Regorafenib (Stivarga) pharmacologically targets epithelial-mesenchymal transition in colorectal cancer
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Yoshino, 2013, Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial, Lancet, 381, 303, 10.1016/S0140-6736(12)61900-X
Zopf, 2011, Regorafenib (BAY 73-4506): a new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity, Int J Cancer, 129, 245, 10.1002/ijc.25864
Lederle, 2013, Regorafenib inhibits growth, angiogenesis, and metastasis in a highly aggressive, orthotopic colon cancer model, Mol Cancer Ther, 12, 1322, 10.1158/1535-7163.MCT-12-1162
Yang, 2016, An hTERT/ZEB1 complex directly regulates E-cadherin to promote epithelial-to-mesenchymal transition (EMT) in colorectal cancer, Oncotarget, 7, 351, 10.18632/oncotarget.5968
Huang, 2016, PDLIM1 stabilizes the E-cadherin/beta-catenin complex to prevent epithelial-mesenchymal transition and metastatic potential of colorectal cancer cells, Cancer Res, 76, 1122, 10.1158/0008-5472.CAN-15-1962
Li, 2016, LRG1 modulates epithelial-mesenchymal transition and angiogenesis in colorectal cancer via HIF-1alpha activation, J Exp Clin Cancer Res, 35, 29, 10.1186/s13046-016-0306-2
Zhao, 2016, MicroRNA-187, a downstream effector of TGFbeta pathway, suppresses Smad-mediated epithelial-mesenchymal transition in colorectal cancer, Cancer Lett, 373, 203, 10.1016/j.canlet.2016.01.037
Ihle, 1992, Protein tyrosine phosphatase containing SH2 domains: characterization, preferential expression in hematopoietic cells, and localization to human chromosome 12p12-p13, Mol Cell Biol, 12, 836, 10.1128/MCB.12.2.836
Zhao, 1996, Mammalian SH2-containing protein tyrosine phosphatases, Cell, 85, 15, 10.1016/S0092-8674(00)81077-6
Chen, 2011, Signal transducer and activator of transcription 3 is a major kinase-independent target of sorafenib in hepatocellular carcinoma, J Hepatol, 55, 1041, 10.1016/j.jhep.2011.01.047
Chen, 2013, Novel sorafenib analogues induce apoptosis through SHP-1 dependent STAT3 inactivation in human breast cancer cells, Breast Cancer Res, 15, R63
Chen, 2015, Pharmacological Targeting SHP-1-STAT3 Signaling Is a Promising Therapeutic Approach for the Treatment of Colorectal Cancer, Neoplasia, 17, 687, 10.1016/j.neo.2015.08.007
Chen, 2014, SHP-1 is a target of regorafenib in colorectal cancer, Oncotarget, 5, 6243, 10.18632/oncotarget.2191
Chen, 2015, SHP-1 is a negative regulator of epithelial-mesenchymal transition in hepatocellular carcinoma, Oncogene, 34, 5252, 10.1038/onc.2014.445
Liu, 2013, Arsenite evokes IL-6 secretion, autocrine regulation of STAT3 signaling, and miR-21 expression, processes involved in the EMT and malignant transformation of human bronchial epithelial cells, Toxicol Appl Pharmacol, 273, 27, 10.1016/j.taap.2013.08.025
Greten, 2014, IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis, J Clin Invest, 124, 1853, 10.1172/JCI73531
Fang, 2012, Roles of STAT3 and ZEB1 proteins in E-cadherin down-regulation and human colorectal cancer epithelial-mesenchymal transition, J Biol Chem, 287, 5819, 10.1074/jbc.M111.295964
Tang, 2013, Relationship between activated STAT3 protein and epithelial-mesenchymal transition in papillary thyroid carcinoma. [Article in Chinese], Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi, 27, 1265
Chen, 2014, Discovery of novel Src homology region 2 domain-containing phosphatase 1 agonists from sorafenib for the treatment of hepatocellular carcinoma, Hepatology, 59, 190, 10.1002/hep.26640
Wang, 2012, CIP2A is a predictor of poor prognosis in colon cancer, J Gastrointest Surg, 16, 1037, 10.1007/s11605-012-1828-3
Christofori, 1998, A causal role for E-cadherin in the transition from adenoma to carcinoma, Nature, 392, 190, 10.1038/32433
Nieto, 2000, The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression, Nat Cell Biol, 2, 76, 10.1038/35000025
Olsen, 2008, Snail and Slug promote epithelial-mesenchymal transition through beta-catenin-T-cell factor-4-dependent expression of transforming growth factor-beta3, Mol Biol Cell, 19, 4875, 10.1091/mbc.e08-05-0506
Zhang, 2012, MicroRNA-200a suppresses the Wnt/β-catenin signaling pathway by interacting with β-catenin, Int J Oncol, 40, 1162
