Seroprevalence of HBV (anti‐HBc, HBsAg and anti‐HBs) and HDV infections among 9006 women at delivery*

Wiley - Tập 16 Số 2 - Trang 110-116 - 1996
Pierre–Alexandre Bart1, P Jacquier2, Patrick Zuber3, Daniel Lavanchy4, P. C. Frei4
1Division of Immunology and Allergy Centre Hospitalier Universitaire Vaudois Lausanne, Switzerland
2Institute of Parasitology, University of Bern
3Federal Office of Public Health, Bern, Switzerland
4Division of Immunology and Allergy, Centre Hospitalier Universitaire Vaudois, Lausanne

Tóm tắt

Abstract: Serum samples from 9006 women, who delivered in Switzerland in 1990 and 1991, were collected around the country. Of these women, 62.7% were Swiss and 37.3% originated from foreign countries. Samples were first screened for anti‐HBc and those found positive were further tested for HBsAg, anti‐HBs and anti‐HDV Anti‐HBc was found in 640 of the 9006 women (overall prevalence, 7.1%; Swiss, 3.3%; foreigners, 13.5%). Of these 640 positive samples, 61 (9.5%) were positive for HBsAg (without anti‐HBs), 467 (73.0%) positive for anti‐HBs (without HBsAg) and 8 (1.3%) positive for both HBsAg and anti‐HBs. The remaining 104 were thus anti‐HBc positive without HBsAg or anti‐HBs. These 104 specimens with the so‐called “isolated anti‐HBc” reactivity represented 1.2% of the whole population or 16.3% of the 640 anti‐HBc positive mothers. All were HBV DNA negative (PCR). Anti‐HDV antibody was found in only five women. HBsAg was seen in 38 of the cord‐blood samples from the anti‐HBc positive mothers. In this large sampling, we observed a relatively high seroprevalence of HBV infection. Cases with isolated anti‐HBc reactivity, being HBV DNA negative by PCR, were probably non‐infectious at the time of blood collection.

Từ khóa


Tài liệu tham khảo

10.1136/gut.34.2_Suppl.S10

10.1136/gut.34.2_Suppl.S48

10.1007/BF00202052

10.1002/jmv.1890390102

10.1111/j.1471-0528.1992.tb13829.x

10.1016/0163-4453(91)91723-B

10.1007/BF01645546

10.1007/BF01726451

10.1002/jmv.1890340404

10.1002/jmv.1890240208

10.1001/jama.1990.03440090052025

Cozen W., 1993, Screening for HIV and hepatitis B virus in Los Angeles County prenatal clinics: a demonstration project, J Acguir Immune Defic Syndr, 6, 95

10.3109/inf.1992.24.suppl-82.01

10.3109/00365549309169663

10.1097/00002030-199306000-00016

10.3109/00365549309008481

Soulié J C, 1991, Transmission périnatale du virus de l'hépatite B dans la région de Paris, Ann Pédiatr (Paris), 38, 595

Roudot‐Thoraval F., 1989, Prévalence du portage de l'antigène HBs et des marqueurs de réplication virale B dans une population de femmes enceintes, en France, Gastroenterol Clin Biol, 13, 353

10.1016/S1140-4639(05)80212-6

Baumann H., 1984, Häufigkeit des HBsAg bei symptomfreien schwangeren Frauen. Resultate eines Screening an der Universitätsfrauenklinik Zürich, Schweiz Med Wochenschr, 114, 783

Röhrig S., 1990, Infektionen mit den Hepatitisviren HAV, HBV und HCV sowie mit dem Aidsvirus HIV bei Drogenabhängigen der Gassenszene Zürichs – eine Prävalenzstudie, Schweiz Med Wochenschr, 120, 621

Kägi M K, 1989, Prävalenz von Cytomegalievirus, Hepatitis‐B‐ und HIV‐1‐Antikörpern bei gesunden Blutspendern, Spitalpatienten, Patienten vor Nierentransplantation, i.v.‐Drogenabhängigen und Homosexuellen, Schweiz Med Wochenschr, 119, 217

10.1093/infdis/147.2.185

10.1016/0016-5085(81)90072-X

10.1056/NEJM197806222982502

Dike A E, 1981, Post‐transfusion hepatitis B transmitted by HBsAg negative blood containing anti‐HBc, Med Lab Sci, 38, 415

Office Fédéral de la Statistique, Switzerland., 1992, Annuaire statistique de la Suisse

Zuber PLF, Toxoplasma infection among pregnant women in Switzerland: a cross‐sectional evaluation of regional and age‐specific lifetime average annual incidence, Am J Epidemiol

Jacquier P., Epidémiologic de la toxoplasmose in Suisse; étude nationale de séro‐prévalence menée chez les femmes enceintes en 1990–1991, J Suisse Méd

Kaneko S., 1989, Rapid and sensitive method for the detection of serum hepatitis B virus DNA using the polymerase chain reaction technique, J Clin Microbiol, 27, 1930, 10.1128/jcm.27.9.1930-1933.1989

10.1126/science.6264599

Guo K J, 1991, Digoxigenin‐labeled probes for the detection of hepatitis B virus DNA in serum, J Clin Microbiol, 29, 506, 10.1128/jcm.29.3.506-509.1991

10.1002/hep.1840080411

10.1056/NEJM198501313120503

10.1016/S0168-8278(05)80207-7

10.1093/infdis/163.2.397

10.1002/jmv.1890350112

Stroun J., 1987, Etude sérologique rétrospective (1970–1984) de l'antigène et de l'anticorps delta, Schweiz Med Wochenschr, 117, 307

Thông tin
Thông tin xuất bản

Wiley

Tập 16 Số 2

110-116

Thông tin tác giả