Role of Akt/protein kinase B in metabolism

Kohn, 1996, Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and GLUT4 translocation, J. Biol. Chem., 271, 31372, 10.1074/jbc.271.49.31372

Calera, 1998, Insulin increases the association of Akt-2 with Glut4-containing vesicles, J. Biol. Chem., 273, 7201, 10.1074/jbc.273.13.7201

Hill, 1999, A role for protein kinase B/Akt2 in insulin-stimulated GLUT4 translocation in adipocytes, Mol. Cell. Biol., 19, 7771, 10.1128/MCB.19.11.7771

Wang, 1999, Protein kinase B/Akt participates in GLUT4 translocation by insulin in L6 myoblasts, Mol. Cell. Biol., 19, 4008, 10.1128/MCB.19.6.4008

Summers, 1998, Regulation of insulin-stimulated glucose transporter GLUT4 translocation and Akt kinase activity by ceramide, Mol. Cell. Biol., 18, 5457, 10.1128/MCB.18.9.5457

Hajduch, 2001, Ceramide impairs the insulin-dependent membrane recruitment of protein kinase B leading to a loss in downstream signalling in L6 skeletal muscle cells, Diabetologia, 44, 173, 10.1007/s001250051596

Kitamura, 1998, Requirement for activation of the serine-threonine kinase Akt (protein kinase Bβ) in insulin stimulation of protein synthesis but not of glucose transport, Mol. Cell. Biol., 18, 3708, 10.1128/MCB.18.7.3708

Guilherme, 1998, Stimulation of IRS-1-associated phosphatidylinositol 3-kinase and Akt/protein kinase B but not glucose transport by β1-integrin signaling in rat adipocytes, J. Biol. Chem., 273, 33119, 10.1074/jbc.273.50.33119

Kim, 1999, Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes, J. Clin. Invest., 104, 733, 10.1172/JCI6928

Kotani, 1998, Requirement of atypical protein kinase Cγ for insulin stimulation of glucose uptake but not for Akt activation in 3T3-L1 adipocytes, Mol. Cell. Biol., 18, 6971, 10.1128/MCB.18.12.6971

Sweeney, 1999, An inhibitor of p38 mitogen-activated protein kinase prevents insulin-stimulated glucose transport but not glucose transporter translocation in 3T3-L1 adipocytes and L6 myotubes, J. Biol. Chem., 274, 10071, 10.1074/jbc.274.15.10071

Baumann, 2000, CAP defines a second signalling pathway required for insulin-stimulated glucose transport, Nature, 407, 202, 10.1038/35025089

Shankar, 2000, Mice with gene disruption of both endothelial and neuronal nitric oxide synthase exhibit insulin resistance, Diabetes, 49, 684, 10.2337/diabetes.49.5.684

Fulton, 1999, Regulation of endothelium-derived nitric oxide production by the protein kinase Akt, Nature, 399, 597, 10.1038/21218

Shah, 2000, 4E-BP1 and S6K1: translational integration sites for nutritional and hormonal information in muscle, Am. J. Physiol. Endocrinol. Metab., 279, E715, 10.1152/ajpendo.2000.279.4.E715

Gingras, 2001, Regulation of translation initiation by FRAP/mTOR, Genes Dev., 15, 807, 10.1101/gad.887201

Ueki, 1998, Potential role of protein kinase B in insulin-induced glucose transport, glycogen synthesis, and protein synthesis, J. Biol. Chem., 273, 5315, 10.1074/jbc.273.9.5315

Hajduch, 1998, Constitutive activation of protein kinase Bα by membrane targeting promotes glucose and system A amino acid transport, protein synthesis, and inactivation of glycogen synthase kinase 3 in L6 muscle cells, Diabetes, 47, 1006, 10.2337/diabetes.47.7.1006

Nave, 1999, Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation, Biochem. J., 344, 427, 10.1042/0264-6021:3440427

Takata, 1999, Requirement for Akt (protein kinase B) in insulin-induced activation of glycogen synthase and phosphorylation of 4E-BP1 (PHAS-1), J. Biol. Chem., 274, 20611, 10.1074/jbc.274.29.20611

Kohn, 1998, Construction and characterization of a conditionally active version of the serine/threonine kinase Akt, J. Biol. Chem., 273, 11937, 10.1074/jbc.273.19.11937

Welsh, 1993, Glycogen synthase kinase-3 is rapidly inactivated in response to insulin and phosphorylates eukaryotic initiation factor eIF-2B, Biochem. J., 294, 625, 10.1042/bj2940625

Redpath, 1996, Regulation of translation elongation factor-2 by insulin via a rapamycin-sensitive signalling pathway, EMBO J., 15, 2291, 10.1002/j.1460-2075.1996.tb00582.x

Dufner, 1999, Protein kinase B localization and activation differentially affect S6 kinase 1 activity and eukaryotic translation initiation factor 4E-binding protein 1 phosphorylation, Mol. Cell. Biol., 19, 4525, 10.1128/MCB.19.6.4525

Radimerski, 2002, dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1, Nat. Cell Biol., 4, 251, 10.1038/ncb763

Potapova, 2000, Phosphorylation of recombinant human ATP:citrate lyase by cAMP-dependent protein kinase abolishes homotropic allosteric regulation of the enzyme by citrate and increases the enzyme activity. Allosteric activation of ATP:citrate lyase by phosphorylated sugars, Biochemistry, 39, 1169, 10.1021/bi992159y

Wang, 1998, Effects of cell-permeable ceramides and tumor necrosis factor-α on insulin signaling and glucose uptake in 3T3-L1 adipocytes, Diabetes, 47, 24, 10.2337/diabetes.47.1.24

Kohn, 1996, Akt, a pleckstrin homology domain containing kinase, is activated primarily by phosphorylation, J. Biol. Chem., 271, 21920, 10.1074/jbc.271.36.21920

Kitamura, 1999, Insulin-induced phosphorylation and activation of cyclic nucleotide phosphodiesterase 3B by the serine-threonine kinase Akt, Mol. Cell. Biol., 19, 6286, 10.1128/MCB.19.9.6286

Wijkander, 1998, Insulin-induced phosphorylation and activation of phosphodiesterase 3B in rat adipocytes: possible role for protein kinase B but not mitogen-activated protein kinase or p70 S6 kinase, Endocrinology, 139, 219, 10.1210/en.139.1.219

Smith, 2000, PKB inhibition prevents the stimulatory effect of insulin on glucose transport and protein translocation but not the antilipolytic effect in rat adipocytes, Biochem. Biophys. Res. Commun., 268, 315, 10.1006/bbrc.2000.2145

Shulman, 1990, Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-insulin-dependent diabetes by 13C nuclear magnetic resonance spectroscopy, N. Engl. J. Med., 322, 223, 10.1056/NEJM199001253220403

Summers, 1999, The role of glycogen synthase kinase 3β in insulin-stimulated glucose metabolism, J. Biol. Chem., 274, 17934, 10.1074/jbc.274.25.17934

Gabbay, 1996, Insulin regulation of phosphoenolpyruvate carboxykinase gene expression does not require activation of the Ras/mitogen-activated protein kinase signaling pathway, J. Biol. Chem., 271, 1890, 10.1074/jbc.271.4.1890

Sutherland, 1995, Phosphatidylinositol 3-kinase, but not p70/p85 ribosomal S6 protein kinase, is required for the regulation of phosphoenolpyruvate carboxykinase (PEPCK) gene expression by insulin. Dissociation of signaling pathways for insulin and phorbol ester regulation of PEPCK gene expression, J. Biol. Chem., 270, 15501, 10.1074/jbc.270.26.15501

Liao, 1998, Activation of protein kinase B/Akt is sufficient to repress the glucocorticoid and cAMP induction of phosphoenolpyruvate carboxykinase gene, J. Biol. Chem., 273, 27320, 10.1074/jbc.273.42.27320

Agati, 1998, Assessment of the roles of mitogen-activated protein kinase, phosphatidylinositol 3-kinase, protein kinase B, and protein kinase C in insulin inhibition of cAMP-induced phosphoenolpyruvate carboxykinase gene transcription, J. Biol. Chem., 273, 18751, 10.1074/jbc.273.30.18751

Paradis, 1998, Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor, Genes Dev., 12, 2488, 10.1101/gad.12.16.2488

Nakae, 1999, Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a wortmannin-sensitive pathway, J. Biol. Chem., 274, 15982, 10.1074/jbc.274.23.15982

Tang, 1999, Negative regulation of the forkhead transcription factor FKHR by Akt, J. Biol. Chem., 274, 16741, 10.1074/jbc.274.24.16741

Nakae, 2001, The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity on to glucose-6-phosphatase expression, J. Clin. Invest., 108, 1359, 10.1172/JCI200112876

Barthel, 2001, Differential regulation of endogenous glucose-6-phosphatase and phosphoenolpyruvate carboxykinase gene expression by the forkhead transcription factor FKHR in H4IIE-hepatoma cells, Biochem. Biophys. Res. Commun., 285, 897, 10.1006/bbrc.2001.5261

Yeagley, 2001, Gene- and activation-specific mechanisms for insulin inhibition of basal and glucocorticoid-induced insulin-like growth factor binding protein-1 and phosphoenolpyruvate carboxykinase transcription. Roles of forkhead and insulin response sequences, J. Biol. Chem., 276, 33705, 10.1074/jbc.M101215200

Hall, 2000, Regulation of phosphoenolpyruvate carboxykinase and insulin-like growth factor-binding protein-1 gene expression by insulin. The role of winged helix/forkhead proteins, J. Biol. Chem., 275, 30169, 10.1074/jbc.M004898200

Yoon, 2001, Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1, Nature, 413, 131, 10.1038/35093050

Cook, 2002, Transcriptional effects of chronic akt activation in the heart, J. Biol. Chem., 277, 22528, 10.1074/jbc.M201462200

Burks, 2001, IRS proteins and β-cell function, Diabetes, 50, S140, 10.2337/diabetes.50.2007.S140

Jetton, 2001, Enhanced expression of insulin receptor substrate-2 and activation of protein kinase B/Akt in regenerating pancreatic duct epithelium of 60%-partial pancreatectomy rats, Diabetologia, 44, 2056, 10.1007/s001250100011

Holst, 1998, Protein kinase B is expressed in pancreatic β cells and activated upon stimulation with insulin-like growth factor I, Biochem. Biophys. Res. Commun., 250, 181, 10.1006/bbrc.1998.9166

Tuttle, 2001, Regulation of pancreatic β-cell growth and survival by the serine/threonine protein kinase Akt1/PKBα, Nat. Med., 7, 1133, 10.1038/nm1001-1133

Rondinone, 1999, Impaired glucose transport and protein kinase B activation by insulin, but not okadaic acid, in adipocytes from subjects with type II diabetes mellitus, Diabetologia, 42, 819, 10.1007/s001250051232

Krook, 1998, Insulin-stimulated Akt kinase activity is reduced in skeletal muscle from NIDDM subjects, Diabetes, 47, 1281, 10.2337/diabetes.47.8.1281

Nadler, 2001, Normal Akt/PKB with reduced PI3K activation in insulin-resistant mice, Am. J. Physiol. Endocrinol. Metab., 281, E1249, 10.1152/ajpendo.2001.281.6.E1249

Kim, 2000, Divergent regulation of Akt1 and Akt2 isoforms in insulin target tissues of obese Zucker rats, Diabetes, 49, 847, 10.2337/diabetes.49.5.847

Cho, 2001, Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKBβ), Science, 292, 1728, 10.1126/science.292.5522.1728

Birnbaum, 2001, Diabetes. Dialogue between muscle and fat, Nature, 409, 672, 10.1038/35055643

Chen, 2001, Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene, Genes Dev., 15, 2203, 10.1101/gad.913901

Cho, 2001, Akt1/PKBα is required for normal growth but dispensable for maintenance of glucose homeostasis in mice, J. Biol. Chem., 276, 38349, 10.1074/jbc.C100462200