Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

Nature - Tập 349 Số 6311 - Trang 704-706 - 1991
Alison Goate1, Marie‐Christine Chartier‐Harlin1, Michael Mullan1, Jeremy Brown1, Fiona Crawford1, Liana Fidani1, L. Giuffra2, Andrew R. Haynes3, N.G. Irving1, Louise James4, R. Mant5, Phillippa Newton1, Karen Rooke1, Penelope Roques1, Chris J. Talbot1, Margaret A. Pericak‐Vance6, A.D. Roses6, Robert Williamson1, Martin N. Rossor1, Mike Owen5, John Hardy1
1Alzheimer's Disease Research Group, Departments of Biochemistry and Neurology, St Mary's Hospital Medical School, London, UK
2Department of Human Genetics, Yale University Medical School, New Haven, USA
3Department of Respiratory Medicine, St Mary's Hospital Medical School, London, UK
4ICI Biotechnology Division, Alderley Park, Macclesfield, Cheshire, UK
5Departments of Psychological Medicine and Medical Genetics, University of Wales College of Medicine, Cardiff, UK.
6Duke University Medical Center, Durham, USA

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