to dilated cardiomyopathy, Lancet, 351, 1233, 10.1016/S0140-6736(97)11329-0

Donath, 1998, Acute cardiovascular effects of insulin-like growth factor I in patients with chronic heart failure, J. Clin. Endocrinol. Metab., 83, 3177, 10.1210/jc.83.9.3177

Schuler-Luttmann, 2000, Insulin-like growth factor-binding protein-3 is associated with the presence and extent of coronary arteriosclerosis, Arterioscler. Thromb. Vasc. Biol., 20, 1175, 10.1161/01.ATV.20.4.e10

Grant, 1994, Localization of insulin-like growth factor I and inhibition of coronary smooth muscle cell growth by somatostatin analogues in human coronary smooth muscle cells. A potential treatment for restenosis?, Circulation, 89, 1511, 10.1161/01.CIR.89.4.1511

Frystyk, 1996, Lanreotide reduces serum free and total insulin-like growth factor-I after angioplasty, Circulation, 94, 2465, 10.1161/01.CIR.94.10.2465

Ruotolo, 2000, Serum insulin-like growth factor-I level is independently associated with coronary artery disease progression in young male survivors of myocardial infarction: beneficial effects of bezafibrate treatment, J. Am. Coll. Cardiol., 35, 647, 10.1016/S0735-1097(99)00591-4

Reeves, 2000, Age-related serum levels of insulin-like growth factor-I, -II and IGF-binding protein-3 following myocardial infarction, Growth Horm. IGF Res., 10, 78, 10.1054/ghir.2000.0143

Harrela, 2002, High serum insulin-like growth factor binding protein-1 is associated with increased cardiovascular mortality in elderly men, Horm. Metab. Res., 34, 144, 10.1055/s-2002-23198

Seck, 1998, Concentration of insulin-like growth factor (IGF)-I and -II in iliac crest bone matrix from pre- and postmenopausal women: relationship to age, menopause, bone turnover, bone volume, and circulating IGFs, J. Clin. Endocrinol. Metab., 83, 2331

Erfurth, 2001, Incidence of a second tumor in hypopituitary patients operated for pituitary tumors, J. Clin. Endocrinol. Metab., 86, 659, 10.1210/jc.86.2.659

Byrne, 2000, Plasma insulin-like growth factor (IGF) I, IGF-binding protein 3, and mammographic density, Cancer Res., 60, 3744

Guo, 2001, Growth factors and stromal matrix proteins associated with mammographic densities, Cancer Epidemiol. Biomarkers Prev., 10, 243

Hartmann, 1998, Hormonal breast augmentation: prognostic relevance of insulin-like growth factor-I, Gynecol. Endocrinol., 12, 123, 10.3109/09513599809024960

Malozowski, 1995, Prepubertal gynecomastia during growth hormone therapy, J. Pediatr., 126, 659, 10.1016/S0022-3476(95)70372-1

Cohn, 1993, Carpal tunnel syndrome and gynaecomastia during growth hormone treatment of elderly men with low circulating IGF-I concentrations, Clin. Endocrinol. (Oxf.), 39, 417, 10.1111/j.1365-2265.1993.tb02388.x

Jernstrom, 1997, Reduced testosterone, 17 beta-oestradiol and sexual hormone binding globulin, and increased insulin-like growth factor-1 concentrations, in healthy nulligravid women aged 19–25 years who were first and/or second degree relatives to breast cancer patients, Eur. J. Cancer Prev., 6, 330, 10.1097/00008469-199708000-00004

Yu, 2001, Polymorphic CA repeats in the IGF-I gene and breast cancer, Breast Cancer Res. Treat, 70, 117, 10.1023/A:1012947027213

Bohlke, 1998, Insulin-like growth factor-I in relation to premenopausal ductal carcinoma in situ of the breast, Epidemiology, 9, 570, 10.1097/00001648-199809000-00018

Ng, 1998, Altered serum levels of insulin-like growth-factor binding proteins in breast cancer patients, Ann. Surg. Oncol., 5, 194, 10.1007/BF02303854

Vadgama, 1999, Plasma insulin-like growth factor-I and serum IGF-binding protein 3 can be associated with the progression of breast cancer, and predict the risk of recurrence and the probability of survival in African-American and Hispanic women, Oncology, 57, 330, 10.1159/000012052

Bruning, 1995, Insulin-like growth-factor-binding protein 3 is decreased in early-stage operable pre-menopausal breast cancer, Int. J. Cancer, 62, 266, 10.1002/ijc.2910620306

Jernstrom, 1999, Obesity, weight change, fasting insulin, proinsulin, C-peptide, and insulin-like growth factor-1 levels in women with and without breast cancer: the Rancho Bernardo Study, J. Womens Health Gend. Based. Med., 8, 1265, 10.1089/jwh.1.1999.8.1265

Favoni, 1995, Insulin-like growth factor-I (IGF-I) and IGF-binding proteins blood serum levels in women with early- and late-stage breast cancer: mutual relationship and possible correlations with patients’ hormonal status, J. Cancer Res. Clin. Oncol., 121, 674, 10.1007/BF01218526

Hankinson, 1998, Circulating concentrations of insulin-like growth factor-I and risk of breast cancer, Lancet, 351, 1393, 10.1016/S0140-6736(97)10384-1

Li, 2001, Free insulin-like growth factor-I and breast cancer risk, Int. J. Cancer, 91, 736, 10.1002/1097-0215(200002)9999:9999<::AID-IJC1111>3.0.CO;2-#

Toniolo, 2000, Serum insulin-like growth factor-I and breast cancer, Int. J. Cancer, 88, 828, 10.1002/1097-0215(20001201)88:5<828::AID-IJC22>3.0.CO;2-8

Kaaks, 2002, Prospective study of IGF-I, IGF-binding proteins, and breast cancer risk, in northern and southern Sweden, Cancer Causes. Control, 13, 307, 10.1023/A:1015270324325

Holdaway, 2001, Effect of breast surgery on serum levels of insulin-like growth factors (IGF-I, IGF-II, and IGF binding protein-3) in women with benign and malignant breast lesions, Ann. Surg. Oncol., 8, 25, 10.1007/s10434-001-0025-5

Lahti, 1994, Plasma insulin-like growth factor I and its binding proteins 1 and 3 in postmenopausal patients with breast cancer receiving long term tamoxifen, Cancer, 74, 618, 10.1002/1097-0142(19940715)74:2<618::AID-CNCR2820740213>3.0.CO;2-J

Mandala, 2001, Effect of tamoxifen on GH and IGF-1 serum level in stage I-II breast cancer patients, Anticancer Res., 21, 585

Helle, 1996, Influence of droloxifene on plasma levels of insulin-like growth factor (IGF)-I, Pro-IGF-IIE, insulin-like growth factor binding protein (IGFBP)-1 and IGFBP-3 in breast cancer patients, J. Steroid Biochem. Mol. Biol., 57, 167, 10.1016/0960-0760(95)00257-X

Helle, 2001, Alterations in the insulin-like growth factor system during treatment with diethylstilboestrol in patients with metastatic breast cancer, Br. J. Cancer, 85, 147, 10.1054/bjoc.2001.1871

Dolan, 2001, Treatment of metastatic breast cancer with somatostatin analogues – a meta-analysis, Ann. Surg. Oncol., 8, 227

Decensi, 2001, Long-term effects of fenretinide, a retinoic acid derivative, on the insulin-like growth factor system in women with early breast cancer, Cancer Epidemiol. Biomarkers Prev., 10, 1047

Peyrat, 1998, Plasma insulin-like growth factor in primary breast cancer patients treated with adjuvant chemotherapy, Br. J. Cancer, 77, 1669, 10.1038/bjc.1998.274

Kajdaniuk, 2000, Influence of adjuvant chemotherapy with cyclophosphamide, methotrexate and 5-fluorouracil on plasma insulin-like growth factor-I and chosen hormones in breast cancer pre-menopausal patients, J. Clin. Pharm. Ther., 25, 67, 10.1046/j.1365-2710.2000.00265.x

Helle, 1999, Effects of treatment with megestrol acetate on the insulin-like growth factor system: time and dose dependency, Eur. J. Cancer, 35, 1070, 10.1016/S0959-8049(99)00055-6

Frost, 1996, Effects of treatment with megestrol acetate, aminoglutethimide, or formestane on insulin-like growth factor (IGF) I and II, IGF-binding proteins (IGFBPs), and IGFBP-3 protease status in patients with advanced breast cancer, J. Clin. Endocrinol. Metab., 81, 2216, 10.1210/jc.81.6.2216

Reed, 1992, The effect of endocrine therapy with medroxyprogesterone acetate, 4-hydroxyandrostenedione or tamoxifen on plasma concentrations of insulin-like growth factor (IGF)-I, IGF-II and IGFBP-1 in women with advanced breast cancer, Int. J. Cancer, 52, 208, 10.1002/ijc.2910520209

Helle, 1998, Influence of treatment with onapristone on the IGF-system in breast cancer patients, J. Steroid Biochem. Mol. Biol., 66, 159, 10.1016/S0960-0760(98)00046-6

Bajetta, 1997, The aromatase inhibitor letrozole in advanced breast cancer: effects on serum insulin-like growth factor (IGF)-I and IGF-binding protein-3 levels, J. Steroid Biochem. Mol. Biol., 63, 261, 10.1016/S0960-0760(97)00120-9

Lien, 1992, Influence of tamoxifen, aminoglutethimide and goserelin on human plasma IGF-I levels in breast cancer patients, J. Steroid Biochem. Mol. Biol., 41, 541, 10.1016/0960-0760(92)90380-2

Mantzoros, 1997, Insulin-like growth factor 1 in relation to prostate cancer and benign prostatic hyperplasia, Br. J. Cancer, 76, 1115, 10.1038/bjc.1997.520

Wolk, 1998, Insulin-like growth factor 1 and prostate cancer risk: a population-based, case-control study, J. Natl. Cancer Inst., 90, 911, 10.1093/jnci/90.12.911

Chokkalingam, 2001, Insulin-like growth factors and prostate cancer: a population-based case-control study in China, Cancer Epidemiol. Biomarkers Prev., 10, 421

Finne, 2000, Insulin-like growth factor I is not a useful marker of prostate cancer in men with elevated levels of prostate-specific antigen, J. Clin. Endocrinol. Metab., 85, 2744, 10.1210/jc.85.8.2744

Baffa, 2000, Low serum insulin-like growth factor1 (IGF-1): a significant association with prostate cancer, Tech. Urol., 6, 236

Cutting, 1999, Serum insulin-like growth factor-1 is not a useful marker of prostate cancer, BJU Int., 83, 996, 10.1046/j.1464-410x.1999.00088.x

Kurek, 2000, The significance of serum levels of insulin-like growth factor-1 in patients with prostate cancer, BJU Int., 85, 125, 10.1046/j.1464-410x.2000.00350.x

Djavan, 1999, Insulin-like growth factor 1 (IGF-1), IGF-1 density, and IGF-1/PSA ratio for prostate cancer detection, Urology, 54, 603, 10.1016/S0090-4295(99)00280-0

Yu, 2001, Levels of insulin-like growth factor I (IGF-I) and IGF binding proteins 2 and 3 in serial postoperative serum samples and risk of prostate cancer recurrence, Urology, 57, 471, 10.1016/S0090-4295(00)01003-7

Shariat, 2000, Correlation of preoperative plasma IGF-I levels with pathologic parameters and progression in patients undergoing radical prostatectomy, Urology, 56, 423, 10.1016/S0090-4295(00)00648-8

Colao, 1999, Effect of growth hormone (GH) and insulin-like growth factor I on prostate diseases: an ultrasonographic and endocrine study in acromegaly, GH deficiency, and healthy subjects, J. Clin. Endocrinol. Metab., 84, 1986, 10.1210/jc.84.6.1986

Chan, 1998, Plasma insulin-like growth factor-I and prostate cancer risk: a prospective study, Science, 279, 563, 10.1126/science.279.5350.563

Harman, 2000, Serum levels of insulin-like growth factor I (IGF-I), IGF-II, IGF-binding protein-3, and prostate-specific antigen as predictors of clinical prostate cancer, J. Clin. Endocrinol. Metab., 85, 4258, 10.1210/jc.85.11.4258

Stattin, 1910, Plasma insulin-like growth factor-I, insulin-like growth factor-binding proteins, and prostate cancer risk: a prospective study, J. Natl. Cancer Inst., 92, 1910, 10.1093/jnci/92.23.1910

Chan, 2002, Insulin-like growth factor-I (IGF-I) and IGF binding protein-3 as predictors of advanced-stage prostate cancer, J. Natl. Cancer Inst., 94, 1099, 10.1093/jnci/94.14.1099

Shi, 2001, Insulin-like growth factor-I and prostate cancer: a meta-analysis, Br. J. Cancer, 85, 991, 10.1054/bjoc.2001.1961

Sarma, 2002, Insulin-like growth factor-I, insulin-like growth factor binding protein-3, and body mass index: clinical correlates of prostate volume among black men, Urology, 59, 362, 10.1016/S0090-4295(01)01546-1

Freier, 1999, Expression of the insulin-like growth factors and their receptors in adenocarcinoma of the colon, Gut, 44, 704, 10.1136/gut.44.5.704

Cats, 1996, Increased epithelial cell proliferation in the colon of patients with acromegaly, Cancer Res., 56, 523

Beentjes, 2000, One year growth hormone replacement therapy does not alter colonic epithelial cell proliferation in growth hormone deficient adults, Clin. Endocrinol. (Oxf.), 52, 457, 10.1046/j.1365-2265.2000.00993.x

Jenkins, 2000, Insulin-like growth factor I and the development of colorectal neoplasia in acromegaly, J. Clin. Endocrinol. Metab., 85, 3218, 10.1210/jc.85.9.3218

Terzolo, 1994, High prevalence of colonic polyps in patients with acromegaly. Influence of sex and age, Arch. Intern. Med., 154, 1272, 10.1001/archinte.154.11.1272

Renehan, 2000, The prevalence and characteristics of colorectal neoplasia in acromegaly, J. Clin. Endocrinol. Metab., 85, 3417, 10.1210/jc.85.9.3417

Manousos, 1999, IGF-I and IGF-II in relation to colorectal cancer, Int. J. Cancer, 83, 15, 10.1002/(SICI)1097-0215(19990924)83:1<15::AID-IJC4>3.0.CO;2-Y

Renehan, 2001, High-risk colorectal adenomas and serum insulin-like growth factors, Br. J. Surg., 88, 107, 10.1046/j.1365-2168.2001.01645.x

Probst-Hensch, 2001, IGF-1, IGF-2 and IGFBP-3 in prediagnostic serum: association with colorectal cancer in a cohort of Chinese men in Shanghai, Br. J. Cancer, 85, 1695, 10.1054/bjoc.2001.2172

Kaaks, 2000, Serum C-peptide, insulin-like growth factor (IGF)-I, IGF-binding proteins, and colorectal cancer risk in women, J. Natl. Cancer Inst., 92, 1592, 10.1093/jnci/92.19.1592

Giovannucci, 2000, A prospective study of plasma insulin-like growth factor-1 and binding protein-3 and risk of colorectal neoplasia in women, Cancer Epidemiol. Biomarkers. Prev., 9, 345

Lee, 1997, Serum insulin-like growth factors (IGFs) and IGF binding protein (IGFBP)-3 in patients with gastric cancer: IGFBP-3 protease activity induced by surgery, J. Korean Med. Sci., 12, 32, 10.3346/jkms.1997.12.1.32

Evans, 1997, Serum levels of insulin-like growth factors (IGF-I and IGF-II) and their binding protein (IGFBP-3) are not elevated in pancreatic cancer, Int. J. Pancreatol., 22, 95, 10.1007/BF02787466

Lee, 1999, Serum insulin-like growth factor (IGF)-I and IGF-binding proteins in lung cancer patients, J. Korean Med. Sci., 14, 401, 10.3346/jkms.1999.14.4.401

London, 2002, Insulin-like growth factor I, IGF-binding protein 3, and lung cancer risk in a prospective study of men in China, J. Natl. Cancer Inst., 94, 749, 10.1093/jnci/94.10.749

Wu, 2000, Joint effect of insulin-like growth factors and mutagen sensitivity in lung cancer risk, J. Natl. Cancer Inst., 92, 737, 10.1093/jnci/92.9.737

Shah, 1994, Circulating epidermal growth factor (EGF) and insulin-like growth factor-I (IGF-I) in patients with epithelial ovarian carcinoma, Neoplasma, 41, 241

Flyvbjerg, 1997, Elevated serum insulin-like growth factor-binding protein 2 (IGFBP-2) and decreased IGFBP-3 in epithelial ovarian cancer: correlation with cancer antigen 125 and tumor-associated trypsin inhibitor, J. Clin. Endocrinol. Metab., 82, 2308, 10.1210/jc.82.7.2308

Bese, 2001, The importance of serum insulin-like growth factor-I level determination in the follow-up of patients with epithelial ovarian cancer, Eur. J. Gynaecol. Oncol., 22, 372

Ayabe, 1997, Increased circulating levels of insulin-like growth factor-I and decreased circulating levels of insulin-like growth factor binding protein-1 in postmenopausal women with endometrial cancer, Endocr. J., 44, 419, 10.1507/endocrj.44.419

Rutanen, 1993, Relationship between carbohydrate metabolism and serum insulin-like growth factor system in postmenopausal women: comparison of endometrial cancer patients with healthy controls, J. Clin. Endocrinol. Metab., 77, 199, 10.1210/jc.77.1.199

Mohnike, 1996, Serum levels of insulin-like growth factor-I, -II and insulin-like growth factor binding proteins -2 and -3 in children with acute lymphoblastic leukaemia, Eur. J. Pediatr., 155, 81, 10.1007/BF02075755

Arguelles, 2000, Modifications of growth velocity and the insulin-like growth factor system in children with acute lymphoblastic leukemia: a longitudinal study, J. Clin. Endocrinol. Metab., 85, 4087, 10.1210/jc.85.11.4087

Schmiegelow, 1999, Insulin-like growth factor-I and insulin-like growth factor binding protein-3 during maintenance chemotherapy of acute lymphoblastic leukemia in children, J. Pediatr. Hematol. Oncol., 21, 268, 10.1097/00043426-199907000-00006

Attard-Montalto, 1998, Changes in protein turnover, IGF-I and IGF binding proteins in children with cancer, Acta Paediatr., 87, 54, 10.1111/j.1651-2227.1998.tb01386.x

Petridou, 2001, Insulin-like growth factor binding protein-3 predicts survival from acute childhood leukemia, Oncology, 60, 252, 10.1159/000055326

Tauber, 1994, Growth hormone secretion in children and adolescents with familial tall stature, Eur. J. Pediatr., 153, 311, 10.1007/BF01956408

Krassas, 1997, Serum levels of insulin-like growth factor-I (IGF-I) and IGF binding protein-3 (IGFBP-3) in idiopathic tall basketball players, Endocrinol. Metab., 4, 339

Gourmelen, 1984, Serum levels of insulin-like growth factor (IGF) and IGF binding protein in constitutionally tall children and adolescents, J. Clin. Endocrinol. Metab., 59, 1197, 10.1210/jcem-59-6-1197

Marin, 1994, The effects of estrogen priming and puberty on the growth hormone response to standardized treadmill exercise and arginine-insulin in normal girls and boys, J. Clin. Endocrinol. Metab., 79, 537, 10.1210/jc.79.2.537

Martinez, 2000, Estrogen priming effect on growth hormone (GH) provocative test: a useful tool for the diagnosis of GH deficiency, J. Clin. Endocrinol. Metab., 85, 4168, 10.1210/jc.85.11.4168

Ghigo, 1996, Reliability of provocative tests to assess growth hormone secretory status. Study in 472 normally growing children, J. Clin. Endocrinol. Metab., 81, 3323, 10.1210/jc.81.9.3323

Granada, 1990, Assay-dependent results of immunoassayable spontaneous 24-h growth hormone secretion in short children, Acta Paediatr. Scand. Suppl., 370, 63, 10.1111/j.1651-2227.1990.tb11675.x

Andersson, 1995, Interpretation of growth hormone provocative tests: comparison of cut-off values in four European laboratories, Eur. J. Endocrinol., 132, 340, 10.1530/eje.0.1320340

Zapf, 1981, Radioimmunological determination of insulinlike growth factors I and II in normal subjects and in patients with growth disorders and extrapancreatic tumor hypoglycemia, J. Clin. Invest., 68, 1321, 10.1172/JCI110379

Furlanetto, 1977, Estimation of somatomedin-C levels in normals and patients with pituitary disease by radioimmunoassay, J. Clin. Invest., 60, 648, 10.1172/JCI108816

Bala, 1979, Radioimmunoassay of a basic somatomedin: comparison of various assay techniques and somatomedin levels in various sera, J. Clin. Endocrinol. Metab., 49, 770, 10.1210/jcem-49-5-770

Juul, 1997, Prediction of the outcome of growth hormone provocative testing in short children by measurement of serum levels of insulin-like growth factor I and insulin-like growth factor binding protein3, J. Pediatr., 130, 197, 10.1016/S0022-3476(97)70343-3

Lee, 1990, Efficacy of insulin-like growth factor I levels in predicting the response to provocative growth hormone testing, Pediatr. Res., 27, 45, 10.1203/00006450-199001000-00015

Smith, 1993, Use of insulin-like growth factor-binding protein-2 (IGFBP-2), IGFBP-3, and IGF-I for assessing growth hormone status in short children, J. Clin. Endocrinol. Metab., 77, 1294, 10.1210/jc.77.5.1294

Cianfarani, 1995, Is IGF binding protein-3 assessment helpful for the diagnosis of GH deficiency?, Clin. Endocrinol. (Oxf.), 43, 43, 10.1111/j.1365-2265.1995.tb01891.x

Hasegawa, 1996, Plasma free insulin-like growth factor I concentrations in growth hormone deficiency in children and adolescents, Eur. J. Endocrinol., 134, 184, 10.1530/eje.0.1340184

Bussieres, 2000, The use of insulin-like growth factor 1 reference values for the diagnosis of growth hormone deficiency in prepubertal children, Clin. Endocrinol. (Oxf.), 52, 735, 10.1046/j.1365-2265.2000.00999.x

Tillmann, 1997, Biochemical tests in the diagnosis of childhood growth hormone deficiency, J. Clin. Endocrinol. Metab., 82, 531, 10.1210/jc.82.2.531

Sklar, 1993, Efficacy of insulin-like growth factor binding protein 3 in predicting the growth hormone response to provocative testing in children treated with cranial irradiation, Acta Endocrinol. (Copenh.), 129, 511, 10.1530/acta.0.1290511

Weinzimer, 1999, Serum IGF-I and IGFBP-3 concentrations do not accurately predict growth hormone deficiency in children with brain tumours, Clin. Endocrinol. (Oxf.), 51, 339, 10.1046/j.1365-2265.1999.00804.x

Oerter, 1992, Combining insulin-like growth factor-I and mean spontaneous nighttime growth hormone levels for the diagnosis of growth hormone deficiency, J. Clin. Endocrinol. Metab., 75, 1413, 10.1210/jc.75.6.1413

Hasegawa, 1994, Clinical utility of insulin-like growth factor binding protein-3 in the evaluation and treatment of short children with suspected growth hormone deficiency, Eur. J. Endocrinol., 131, 27, 10.1530/eje.0.1310027

Aguiar-Oliveira, 1999, Effect of severe growth hormone (GH) deficiency due to a mutation in the GH-releasing hormone receptor on insulin-like growth factors (IGFs), IGF-binding proteins, and ternary complex formation throughout life, J. Clin. Endocrinol. Metab., 84, 4118, 10.1210/jc.84.11.4118

Barrios, 2001, Diagnostic interest of acid-labile subunit measurement in relationship to other components of the IGF system in pediatric patients with growth or eating disorders, Eur. J. Endocrinol., 144, 245, 10.1530/eje.0.1440245

Rosenfeld, 1997, Is growth hormone deficiency a viable diagnosis?, J. Clin. Endocrinol. Metab., 82, 349, 10.1210/jc.82.2.349

Ranke, 1999, Derivation and validation of a mathematical model for predicting the response to exogenous recombinant human growth hormone (GH) in prepubertal children with idiopathic GH deficiency. KIGS International Board. Kabi Pharmacia International Growth Study, J. Clin. Endocrinol. Metab., 84, 1174, 10.1210/jc.84.4.1174

Spagnoli, 1995, Prediction of the outcome of growth hormone therapy in children with idiopathic short stature. A multivariate discriminant analysis, J. Pediatr., 126, 905, 10.1016/S0022-3476(95)70206-7

Bell, 1998, Lack of correlation between growth hormone provocative test results and subsequent growth rates during growth hormone therapy, Pediatrics, 102, 518, 10.1542/peds.102.S3.518

Van den Broeck, 2000, Growth response to recombinant human growth hormone (GH) in children with idiopathic growth retardation by level of maximum GH peak during GH stimulation tests, Horm. Res., 53, 267, 10.1159/000053182

Wikland, 2000, Validated multivariate models predicting the growth response to GH treatment in individual short children with a broad range in GH secretion capacities, Pediatr. Res., 48, 475, 10.1203/00006450-200010000-00010

Rosenfeld, 1981, Constancy of somatomedin response to growth hormone treatment of hypopituitary dwarfism, and lack of correlation with growth rate, J. Clin. Endocrinol. Metab., 53, 611, 10.1210/jcem-53-3-611

de Muinck, 1992, Dose-response study of biosynthetic human growth hormone (GH) in GH-deficient children: effects on auxological and biochemical parameters. Dutch Growth Hormone Working Group, J. Clin. Endocrinol. Metab., 74, 898, 10.1210/jc.74.4.898

Kristrom, 1997, Growth response to growth hormone (GH) treatment relates to serum insulin-like growth factor I (IGF-I) and IGF-binding protein-3 in short children with various GH secretion capacities. Swedish Study Group for Growth Hormone Treatment, J. Clin. Endocrinol. Metab., 82, 2889, 10.1210/jc.82.9.2889

Ranke, 2001, Relevance of IGF-I, IGFBP-3, and IGFBP-2 measurements during GH treatment of GH-deficient and non-GH-deficient children and adolescents, Horm. Res., 55, 115, 10.1159/000049982

Cohen, 2002, Effects of dose and gender on the growth and growth factor response to GH in GH-deficient children: implications for efficacy and safety, J. Clin. Endocrinol. Metab., 87, 90, 10.1210/jc.87.1.90

Mandel, 1995, Changes in insulin-like growth factor-I (IGF-I), IGF-binding protein-3, growth hormone (GH)-binding protein, erythrocyte IGF-I receptors, and growth rate during GH treatment, J. Clin. Endocrinol. Metab., 80, 190, 10.1210/jc.80.1.190

Schonau, 2001, A new and accurate prediction model for growth response to growth hormone treatment in children with growth hormone deficiency, Eur. J. Endocrinol., 144, 13, 10.1530/eje.0.1440013

Hoffman, 1994, Diagnosis of growth-hormone deficiency in adults, Lancet, 343, 1064, 10.1016/S0140-6736(94)90181-3

de Boer, 1994, Diagnosis of growth hormone deficiency in adults, Lancet, 343, 1645, 10.1016/S0140-6736(94)93104-6

Janssen, 1997, A low starting dose of genotropin in growth hormone-deficient adults, J. Clin. Endocrinol. Metab., 82, 129, 10.1210/jc.82.1.129

Juul, 1997, Growth hormone (GH) provocative retesting of 108 young adults with childhood-onset GH deficiency and the diagnostic value of insulin-like growth factor I (IGF-I) and IGF-binding protein-3, J. Clin. Endocrinol. Metab., 82, 1195, 10.1210/jc.82.4.1195

Rahim, 1996, The assessment of growth hormone status in normal young adult males using a variety of provocative agents, Clin. Endocrinol. (Oxf.), 45, 557, 10.1046/j.1365-2265.1996.00855.x

Hoeck, 1995, Test of growth hormone secretion in adults: poor reproducibility of the insulin tolerance test, Eur. J. Endocrinol., 133, 305, 10.1530/eje.0.1330305

AnonymousConsensus guidelines for the diagnosis and treatment of growth hormone (GH) deficiency in childhood and adolescence: summary statement of the GH Research Society. GH Research Society. J. Clin. Endocrinol. Metab. 85(11) (2000) 3990–3993

Maghnie, 1999, Growth hormone (GH) deficiency (GHD) of childhood onset: reassessment of GH status and evaluation of the predictive criteria for permanent GHD in young adults, J. Clin. Endocrinol. Metab., 84, 1324, 10.1210/jc.84.4.1324

Granada, 2000, Diagnostic efficiency of serum IGF-I, IGF-binding protein-3 (IGFBP-3), IGF-I/IGFBP-3 molar ratio and urinary GH measurements in the diagnosis of adult GH deficiency: importance of an appropriate reference population, Eur. J. Endocrinol., 142, 243, 10.1530/eje.0.1420243

Aimaretti, 2000, Retesting young adults with childhood-onset growth hormone (GH) deficiency with GH-releasing-hormone-plus-arginine test, J. Clin. Endocrinol. Metab., 85, 3693, 10.1210/jc.85.10.3693

Svensson, 1997, Insulin-like growth factor-I in growth hormone-deficient adults: relationship to population-based normal values, body composition and insulin tolerance test, Clin. Endocrinol. (Oxf.), 46, 579, 10.1046/j.1365-2265.1997.1851001.x

Cuneo, 1998, The Australian multicenter trial of growth hormone (GH) treatment in GH-deficient adults, J. Clin. Endocrinol. Metab., 83, 107, 10.1210/jc.83.1.107

Bates, 1995, Assessment of GH status in adults with GH deficiency using serum growth hormone, serum insulin-like growth factor-I and urinary growth hormone excretion, Clin. Endocrinol. (Oxf.), 42, 425, 10.1111/j.1365-2265.1995.tb02652.x

Roelen, 1996, High-affinity growth hormone binding protein, insulin-like growth factor I and insulin-like growth factor binding protein 3 in adults with growth hormone deficiency, Eur. J. Endocrinol., 135, 82, 10.1530/eje.0.1350082

Andersen, 1996, The pyridostigmine-growth hormone-releasing hormone test in adults. The reference interval and a comparison with the insulin tolerance test, Endocrinol. Metab., 3, 197

Span, 1999, Plasma IGF-I is a useful marker of growth hormone deficiency in adults, J. Endocrinol. Invest., 22, 446, 10.1007/BF03343588

Toogood, 1998, The diagnosis of severe growth hormone deficiency in elderly patients with hypothalamic-pituitary disease, Clin. Endocrinol. (Oxf.), 48, 569, 10.1046/j.1365-2265.1998.00440.x

Sassolas, 1999, GH deficiency in adults: an epidemiological approach, Eur. J. Endocrinol., 141, 595, 10.1530/eje.0.1410595

Musolino, 1999, Evaluation of free insulin-like growth factor-I measurement on the diagnosis and follow-up treatment of growth hormone-deficient adult patients, Clin. Endocrinol. (Oxf.), 50, 441, 10.1046/j.1365-2265.1999.00677.x

Colao, 1999, The growth hormone (GH) response to the arginine plus GH-releasing hormone test is correlated to the severity of lipid profile abnormalities in adult patients with GH deficiency, J. Clin. Endocrinol. Metab., 84, 1277, 10.1210/jc.84.4.1277

Marzullo, 2001, Usefulness of different biochemical markers of the insulin-like growth factor (IGF) family in diagnosing growth hormone excess and deficiency in adults, J. Clin. Endocrinol. Metab., 86, 3001, 10.1210/jc.86.7.3001

Kim, 2001, Diagnostic Value of Serum IGF-I and IGFBP-3 in Growth Hormone Disorders in Adults, Horm. Res., 56, 117, 10.1159/000048103

Hartman, 2002, Which patients do not require a GH stimulation test for the diagnosis of adult GH deficiency?, J. Clin. Endocrinol. Metab., 87, 477, 10.1210/jc.87.2.477

Attanasio, 2002, Confirmation of severe GH deficiency after final height in patients diagnosed as GH deficient during childhood, Clin. Endocrinol. (Oxf.), 56, 503, 10.1046/j.1365-2265.2002.01515.x

Fisker, 1999, Impact of gender and androgen status on IGF-I levels in normal and GH-deficient adults, Eur. J. Endocrinol., 141, 601, 10.1530/eje.0.1410601

Gillberg, 2001, Commencing growth hormone replacement in adults with a fixed low dose. Effects on serum lipoproteins, glucose metabolism, body composition, and cardiovascular function, Growth Horm. IGF Res., 11, 273, 10.1054/ghir.2001.0240

Kehely, 2002, Short-term safety and efficacy of human GH replacement therapy in 595 adults with GH deficiency: a comparison of two dosage algorithms, J. Clin. Endocrinol. Metab., 87, 1974, 10.1210/jc.87.5.1974

Ghigo, 1996, New approach to the diagnosis of growth hormone deficiency in adults, Eur. J. Endocrinol., 134, 352, 10.1530/eje.0.1340352

Ono, 1996, Growth hormone (GH) treatment of GH-deficient children increases serum levels of insulin-like growth factors (IGFs), IGF-binding protein-3 and -5, and bone alkaline phosphatase isoenzyme, J. Clin. Endocrinol. Metab., 81, 2111, 10.1210/jc.81.6.2111

Coutant, 2001, Body composition, fasting leptin, and sex steroid administration determine GH sensitivity in peripubertal short children, J. Clin. Endocrinol. Metab., 86, 5805, 10.1210/jc.86.12.5805

Yuen, 2002, The effects of short-term administration of two low doses versus the standard GH replacement dose on insulin sensitivity and fasting glucose levels in young healthy adults, J. Clin. Endocrinol. Metab., 87, 1989, 10.1210/jc.87.5.1989

Jorgensen, 1991, Short-term changes in serum insulin-like growth factors (IGF) and IGF binding protein 3 after different modes of intravenous growth hormone (GH) exposure in GH-deficient patients, J. Clin. Endocrinol. Metab., 72, 582, 10.1210/jcem-72-3-582

Jorgensen, 1989, Beneficial effects of growth hormone treatment in GH-deficient adults, Lancet, 1, 1221, 10.1016/S0140-6736(89)92328-3

Juul, 1998, Effects of growth hormone replacement therapy on IGF-related parameters and on the pituitary-gonadal axis in GH-deficient males. A double-blind, placebo-controlled crossover study, Horm. Res., 49, 269, 10.1159/000023186

de Boer, 1996, Monitoring of growth hormone replacement therapy in adults, based on measurement of serum markers, J. Clin. Endocrinol. Metab., 81, 1371, 10.1210/jc.81.4.1371

Abs, 1999, GH replacement in 1034 growth hormone deficient hypopituitary adults: demographic and clinical characteristics, dosing and safety, Clin. Endocrinol. (Oxf.), 50, 703, 10.1046/j.1365-2265.1999.00695.x

Chipman, 1997, The safety profile of GH replacement therapy in adults, Clin. Endocrinol. (Oxf.), 46, 473, 10.1046/j.1365-2265.1997.1660984.x

Johannsson, 1996, The individual responsiveness to growth hormone (GH) treatment in GH-deficient adults is dependent on the level of GH-binding protein, body mass index, age, and gender, J. Clin. Endocrinol. Metab., 81, 1575, 10.1210/jc.81.4.1575

Florkowski, 1999, Growth hormone binding protein correlates strongly with leptin and percentage body fat in GH-deficient adults, is increased by GH replacement but does not predict IGF-I response, Growth Horm. IGF Res., 9, 35, 10.1054/ghir.1998.0084

Toogood, 1999, Growth hormone replacement therapy in the elderly with hypothalamic-pituitary disease: a dose-finding study, J. Clin. Endocrinol. Metab., 84, 131, 10.1210/jc.84.1.131

Juul, 1994, Growth hormone (GH) treatment increases serum insulin-like growth factor binding protein-3, bone isoenzyme alkaline phosphatase and forearm bone mineral content in young adults with GH deficiency of childhood onset, Eur. J. Endocrinol., 131, 41, 10.1530/eje.0.1310041

Burman, 1997, Growth hormone (GH)-deficient men are more responsive to GH replacement therapy than women, J. Clin. Endocrinol. Metab., 82, 550, 10.1210/jc.82.2.550

Johansson, 1999, Gender differences in the effects of long term growth hormone (GH) treatment on bone in adults with GH deficiency, J. Clin. Endocrinol. Metab., 84, 2002, 10.1210/jc.84.6.2002

Hayes, 1999, Gender difference in the response of growth hormone (GH)-deficient adults to GH therapy, Metabolism, 48, 308, 10.1016/S0026-0495(99)90077-X

Drake, 1998, Optimizing growth hormone replacement therapy by dose titration in hypopituitary adults, J. Clin. Endocrinol. Metab., 83, 3913, 10.1210/jc.83.11.3913

Bengtsson, 1999, The effects of treatment and the individual responsiveness to growth hormone (GH) replacement therapy in 665 GH-deficient adults. KIMS Study Group and the KIMS International Board, J. Clin. Endocrinol. Metab., 84, 3929, 10.1210/jc.84.11.3929

Ekman, 2002, A dose titration model for recombinant GH substitution aiming at normal plasma concentrations of IGF-I in hypopituitary adults, Eur. J. Endocrinol., 147, 49, 10.1530/eje.0.1470049

Fisker, 2001, The growth hormone (GH)-insulin-like growth factor axis during testosterone replacement therapy in GH-treated hypopituitary males, Growth Horm. IGF Res., 11, 104, 10.1054/ghir.2001.0195

Gentili, 2002, Unequal impact of short-term testosterone repletion on the somatotropic axis of young and older men, J. Clin. Endocrinol. Metab., 87, 825, 10.1210/jc.87.2.825

Janssen, 2000, A switch from oral (2mg/day) to transdermal (50μg/day) 17beta-estradiol therapy increases serum insulin-like growth factor-I levels in recombinant human growth hormone (GH)-substituted women with GH deficiency, J. Clin. Endocrinol. Metab., 85, 464, 10.1210/jc.85.1.464

Cook, 1999, Route of estrogen administration helps to determine growth hormone (GH) replacement dose in GH-deficient adults, J. Clin. Endocrinol. Metab., 84, 3956, 10.1210/jc.84.11.3956

Span, 2000, Gender difference in insulin-like growth factor I response to growth hormone (GH) treatment in GH-deficient adults: role of sex hormone replacement, J. Clin. Endocrinol. Metab., 85, 1121, 10.1210/jc.85.3.1121

Murray, 2000, Pre-treatment IGF-I level is the major determinant of GH dosage in adult GH deficiency, Clin. Endocrinol. (Oxf.), 52, 537, 10.1046/j.1365-2265.2000.00971.x

Laron, 1966, Genetic pituitary dwarfism with high serum concentration of growth hormone – a new inborn error of metabolism, Isr. J. Med. Sci., 2, 152

Guevara-Aguirre, 1993, Growth hormone receptor deficiency in Ecuador: clinical and biochemical phenotype in two populations, J. Clin. Endocrinol. Metab., 76, 417, 10.1210/jc.76.2.417

Woods, 1997, Phenotype: genotype relationships in growth hormone insensitivity syndrome, J. Clin. Endocrinol. Metab., 82, 3529, 10.1210/jc.82.11.3529

Blum, 1994, Improvement of diagnostic criteria in growth hormone insensitivity syndrome: solutions and pitfalls. Pharmacia Study Group on insulin-like growth factor I treatment in growth hormone insensitivity syndromes, Acta Paediatr. Suppl., 399, 117, 10.1111/j.1651-2227.1994.tb13303.x

Cotterill, 1998, Changes in serum IGF-I and IGFBP-3 concentrations during the IGF-I generation test performed prospectively in children with short stature, Clin. Endocrinol. (Oxf.), 48, 719, 10.1046/j.1365-2265.1998.00407.x

Jorge, 2002, Poor reproducibility of IGF-I and IGF binding protein-3 generation test in children with short stature and normal coding region of the GH receptor gene, J. Clin. Endocrinol. Metab., 87, 469, 10.1210/jc.87.2.469

Buckway, 2001, The IGF-I generation test revisited: a marker of GH sensitivity, J. Clin. Endocrinol. Metab., 86, 5176, 10.1210/jc.86.11.5176

Thalange, 1996, Insulin-like growth factor binding protein-3 generation: an index of growth hormone insensitivity, Pediatr. Res., 39, 849, 10.1203/00006450-199605000-00018

Mauras, 1991, Function of the growth hormone-insulin-like growth factor I axis in the profoundly growth-retarded diabetic child: evidence for defective target organ responsiveness in the Mauriac syndrome, Metabolism, 40, 1106, 10.1016/0026-0495(91)90138-M

Jain, 1998, Insulin-like growth factor-I resistance, Endocr. Rev., 19, 625, 10.1210/er.19.5.625

Dulloo, 1996, Dissociation of systemic GH-IGF-I axis from a genetic basis for short stature in African Pygmies, Eur. J. Clin. Nutr., 50, 371

Schwartz, 1987, Short stature, growth hormone, insulin-like growth factors, and serum proteins in the Mountain Ok people of Papua New Guinea, J. Clin. Endocrinol. Metab., 65, 901, 10.1210/jcem-65-5-901

Merimee, 1981, Dwarfism in the pygmy. An isolated deficiency of insulin-like growth factor I, N. Engl. J. Med., 305, 965, 10.1056/NEJM198110223051701

Merimee, 1982, Insulin-like growth factors (IGFs) in pygmies and subjects with the pygmy trait: characterization of the metabolic actions of IGF I and IGF II in man, J. Clin. Endocrinol. Metab., 55, 1081, 10.1210/jcem-55-6-1081

Merimee, 1987, Insulin-like growth factors in pygmies. The role of puberty in determining final stature, N. Engl. J. Med., 316, 906, 10.1056/NEJM198704093161503

Clavano-Harding, 1999, Initial characterization of the GH-IGF axis and nutritional status of the Ati Negritos of the Philippines, Clin. Endocrinol. (Oxf.), 51, 741, 10.1046/j.1365-2265.1999.00877.x

Rieu, 1982, The importance of insulin-like growth factor (somatomedin) measurements in the diagnosis and surveillance of acromegaly, J. Clin. Endocrinol. Metab., 55, 147, 10.1210/jcem-55-1-147

Clemmons, 1979, Evaluation of acromegaly by radioimmunoassay of somatomedin-C, N. Engl. J. Med., 301, 1138, 10.1056/NEJM197911223012102

Barkan, 1988, Plasma insulin-like growth factor-I/somatomedin-C in acromegaly: correlation with the degree of growth hormone hypersecretion, J. Clin. Endocrinol. Metab., 67, 69, 10.1210/jcem-67-1-69

Thissen, 1996, Use of insulin-like growth factor-I (IGF-I) and IGF-binding protein-3 in the diagnosis of acromegaly and growth hormone deficiency in adults, Growth Regul., 6, 222

de Herder, 1995, IGFBP-3 is a poor parameter for assessment of clinical activity in acromegaly, Clin. Endocrinol. (Oxf.), 43, 501, 10.1111/j.1365-2265.1995.tb02623.x

Paramo, 1997, Comparative study of insulin-like growth factor-I (IGF-I) and IGF-binding protein-3 (IGFBP-3) level and IGF-I/IGFBP-3 ratio measurements and their relationship with an index of clinical activity in the management of patients with acromegaly, Metabolism, 46, 494, 10.1016/S0026-0495(97)90183-9

Stoffel-Wagner, 1997, A comparison of different methods for diagnosing acromegaly, Clin. Endocrinol. (Oxf.), 46, 531, 10.1046/j.1365-2265.1997.1430983.x

van der Lely, 1997, Acromegaly: the significance of serum total and free IGF-I and IGF-binding protein-3 in diagnosis, J. Endocrinol., 155, S9

Baxter, 1992, Radioimmunoassay of insulin-like growth factor-binding protein-6 in human serum and other body fluids, J. Endocrinol., 134, 133, 10.1677/joe.0.1340133

Jorgensen, 1994, Insulin-like growth factors (IGF)-I and -II and IGF binding protein-1, -2, and -3 in patients with acromegaly before and after adenomectomy, Metabolism, 43, 579, 10.1016/0026-0495(94)90199-6

Grinspoon, 1995, Serum insulin-like growth factor-binding protein-3 levels in the diagnosis of acromegaly, J. Clin. Endocrinol. Metab., 80, 927, 10.1210/jc.80.3.927

Giustina, 2000, Criteria for cure of acromegaly: a consensus statement, J. Clin. Endocrinol. Metab., 85, 526, 10.1210/jc.85.2.526

Melmed, 2002, Guidelines for acromegaly management, J. Clin. Endocrinol. Metab., 87, 4054, 10.1210/jc.2002-011841

Parfitt, 1998, Outpatient assessment of residual growth hormone secretion in treated acromegaly with overnight urinary growth hormone excretion, random serum growth hormone and insulin like growth factor-1, Clin. Endocrinol. (Oxf.), 49, 647, 10.1046/j.1365-2265.1998.00534.x

Bates, 1995, Assessment of GH status in acromegaly using serum growth hormone, serum insulin-like growth factor-1 and urinary growth hormone excretion, Clin. Endocrinol. (Oxf.), 42, 417, 10.1111/j.1365-2265.1995.tb02651.x

Arafah, 1987, Value of growth hormone dynamics and somatomedin C (insulin-like growth factor I) levels in predicting the long-term benefit after transsphenoidal surgery for acromegaly, J. Lab. Clin. Med., 109, 346

Lindholm, 1987, Investigation of the criteria for assessing the outcome of treatment in acromegaly, Clin. Endocrinol. (Oxf.), 27, 553, 10.1111/j.1365-2265.1987.tb01185.x

Sneppen, 2001, Total and free insulin-like growth factor I, insulin-like growth factor binding protein 3 and acid-labile subunit reflect clinical activity in acromegaly, Growth Horm. IGF Res., 11, 384, 10.1054/ghir.2001.0254

Bates, 1993, An audit of outcome of treatment in acromegaly, Q. J. Med., 86, 293

Rajasoorya, 1994, Determinants of clinical outcome and survival in acromegaly, Clin. Endocrinol. (Oxf.), 41, 95, 10.1111/j.1365-2265.1994.tb03789.x

Wass, 1997, Growth hormone, insulin-like growth factor-I and its binding proteins in the follow-up of acromegaly, J. Endocrinol., 155, S17

Karachaliou, 1996, Serum levels of IGFBP-3: usefulness in diagnosis of GH deficiency and relationship to measurements of GH secretion in children, J. Pediatr. Endocrinol. Metab., 9, 169