STAT3 in CD4+ T helper cell differentiation and inflammatory diseases

Medzhitov, 2007, Recognition of microorganisms and activation of the immune response, Nature, 449, 819, 10.1038/nature06246

Steinman, 2006, Linking innate to adaptive immunity through dendritic cells, Novartis Found Symp, 279, 101, 10.1002/9780470035399.ch9

Steinman, 2006, Dendritic cells: translating innate to adaptive immunity, Curr Top Microbiol Immunol, 311, 17, 10.1007/3-540-32636-7_2

Zhu, 2008, CD4 T cells: fates, functions, and faults, Blood, 112, 1557, 10.1182/blood-2008-05-078154

Hunter, 2005, New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions, Nat Rev Mol Cell Biol, 5, 521, 10.1038/nri1648

Schindler, 2007, JAK-STAT signaling: from interferons to cytokines, J Biol Chem, 282, 20059, 10.1074/jbc.R700016200

Levy, 2002, Stats: transcriptional control and biological impact, Nat Rev Mol Cell Biol, 3, 651, 10.1038/nrm909

Mertens, 2007, SnapShot: JAK-STAT signaling, Cell, 131, 612, 10.1016/j.cell.2007.10.033

Wenta, 2008, Tyrosine phosphorylation regulates the partitioning of STAT1 between different dimer conformations, Proc Natl Acad Sci USA, 105, 9238, 10.1073/pnas.0802130105

Mao, 2005, Structural bases of unphosphorylated STAT1 association and receptor binding, Mol Cell, 17, 761, 10.1016/j.molcel.2005.02.021

Zhong, 2005, Implications of an antiparallel dimeric structure of nonphosphorylated STAT1 for the activation–inactivation cycle, Proc Natl Acad Sci USA, 102, 3966, 10.1073/pnas.0501063102

Meyer, 2004, Nucleocytoplasmic shuttling of STAT transcription factors, Eur J Biochem, 271, 4606, 10.1111/j.1432-1033.2004.04423.x

Darnell, 1997, STATs and gene regulation, Science, 277, 1630, 10.1126/science.277.5332.1630

Yang, 2008, Roles of unphosphorylated STATs in signaling, Cell Res, 18, 443, 10.1038/cr.2008.41

Yang, 2005, Novel roles of unphosphorylated STAT3 in oncogenesis and transcriptional regulation, Cancer Res, 65, 939, 10.1158/0008-5472.939.65.3

Yang, 2007, Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFkappaB, Genes Dev, 21, 1396, 10.1101/gad.1553707

Reich, 2006, Tracking STAT nuclear traffic, Nat Rev Immunol, 6, 602, 10.1038/nri1885

Shuai, 2003, Regulation of JAK-STAT signalling in the immune system, Nat Rev Immunol, 3, 900, 10.1038/nri1226

Li, 2008, Canonical and non-canonical JAK-STAT signaling, Trends Cell Biol, 18, 545, 10.1016/j.tcb.2008.08.008

Kisseleva, 2002, Signaling through the JAK/STAT pathway, recent advances and future challenges, Gene, 285, 1, 10.1016/S0378-1119(02)00398-0

Shi, 1996, The genomic structure and chromosomal localization of the mouse STAT3 gene, Int Immunol, 8, 1205, 10.1093/intimm/8.8.1205

Becker, 1998, Three-dimensional structure of the Stat3beta homodimer bound to DNA, Nature, 394, 145, 10.1038/28101

Decker, 1997, GAS elements: a few nucleotides with a major impact on cytokine-induced gene expression, J Interferon Cytokine Res, 17, 121, 10.1089/jir.1997.17.121

Takeda, 1997, Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality, Proc Natl Acad Sci USA, 94, 3801, 10.1073/pnas.94.8.3801

Takeda, 1998, Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: generation and characterization of T cell-specific Stat3-deficient mice, J Immunol, 161, 4652, 10.4049/jimmunol.161.9.4652

Brantley, 2008, Signal transducer and activator of transcription-3: a molecular hub for signaling pathways in gliomas, Mol Cancer Res, 6, 675, 10.1158/1541-7786.MCR-07-2180

Kortylewski, 2008, Role of Stat3 in suppressing anti-tumor immunity, Curr Opin Immunol, 20, 228, 10.1016/j.coi.2008.03.010

El Kasmi, 2006, General nature of the STAT3-activated anti-inflammatory response, J Immunol, 177, 7880, 10.4049/jimmunol.177.11.7880

El Kasmi, 2007, Cutting edge: A transcriptional repressor and corepressor induced by the STAT3-regulated anti-inflammatory signaling pathway, J Immunol, 179, 7215, 10.4049/jimmunol.179.11.7215

Ernst, 2004, Acquiring signalling specificity from the cytokine receptor gp130, Trends Genet, 20, 23, 10.1016/j.tig.2003.11.003

Trinchieri, 2003, The IL-12 family of heterodimeric cytokines: new players in the regulation of T cell responses, Immunity, 19, 641, 10.1016/S1074-7613(03)00296-6

Kuo, 1999, Transcriptional regulation of T lymphocyte development and function, Annu Rev Immunol, 17, 149, 10.1146/annurev.immunol.17.1.149

Janson, 2008, At the crossroads of T helper lineage commitment-Epigenetics points the way, Biochim Biophys Acta

Wilson, 2009, Epigenetic control of T-helper-cell differentiation, Nat Rev Immunol, 9, 91, 10.1038/nri2487

Glimcher, 2004, Recent developments in the transcriptional regulation of cytolytic effector cells, Nat Rev Immunol, 4, 900, 10.1038/nri1490

Flavell, 1999, Molecular basis of T-cell differentiation, Cold Spring Harb Symp Quant Biol, 64, 563, 10.1101/sqb.1999.64.563

Szabo, 2003, Molecular mechanisms regulating Th1 immune responses, Annu Rev Immunol, 21, 713, 10.1146/annurev.immunol.21.120601.140942

Murphy, 2000, Signaling and transcription in T helper development, Annu Rev Immunol, 18, 451, 10.1146/annurev.immunol.18.1.451

Sauer, 2008, T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR, Proc Natl Acad Sci USA, 105, 7797, 10.1073/pnas.0800928105

Marsland, 2008, T-cell fate and function: PKC-theta and beyond, Trends Immunol, 29, 179, 10.1016/j.it.2008.01.005

Haxhinasto, 2008, The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells, J Exp Med, 205, 565, 10.1084/jem.20071477

Bommireddy, 2007, TGFbeta1 and Treg cells: alliance for tolerance, Trends Mol Med, 13, 492, 10.1016/j.molmed.2007.08.005

Hu, 2007, Transcriptional partners in regulatory T cells: Foxp3, Runx and NFAT, Trends Immunol, 28, 329, 10.1016/j.it.2007.06.006

Hayes, 2006, Strength of signal: a fundamental mechanism for cell fate specification, Immunol Rev, 209, 170, 10.1111/j.0105-2896.2006.00356.x

Wu, 2006, FOXP3 controls regulatory T cell function through cooperation with NFAT, Cell, 126, 375, 10.1016/j.cell.2006.05.042

Korn, 2009, IL-17 and Th17 cells, Annu Rev Immunol, 27, 485, 10.1146/annurev.immunol.021908.132710

Dong, 2008, TH17 cells in development: an updated view of their molecular identity and genetic programming, Nat Rev Immunol, 8, 337, 10.1038/nri2295

Takatori, 2008, New complexities in helper T cell fate determination and the implications for autoimmune diseases, Mod Rheumatol, 18, 533, 10.1007/s10165-008-0099-z

Yang, 2008, Regulation of inflammatory responses by IL-17F, J Exp Med, 205, 1063, 10.1084/jem.20071978

Chen, 1999, Interleukin-6 inhibits transforming growth factor-beta-induced apoptosis through the phosphatidylinositol 3-kinase/Akt and signal transducers and activators of transcription 3 pathways, J Biol Chem, 274, 23013, 10.1074/jbc.274.33.23013

Belkaid, 2007, Regulatory T cells and infection: a dangerous necessity, Nat Rev Immunol, 7, 875, 10.1038/nri2189

Vignali, 2008, How regulatory T cells work, Nat Rev Immunol, 8, 523, 10.1038/nri2343

Tone, 2008, Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer, Nat Immunol, 9, 194, 10.1038/ni1549

Yao, 2007, Nonredundant roles for Stat5a/b in directly regulating Foxp3, Blood, 109, 4368, 10.1182/blood-2006-11-055756

Zorn, 2006, IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo, Blood, 108, 1571, 10.1182/blood-2006-02-004747

Kortylewski, 2009, Regulation of the IL-23 and IL-12 balance by Stat3 signaling in the tumor microenvironment, Cancer Cell, 15, 114, 10.1016/j.ccr.2008.12.018

Chatila, 2007, The regulatory T cell transcriptosome: E pluribus unum, Immunity, 27, 693, 10.1016/j.immuni.2007.11.004

Roncarolo, 2006, Interleukin-10-secreting type 1 regulatory T cells in rodents and humans, Immunol Rev, 212, 28, 10.1111/j.0105-2896.2006.00420.x

Akdis, 2006, Healthy immune response to allergens: T regulatory cells and more, Curr Opin Immunol, 18, 738, 10.1016/j.coi.2006.06.003

Hill, 2007, Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signature, Immunity, 27, 786, 10.1016/j.immuni.2007.09.010

Bettelli, 2007, Th17: the third member of the effector T cell trilogy, Curr Opin Immunol, 19, 652, 10.1016/j.coi.2007.07.020

Ivanov, 2007, Transcriptional regulation of Th17 cell differentiation, Semin Immunol, 19, 409, 10.1016/j.smim.2007.10.011

Liu, 2008, Loss of STAT3 in CD4+ T cells prevents development of experimental autoimmune diseases, J Immunol, 180, 6070, 10.4049/jimmunol.180.9.6070

Chen, 2008, Regulation of IL-17 production in human lymphocytes, Cytokine, 41, 71, 10.1016/j.cyto.2007.09.009

Jankovic, 2007, IL-10 or not IL-10: that is the question, Nat Immunol, 8, 1281, 10.1038/ni1207-1281

Murray, 2006, STAT3-mediated anti-inflammatory signalling, Biochem Soc Trans, 34, 1028, 10.1042/BST0341028

Amadi-Obi, 2007, T(H)17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1, Nat Med, 13, 711, 10.1038/nm1585

Griffiths, 2007, Innate immunity and protective neuroinflammation: new emphasis on the role of neuroimmune regulatory proteins, Int Rev Neurobiol, 82, 29, 10.1016/S0074-7742(07)82002-2

Chang, 2006, Toll-like receptors in ocular immunity and the immunopathogenesis of inflammatory eye disease, Br J Ophthalmol, 90, 103, 10.1136/bjo.2005.072686

Nussenblatt, 2002, Bench to bedside: new approaches to the immunotherapy of uveitic disease, Int Rev Immunol, 21, 273, 10.1080/08830180212067

Nussenblatt, 1999, Treatment of noninfectious intermediate and posterior uveitis with the humanized anti-Tac mAb: a phase I/II clinical trial, Proc Natl Acad Sci USA, 96, 7462, 10.1073/pnas.96.13.7462

Mathur, 2007, Stat3 and Stat4 direct development of IL-17-secreting Th cells, J Immunol (Baltimore, MD), 178, 4901

Yang, 2007, STAT3 regulates cytokine-mediated generation of inflammatory helper T cells, J Biol Chem, 282, 9358, 10.1074/jbc.C600321200

Harris, 2007, Cutting edge: an in vivo requirement for STAT3 signaling in TH17 development and TH17-dependent autoimmunity, J Immunol, 179, 4313, 10.4049/jimmunol.179.7.4313

Sugimoto, 2008, Role of STAT3 in inflammatory bowel disease, World J Gastroenterol, 14, 5110, 10.3748/wjg.14.5110

Cho, 2008, The genetics and immunopathogenesis of inflammatory bowel disease, Nat Rev Immunol, 8, 458, 10.1038/nri2340

Lovato, 2003, Constitutive STAT3 activation in intestinal T cells from patients with Crohn’s disease, J Biol Chem, 278, 16777, 10.1074/jbc.M207999200

Chang, 2009, IL-17F: regulation, signaling and function in inflammation, Cytokine, 46, 7, 10.1016/j.cyto.2008.12.024

Ogawa, 2004, Neutralization of interleukin-17 aggravates dextran sulfate sodium-induced colitis in mice, Clin Immunol, 110, 55, 10.1016/j.clim.2003.09.013

Sugimoto, 2008, IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis, J Clin Invest, 118, 534

Zenewicz, 2008, Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease, Immunity, 29, 947, 10.1016/j.immuni.2008.11.003

Takeda, 1999, Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils, Immunity, 10, 39, 10.1016/S1074-7613(00)80005-9

Alexander, 2002, Suppressors of cytokine signalling (SOCS) in the immune system, Nat Rev Immunol, 2, 410, 10.1038/nri818

Naka, 1999, Negative regulation of cytokine signaling: STAT-induced STAT inhibitor, Trends Biochem Sci, 24, 394, 10.1016/S0968-0004(99)01454-1

Boyd, 2003, Interleukin-10 receptor signaling through STAT-3 regulates the apoptosis of retinal ganglion cells in response to stress, Invest Ophthalmol Vis Sci, 44, 5206, 10.1167/iovs.03-0534

Samardzija, 2006, Differential role of Jak-STAT signaling in retinal degenerations, FASEB J, 20, 2411, 10.1096/fj.06-5895fje

Zhang, 2008, STAT3 activation protects retinal ganglion cell layer neurons in response to stress, Exp Eye Res, 86, 991, 10.1016/j.exer.2008.03.020

Liu, 2008, Suppressors of cytokine-signaling proteins induce insulin resistance in the retina and promote survival of retinal cells, Diabetes, 57, 1651, 10.2337/db07-1761

Egwuagu, 2006, Cytokine-induced retinal degeneration: role of suppressors of cytokine signaling (SOCS) proteins in protection of the neuroretina, Adv Exp Med Biol, 572, 275, 10.1007/0-387-32442-9_38

Egwuagu, 1999, Expression of interferon-gamma in the lens exacerbates anterior uveitis and induces retinal degenerative changes in transgenic Lewis rats, Clin Immunol, 91, 196, 10.1006/clim.1999.4701

He, 2003, SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancer, Proc Natl Acad Sci USA, 100, 14133, 10.1073/pnas.2232790100

Sutherland, 2004, Differential hypermethylation of SOCS genes in ovarian and breast carcinomas, Oncogene, 23, 7726, 10.1038/sj.onc.1207787

Weber, 2005, SOCS-3 is frequently methylated in head and neck squamous cell carcinoma and its precursor lesions and causes growth inhibition, Oncogene, 24, 6699, 10.1038/sj.onc.1208818

Niwa, 2005, Methylation silencing of SOCS-3 promotes cell growth and migration by enhancing JAK/STAT and FAK signalings in human hepatocellular carcinoma, Oncogene, 24, 6406, 10.1038/sj.onc.1208788