Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice

Richard A. Miller1,2,3, David E. Harrison4, Clinton M. Astle4, Joseph A. Baur5,6, Angela R. Boyd7, Rafael de Cabo8, Elizabeth Fernández9,5, Kevin Flurkey4, Martin A. Javors9,5, James F. Nelson9,5, Carlos J. Orihuela7, Scott D. Pletcher10,2, Z. Dave Sharp11,12, David Sinclair13, Joseph W. Starnes14, John E. Wilkinson15, Nancy L. Nadon16, Randy Strong9,17,18,19
1Department of Pathology
2Geriatrics Center, University of Michigan, Ann Arbor
3Graduate Research, Education and Clinical Center, Ann Arbor VA Medical Center
4The Jackson Laboratory, Bar Harbor, Maine
5Department of Physiology
6Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia
7Department of Microbiology and Immunology, The University of Texas Health Science Center at San Antonio
8Laboratory of Experimental Gerontology, National Institute on Aging, Baltimore, Maryland
9Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio
10Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor
11Department of Molecular Medicine, University of Texas Health Science Center at San Antonio
12Institute of Biotechnology
13Department of Pathology, Harvard Medical School, Boston, Massachusetts
14Department of Kinesiology, University of North Carolina at Greensboro
15Unit for Laboratory Animal Medicine, University of Michigan School of Medicine, Ann Arbor
16Biology of Aging Program, National Institute on Aging, Bethesda, Maryland
17Department of Pharmacology, The University of Texas Health Science Center at San Antonio
18Geriatric Research, Education and Clinical Center
19Research Service, South Texas Veterans Health Care System

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