Pursuing novel molecular mechanisms and treatment strategies to enhance lung growth in neonatal chronic lung disease (CLD)

Miguel A Alejandre Alcazar1,2, Mark Kaschwich2, Stefanie Preuss2, Robert Ertsey2, Sana Mujahid2, Eva Rother1, Katharina Dinger1, Jörg Dötsch1, Marlene Rabinovitch2, Richard Bland2
1Department of Pediatrics and Adolescent Medicine, University of Cologne, Germany
2Department of Pediatrics, Cardiovascular Institute, Stanford University, Stanford, USA

Tóm tắt

Từ khóa


Tài liệu tham khảo

Hilgendorff A, Parai K, Ertsey R, Navarro EF, Jain N, Carandang F, et al.: Lung matrix and vascular remodeling in mechanically ventilated elastin haplo-insufficient (Eln+/-) newborn mice. Am J Physiol Lung Cell Mol Physiol 2014,308(5):L464-L478. Alejandre-Alcázar MA, Michiels-Corsten M, Vicencio AG, Reiss I, Ryu J, de Krijger RR, et al.: TGF-beta signaling is dynamically regulated during the alveolarization of rodent and human lungs. Dev Dyn 2008,237(1):259–269. 10.1002/dvdy.21403 Alejandre Alcázar MA, Kwapiszewska G, Reiss I, Amarie OV, Marsh LM, Sevilla-Pérez J, et al.: Hyperoxia modulates TGF-β/BMP signaling in the neonatal lung: implications for the pathogenesis of bronchopulmonary dysplasia. Am J Physiol Lung Cell Mol Physiol 2007,292(2):L537-L549. Alejandre Alcázar MA, Morty RE, Lendzian L, Vohlen C, Oestreicher I, Plank C, et al.: Inhibition of TGF-β Signaling and Decreased Apoptosis in IUGR-Associated Lung Disease in Rats. PLoS One 2011,6(10):e26371.. 10.1371/journal.pone.0026371 Alejandre Alcázar MA, Östreicher I, Appel S, Rother E, Vohlen C, Plank C, Dötsch J: Developmental regulation of Stat3-mediated inflammation: the missing link between intrauterine growth restriction and pulmonary dysfunction? J Mol Med 2012,90(8):945–957. 10.1007/s00109-012-0860-9 Alejandre Alcázar MA, Dinger K, Vohlen C, Rother E, Plank C, Dötsch J: Prevention of postnatal hyperalimentation protects against disrupted TGF-β and IL-6 signaling in Lungs after IUGR. J Nutr 2014.