Revisiting biomarker discovery by plasma proteomics

Molecular Systems Biology - Tập 13 Số 9 - 2017
Philipp E. Geyer1,2, Lesca M. Holdt3, Daniel Teupser3, Matthias Mann1,2
1Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany
2Faculty of Health Sciences, NNF Center for Protein Research, University of Copenhagen, Copenhagen, Denmark
3Institute of Laboratory Medicine, University Hospital, LMU Munich, Munich, Germany

Tóm tắt

Abstract

Clinical analysis of blood is the most widespread diagnostic procedure in medicine, and blood biomarkers are used to categorize patients and to support treatment decisions. However, existing biomarkers are far from comprehensive and often lack specificity and new ones are being developed at a very slow rate. As described in this review, mass spectrometry (MS)‐based proteomics has become a powerful technology in biological research and it is now poised to allow the characterization of the plasma proteome in great depth. Previous “triangular strategies” aimed at discovering single biomarker candidates in small cohorts, followed by classical immunoassays in much larger validation cohorts. We propose a “rectangular” plasma proteome profiling strategy, in which the proteome patterns of large cohorts are correlated with their phenotypes in health and disease. Translating such concepts into clinical practice will require restructuring several aspects of diagnostic decision‐making, and we discuss some first steps in this direction.

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Molecular Systems Biology

Tập 13 Số 9

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