Relationship between lindane concentration in blood and brain and convulsant response in rats after oral or intraperitoneal administration

Josep Maria Tusell1, Cristina Suñol1, E. Gelpí1, Eduard Rodrı́guez-Farré2
1Department of Neurochemistry, Consejo Superior de Investigaciones Científicas, Barcelona, Spain.
2Department of Pharmacology and Toxicology, Consejo Superior de Investigaciones Científicas, Barcelona, Spain

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Broadwell RD, Dalcman M, Kaplan RS (1982) Morphologic effect of dimethylsulfoxide on the blood-brain barrier. Science 217: 164?166

Cattabeni F, Pastorello MC, Eli M (1983) Convulsions induced by lindane and the involvement of the GABAergic system. Arch Toxicol (Suppl) 6: 244?249

Dale WE, Gaines TB, Hayes WI Jr (1963) Poisoning by DDT: relation between clinical signs and concentration in rat brain. Science 142: 1474?1476

EPA (ed) (1983) Lindane Position Document 4. US Environmental Protection Agency, Washington

EPA (ed) (1984) Analytical reference Standard and Supplemental data: pesticides and industrial chemicals repository. US Environmental Protection Agency, Las Vegas

Joy RM (1976) Convulsive properties of chlorinated hydrocarbon insecticides in the cat central nervous system. Toxicol Appl Pharmacol 35: 95?106

Joy RM, Albertson TE (1985) Lindane and limbic system excitability. Neurotoxicology 6: 193?214

Murphy SD (1980) Pesticides. In: Doull J, Klaassen CD, Amdur MO (eds) Casarett and Doull's Toxicology. Mc Millan, New York, pp 357?408

Portig J, Stein K (1981) Neuropharmacological effects of isomers of hexachlorocyclohexane. 2 ? Selective inhibition of (myo-) clonic seizures as a sequel to CNS excitation by the gamma isomer. Neuropharmacology 20: 773?781

Ramzan IM, Levy G (1985) Kinetics of drug action in disease states. XIV. Effect of infusion rate on pentylenetetrazol concentrations in serum, brain and cerebrospinal fluid of rats at onset of convulsions. J Pharmacol Exp Therap 234: 624?628

Srinivasan K, Radhakrishnamutry R (1983) Studies in the distribution of beta and gamma-isomers of hexachlorocyclohexane in rat tissues. J Environ Sci Health B 18: 401?418

Stein K, Portig J, Fuhrmann H, Koransky W, Noack G (1980) Steric factors in the pharmacokinetics of lindane and alpha-hexachlorocyclohexane in rats. Xenobiotica 10: 65?77

Stein K, Portig J, Noack G (1981) Neuropharmacological effects of isomers of hexachlorocyclohexane. 3 ? An account of the convulsant activity of the gamma-isomers in rats. Neuropharmacology 20: 1017?1024

St Omer V (1971) Investigations into mechanisms responsible for seizures induced by chlorinated hydrocarbon insecticide: the role of brain ammonia and glutamine in convulsions in the rat and cockerel. J Neurochem 18: 365?374

Tallarida RJ, Murray RB (eds) (1981) Manual of pharmacologic calculations. Springer Verlag, New York, Heidelberg, Berlin

Vohland HW, Portig J, Stein K (1981) Neuropharmacological effects of isomers of hexachlorocylohexane. 1-Protection against pentylenetetrazol-induced convulsion. Toxicol Appl Pharmacol 57: 425?438

Windholz M (ed) (1983) The Merck Index. Merck Co Inc, Rahway

Woolley D, Zimmer L, Dodge D, Swanson R (1985) Effects of lindane-type insecticides in mammals: unsolved problems. Neurotoxicology 6: 165?192