Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α

Cell - Tập 127 Số 6 - Trang 1109-1122 - 2006
Marie Lagouge1, Carmen Argmann1, Zachary Gerhart‐Hines2, Hamid Meziane3, Carles Lerín2, Frédéric Daussin4, Nadia Messadeq3, Jill C. Milne5, Philip Lambert5, Peter J. Elliott5, Bernard Gény4, Markku Laakso6, Pere Puigserver2, Johan Auwerx7,3,1
1Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, 67404 Illkirch, France
2Department of Cell Biology, John Hopkins University School of Medicine, Baltimore, MD 21205, USA
3Institut Clinique de la Souris, BP10142, 67404 Illkirch, France
4Department of Respiratory, Cardiocirculatory and Exercise Physiology, Hôpitaux Universitaires, 67000 Strasbourg, France
5Sirtris Pharmaceutical, Cambridge, MA 02139, USA
6Department of Medicine, University of Kuopio, 70211 Kuopio, Finland
7IGBMC-ICS, 67404 Illkirch, France

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