Safety assessment of non-animal chondroitin sulfate sodium: Subchronic study in rats, genotoxicity tests and human bioavailability

Food and Chemical Toxicology - Tập 93 - Trang 89-101 - 2016
Niccolò Miraglia1, Davide Bianchi1, Antonella Trentin1, Nicola Volpi2, Madhu G. Soni3
1Gnosis S.p.A. Via Lavoratori Autobianchi, 1 20832 Desio (MB), Italy
2Department of Life Sciences, University of Modena and Reggio Emilia, Via Campi 213/D, Modena, MO, Italy
3Soni and Associates Inc., 973 37th Place, Vero Beach, FL 32960, USA

Tài liệu tham khảo

Adebowale, 2000, Analysis of glucosamine and chondroitin sulfate content in marketed products and the Caco-2 permeability of chondroitin sulfate raw materials, J. Am. Nutraceutical Assoc., 3, 37 Bauerova, 2014, Effect of nonanimal high- and low-molecular-mass chondroitin sulfates produced by a biotechnological process in an animal model of polyarthritis, Pharmacology, 94, 109, 10.1159/000366285 Harris, 2005 Hathcock, 2007, Risk assessment for glucosamine and chondroitin sulfate, Regul. Toxicol. Pharmacol., 47, 78, 10.1016/j.yrtph.2006.07.004 Hendler, 2001, Chondroitin sulfate, 93 Jordan, 2003, EULAR recommendations 2003: an evidence based approach to the management of knee osteoarthritis: report of a task force of the standing committee for international clinical studies including therapeutic trials (ESCISIT), Ann. Rheum. Dis., 62, 1145, 10.1136/ard.2003.011742 Kao, 1968, Genetics of somatic mammalian cells, VII. Induction and isolation of nutritional mutants in Chinese hamster cells, Proc. Natl. Acad. Sci. U. S. A., 60, 1275, 10.1073/pnas.60.4.1275 McAlindon, 2000, Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysis, JAMA, 283, 1469, 10.1001/jama.283.11.1469 Stuber, 2011, Efficacy of glucosamine, chondroitin, and methylsulfonylmethane for spinal degenerative joint disease and degenerative disc disease: a systematic review, J. Can. Chiropr. Assoc., 55, 47 Volpi, 2002, Oral bioavailability of chondroitin sulfate (Condrosulf) and its constituents in healthy male volunteers, Osteoarthr. Cartil., 10, 768, 10.1053/joca.2002.0824 Volpi, 2003, Oral absorption and bioavailability of ichthyic origin chondroitin sulfate in healthy male volunteers, Osteoarthr. Cartil., 11, 433, 10.1016/S1063-4584(03)00051-7 Volpi, 2003, Milligram-scale preparation and purification of oligosaccharides of defined length possessing the structure of chondroitin from defructosylated capsular polysaccharide K4, Glycobiology, 13, 635, 10.1093/glycob/cwg074 Volpi, 2004, Separation of capsular polysaccharide K4 and defructosylated K4 by high-performance capillary electrophoresis, Electrophoresis, 25, 692, 10.1002/elps.200305563 Volpi, 2007, Mass spectrometry characterization of Escherichia coli K4 oligosaccharides from 2-mers to more than 20-mers, Rapid Commun. Mass Spectrom., 21, 3459, 10.1002/rcm.3245 Volpi, 2008, Quantitative and qualitative evaluations of chondroitin sulfate in dietary supplements, Food Anal. Methods, 1, 195, 10.1007/s12161-008-9020-9 Zhang, 2007, EULAR evidence based recommendations for the management of hand osteoarthritis: report of a task force of the EULAR standing committee for international clinical studies including therapeutics (ESCISIT), Ann. Rheum. Dis., 66, 377, 10.1136/ard.2006.062091