Role of pH on stability and mechanical properties of gelatin films

Journal of Bioactive and Compatible Polymers - Tập 27 Số 1 - Trang 67-77 - 2012
Michela Gioffrè1, Paola Torricelli2, Silvia Panzavolta1, Katia Rubini1, Adriana Bigi1
1Department of Chemistry “G. Ciamician”, University of Bologna, Bologna, Italy
2Laboratory of Preclinical and Surgical Studies, Research Institute Codivilla Putti-Rizzoli Orthopaedic Institute, Bologna, Italy.

Tóm tắt

The effect of the film-forming solution pH on the triple-helix content, thermal stability, and mechanical properties of gelatin films was investigated. The films were prepared from solutions at different pHs of type A pigskin gelatin, and their mechanical characteristics were determined. At pHs higher than 9 and lower than 5, Young’s modulus, E, and the stress at break, σb, of the films decreased significantly. Cross-linking with genipin reduced deformation at break, ϵb, and increased Young’s modulus. The intensity of the 1.1-nm X-ray diffraction reflection and the denaturation enthalpy decreased at these pHs, indicating that the triple helix reduced. Preliminary in vitro tests on the cross-linked samples indicated good cell proliferation and viability.

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Tài liệu tham khảo

10.1098/rsif.2007.0220

10.1016/j.foodhyd.2006.09.014

10.1021/bm801039n

10.1177/0883911509350262

10.1106/NYTK-W829-UWC1-PMLW

10.1016/j.biomaterials.2004.01.033

10.1016/j.foodhyd.2003.08.009

10.1039/b819708c

10.1016/S0169-409X(97)00125-7

10.1016/j.jconrel.2005.09.023

10.1023/A:1010117401098

10.1002/polb.1990.090281013

10.1039/b713075a

10.1016/S0142-9612(98)00149-5

10.1016/0032-3861(95)93109-Y

10.1016/j.polymer.2005.10.090

10.1002/polb.21120

10.1016/j.jfoodeng.2008.04.030

10.1016/j.actbio.2009.06.015

10.1007/BF00654053

10.1007/s003960050087

10.1016/S0142-9612(02)00235-1

10.1177/0883911511400251

10.1023/A:1016029023910

10.1088/0508-3443/5/3/302

10.1016/j.foodhyd.2009.06.007

10.1016/S0142-9612(00)00236-2

10.1002/1097-4636(200010)52:1<58::AID-JBM8>3.0.CO;2-0

10.1163/156856299X00621

10.1016/j.actbio.2010.11.021

10.1177/0883911511399410

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Thông tin xuất bản

Journal of Bioactive and Compatible Polymers

Tập 27 Số 1

67-77

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