Regional anaesthesia and antithrombotic agents: recommendations of the European Society of Anaesthesiology

European Journal of Anaesthesiology - Tập 27 Số 12 - Trang 999-1015 - 2010
Wiebke Gogarten1,2,3,4,5,6,7,8,9,10, Erik Vandermeulen1,2,3,4,5,6,9, Hugo Van Aken1,2,3,4,5,6,9, S. Kozek1,2,3,4,5,6,9, Juan V. Llau1,2,3,4,5,6,9, Charles Marc Samama1,2,3,4,5,6,9
1During platelet activation, ADP is released from granules to bind with platelet receptor P2Y12, promoting further activation. It provides an opportunity for pharmacological antagonism.
2Inhibition constant Ki
3Platelet factor 4
4Published online 1 October 2010
5The editors would like to thank Alain Borgeat (Switzerland), Elisabeth Gaertner (France, ESA Scientific subcommittee 8), Daniela Filipescu (Romania, ESA Scientific subcommittee 6), Klaus Görlinger (Germany, ESA Scientific subcommittee 6), Markus W. Hollmann (Netherlands, ESA Scientific subcommittee 8), Susan Mallett (UK, ESA Scientific subcommittee 6), and Andrew F. Smith (UK, Chair of the ESA Guidelines Committee) for their help in critically appraising the scientific content of this article. Potential conflicts of interest of the assessors are stated in the Acknowledgements section at the end of this paper.
6The inhibition constant Ki represents the concentration of inhibitor that is needed to reduce the maximal rate of reaction to half that of the uninhibited value. The lower the Ki, the lower the concentration of inhibitor needed, and the more potent the inhibition.
7e-mail: [email protected]
8fax: +49 89 6210 3245
9the Department of Anaesthesiology, Intensive Care and Pain Therapy, Harlaching Hospital, Municipal Hospitals of Munich, Munich, Germany (WG), Department of Anaesthesiology, University Hospitals, Katholieke Universiteit, Leuven, Leuven, Belgium (EV), Department of Anesthesiology and Intensive Care Medicine, University Hospital, Munster, Germany (WG, HVA), Department of Anaesthesiology, Intensive Care and Pain Management, Vienna, Medical University, Vienna, Austria (SK), Department of Anaesthesiology and Postsurgical Critical Care, Hospital Clinic Universiari, Valencia, Spain (JVL) and Department of Anaesthesiology and Intensive Care, Hotel-Dieu University Hospital, Paris (CMS), France
10to Wiebke Gogarten, MD, PhD, Department of Anaesthesiology, Intensive Care and Pain Therapy, Harlaching Hospital, Municipal Hospitals of Munich, Munich, Germany Tel: +49 89 6210 2365

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