Relationship between megakaryocyte mass and serum thrombopoietin levels as revealed by a case of cyclic amegakaryocytic thrombocytopenic purpura

British Journal of Haematology - Tập 105 Số 2 - Trang 452-458 - 1999
Claire Francastel1, Janina Ratajczak, Mariusz Z. Ratajczak, John Anastasi, Philip C. Hoffman, Alan M. Gewirtz
1Section of Hematology/Oncology, Department of Internal Medicine, University of Chicago, Illinois, USA.

Tóm tắt

Cyclic amegakaryocytic thrombocytopenic purpura is a rare syndrome characterized by periodic failure of megakaryocytopoiesis. In this report we describe a patient with cyclic amegakaryocytic thrombocytopenic purpura associated with a megakaryocyte specific serum IgG antibody, who responded to cyclosporin A therapy. Serial serum thrombopoietin assays during an episode of platelet cycling demonstrated a reciprocal relationship between serum thrombopoietin level and megakaryocyte mass, suggesting that megakaryocytes have an important role in the regulation of thrombopoietin metabolism.

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British Journal of Haematology

Tập 105 Số 2

452-458

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