SK-7041, a new histone deacetylase inhibitor, induces G2-M cell cycle arrest and apoptosis in pancreatic cancer cell lines

Richon, 2000, Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylation, Proc. Natl Acad. Sci. USA, 97, 10014, 10.1073/pnas.180316197 Marks, 2001, Histone deacetylases and cancer: causes and therapies, Nat. Rev. Cancer, 1, 287, 10.1038/35106079 Johnstone, 2001, Histone-deacetylase inhibitors: novel drugs for the treatment of cancer, Nat. Rev. Drug Discov., 1, 287, 10.1038/nrd772 Qiu, 2000, Histone deacetylase inhibitors trigger a G2 checkpoint in normal cells that is defective in tumor cells, Mol. Biol. Cell, 11, 2069, 10.1091/mbc.11.6.2069 Donadelli, 2003, an inhibitor of histone deacetylases, strongly suppresses growth of pancreatic adenocarcinoma cells, Mol. Carcinog., 38, 59, 10.1002/mc.10145 Saito, 1996, A synthetic inhibitor of histone deacetylase, MS-27-275, with marked in vivo antitumor activity against human tumors, Proc. Natl Acad. Sci. USA, 96, 4592, 10.1073/pnas.96.8.4592 Kim, 2003, Synthesis and biological evaluation of 3-(4-substituted-phenyl)-N-hydroxy-2-propenamides, a new class of histone deacetylase inhibitors, J. Med. Chem., 46, 5745, 10.1021/jm030377q Park, 2004, Class I histone deacetylase-selective novel synthetic inhibitors potently inhibit human tumor proliferation, Clin. Cancer Res., 10, 5271, 10.1158/1078-0432.CCR-03-0709 Donadelli, 2003, an inhibitor of histone deacetylases, strongly suppresses growth of pancreatic adenocarcinoma cells, Mol. Carcinog., 38, 59, 10.1002/mc.10145 Sato, 2004, FR901228, a novel histone deacetylase inhibitor, induces cell cycle arrest and subsequent apoptosis in refractory human pancreatic cancer cells, Int. J. Oncol., 24, 679 Coffey, 2001, The histone deacetylase inhibitor, CBHA, inhibits growth of human neuroblastoma xenografts in vivo, alone and synergistically with all-trans retinoic acid, Cancer Res., 61, 3591 Sandor, 2002, Phase I trial of the histone deacetylase inhibitor, depsipeptide (FR901228, NSC 630176), in patients with refractory neoplasm, Clin. Cancer Res., 8, 718 Butler, 2000, Suberoylanilide hydroxamic acid, an inhibitor of histone deacetylase, suppresses the growth of prostate cancer cells in vitro and in vivo, Cancer Res., 60, 5165 Wittich, 2002, Structure-activity relationships on phenylalanine-containing inhibitors of histone deacetylase: in vitro enzyme inhibition, induction of differentiation, and inhibition of proliferation in Friend leukemic cells, J. Med. Chem., 45, 3296, 10.1021/jm0208119 Xiao, 1999, Both Sp1 and Sp3 are responsible for p21waf1 promoter activity induced by histone deacetylase inhibitor in NIH3T3 cells, J. Cell. Biochem., 73, 291, 10.1002/(SICI)1097-4644(19990601)73:3<291::AID-JCB1>3.0.CO;2-5 Yamashita, 2003, Histone deacetylase inhibitor trichostatin A induces cell-cycle arrest/apoptosis and hepatocyte differentiation in human hepatoma cells, Int. J. Cancer, 103, 572, 10.1002/ijc.10699 Peart, 2003, Novel mechanisms of apoptosis induced by histone deacetylase inhibitors, Cancer Res., 63, 4460 Noh, 2003, Functional interplay between modulation of histone deacetylase activity and its regulatory role in G2-M transition, Biochem. Biophys. Res. Commun., 310, 267, 10.1016/j.bbrc.2003.09.013 Nurse, 1990, Universal control mechanism regulating onset of M-phase, Nature, 344, 503, 10.1038/344503a0 Lallemand, 1999, Sodium butyrate induces G2 arrest in the human breast cancer cells MDA-MB-231 and renders them competent for DNA rereplication, Cell Res., 247, 432, 10.1006/excr.1998.4370 Sherr, 1994, G1 phase progression: cycling on cue, Cell, 79, 551, 10.1016/0092-8674(94)90540-1 Meyyappan, 1998, Increased expression of cyclin D2 during multiple states of growth arrest in primary and established cells, Mol. Cell. Biol., 18, 3163, 10.1128/MCB.18.6.3163 Matsubayashi, 2003, Methylation of cyclin D2 is observed frequently in pancreatic cancer but is also an age-related phenomenon in gastrointestinal tissues, Clin. Cancer Res., 9, 1446 Hague, 1997, Bcl-2 and bak may play a pivotal role in sodium butyrate-induced apoptosis in colonic epithelial cells; however overexpression of bcl-2 does not protect against bak-mediated apoptosis, Int. J. Cancer, 72, 898, 10.1002/(SICI)1097-0215(19970904)72:5<898::AID-IJC30>3.0.CO;2-2 Cao, 2001, Histone deacetylase inhibitor down regulation of bcl-xl gene expression leads to apoptotic cell death in mesothelioma, Am. J. Respir. Cell. Mol. Biol., 25, 562, 10.1165/ajrcmb.25.5.4539 Bernhard, 2001, Inhibition of histone deacetylase activity enhances Fas receptor-mediated apoptosis in leukemic lymphoblasts, Cell Death Differ., 8, 1014, 10.1038/sj.cdd.4400914 Zhang, 2004, The histone deacetylase inhibitor suberic bishydroxamate regulates the expression of multiple apoptotic mediators and induces mitochondria-dependent apoptosis of melanoma cells, Mol. Cancer Ther., 3, 425, 10.1158/1535-7163.425.3.4 Doi, 2004, The histone deacetylase inhibitor FR901228 induces caspase-dependent apoptosis via the mitochondrial pathway in small cell lung cancer cells, Mol. Cancer Ther., 3, 1397, 10.1158/1535-7163.1397.3.11 Herold, 2002, The histone-deacetylase inhibitor Trichostatin A blocks proliferation and triggers apoptotic programs in hepatoma cells, J. Hepatol., 36, 233, 10.1016/S0168-8278(01)00257-4 Glaser, 2004, Differential protein acetylation induced by novel histone deacetylase inhibitors, Biochem. Biophys. Res. Commun., 325, 683, 10.1016/j.bbrc.2004.10.082