Regulatory T cells and transcription factors: gatekeepers in allergic inflammation

Wills-Karp, 1998, Interleukin-13: central mediator of allergic asthma, Science, 282, 2258, 10.1126/science.282.5397.2258 Yazdanbakhsh, 2002, Allergy, parasites, and the hygiene hypothesis, Science, 296, 490, 10.1126/science.296.5567.490 Martinez, 2001, The coming-of-age of the hygiene hypothesis, Respir Res, 2, 129, 10.1186/rr48 Tang, 1998, Reduced prevalence of allergic disease in patients with multiple sclerosis is associated with enhanced IL-12 production, J Allergy Clin Immunol, 102, 428, 10.1016/S0091-6749(98)70131-9 van Roon, 2002, Th2 mediated regulation in RA and the spondyloarthropathies, Ann Rheum Dis, 61, 951, 10.1136/ard.61.11.951 Ashcroft, 2000, Secretory leukocyte protease inhibitor mediates non-redundant functions necessary for normal wound healing, Nat Med, 6, 1147, 10.1038/80489 Akbari, 2003, Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity, Nat Med, 9, 582, 10.1038/nm851 Akimoto, 1998, Abrogation of bronchial eosinophilic inflammation and airway hyperreactivity in signal transducers and activators of transcription (STAT)6-deficient mice, J Exp Med, 187, 1537, 10.1084/jem.187.9.1537 Zheng, 1997, The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells, Cell, 89, 587, 10.1016/S0092-8674(00)80240-8 Pai, 2004, GATA-3 deficiency abrogates the development and maintenance of T helper type 2 cells, Proc Natl Acad Sci USA, 101, 1993, 10.1073/pnas.0308697100 Zhang, 1999, Inhibition of allergic inflammation in a murine model of asthma by expression of a dominant-negative mutant of GATA-3, Immunity, 11, 473, 10.1016/S1074-7613(00)80122-3 Kim, 1999, The transcription factor c-Maf controls the production of interleukin-4 but not other Th2 cytokines, Immunity, 10, 745, 10.1016/S1074-7613(00)80073-4 Das, 2001, A critical role for NF-kappa B in GATA3 expression and TH2 differentiation in allergic airway inflammation, Nat Immunol, 2, 45, 10.1038/83158 Ouyang, 2000, Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment, Immunity, 12, 27, 10.1016/S1074-7613(00)80156-9 Wahl, 2003, TGF-β: how tolerant can it be?, Immunol Res, 28, 167, 10.1385/IR:28:3:167 Romagnani, 2004, Immunologic influences on allergy and the TH1/TH2 balance, J Allergy Clin Immunol, 113, 395, 10.1016/j.jaci.2003.11.025 Umetsu, 2003, Regulatory T cells control the development of allergic disease and asthma, J Allergy Clin Immunol, 112, 480, 10.1016/S0091-6749(03)01869-4 Chen, 2003, Conversion of peripheral CD4+CD25− naive T cells to CD4+CD25+ regulatory T cells by TGF-β induction of transcription factor Foxp3, J Exp Med, 198, 1875, 10.1084/jem.20030152 Shevach, 2002, CD4+ CD25+ suppressor T cells: more questions than answers, Nat Rev Immunol, 2, 389, 10.1038/nri821 Sakaguchi, 2000, Regulatory T cells: key controllers of immunologic self-tolerance, Cell, 101, 455, 10.1016/S0092-8674(00)80856-9 Chen, 2003, TGF-β: the missing link in CD4+CD25+ regulatory T cell-mediated immunosuppression, Cytokine Growth Factor Rev, 14, 85, 10.1016/S1359-6101(03)00003-0 Gambineri, 2003, Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX), a syndrome of systemic autoimmunity caused by mutations of FOXP3, a critical regulator of T-cell homeostasis, Curr Opin Rheumatol, 15, 430, 10.1097/00002281-200307000-00010 Khattri, 2003, An essential role for Scurfin in CD4+CD25+ T regulatory cells, Nat Immunol, 4, 337, 10.1038/ni909 Fontenot, 2003, Foxp3 programs the development and function of CD4+CD25+ regulatory T cells, Nat Immunol, 4, 330, 10.1038/ni904 Hori, 2003, Control of regulatory T cell development by the transcription factor Foxp3, Science, 299, 1057, 10.1126/science.1079490 Schubert, 2001, Scurfin (FOXP3) acts as a repressor of transcription and regulates T cell activation, J Biol Chem, 276, 37672, 10.1074/jbc.M104521200 Yamazaki, 2003, Direct expansion of functional CD25+ CD4+ regulatory T cells by antigen-processing dendritic cells, J Exp Med, 198, 235, 10.1084/jem.20030422 Nakamura, 2004, TGF-β1 plays an important role in the mechanism of CD4+CD25+ regulatory T cell activity in both humans and mice, J Immunol, 172, 834, 10.4049/jimmunol.172.2.834 Yu, 2002, TGF-β receptor-activated p38 MAP kinase mediates Smad-independent TGF-beta responses, EMBO J, 21, 3749, 10.1093/emboj/cdf366 Kulkarni, 1995, Transforming growth factor- β 1 null mice. An animal model for inflammatory disorders, Am J Pathol, 146, 264 Gorelik, 2002, Mechanism of transforming growth factor β-induced inhibition of T helper type 1 differentiation, J Exp Med, 195, 1499, 10.1084/jem.20012076 Gorelik, 2000, Cutting edge: TGF- β inhibits Th type 2 development through inhibition of GATA-3 expression, J Immunol, 165, 4773, 10.4049/jimmunol.165.9.4773 Chen, 2003, Transforming growth factor β blocks Tec kinase phosphorylation, Ca2+ influx, and NFATc translocation causing inhibition of T cell differentiation, J Exp Med, 197, 1689, 10.1084/jem.20021170 Szabo, 2002, Distinct effects of T-bet in Th1 lineage commitment and IFN-γ production in CD4 and CD8 T cells, Science, 295, 338, 10.1126/science.1065543 Takeda, 2003, Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment, J Immunol, 170, 4886, 10.4049/jimmunol.170.10.4886 Townsend, 2004, T-bet regulates the terminal maturation and homeostasis of NK and Valpha14i NKT cells, Immunity, 20, 477, 10.1016/S1074-7613(04)00076-7 Finotto, 2002, Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet, Science, 295, 336, 10.1126/science.1065544 Kaplan, 1996, Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice, Nature, 382, 174, 10.1038/382174a0 Thierfelder, 1996, Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells, Nature, 382, 171, 10.1038/382171a0 Alexander, 2002, Suppressors of cytokine signalling (SOCS) in the immune system, Nat Rev Immunol, 2, 410, 10.1038/nri818 Seki, 2003, SOCS-3 regulates onset and maintenance of T(H)2-mediated allergic responses, Nat Med, 9, 1047, 10.1038/nm896 Sabatos, 2003, Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance, Nat Immunol, 4, 1102, 10.1038/ni988 Sanchez-Fueyo, 2003, Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance, Nat Immunol, 4, 1093, 10.1038/ni987 McIntire, 2004, TIM-1, a novel allergy and asthma susceptibility gene, Springer Semin Immunopathol, 25, 335, 10.1007/s00281-003-0141-3 Feigelstock, 1998, The human homolog of HAVcr-1 codes for a hepatitis A virus cellular receptor, J Virol, 72, 6621, 10.1128/JVI.72.8.6621-6628.1998 Laitinen, 2004, Characterization of a common susceptibility locus for asthma-related traits, Science, 304, 300, 10.1126/science.1090010