Pulsatility of growth hormone (GH) signalling in liver cells: Role of the JAK-STAT5b pathway in GH action

Isaksson, 1985, Mode of action of pituitary growth hormone on target cells, Annu Rev Physiol, 47, 483, 10.1146/annurev.ph.47.030185.002411

Jansson, 1985, Sexual dimorphism in the control of growth hormone secretion, Endocr Rev, 6, 128, 10.1210/edrv-6-2-128

Waxman, 1988, Interactions of hepatic cytochromes P-450 with steroid hormones. Regioselectivity and stereospecificity of steroid metabolism and hormonal regulation of rat P-450 enzyme expression, Biochem Pharmacol, 37, 71, 10.1016/0006-2952(88)90756-3

Waxman, 1992, Regulation of liver-specific steroid metabolizing cytochromes P450: cholesterol 7 alpha-hydroxylase, bile acid 6beta-hydroxylase, and growth hormone-responsive steroid hormone hydroxylases, J Steroid Biochem Molec Biol, 43, 1055, 10.1016/0960-0760(92)90333-E

Mode, 1992, Growth hormone regulation of hepatic cytochrome P450 expression in the rat, Adv Enzyme Regul, 32, 255, 10.1016/0065-2571(92)90021-Q

Veldhuis, 1996, Gender differences in secretory activity of the human somatotropic (growth hormone) axis, Eur J Endocrinol, 134, 287, 10.1530/eje.0.1340287

Eden, 1979, Age- and sex-related differences in episodic growth hormone secretion in the rat, Endocrinology, 105, 555, 10.1210/endo-105-2-555

Tannenbaum, 1976, Evidence for an endogenous ultradian rhythm governing growth hormone secretion in the rat, Endocrinology, 98, 562, 10.1210/endo-98-3-562

Sundseth, 1992, Sex-specific, growth hormone-regulated transcription of the cytochrome P450 2C11 and 2C12 genes, J Biol Chem, 267, 3907, 10.1016/S0021-9258(19)50612-3

Legraverend, 1992, Transcriptional regulation of rat P-450 2C gene subfamily members by the sexually dimorphic pattern of growth hormone secretion, Mol Endocrinol, 6, 259, 10.1210/me.6.2.259

Waxman, 1991, Interpulse interval in circulating growth hormone patterns regulates sexually dimorphic expression of hepatic cytochrome P450, 88, 6868

Waxman, 1984, Rat hepatic cytochrome P-450 isoenzyme 2c. Identification as a male-specific, developmentally induced steroid 16 alpha-hydroxylase and comparisonto a female-specific cytochrome P-450 isoenzyme, J Biol Chem, 259, 15481, 10.1016/S0021-9258(17)42574-9

Morgan, 1985, Hormonal and developmental regulation of expression of the hepatic microsomal steroid 16 alpha-hydroxylase cytochrome P-450 apoprotein in the rat, J Biol Chem, 260, 11895, 10.1016/S0021-9258(17)38963-9

MacGeoch, 1985, Hypothalamo-pituitary regulation of cytochrome P-450(15) beta apoprotein levels in rat liver, Endocrinology, 117, 2085, 10.1210/endo-117-5-2085

Waxman, 1985, Regulation of rat hepatic cytochrome P-450: age-dependent expression, hormonal imprinting, and xenobiotic inducibility of sex-specific isoenzymes, Biochemistry, 124, 4409, 10.1021/bi00337a023

Waxman, 1995, Intermittent plasma growth hormone triggers tyrosine phosphorylation and nuclear translocation of a liver-expressed, Stat 5-related DNA bindingprotein. Proposed role as an intracellular regulator of male-specific liver gene transcription, J Biol Chem, 270, 13262, 10.1074/jbc.270.22.13262

Moutoussamy, 1998, Growth-hormone-receptor and cytokine-receptor-family signaling, Eur J Biochem, 255, 1, 10.1046/j.1432-1327.1998.2550001.x

Cunningham, 1991, Dimerization of the extracellular domain of the human growth hormone receptor by a single hormone molecule, Science, 254, 821, 10.1126/science.1948064

Argetsinger, 1993, Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase, Cell, 74, 237, 10.1016/0092-8674(93)90415-M

Davey, 1999, STAT5 signalling in sexually dimorphic gene expression and growth patterns, Am J Hum Genet, 65, 959, 10.1086/302599

Ram, 1996, Growth hormone activation of Stat 1, Star 3, and Stat 5 in rat liver. Differential kinetics of hormone desensitization and growth hormonestimulation of both tyrosine phosphorylation and serine/threonine phosphorylation, J Biol Chem, 271, 5929, 10.1074/jbc.271.10.5929

Choi, 1999, GH, but not prolactin, maintains lowlevel activation of STAT5a and STAT5b in female rat liver, Endocrinology, 140, 5126, 10.1210/en.140.11.5126

Hansen, 1997, The role of GH receptor tyrosine phosphorylation in Stat5 activation, J Mol Endocrinol, 18, 213, 10.1677/jme.0.0180213

Yi, 1996, Growth hormone receptor cytoplasmic domain differentially promotes tyrosine phosphorylation of STAT5b and STAT3 by activated JAK2 kinase, Mol Endocrinol, 10, 1425, 10.1210/me.10.11.1425

Yamashita, 1998, Differential control of the phosphorylation state of prolinejuxtaposed serine residues Ser725 of Stat5a and Ser730 of Stat5b in prolactin-sensitivecells, J Biol Chem, 273, 30218, 10.1074/jbc.273.46.30218

Gebert, 1997, Regulation of signal transducer and activator of transcription (STAT) 5b activation by the temporal pattern of growth hormone stimulation, Mol Endocrinol, 11, 400, 10.1210/me.11.4.400

Ram, 1997, Interaction of growth hormone-activated STATs with SH2-containing phosphotyrosine phosphatase SHP-1 and nuclear JAK2 tyrosine kinase, J Biol Chem, 272, 17694, 10.1074/jbc.272.28.17694

Bergad, 1995, Growth hormone induction of hepatic serine protease inhibitor 2.1 transcription is mediated by a Stat5-related factor binding synergistically to two gamma-activated sites, J Biol Chem, 270, 24903, 10.1074/jbc.270.42.24903

Ganguly, 1997, Regulation of the rat liver sodium-dependent bile acid cotransporter gene by prolactin. Mediation of transcriptional activation by Stat5, J Clin Invest, 99, 2906, 10.1172/JCI119485

Subramanian, 1998, STAT5 and NF-Y are involved in expression and growth hormone-mediated sexually dimorphic regulation of cytochrome P450 3A10/lithocholic acid 6beta-hydroxylase, Nucleic Acids Res, 26, 2173, 10.1093/nar/26.9.2173

Choi, 2000, Plasma growth hormone pulse activation of hepatic JAK-STAT5 signaling: developmental regulation and role in male-specific liver gene expression, Endocrinology, 10.1210/en.141.9.3245

Udy, 1997, Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression, 94, 7239

Park, 1999, Distinctive roles of STAT5a and STAT5b in sexual dimorphism of hepatic P450 gene expression. Impact of Stat5a gene disruption, J Biol Chem, 274, 7421, 10.1074/jbc.274.11.7421

Norstedt, 1984, Secretory rhythm of growth hormone regulates sexual differentiation of mouse liver, Cell, 36, 805, 10.1016/0092-8674(84)90030-8

Noshiro, 1986, Pretranslational regulation of sexdependent testosterone hydroxylases by growth hormone in mouse liver, J Biol Chem, 261, 15923, 10.1016/S0021-9258(18)66653-0

Mui, 1995, Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs, EMBO J, 14, 1166, 10.1002/j.1460-2075.1995.tb07100.x

Liu, 1995, Cloning and expression of Star 5 and an additional homologue (Stat 5b) involved in prolactin signal transduction in mouse mammary tissue, 92, 8831

Davey, 1999, STAT5b-deficient mice are growth hormone pulse-resistant: role of STAT5b in sex-specific liver P450 expression, J Biol Chem, 274, 35331, 10.1074/jbc.274.50.35331

Kempe, 1995, Responsiveness of an SV40immortalized hepatocyte cell line to growth hormone, Biochem Pharmacol, 49, 1091, 10.1016/0006-2952(95)98506-5

Gebert, 1999, Termination of growth hormone pulse-induced STAT5b signaling, Mol Endocrinol, 13, 38, 10.1210/me.13.1.38

Gebert, 1999, Down-regulation of liver JAK2-STAT5b signaling by the female pattern of continuous GH stimulation, Mol Endocrinol, 13, 213, 10.1210/me.13.2.213

Endo, 1997, A new protein containing an SH2 domain that inhibits JAK kinases, Nature, 387, 921, 10.1038/43213

Naka, 1997, Structure and function of a new STAT induced STAT inhibitor, Nature, 387, 924, 10.1038/43219

Starr, 1997, A family of cytokineinducible inhibitors of signalling, Nature, 387, 917, 10.1038/43206

Ram, 1999, SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms, J Biol Chem, 274, 35553, 10.1074/jbc.274.50.35553

Yasukawa, 1999, The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop, EMBO J, 18, 1309, 10.1093/emboj/18.5.1309

Lobie, 1995, Requirement of tyrosine residues 333 and 338 of the growth hormone (GH) receptor for selected GH-stimulated function, J Biol Chem, 270, 21745, 10.1074/jbc.270.37.21745

Smit, 1997, Growth hormone-induced tyrosyl phosphorylation and deoxyribonucleic acid binding activity of Stat5A and Stat5B, Endocrinology, 138, 3426, 10.1210/en.138.8.3426

Wang, 1996, Identification of growth hormone receptor (GHR) tyrosine residues required for GHR phosphorylation and JAK2 and STAT5 activation, Mol Endocrinol, 10, 1249, 10.1210/me.10.10.1249

Matsumoto, 1999, Suppression of STAT5 functions in liver, mammary glands, and T cells in cytokineinducible SH2-containing protein 1 transgenic mice, Mol Cell Biol, 19, 6396, 10.1128/MCB.19.9.6396

Waxman, 2000, Growth hormone pulse-activated STAT5 signalling: a unique regulatory mechanism governing sexual dimorphism of liver gene expression, 227, 61