Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

Webb, 1963, Vol. 1, 55

Dixon, 1979, Enzymes, 332

Cleland, 1963, The kinetics of enzyme catalyzed reactions with two or more substrates or products, Biochim. Biophys. Acta, 67, 173, 10.1016/0926-6569(63)90226-8

Segel, 1975, Multiple inhibition analysis, 465

Chou, 1974, Relationships between inhibition constants and fractional inhibition in enzyme-catalyzed reactions with different numbers of reactants, different reaction mechanisms, and different types and mechanisms of inhibition, Mol. Pharmacol., 10, 235

Chou, 1976, Derivation and properties of Michaelis-Menten type and Hill type equations for reference ligands, J. Theor. Biol., 59, 253, 10.1016/0022-5193(76)90169-7

Chou, 1977, On the determination of availability of ligand binding sites in steady-state systems, J. Theor. Biol., 65, 345, 10.1016/0022-5193(77)90329-0

Chou, 1977, A simple generalized equation for the analysis of multiple inhibitions of Michaelis-Menten kinetic systems, J. Biol. Chem., 252, 6438, 10.1016/S0021-9258(17)39978-7

Finney, 1952, Probit Analysis, 146

Bliss, 1967

Reed, 1929, The application of the logistic function to experimental data, J. Physical Chem., 33, 760, 10.1021/j150299a014

Nordling, 1953, A new theory of the cancer-inducing mechanism, Brit. J. Cancer, 7, 68, 10.1038/bjc.1953.8

Chou, 1983, Analysis of combined drug effects: A new look at a very old problem, Trends in Pharmacol. Sci., 4, 450, 10.1016/0165-6147(83)90490-X

Michaelis, 1913, Die Kinetik der Invertinwirkung, Biochem. Z., 49, 333

Hill, 1913, The combinations of hemoglobin with oxygen and with carbon monoxide, Biochem. J., 7, 471, 10.1042/bj0070471

Langmuir, 1918, The adsorption of gases on plane surfaces of glass, mica and platinum, J. Am. Chem. Soc., 40, 1361, 10.1021/ja02242a004

Clark, 1928

Catchard, 1949, The attractions of proteins for small molecules and ions, Ann., N.Y. Acad. Sci., 51, 660, 10.1111/j.1749-6632.1949.tb27297.x

Tallarida, 1979

Chou, 1975, Metabolism and selective effects of 1-β-d-arabinofuranosylcytosine in L1210 and host tissues in vivo, Cancer Res, 35, 225

Kremer, 1980, The active site of transketolase: Two arginine residues are essential for activity, J. Biol. Chem., 255, 2405, 10.1016/S0021-9258(19)85906-9

Bounias, 1980, Correlations between glucose-inhibition and control parameters of α-glucosidase kinetics in Apis mellifica haemolymph, Experienta, 36, 157, 10.1007/BF01953704

Finotti, 1981, Canrenome as a partial agonist at the digitalis receptor site of sodium-potassium-activated adenosine triphosphatase, J. Pharmacol. Exptl. Therap., 217, 784

Hata, 1981, Purification and properties of γ-glutamyl transpeptidase from bovine parotid gland, Int. J. Biochem., 13, 681, 10.1016/0020-711X(81)90036-7

Bounias, 1982, Kinetic study of the inhibition of the honeybee haemolymph α-glucosidase in vitro by BAYe 4609, BAYg 5421 and BAYn 5595, Biochem. Pharmacol., 31, 2769, 10.1016/0006-2952(82)90131-9

Steckel, 1983, Kinetic properties and inhibition of Acinetobacter glutaminase-asparaginase, Biochem. Pharmacol., 32, 971, 10.1016/0006-2952(83)90613-5

Friedman, 1980, Membrane-active drugs potentiate the killing of tumor cells by d-glucosamine, 77, 1172

Rosenberg, 1981, A kinetic analysis of l-tryptophan transport in human red blood cells, Biochim. Biophys. Acta, 649, 262, 10.1016/0005-2736(81)90414-4

Chou, 1975, A general procedure for determination of median-effect doses by a double logarithmic transformation of dose-response relationships, 34, 228

Chou, 1980, Comparison of dose-effect relationships of carcinogens following low-dose chronic exposure and high-dose single injection: An analysis by the median-effect principle, Carcinogenesis, 1, 203, 10.1093/carcin/1.3.203

Chou, 1981, Carcinogenic risk assessment by a mass-action law principle: Application to large scale chronic feeding experiment with 2-acetylaminofluorene (2-AAF), 22, 141

Teller, 1982, Therapy of DMBA-induced rat mammary carcinomas with combinations of 5-fluorouracil and 2α-methyldihydrotestosterone propionate, Cancer Res., 42, 4408

Murphy, 1982, Heterogeneity of adenosine A1 receptor binding in brain tissue, Mol. Pharmacol., 22, 250

Vauquelin, 1982, Agonist-mediated conformational changes of muscarinic receptors in rat brain, Europ. J. Biochem., 125, 117, 10.1111/j.1432-1033.1982.tb06658.x

Viswanathan, 1981, Effects of 1-arylpyrroles and naphthoflavones upon cytochrome P-450 dependent monooxygenase activities, J. Med. Chem., 24, 822, 10.1021/jm00139a011

Smith, 1982, A model of labelled-ligand displacement assay resulting in logit-log relationships, J. Theor. Biol., 98, 475, 10.1016/0022-5193(82)90132-1

Chou, 1983, Computer simulation of drug effects: Quantitation of synergism, summation and antagonism of multiple drugs, Pharmacologist, 25, 175

Goldin, 1957, The employment of combinations of drugs in the chemotherapy of neoplasia: A review, Cancer Res., 17, 635

Berenbaum, 1977, Synergy, additivism and antagonism in immunosuppression: A critical review, Clin. Exptl. Immunol., 28, 1

Loewe, 1928, Die quantitation probleme der pharmakologie, Ergebn. Physiol., 27, 47, 10.1007/BF02322290

Loewe, 1953, The problem of synergism and antagonism of combined drugs, Arzeimittelforsch., 3, 285

Webb, 1963, Effect of more than one inhibitor, Vol. 1, 66

Webb, 1963, Effect of more than one inhibitor, Vol. 1, 488

Veldstra, 1956, Synergism and potentiation with special reference to the combination of structural analogues, Pharmacol. Rev., 8, 339

Lacey, 1958, Mechanisms of chemotherapeutic synergy, 247

Goodman, 1964, The problem of drug efficacy: An exercise in dissection, 49

Venditti, 1964, Drug synergism in anti-neoplastic chemotherapy, Vol. 1, 397

Sartorelli, 1965, Approaches to the combination chemotherapy of transplantable neoplasms, Vol. 6, 229

Goldin, 1968, Evaluation of combination chemotherapy with three drugs, Cancer Res., 28, 950

Skipper, 1974, Combination therapy: Some concepts and results, Cancer Chemother. Rep., 5, 137

Schabel, 1975, Synergism and antagonism among antitumor agents, 595

Grindey, 1975, Approaches to the rational combination of antimetabolites for cancer chemotherapy, Vol. 5, 169

Johnson, 1945, The nature and control of reactions in bioluminescence, J. Gen. Physiol., 28, 463, 10.1085/jgp.28.5.463

Yagi, 1960, Complex formation of apo-enzyme, coenzyme and substrate of d-amino acid oxidase, Biochim. Biophys. Acta, 42, 381, 10.1016/0006-3002(60)90815-5

Ariens, 1961, Analysis of the action of drugs and drug combinations, 286

Ariens, 1961, Analysis of the action of drugs and drug combinations, 318

Yonetani, 1964, Studies on liver alcohol dehydrogenase complexes, 106, 243

Keleti, 1971, The system of double inhibitions, Math. Biosci., 12, 197, 10.1016/0025-5564(71)90016-2

Fajszi, 1974, Methods of analysis of double inhibitor experiments, 18, 77

Northrop, 1974, The kinetics of pig heart triphosphopyridine nucleotide-isocitrate dehydrogenase, J. Biol. Chem., 249, 2928, 10.1016/S0021-9258(19)42720-8

Chou, 1981, Generalized equations for the analysis of inhibitions of Michaelis-Menten and higher-order kinetic systems with two or more mutually exclusive and nonexclusive inhibitors, Europ. J. Biochem., 115, 207, 10.1111/j.1432-1033.1981.tb06218.x

Le Pelley, 1936, Toxicity of rotenone and pyrethrins alone and in combination, J. Econom. Entomol., 29, 791, 10.1093/jee/29.4.791