Rho GTPases and the regulation of endothelial permeability
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Adamson, 1992, Post-translational modifications of p21rho proteins, J. Biol. Chem., 267, 20033, 10.1016/S0021-9258(19)88661-1
Adamson, 1999, Lymphocyte migration through brain endothelial cell monolayers involves signaling through endothelial ICAM-1 via a rho-dependent pathway, J. Immunol., 162, 2964, 10.4049/jimmunol.162.5.2964
Adamson, 2002, Rho and Rho kinase modulation of barrier properties: cultured endothelial cells and intact microvessels of rats and mice, J. Physiol., 539, 295, 10.1113/jphysiol.2001.013117
Aepfelbacher, 2001, Disturbance of endothelial barrier function by bacterial toxins and atherogenic mediators: a role for Rho/Rho kinase, Cell. Microbiol., 3, 649, 10.1046/j.1462-5822.2001.00145.x
Aepfelbacher, 1999, The tranquilizing injection of Yersinia proteins: a pathogen's strategy to resist host defense, Biol. Chem., 380, 795, 10.1515/BC.1999.099
Aktories, 1989, Botulinum ADP-ribosyltransferase C3: a new tool to study low molecular weight GTP-binding proteins, Trends Pharmacol. Sci., 10, 415, 10.1016/0165-6147(89)90191-0
Aktories, 2000, Rho GTPases as targets of bacterial protein toxins, Biol. Chem., 381, 421, 10.1515/BC.2000.054
Amano, 1999, The COOH terminus of Rho-kinase negatively regulates Rho-kinase activity, J. Biol. Chem., 45, 32418, 10.1074/jbc.274.45.32418
Andor, 2001, YopE of Yersinia, a GAP for Rho GTPases, selectively modulates Rac-dependent actin structures in endothelial cells, Cell. Microbiol., 3, 301, 10.1046/j.1462-5822.2001.00114.x
Andres, 1993, Mutational analysis of alpha-subunit of protein farnesyltransferase. Evidence for a catalytic role, J. Biol. Chem., 268, 1383, 10.1016/S0021-9258(18)54087-4
Aoki, 1998, Angiotensin II activates RhoA in cardiac myocytes: a critical role of RhoA in angiotensin II-induced premyofibril formation, Circ. Res., 82, 666, 10.1161/01.RES.82.6.666
Braga, 2002, Cell–cell adhesion and signaling, Curr. Opin. Cell Biol., 14, 546, 10.1016/S0955-0674(02)00373-3
Bretscher, 2002, ERM proteins and merlin: integrators at the cell cortex, Nat. Rev. Mol. Cell. Biol., 8, 586, 10.1038/nrm882
Buhl, 1995, G alpha 12 and G alpha 13 stimulate Rho-dependent stress fiber formation and focal adhesion assembly, J. Biol. Chem., 270, 24631, 10.1074/jbc.270.42.24631
Cannon, 2001, Wasp recruitment to the T cell, APC contact site occurs independently of Cdc42 activation, Immunity, 15, 249, 10.1016/S1074-7613(01)00178-9
Carbajal, 1999, RhoA inactivation enhances endothelial barrier function, Am. J. Physiol., 277, C955, 10.1152/ajpcell.1999.277.5.C955
Carson, 1989, Histamine and inositol phosphate accumulation in endothelium: cAMP and a G protein, Am. J. Physiol., 257, L259
Chen, 2000, Interaction of endothelin-1 with vasoactive factors in mediating glucose-induced increased permeability in endothelial cells, Lab. Invest., 80, 1311, 10.1038/labinvest.3780139
Chen, 2000, Endothelin-1 and nitric oxide affect human cerebromicrovascular endothelial responses and signal transduction, Acta Neurochir., Suppl., 76, 131
Chen, 2002, Comparison of the average structures, from molecular dynamics, of complexes of GTPase activating protein (GAP) with oncogenic and wild-type ras-p21: identification of potential effector domains, J. Protein Chem., 21, 349, 10.1023/A:1019994302273
Corada, 1999, Vascular endothelial-cadherin is an important determinant of microvascular integrity in vivo, Proc. Natl. Acad. Sci. U. S. A., 96, 9815, 10.1073/pnas.96.17.9815
Cornelis, 1998, The Yersinia Yop virulon, a bacterial system to subvert cells of the primary host defense, Folia Microbiol., 43, 253, 10.1007/BF02818610
Davies, 2000, Specificity and mechanism of action of some commonly used protein kinase inhibitors, Biochem. J., 351, 95, 10.1042/0264-6021:3510095
Dejana, 2000, The molecular organization of endothelial junctions and their functional role in vascular morphogenesis and permeability, Int. J. Dev. Biol., 44, 743
Del Maschio, 1996, Polymorphonuclear leukocyte adhesion triggers the disorganization of endothelial cell-to-cell adherens junctions, J. Cell Biol., 135, 497, 10.1083/jcb.135.2.497
Dormond, 2002, Prostaglandin E2 promotes integrin aVb3-dependent endothelial cell adhesion, Rac-activation and spreading through cAMP/PKA signaling, J. Biol. Chem., 16, 16
Draijer, 1995, cGMP and nitric oxide modulate thrombin-induced endothelial permeability. Regulation via different pathways in human aortic and umbilical vein endothelial cells, Circ. Res., 76, 199, 10.1161/01.RES.76.2.199
Drenckhahn, 1997, The endothelial contractile cytoskeleton, 1
Essler, 1998, Pasteurella multocida toxin increases endothelial permeability via Rho kinase and myosin light chain phosphatase, J. Immunol., 161, 5640, 10.4049/jimmunol.161.10.5640
Essler, 1999, Mildly oxidized low density lipoprotein induces contraction of human endothelial cells through activation of Rho/Rho kinase and inhibition of myosin light chain phosphatase, J. Biol. Chem., 274, 30361, 10.1074/jbc.274.43.30361
Essler, 2000, Cyclic AMP blocks bacterial lipopolysaccharide-induced myosin light chain phosphorylation in endothelial cells through inhibition of Rho/Rho kinase signaling, J. Immunol., 164, 6543, 10.4049/jimmunol.164.12.6543
Etienne-Manneville, 2000, ICAM-1-coupled cytoskeletal rearrangements and transendothelial lymphocyte migration involve intracellular calcium signaling in brain endothelial cell lines, J. Immunol., 165, 3375, 10.4049/jimmunol.165.6.3375
Eto, 2001, Thrombin suppresses endothelial nitric oxide synthase and upregulates endothelin-converting enzyme-1 expression by distinct pathways: role of Rho/ROCK and mitogen-activated protein kinase, Circ. Res., 89, 583, 10.1161/hh1901.097084
Fleming, 1996, Differential translocation of rho family GTPases by lysophosphatidic acid, endothelin-1, and platelet-derived growth factor, J. Biol. Chem., 271, 33067, 10.1074/jbc.271.51.33067
Garcia, 1998, Adherent neutrophils activate endothelial myosin light chain kinase: role in transendothelial migration, J. Appl. Physiol., 84, 1817, 10.1152/jappl.1998.84.5.1817
Garcia, 2001, Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement, J. Clin. Invest., 108, 689, 10.1172/JCI12450
Gewaltig, 2002, Vasoprotection by nitric oxide, mechanisms and therapeutic potential, Cardiovasc. Res., 55, 250, 10.1016/S0008-6363(02)00327-9
Ghabriel, 1999, Substance P-induced enhanced permeability of dura mater microvessels is accompanied by pronounced ultrastructural changes, but is not dependent on the density of endothelial cell anionic sites, Acta Neuropathol. (Berl.), 97, 297, 10.1007/s004010050988
Gingras, 2000, Tyrosine phosphorylation of the vascular endothelial-growth-factor receptor-2 (VEGFR-2) is modulated by Rho proteins, Biochem. J., 348, 273, 10.1042/0264-6021:3480273
Goeckeler, 1995, Myosin light chain kinase-regulated endothelial cell contraction: the relationship between isometric tension, actin polymerization, and myosin phosphorylation, J. Cell. Biol., 130, 613, 10.1083/jcb.130.3.613
Goeckeler, 2000, Phosphorylation of myosin light chain kinase by p21-activated kinase PAK2, J. Biol. Chem., 275, 18366, 10.1074/jbc.M001339200
Gopalakrishnan, 2002, Rac1, but not RhoA, signaling protects epithelial adherens junction assembly during ATP depletion, Am. J. Physiol., Cell Physiol., 283, C261, 10.1152/ajpcell.00604.2001
Haddad, 2001, The interaction between Cdc42 and WASP is required for SDF-1-induced T-lymphocyte chemotaxis, Blood, 97, 33, 10.1182/blood.V97.1.33
Hart, 1998, Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13, Science, 280, 2112, 10.1126/science.280.5372.2112
Hippenstiel, 1997, Glucosylation of small GTP-binding Rho proteins disrupts endothelial barrier function, Am. J. Physiol., 272, L38
Hirao, 1996, Regulation mechanism of ERM (ezrin/radixin/moesin) protein/plasma membrane association: possible involvement of phosphatidylinositol turnover and Rho-dependent signaling pathway, J. Cell Biol., 135, 37, 10.1083/jcb.135.1.37
Hirase, 2001, Regulation of tight junction permeability and occludin phosphorylation by Rhoa-p160ROCK-dependent and -independent mechanisms, J. Biol. Chem., 276, 10423, 10.1074/jbc.M007136200
Hirata, 1995, Location of focal silver staining at endothelial gaps in inflamed venules examined by scanning electron microscopy, Am. J. Physiol., 269, L403
Hordijk, 1999, Vascular-endothelial-cadherin modulates endothelial monolayer permeability, J. Cell. Sci., 112, 1915, 10.1242/jcs.112.12.1915
Ikenoya, 2002, Inhibition of Rho-kinase-induced myristoylated alanine-rich C kinase substrate (MARCKS) phosphorylation in human neuronal cells by H-1152, a novel and specific Rho-kinase inhibitor, J. Neurochem., 81, 9, 10.1046/j.1471-4159.2002.00801.x
Ishizaki, 2000, Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases, Mol. Pharmacol., 5, 976
Just, 1995, The low molecular mass GTP-binding protein Rho is affected by toxin A from Clostridium difficile, J. Clin. Invest., 95, 1026, 10.1172/JCI117747
Katso, 2001, Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer, Annu. Rev. Cell Dev. Biol., 17, 615, 10.1146/annurev.cellbio.17.1.615
Kawano, 1999, Phosphorylation of myosin-binding subunit (MBS) of myosin phosphatase by Rho-kinase in vivo, J. Cell Biol., 147, 1023, 10.1083/jcb.147.5.1023
Kolodney, 1992, Isometric contraction by fibroblasts and endothelial cells in tissue culture: a quantitative study, J. Cell Biol., 117, 73, 10.1083/jcb.117.1.73
Kovacs, 2002, E-cadherin homophilic ligation directly signals through Rac and phosphatidylinositol 3-kinase to regulate adhesive contacts, J. Biol. Chem., 277, 6708, 10.1074/jbc.M109640200
Kozasa, 1998, p115 RhoGEF, a GTPase activating protein for Galpha12 and Galpha13, Science, 280, 2109, 10.1126/science.280.5372.2109
Kraynov, 2000, Localized Rac activation dynamics visualized in living cells, Science, 290, 333, 10.1126/science.290.5490.333
Kuroda, 1996, Identification of IQGAP as a putative target for the small GTPases, Cdc42 and Rac1, J. Biol. Chem., 271, 23363, 10.1074/jbc.271.38.23363
Lampugnani, 2002, VE-cadherin regulates endothelial actin activating Rac and increasing membrane association of tiam, Mol. Biol. Cell, 13, 1175, 10.1091/mbc.01-07-0368
Lang, 1996, Protein kinase A phosphorylation of RhoA mediates the morphological and functional effects of cyclic AMP in cytotoxic lymphocytes, EMBO J., 15, 510, 10.1002/j.1460-2075.1996.tb00383.x
Langeler, 1991, Norepinephrine and iloprost improve barrier function of human endothelial cell monolayers: role of cAMP, Am. J. Physiol., 260, C1052, 10.1152/ajpcell.1991.260.5.C1052
Laufs, 2000, Neuroprotection mediated by changes in the endothelial actin cytoskeleton, J. Clin. Invest., 106, 15, 10.1172/JCI9639
Lee, 2000, Sphingosine 1-phosphate stimulates tyrosine phosphorylation of focal adhesion kinase and chemotactic motility of endothelial cells via the G(i) protein-linked phospholipase C pathway, Biochem. Biophys. Res. Commun., 268, 47, 10.1006/bbrc.2000.2087
Lin, 1999, Specific contributions of the small GTPases Rho, Rac, and Cdc42 to Dbl transformation, J. Biol. Chem., 274, 23633, 10.1074/jbc.274.33.23633
Liu, 2002, Hepatocyte growth factor enhances endothelial cell barrier function and cortical cytoskeletal rearrangement: potential role of glycogen synthase kinase-3beta, FASEB J., 16, 950, 10.1096/fj.01-0870com
Lum, 1994, Regulation of vascular endothelial barrier function, Am. J. Physiol., 267, L223
Lynch, 1990, Increased endothelial albumin permeability mediated by protein kinase C activation, J. Clin. Invest., 85, 1991, 10.1172/JCI114663
Mehta, 2001, Protein kinase C-alpha signals rho-guanine nucleotide dissociation inhibitor phosphorylation and rho activation and regulates the endothelial cell barrier function, J. Biol. Chem., 276, 22614, 10.1074/jbc.M101927200
Miao, 2002, Mechanism of RhoA/Rho kinase activation in endothelin-1-induced contraction in rabbit basilar artery, Am. J. Physiol, Heart Circ. Physiol., 283, H983, 10.1152/ajpheart.00141.2002
Minnear, 2001, Platelet lipid(s) bound to albumin increases endothelial electrical resistance: mimicked by LPA, Am. J. Physiol., Lung Cell. Mol. Physiol., 281, L1334, 10.1152/ajplung.2001.281.6.L1337
Mitani, 2002, Adenovirus as an integrating vector, Curr. Gene Ther., 2, 135, 10.2174/1566523024605591
Moy, 1996, Histamine and thrombin modulate endothelial focal adhesion through centripetal and centrifugal forces, J. Clin. Invest., 97, 1020, 10.1172/JCI118493
Nakasone, 2002, Mast cell-derived VEGF enhances the passage of IgE FE-3 through the rat aortic endothelial cell monolayer, Int. Arch. Allergy Immunol., 129, 76, 10.1159/000065176
Nobes, 1995, Rho, rac and cdc42 GTPases: regulators of actin structures, cell adhesion and motility, Biochem. Soc. Trans., 23, 456, 10.1042/bst0230456
Noren, 2001, Cadherin engagement regulates Rho family GTPases, J. Biol. Chem., 276, 33305, 10.1074/jbc.C100306200
Panetti, 2002, Differential effects of sphingosine 1-phosphate and lysophosphatidic acid on endothelial cells, Biochim. Biophys. Acta, 1582, 190, 10.1016/S1388-1981(02)00155-5
Park, 2002, 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors interfere with angiogenesis by inhibiting the geranylgeranylation of RhoA, Circ. Res., 91, 143, 10.1161/01.RES.0000028149.15986.4C
Petrache, 2001, Differential effect of MLC kinase in TNF-alpha-induced endothelial cell apoptosis and barrier dysfunction, Am. J. Physiol., Lung Cell. Mol. Physiol., 280, L1168, 10.1152/ajplung.2001.280.6.L1168
Rabiet, 1996, Thrombin-induced increase in endothelial permeability is associated with changes in cell-to-cell junction organization, Arterioscler. Thromb. Vasc. Biol., 16, 488, 10.1161/01.ATV.16.3.488
Ren, 2000, Determination of GTP loading on Rho, Methods Enzymol., 325, 264, 10.1016/S0076-6879(00)25448-7
Ridley, 2000, Rho, 89
Ridley, 2001, Rho family proteins: coordinating cell responses, Trends Cell Biol., 11, 471, 10.1016/S0962-8924(01)02153-5
Ridley, 1992, The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors, Cell, 70, 389, 10.1016/0092-8674(92)90163-7
Ridley, 1992, The small GTP-binding protein rac regulates growth factor-induced membrane ruffling, Cell, 70, 401, 10.1016/0092-8674(92)90164-8
Rottner, 1999, Interplay between Rac and Rho in the control of substrate contact dynamics, Curr. Biol., 17, 640, 10.1016/S0960-9822(99)80286-3
Sah, 2000, The role of Rho in G protein-coupled receptor signal transduction, Annu. Rev. Pharmacol. Toxicol., 40, 459, 10.1146/annurev.pharmtox.40.1.459
Sahai, 1999, Transformation mediated by RhoA requires activity of ROCK kinases, Curr. Biol., 9, 136, 10.1016/S0960-9822(99)80067-0
Sahai, 2001, Cross-talk between Ras and Rho signaling pathways in transformation favours proliferation and increased motility, EMBO J., 20, 755, 10.1093/emboj/20.4.755
Saito, 1998, Endothelial myosin light chain kinase regulates neutrophil migration across human umbilical vein endothelial cell monolayer, J. Immunol., 161, 1533, 10.4049/jimmunol.161.3.1533
Sander, 1999, Rac downregulates Rho activity: reciprocal balance between both GTPases determines cellular morphology and migratory behavior, J. Cell Biol., 147, 1009, 10.1083/jcb.147.5.1009
Sauzeau, 2000, Cyclic GMP-dependent protein kinase signaling pathway inhibits RhoA-induced Ca2+ sensitization of contraction in vascular smooth muscle, J. Biol. Chem., 275, 21722, 10.1074/jbc.M000753200
Schneeberger, 1992, Structure, function, and regulation of cellular tight junctions, Am. J. Physiol., 262, L647
Schraufstatter, 2002, Complement c3a and c5a induce different signal transduction cascades in endothelial cells, J. Immunol., 169, 2102, 10.4049/jimmunol.169.4.2102
Shaw, 1998, RhoA-dependent phosphorylation and relocalization of ERM proteins into apical membrane/actin protrusions in fibroblasts, Mol. Biol. Cell, 9, 403, 10.1091/mbc.9.2.403
Simonson, 1993, Endothelins: multifunctional renal peptides, Physiol. Rev., 73, 375, 10.1152/physrev.1993.73.2.375
Soga, 2001, Rho family GTPases regulate VEGF-stimulated endothelial cell motility, Exp. Cell Res., 269, 73, 10.1006/excr.2001.5295
Sokol, 2001, The effect of IQGAP1 on Xenopus embryonic ectoderm requires Cdc42, J. Biol. Chem., 276, 48425, 10.1074/jbc.M107975200
Spyridopoulos, 2002, Divergence of angiogenic and vascular permeability signaling by VEGF, inhibition of protein kinase C suppresses VEGF-induced angiogenesis, but promotes VEGF-induced, NO-dependent vascular permeability, Arterioscler. Thromb. Vasc. Biol., 22, 901, 10.1161/01.ATV.0000020006.89055.11
Stasek, 1992, The role of protein kinase C in alpha-thrombin-mediated endothelial cell activation, Semin. Thromb. Hemost., 18, 117, 10.1055/s-2007-1002416
Suttorp, 1993, Role of phosphodiesterases in the regulation of endothelial permeability in vitro, J. Clin. Invest., 91, 1421, 10.1172/JCI116346
Takahashi, 1997, Direct interaction of the Rho GDP dissociation inhibitor with ezrin/radixin/moesin initiates the activation of the Rho small G protein, J. Biol. Chem., 272, 23371, 10.1074/jbc.272.37.23371
Takemoto, 2002, Rho-kinase mediates hypoxia-induced downregulation of endothelial nitric oxide synthase, Circulation, 106, 57, 10.1161/01.CIR.0000020682.73694.AB
Taylor, 1999, Cytoskeletal changes induced by GRAF, the GTPase regulator associated with focal adhesion kinase, are mediated by Rho, J. Cell Sci., 112, 231, 10.1242/jcs.112.2.231
Thompson, 2002, Intercellular adhesion molecule (ICAM)-1, but not ICAM-2, activates RhoA and stimulates c-fos and rhoA transcription in endothelial cells, J. Immunol., 169, 1007, 10.4049/jimmunol.169.2.1007
Tinsley, 1999, Activated neutrophils induce hyperpermeability and phosphorylation of adherens junction proteins in coronary venular endothelial cells, J. Biol. Chem., 274, 24930, 10.1074/jbc.274.35.24930
Tokuyama, 2002, Effects of Y-27632, a Rho/Rho kinase inhibitor, on leukotriene D(4)- and histamine-induced airflow obstruction and airway microvascular leakage in guinea pigs in vivo, Pharmacology, 64, 189, 10.1159/000056170
Tseng, 2002, Translocation of liposomes into cancer cells by cell-penetrating peptides penetratin and tat: a kinetic and efficacy study, Mol. Pharmacol., 62, 864, 10.1124/mol.62.4.864
Tsuji, 2002, ROCK and mDia1 antagonize in Rho-dependent Rac activation in Swiss 3T3 fibroblasts, J. Cell Biol., 157, 819, 10.1083/jcb.200112107
Uehata, 1997, Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension, Nature, 389, 990, 10.1038/40187
Vallota, 1973, Formation of C3a and C5a anaphylatoxins in whole human serum after inhibition of the anaphylatoxin inactivator, J. Exp. Med., 137, 1109, 10.1084/jem.137.5.1109
van Buul, 2002, Migration of human hematopoietic progenitor cells across bone marrow endothelium is regulated by vascular endothelial cadherin, J. Immunol., 168, 588, 10.4049/jimmunol.168.2.588
van Hinsbergh, 2002, Intracellular signalling involved in modulating human endothelial barrier function, J. Anat., 200, 549, 10.1046/j.1469-7580.2002.00060.x
van Leeuwen, 1999, Rac regulates phosphorylation of the myosin-II heavy chain, actinomyosin disassembly and cell spreading, Nat. Cell Biol., 1, 242, 10.1038/12068
van Nieuw Amerongen, 2001, Cytoskeletal effects of rho-like small guanine nucleotide-binding proteins in the vascular system, Arterioscler. Thromb. Vasc. Biol., 21, 300, 10.1161/01.ATV.21.3.300
van Nieuw Amerongen, 1998, Transient and prolonged increase in endothelial permeability induced by histamine and thrombin: role of protein kinases, calcium, and RhoA, Circ. Res., 83, 1115, 10.1161/01.RES.83.11.1115
van Nieuw Amerongen, 2000, Activation of RhoA by thrombin in endothelial hyperpermeability: role of Rho kinase and protein tyrosine kinases, Circ. Res., 87, 335, 10.1161/01.RES.87.4.335
van Nieuw Amerongen, 2000, Simvastatin improves disturbed endothelial barrier function, Circulation, 102, 2803, 10.1161/01.CIR.102.23.2803
van Nieuw Amerongen, 2000, Role of RhoA and Rho kinase in lysophosphatidic acid-induced endothelial barrier dysfunction, Arterioscler. Thromb. Vasc. Biol., 20, E127, 10.1161/01.ATV.20.12.e127
van Wetering, 2002, Reactive oxygen species mediate Rac-induced loss of cell–cell adhesion in primary human endothelial cells, J. Cell Sci., 115, 1837, 10.1242/jcs.115.9.1837
Vastrik, 1999, Sema3A-induced growth-cone collapse is mediated by rac1 amino acids 17–32, Curr. Biol., 18, 991, 10.1016/S0960-9822(99)80447-3
Von Pawel-Rammingen, 2000, GAP activity of the Yersinia YopE cytotoxin specifically targets the Rho pathway: a mechanism for disruption of actin microfilament structure, Mol. Microbiol., 36, 737, 10.1046/j.1365-2958.2000.01898.x
Vouret-Craviari, 1998, Regulation of the actin cytoskeleton by thrombin in human endothelial cells: role of Rho proteins in endothelial barrier function, Mol. Biol. Cell, 9, 2639, 10.1091/mbc.9.9.2639
Vouret-Craviari, 1999, Effects of cytotoxic necrotizing factor 1 and lethal toxin on actin cytoskeleton and VE-cadherin localization in human endothelial cell monolayers, Infect. Immun., 67, 3002, 10.1128/IAI.67.6.3002-3008.1999
Vouret-Craviari, 2002, Distinct signals via Rho GTPases and Src drive shape changes by thrombin and sphingosine-1-phosphate in endothelial cells, J. Cell. Sci., 115, 2475, 10.1242/jcs.115.12.2475
Wang, 2001, Mechanisms of sodium fluoride-induced endothelial cell barrier dysfunction: role of MLC phosphorylation, Am. J. Physiol., Lung Cell. Mol. Physiol., 281, L1472, 10.1152/ajplung.2001.281.6.L1472
Wojciak-Stothard, 1998, Regulation of TNF-alpha-induced reorganization of the actin cytoskeleton and cell–cell junctions by Rho, Rac, and Cdc42 in human endothelial cells, J. Cell. Physiol., 176, 150, 10.1002/(SICI)1097-4652(199807)176:1<150::AID-JCP17>3.0.CO;2-B
Wojciak-Stothard, 1999, Monocyte adhesion and spreading on human endothelial cells is dependent on Rho-regulated receptor clustering, J. Cell Biol., 145, 1293, 10.1083/jcb.145.6.1293
Wojciak-Stothard, 2001, Rho and Rac but not Cdc42 regulate endothelial cell permeability, J. Cell. Sci., 114, 1343, 10.1242/jcs.114.7.1343
Zhao, 2002, Substance P-stimulated interleukin-8 expression in human colonic epithelial cells involves Rho family small GTPases, Biochem. J., 368, 665, 10.1042/bj20020950
Zondag, 2000, Oncogenic Ras downregulates Rac activity which leads to increased Rho activity and epithelial-mesenchymal transition, J. Cell Biol., 149, 775, 10.1083/jcb.149.4.775