Quantitative autoradiographic mapping of serotonin receptors in the rat brain. I. Serotonin-1 receptors

Brain Research - Tập 346 Số 2 - Trang 205-230 - 1985
Ángel Pazos1, J.M. Palacios1
1Preclinical Research, Sandoz Ltd., CH-4002 Basel, Switzerland

Tóm tắt

Từ khóa


Tài liệu tham khảo

Aghajanian, 1981, The modulatory role of serotonin at multiple receptors in brain, 156

Ahlenius, 1984, Failure to antagonize the 8-hydroxy-2-(di-n-propylamino)tetralin-induced facilitation of male rat sexual behaviour by the administration of 5-HT receptor antagonists, Eur. J. Pharmacol., 99, 279, 10.1016/0014-2999(84)90134-1

Ahlenius, 1980, Further evidence for an inhibitory role of central 5-HT in male rat sexual behaviour, Psychopharmacology, 68, 217, 10.1007/BF00428106

Ahlenius, 1981, Effects of a new type of 5-HT receptor agonist on male rat sexual behaviour, Pharmacol. Biochem. Behav., 15, 785, 10.1016/0091-3057(81)90023-X

Alonso, 1984, A study of the reciprocal connections between the septum and the entorhinal area using anterograde and retrograde methods in the rat brain, J. Comp. Neurol., 225, 327, 10.1002/cne.902250303

Anderson, 1983, Serotonin receptor changes after chronic anti-depressant treatments: ligand binding, electrophysiological and behavioural studies, Life Sci., 32, 1791, 10.1016/0024-3205(83)90056-5

Archer, 1982, Serotonin involvement in aversive conditioning: reversal of the fear retention deficit by long-term p-chloroamphetamine but not p-chlorophenylalanine, Neurosci. Lett., 34, 75, 10.1016/0304-3940(82)90095-7

Armijo, 1974, The influence of increased brain 5-hydroxytryptamine upon the respiratory activity of cats, Neuropharmacology, 13, 977, 10.1016/0028-3908(74)90089-6

Azmitia, 1978, An autoradiographic analysis of the differential ascending projections of the dorsal and median raphénuclei in the rat, J. Comp. Neurol., 179, 641, 10.1002/cne.901790311

Basbaum, 1978, Endogeneous pain control mechanism: review and hypothesis, Ann. Neurol., 4, 451, 10.1002/ana.410040511

Bennet, 1979, Neurotransmitter receptors in frontal cortex of schizophrenics, Arch. Gen. Psychiatr., 36, 927, 10.1001/archpsyc.1979.01780090013001

Berge, 1983, Attenuation of morphine-induced analgesia by p-chlorophenylalanine and p-chloroamphetamine: test-dependent effects and evidence for brainstem 5-hydroxytryptamine involvement, Brain Research, 271, 51, 10.1016/0006-8993(83)91364-1

Berge, 1984, Selective lesions of the bulbospinal serotonergic pathways reduce the analgesia induced by p-chloroamphetamine in the hot-plate test, Neurosci. Lett., 44, 25, 10.1016/0304-3940(84)90215-5

Biegon, 1982, Quantitative autoradiography of serotonin receptors in the rat brain, Brain Research, 242, 197, 10.1016/0006-8993(82)90301-8

Blackburn, 1984, Evidence that 5-HT agonist-induced rotational behaviour in the rat is mediated via 5-HT1 receptors, Psychopharmacology, 83, 163, 10.1007/BF00429727

Blackshear, 1981, Multiple serotonin receptors: regional distribution and effect of raphélesions, Eur. J. Pharmacol., 76, 325, 10.1016/0014-2999(81)90103-5

Bockaert, 1981, Serotonin receptors coupled with an adenylate cyclase in the rat brain: non-identity with3H-5-HT binding sites, 327

Bowen, 1983, Biochemical assessment of serotonergic and cholinergic dysfunction and cerebral atrophy in Alzheimer's disease, J. Neurochem., 41, 266, 10.1111/j.1471-4159.1983.tb11838.x

Burt, 1976, Binding interactions of lysergic acid diethylamide and related agents with dopamine receptors in the brain, Mol. Pharmacol., 12, 631

Caviness, 1980, Headache, N. Engl. J. Med., 302, 446, 10.1056/NEJM198002213020806

Chan-Palay, 1976, Serotonin axons in the supra- and subependymal plexuses and in the leptomeninges; their roles in local alterations of cerebro-spinal fluid and vasomotor activity, Brain Research, 102, 103, 10.1016/0006-8993(76)90578-3

Closse, 1983, [3H]Mesulergine, a selective ligand for serotonin-2 receptors, Life Sci., 32, 2485, 10.1016/0024-3205(83)90375-2

Colpaert, 1983, The head-twitch response to intraperitoneal injection of 5-hydroxytryptophan in the rat: antagonistic effects of purported 5-hydroxytryptamine antagonists and of pirenperone, a LSD antagonist, Neuropharmacology, 22, 993, 10.1016/0028-3908(83)90215-0

Consolazione, 1982, CNS serotonin pathways, 29

Cortés, 1984, Visualization of multiple serotonin receptors in the rat brain by autoradiography, Br. J. Pharmacol., 82, 202

Cortés, 1984, Quantitative light microscopic autoradiographic localization of cholinergic muscarinic receptors in the human brain: brainstem, Neuroscience, 12, 1003, 10.1016/0306-4522(84)90001-0

Costain, 1978, β-Adrenoceptor antagonists inhibit the behavioural responses of rats to increased brain 5-hydroxytryptamine, Br. J. Pharmacol., 64, 193, 10.1111/j.1476-5381.1978.tb17289.x

Crescimanno, 1984, Functional relationship between claustrum and pyramidal tract neurons in the cat, Neurosci. Lett., 44, 125, 10.1016/0304-3940(84)90069-7

Cross, 1982, Interaction of [3H]LSD with serotonin receptors in human brain, Eur. J. Pharmacol., 82, 77, 10.1016/0014-2999(82)90555-6

Cross, 1984, Serotonin receptor changes in dementia of the Alzheimer type, J. Neurochem., 43, 1574, 10.1111/j.1471-4159.1984.tb06081.x

Crow, 1979, Monoamine mechanisms in chronic schizophrenia: postmortem neurochemical findings, Br. J. Psychiatr., 134, 249, 10.1192/bjp.134.3.249

Dahlstrom, 1964, Evidence for the existence of monoamine-containing neurons in the central neurons system. I. Demonstration of monoamines in the cell bodies of brainstem neurons, Acta Physiol. Scand., 62, 1

Dawson, 1967

Deshmukh, 1983, Computer-assisted autoradiographic localization of subtypes of serotonin-1 receptors in rat brain, Brain Research, 288, 338, 10.1016/0006-8993(83)90114-2

Dickinson, 1984, The effects of lesions produced by 5,7-dihydroxytryptamine on 5-hydroxytryptamine-mediated behavioural induced by amphetamine in large doses in the rat, Neuropharmacology, 23, 423, 10.1016/0028-3908(84)90250-8

Dickinson, 1983, Roles of dopamine and 5-hydroxytryptamine in stereotyped and non-stereotyped behaviour, Neuropharmacology, 22, 805, 10.1016/0028-3908(83)90124-7

Dray, 1982, Serotonin in the basal ganglia, 335

Engel, 1983, Evidence for common pharmacological properties of [3H]5-hydroxytryptamine binding sites, presynaptic 5-hydroxytryptamine autoreceptors in CNS and inhibitory presynaptic 5-hydroxytryptamine receptors on sympathetic nerves, Naunyn-Schmiedeberg's Arch. Pharmacol., 324, 116, 10.1007/BF00497016

Engel, 1980, Radioreceptor assay for the determination of β-adrenoceptor blocking agents in blood and brain of rats, Experientia, 36, 706

Euvrard, 1980, Biochemical assessment of the central 5-HT agonist activity of RU-24 969 (a piperidinylindole), Eur. J. Pharmacol., 63, 65, 10.1016/0014-2999(80)90117-X

Fessler, 1984, Evidence that the medial and dorsal raphénuclei mediate serotonergically induced increases in prolactin release from the pituitary, Brain Research, 299, 231, 10.1016/0006-8993(84)90704-2

Fillion, 1979, Decrease of [3H]5-HT high affinity binding and 5-HT adenylate cyclase activation after kainic acid lesion in rat brain striatum, J. Neurochem., 33, 567, 10.1111/j.1471-4159.1979.tb05189.x

Forssman, 1976, Propranolol for migraine prophylaxis, Headache, 16, 238, 10.1111/j.1526-4610.1976.hed1605238.x

Fozard, 1983, Functional correlates of 5-HT1 recognition sites, TIPS, 4, 288

Fuxe, 1965, Evidence for the existence of monoamine neurons in the central nervous system. IV: Distribution of monoamine nerve terminals in the central nervous system, Acta Physiol. Scand., 64, 39

Gall, 1984, Distribution of enkephalin, substance P, tyrosine hydroxylase and 5-hydroxytryptamine immunoreactivity in the septal region of the rat, J. Comp. Neurol., 225, 212, 10.1002/cne.902250207

Gilbert, 1979, Morphology and intracortical projections of functionally characterized neurons in the cat visual cortex, Nature (London), 280, 120, 10.1038/280120a0

Göthert, 1983, Autoreceptor-mediated inhibition of3H-5-hydroxytryptamine release from rat brain cortex slices by analogues of 5-hydroxytryptamine, Life Sci., 32, 1183, 10.1016/0024-3205(83)90186-8

Gozlan, 1983, Identification of presynaptic serotonin autoreceptors using a new ligand:3H-PAT, Nature (London), 305, 140, 10.1038/305140a0

Grahame-Smith, 1971, Inhibitory effects of chloropromazine on the syndrome of hyperactivity produced by l-tryptophan or 5-methoxy-N,N-dimethyltryptamine in rats treated with a monoamine oxidase inhibitor, Br. J. Pharmacol., 43, 856, 10.1111/j.1476-5381.1971.tb07222.x

Green, 1976, (−)-Propranolol inhibits the behavioural responses of rats to increased 5-hydroxytryptamine in the central nervous system, Nature (London), 262, 594, 10.1038/262594a0

Green, 1984, The behavioural effects of RU-24 969, a suggested 5-HT1 receptor agonist in rodents and the effect on the behaviour of treatment with antidepressants, Neuropharmacology, 23, 655, 10.1016/0028-3908(84)90147-3

Green, 1981, A behavioural and biochemical study in rats of 5-hydroxytryptamine receptor agonists and antagonists with observation on structure-activity requirements for the agonists, Br. J. Pharmacol., 73, 703, 10.1111/j.1476-5381.1981.tb16806.x

Hamon, 1984, Biochemical evidence for the 5-HT agonist properties of PAT (8-hydroxy-2-[Di-n-propylamino]tetralin) in the rat brain, Eur. J. Pharmacol., 100, 263, 10.1016/0014-2999(84)90002-5

Hjorth, 1982, 8-Hydroxy-2-(di-n-propylamino)tetralin, 8-OH-DPAT, a potent and selective simplified ergot congener with central 5-HT receptor stimulating activity, J. Neural. Transm., 55, 169, 10.1007/BF01276574

Hökfelt, 1973, Immunohistochemical localization of aromatic l-aminoacid decar☐ylase (DOPA-decar☐ylase) in central dopamine and 5-hydroxytryptamine nerve cell bodies of the rat brain, Brain Research, 53, 175, 10.1016/0006-8993(73)90776-2

Hunt, 1981, The interaction of indole derivatives with the serotonin receptor and non-dopaminergic circling behaviour, 547

Jacobs, 1976, An animal behaviour model for studying central serotonergic synapses, Life Sci., 19, 777, 10.1016/0024-3205(76)90303-9

Jacobs, 1975, Brainstem and spinal cord mediation of a serotonergic behaviour syndrome, Brain Research, 100, 450, 10.1016/0006-8993(75)90500-4

Krieg, 1947, Connections of the cerebral cortex. I. The albino rat. A. Topography of the cortical areas, J. Comp. Neurol., 84, 221, 10.1002/cne.900840205

Krieg, 1947, Connections of the cerebral cortex. I. The albino rat. B. Structure of the cortical areas, J. Comp. Neurol., 84, 277, 10.1002/cne.900840302

Kuhar, 1981, Autoradiographic localization of drug and neurotransmitter receptors in brain, Trends Neurosci., 4, 60, 10.1016/0166-2236(81)90021-7

Kuhn, 1980, Review of the role of the central serotonergic neuronal system in blood pressure regulation, Hypertension, 2, 243, 10.1161/01.HYP.2.3.243

Lance, 1982

Le Vay, 1981, The visual claustrum of the cat. I. Structure and connections, J. Neurosci., 1, 956, 10.1523/JNEUROSCI.01-09-00956.1981

Leysen, 1984, Problems in in vitro receptor binding studies and identification and role of serotonin receptor sites, Neuropharmacology, 23, 247, 10.1016/0028-3908(84)90066-2

Leysen, 1982, [3H]Ketanserin (R-41 468), a selective3H-ligand for serotonin2 receptor binding sites, Mol. Pharmacol., 21, 301

Lidov, 1980, The serotonin innervation of the cerebral cortex in the rat. An immunohistochemical analysis, Neuroscience, 5, 207, 10.1016/0306-4522(80)90099-8

Lucki, 1984, Differential actions of serotonin antagonists on two behavioural models of serotonin receptor activation in the rat, J. Pharmacol. Exp. Ther., 228, 133

Luscombe, 1984, 5-Hydroxytryptamine (5-HT)-dependent myoclonus in guinea pig is induced through brainstem 5-HT1 receptors, Neurosci. Lett., 44, 241, 10.1016/0304-3940(84)90029-6

Lynch, 1978, Anatomical and functional aspects of the septo-hippocampal projections, 5

Marcinkiewicz, 1984, Autoradiographic evidence for the heterogeneity of 5-HT1 sites in the rat brain, Brain Research, 291, 159, 10.1016/0006-8993(84)90664-4

Martin, 1982, Comparison of the pharmacological characteristics of 5-HT1 and 5-HT2 binding sites with those of serotonin autoreceptors which modulate serotonin release, Naunyn-Schmiedeberg's Arch. Pharmacol., 321, 165, 10.1007/BF00505480

Meibach, 1982, A detailed protocol for the in vitro radio-autographic visualization of serotonergic receptors, J. Histochem. Cytochem., 30, 831, 10.1177/30.8.7119426

Meibach, 1980, Characterization and radoiautography of [3H]LSD binding by rat brain slices in vitro: the effect of 5-hydroxytryptamine, Eur. J. Pharmacol., 67, 371, 10.1016/0014-2999(80)90178-8

Meltzer, 1983, Effects of pirenperone and ketanserin on rat prolactin secretion in vivo and in vitro, Eur. J. Pharmacol., 92, 83, 10.1016/0014-2999(83)90111-5

Meltzer, 1982, Effect of serotonin precursors and serotonin agonists on plasma hormone levels, Adv. Biol. Psychiatr., 34, 117

Middlemiss, 1984, 8-Hydroxy-2-(di-n-propylamino)tetralin is devoid of activity at the 5-hydroxytryptamine autoreceptor in rat brain. Implication for the proposed link between the autoreceptor and the [3H]5-HT recognition site, Naunyn-Schmiedeberg's Arch. Pharmacol., 327, 18, 10.1007/BF00504986

Middlemiss, 1984, Stereoselective blockade at [3H]5-HT binding sites and at the 5-HT autoreceptor by propranolol, Eur. J. Pharmacol., 101, 289, 10.1016/0014-2999(84)90173-0

Middlemiss, 1977, Direct evidence for an interaction of β-adrenergic blockers with the 5-HT receptor, Nature (London), 267, 289, 10.1038/267289a0

Middlemiss, 1983, 8-Hydroxy-2-(di-n-propylamino)tetralin discriminates between subtypes of the 5-HT1 recognition site, Eur. J. Pharmacol., 90, 151, 10.1016/0014-2999(83)90230-3

Mikuni, 1984, Reduction of serotonin-2 receptors in rat cerebral cortex after subchronic administration of imipramine, chlorpromazine and the combination thereof, Life Sci., 34, 87, 10.1016/0024-3205(84)90334-5

Moskowitz, 1979, Raphéorigin of serotonin-containing neurons within choroid plexus of the rat, Brain Research, 169, 590, 10.1016/0006-8993(79)90410-4

Mounsey, 1982, K+-evoked [3H]5-HT release from rat frontal cortex slices: the effect of 5-HT agonists and antagonists, Biochem. Pharmacol., 31, 49, 10.1016/0006-2952(82)90234-9

Müller-Schweinitzer, 1983, Evidence for mediation by 5-HT2 receptors of 5-hydroxytryptamine-induced contraction of canine basilar artery, Naunyn-Schmiedeberg's Arch. Pharmacol., 324, 287, 10.1007/BF00502625

Nahorski, 1983, Interactions of β-adrenoceptor antagonists with 5-hydroxytryptamine receptor subtypes in rat cerebral cortex, Br. J. Pharmacol., 78, 107

Napoleone, 1982, Indoleaminergic innervation of rat choroid plexus: a fluorescence histochemical study, Neurosci. Lett., 34, 143, 10.1016/0304-3940(82)90166-5

Nelson, 1980, Serotonin-sensitive adenylate cyclase and [3H]serotonin binding sites in the CNS of the rat. II. Respective regional and subcellular distributions and ontogenetic developments, Biochem. Pharmacol., 29, 2455, 10.1016/0006-2952(80)90349-4

Nelson, 1978, Characteristics of central 5-HT receptors and their adaptative changes following intracerebral 5,7-dihydroxytryptamine administration in the cat, Mol. Pharmacol., 14, 983

Nelson, 1980, Multiple types of serotonin receptors, 325

Nimgaonkar, 1983, Studies on the mechanisms by which clenbuterol, a β-adrenoceptor agonist, enhances 5-HT-mediated behaviour and increases metabolism of 5-HT in the brain of the rat, Neuropharmacology, 6, 739, 10.1016/0028-3908(83)90098-9

Oegren, 1982, Central serotonin neurons and learning in the rat, 317

Ortmann, 1982, Correlations between different measures of antiserotonin activity of drugs. Study with neuroleptics and serotonin receptor blockers, Naunyn-Schmiedeberg's Arch. Pharmacol., 321, 265, 10.1007/BF00498511

Ortmann, 1981, Interaction of β-adrenoceptor agonists with the serotonergic system in rat brain, Naunyn-Schmiedeberg's Arch. Pharmacol., 316, 225, 10.1007/BF00505653

Palacios, 1983, Quantitative receptor autoradiography: application to the study of multiple serotonin receptors in rat cortex, 455

Palacios, 1982, Beta adrenergic receptor localization in rat brain by light microscopic autoradiography, Neurochem. Int., 4, 473, 10.1016/0197-0186(82)90036-5

Palacios, 1983, The distribution of serotonin receptors in the human brain: high density of [3H]LSD binding sites in the raphénuclei of the brainstem, Brain Res., 274, 150, 10.1016/0006-8993(83)90531-0

Palacios, 1981, The distribution of histamine H1-receptors in the rat brain: an autoradiographic study, Neuroscience, 6, 15, 10.1016/0306-4522(81)90240-2

Parent, 1981, Organization of ascending serotonin systems in the adult rat brain. A radioautographic study after intraventricular administration of3H-5-hydroxytryptamine, Neuroscience, 6, 115, 10.1016/0306-4522(81)90050-6

Paxinos, 1982

Pazos, 1984, Quantitative receptor autoradiography: application to the characterization of multiple receptor subtypes, J. Receptor Res., 4, 645, 10.3109/10799898409042578

Pazos, 1985, Quantitative autoradiographic mapping of serotonin receptors in the rat brain. II. Serotonin-2 receptors, Brain Research, 346, 231, 10.1016/0006-8993(85)90857-1

Pazos, 1984, The binding of serotoninergic ligand to the porcine choroid plexus: characterization of a new type of serotonin recognition site, Eur. J. Pharmacol., 106, 539, 10.1016/0014-2999(84)90057-8

Pazos, 1984, Mesulergine, a selective serotonin-2 ligand in the rat cortex, does not label these receptors in porcine in human cortex: evidences for species differences on brain serotonin-2 receptors, Eur. J. Pharmacol., 106, 531, 10.1016/0014-2999(84)90056-6

Pedigo, 1981, Discrimination of multiple [3H]5-hydroxytryptamine binding sites by the neuroleptic spiperone in rat brain, J. Neurochem., 36, 220, 10.1111/j.1471-4159.1981.tb02397.x

Peroutka, 1984, 5-HT1 receptor sites and functional correlates, Neuropharmacology, 23, 1487, 10.1016/0028-3908(84)90092-3

Peroutka, 1981, Two distinct central serotonin receptors with different physiological functions, Science, 212, 827, 10.1126/science.7221567

Peroutka, 1983, Serotonin-induced contraction of canine basilar artery mediation by 5-HT1 receptors, Brain Res., 259, 327, 10.1016/0006-8993(83)91268-4

Peroutka, 1979, Multiple serotonin receptors: differential binding of [3H]5-hydroxytryptamine, [3H]lysergic acid diethylamide and [3H]spiroperidol, Mol. Pharmacol., 16, 687

Peroutka, 1981, Two distinct serotonin receptors: regional variations in receptor binding in mammalian brain, Brain Research, 208, 339, 10.1016/0006-8993(81)90562-X

Quik, 1983, Selective destruction of the serotonergic fibers of the fornix-fimbria and cingulum bundle increases 5-HT1 but not 5-HT2 receptors in rat midbrain, Eur. J. Pharmacol., 90, 377, 10.1016/0014-2999(83)90559-9

Raskin, 1981, Pharmacology of migraine, Annu. Rev. Pharmacol. Toxicol., 21, 463, 10.1146/annurev.pa.21.040181.002335

Reynolds, 1984, Reduced binding of3H-ketanserin to cortical 5-HT2 receptors in senile dementia of the Alzheimer type, Neurosci. Lett., 44, 47, 10.1016/0304-3940(84)90219-2

Richards, 1980, Supraependymal nerve fibres in human brain: correlative transmission and scanning electron microscopical and fluorescence histochemical studies, Neuroscience, 5, 1489, 10.1016/0306-4522(80)90011-1

Rogawski, 1981, Serotonin autoreceptors on dorsal raphéneurons: structure-activity relationships of tryptamine analogues, J. Neurosci., 1, 1148, 10.1523/JNEUROSCI.01-10-01148.1981

Saavedra, 1977, Distribution of serotonin and synthesizing enzymes in discrete areas of the brain, 36, 2134

Salis, 1971, p-Chlorophenylalanine facilitates copulatory behaviour in male rats, Nature (London), 232, 400, 10.1038/232400a0

Samanin, 1978, Evidence of an interaction between serotoninergic and cholinergic neurons in the corpus striatum and hippocampus of the rat brain, Brain Research, 151, 73, 10.1016/0006-8993(78)90951-4

Sanides, 1979, Identification of the projection from the visual cortex to the claustrum by anterograde axonal transport in the cat, Exp. Brain Res., 34, 197, 10.1007/BF00238353

Scalia, 1979, Topographic organization of the projections of the retina to the pretectal region in the rat, J. Comp. Neurol., 186, 271, 10.1002/cne.901860210

Schmauss, 1983, Pharmacological antagonism of the antinociceptive effects of serotonin in the rat spinal cord, Eur. J. Pharmacol., 90, 349, 10.1016/0014-2999(83)90556-3

Steinbush, 1981, Distribution of serotonin-immunoreactivity in the central nervous system of the rat — Cell bodies and terminals, Neuroscience, 6, 557, 10.1016/0306-4522(81)90146-9

Stolz, 1983, Effect of chronic antidepressant treatment and subsequent withdrawal on3H-5-hydroxytryptamine and3H-spiperone binding in rat frontal cortex and serotonin receptor mediated behaviour, Psychopharmacology, 80, 150, 10.1007/BF00427959

Suzman, 1981, Use of β-adrenergic receptor blocking agents in psychiatry, 339

Svensson, 1983, Enhancement by the putative 5-HT receptor agonist 8-OH-2-(di-n-propylamino)tetralin of the acoustic startle response in the rat, Psychopharamcology, 79, 104, 10.1007/BF00427793

Toga, 1981, Metabolic response of optic centers to visual stimuli in the albino rat: anatomical and physiological considerations, J. Comp. Neurol., 199, 443, 10.1002/cne.901990402

Tricklebank, 1984, Behavioural effects of 8-hydroxy-2-(di-n-propylamino)tetralin, a putative 5-HT1A receptor agonist, Br. J. Pharmacol., 81, C46

Tricklebank, 1984, Is hyperlocomotion induced by the 5-HT1 agonist, 5-methoxy-3(1,2,3,6-tetrahydropyridin-4-yl)1H-indole (RU-24 969)?, Br. J. Pharmacol., 81, P88

Trulson, 1976, Behavioural evidence for supersensitivity following destruction of central serotonergic nerve terminals by 5,7-dihydroxytryptamine, J. Pharmacol. Exp. Ther., 198, 23

Unnerstall, 1982, Quantitative receptor autoradiography using [3H]Ultrofilm: application to multiple benzodiazepine receptors, J. Neurosci. Meth., 6, 59, 10.1016/0165-0270(82)90016-4

Weber, 1972, The treatment of migraine with propranolol, Neurology, 22, 366, 10.1212/WNL.22.4.366

Weingartner, 1983, Effects of serotonin on memory impairments produced by ethanol, Science, 221, 472, 10.1126/science.6223371

Weinstock, 1980, Behavioral effects of β-adrenoceptor antagonists associated with blockade of central serotoninergic system, 431

Wurtz, 1980, Visual-motor function of the primate superior colliculus, Ann. Rev. Neurosci., 3, 189, 10.1146/annurev.ne.03.030180.001201

Yap, 1983, Involvement of 5-HT2 receptors in the wet-dog shake behaviour induced by 5-hydroxytryptophan in the rat, Neuropharmacology, 22, 801, 10.1016/0028-3908(83)90123-5

York, 1978, Alterations in morphine analgesia produced by chronic deficits of brain catecholamines or serotonin: role of analgesimetric procedure, Psychopharmacology, 56, 119, 10.1007/BF00431836

Yorkston, 1977, Propranolol as an adjunct to the treatment of schizophrenia, Lancet, ii, 575, 10.1016/S0140-6736(77)91427-1

Young, 1980, Serotonin receptor localization in rat brain by light microscopic autoradiography, Eur. J. Pharmacol., 62, 237, 10.1016/0014-2999(80)90284-8

Zemlan, 1983, Spinal serotonin (5-HT) receptor subtypes and nociception, J. Pharmacol. Exp. Ther., 226, 477