Psychosocial treatment and interventions for bipolar disorder: a systematic review

Springer Science and Business Media LLC - Tập 14 - Trang 1-11 - 2015
Stella Miziou1, Eirini Tsitsipa1, Stefania Moysidou1, Vangelis Karavelas2, Dimos Dimelis2, Vagia Polyzoidou3, Konstantinos N Fountoulakis2
1Aristotle University of Thessaloniki, Thessaloníki, Greece
2Division of Neurosciences, 3rd Department of Psychiatry, School of Medicine, Aristotle University of Thessaloniki, Thessaloníki, Greece
3Thessaloníki, Greece

Tóm tắt

Bipolar disorder (BD) is a chronic disorder with a high relapse rate, significant general disability and burden and with a psychosocial impairment that often persists despite pharmacotherapy. This indicates the need for effective and affordable adjunctive psychosocial interventions, tailored to the individual patient. Several psychotherapeutic techniques have tried to fill this gap, but which intervention is suitable for each patient remains unknown and it depends on the phase of the illness. The papers were located with searches in PubMed/MEDLINE through May 1st 2015 with a combination of key words. The review followed the recommendations of the Preferred Items for Reporting of Systematic Reviews and Meta-Analyses statement. The search returned 7,332 papers; after the deletion of duplicates, 6,124 remained and eventually 78 were included for the analysis. The literature supports the usefulness only of psychoeducation for the relapse prevention of mood episodes and only in a selected subgroup of patients at an early stage of the disease who have very good, if not complete remission, of the acute episode. Cognitive-behavioural therapy and interpersonal and social rhythms therapy could have some beneficial effect during the acute phase, but more data are needed. Mindfulness interventions could only decrease anxiety, while interventions to improve neurocognition seem to be rather ineffective. Family intervention seems to have benefits mainly for caregivers, but it is uncertain whether they have an effect on patient outcomes. The current review suggests that the literature supports the usefulness only of specific psychosocial interventions targeting specific aspects of BD in selected subgroups of patients.

Tài liệu tham khảo

Fountoulakis KN, Kasper S, Andreassen O, Blier P, Okasha A, Severus E et al (2012) Efficacy of pharmacotherapy in bipolar disorder: a report by the WPA section on pharmacopsychiatry. Eur Arch Psychiatry Clin Neurosci 262(Suppl 1):1–48

Grunze H, Vieta E, Goodwin GM, Bowden C, Licht RW, Moller HJ et al (2013) The World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for the biological treatment of bipolar disorders: update 2012 on the long-term treatment of bipolar disorder. World J Biol Psychiatry 14(3):154–219

Murray CJ, Vos T, Lozano R, Naghavi M, Flaxman AD, Michaud C et al (2012) Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 380(9859):2197–2223

Rosa AR, Reinares M, Michalak EE, Bonnin CM, Sole B, Franco C et al (2010) Functional impairment and disability across mood states in bipolar disorder. Value Health 13(8):984–988

Tohen M, Hennen J, Zarate CM Jr, Baldessarini RJ, Strakowski SM, Stoll AL et al (2000) Two-year syndromal and functional recovery in 219 cases of first-episode major affective disorder with psychotic features. Am J Psychiatry 157(2):220–228

Rosa AR, Reinares M, Amann B, Popovic D, Franco C, Comes M et al (2011) Six-month functional outcome of a bipolar disorder cohort in the context of a specialized-care program. Bipolar Disord 13(7–8):679–686

Reinares M, Papachristou E, Harvey P, Mar BC, Sanchez-Moreno J, Torrent C et al (2013) Towards a clinical staging for bipolar disorder: defining patient subtypes based on functional outcome. J Affect Disord 144(1–2):65–71

Catala-Lopez F, Genova-Maleras R, Vieta E, Tabares-Seisdedos R (2013) The increasing burden of mental and neurological disorders. Eur Neuropsychopharmacol 23(11):1337–1339

De DC, Ezquiaga E, Agud JL, Vieta E, Soler B, Garcia-Lopez A (2012) Subthreshold symptoms and time to relapse/recurrence in a community cohort of bipolar disorder outpatients. J Affect Disord 143(1–3):160–165

Berk L, Hallam KT, Colom F, Vieta E, Hasty M, Macneil C et al (2010) Enhancing medication adherence in patients with bipolar disorder. Hum Psychopharmacol 25(1):1–16

Fountoulakis K (2015) Bipolar disorder: an evidence-based guide to manic depression. Springer, New York

Geddes JR, Miklowitz DJ (2013) Treatment of bipolar disorder. Lancet 381(9878):1672–1682

Scott J, Paykel E, Morriss R, Bentall R, Kinderman P, Johnson T et al (2006) Cognitive-behavioural therapy for severe and recurrent bipolar disorders: randomised controlled trial. Br J Psychiatry 188:313–320

Miller IW, Solomon DA, Ryan CE, Keitner GI (2004) Does adjunctive family therapy enhance recovery from bipolar I mood episodes? J Affect Disord 82(3):431–436

Meyer TD, Hautzinger M (2012) Cognitive behaviour therapy and supportive therapy for bipolar disorders: relapse rates for treatment period and 2-year follow-up. Psychol Med 42(7):1429–1439

de Barros PK, de O Costa L, Silval KI, Dias VV, Roso MC, Bandeira M et al (2013) Efficacy of psychoeducation on symptomatic and functional recovery in bipolar disorder. Acta Psychiatr Scand 127(2):153–158

Gomes BC, Abreu LN, Brietzke E, Caetano SC, Kleinman A, Nery FG et al (2011) A randomized controlled trial of cognitive behavioral group therapy for bipolar disorder. Psychother Psychosom 80(3):144–150

Reinares M, Sanchez-Moreno J, Fountoulakis KN (2014) Psychosocial interventions in bipolar disorder: what, for whom, and when. J Affect Disord 156:46–55

Fountoulakis KN, Siamouli M (2009) Re: how well do psychosocial interventions work in bipolar disorder? Can J Psychiatry (Revue canadienne de psychiatrie) 54(8):578

Moher D, Liberati A, Tetzlaff J, Altman DG (2010) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Int J Surg 8(5):336–341

Lam DH, Watkins ER, Hayward P, Bright J, Wright K, Kerr N et al (2003) A randomized controlled study of cognitive therapy for relapse prevention for bipolar affective disorder: outcome of the first year. Arch Gen Psychiatry 60(2):145–152

Lam DH, McCrone P, Wright K, Kerr N (2005) Cost-effectiveness of relapse-prevention cognitive therapy for bipolar disorder: 30-month study. Br J Psychiatry 186:500–506

Ball JR, Mitchell PB, Corry JC, Skillecorn A, Smith M, Malhi GS (2006) A randomized controlled trial of cognitive therapy for bipolar disorder: focus on long-term change. J Clin Psychiatry 67(2):277–286

Gonzalez IA, Echeburua E, Liminana JM, Gonzalez-Pinto A (2014) Psychoeducation and cognitive-behavioral therapy for patients with refractory bipolar disorder: a 5-year controlled clinical trial. Eur Psychiatry 29(3):134–141

Zaretsky A, Lancee W, Miller C, Harris A, Parikh SV (2008) Is cognitive-behavioural therapy more effective than psychoeducation in bipolar disorder? Can J Psychiatry 53(7):441–448

Costa RT, Cheniaux E, Rosaes PA, Carvalho MR, Freire RC, Versiani M et al (2011) The effectiveness of cognitive behavioral group therapy in treating bipolar disorder: a randomized controlled study. Rev Bras Psiquiatr 33(2):144–149

Gonzalez Isasi A, Echeburua E, Liminana JM, Gonzalez-Pinto A (2014) Psychoeducation and cognitive-behavioral therapy for patients with refractory bipolar disorder: a 5-year controlled clinical trial. Eur Psychiatry 29(3):134–141

Fracalanza K, McCabe RE, Taylor VH, Antony MM (2014) The effect of comorbid major depressive disorder or bipolar disorder on cognitive behavioral therapy for social anxiety disorder. J Affect Disord 162:61–66

Hollandare F, Eriksson A, Lovgren L, Humble MB, Boersma K (2015) Internet-based cognitive behavioral therapy for residual symptoms in bipolar disorder type II: a single-subject design pilot study. JMIR Res Protoc 4(2):e44

Jones SH, Smith G, Mulligan LD, Lobban F, Law H, Dunn G et al (2015) Recovery-focused cognitive-behavioural therapy for recent-onset bipolar disorder: randomised controlled pilot trial. Br J Psychiatry 206(1):58–66

Steinan MK, Krane-Gartiser K, Langsrud K, Sand T, Kallestad H, Morken G (2014) Cognitive behavioral therapy for insomnia in euthymic bipolar disorder: study protocol for a randomized controlled trial. Trials 15:24

Peet M, Harvey NS (1991) Lithium maintenance: 1. A standard education programme for patients. Br J Psychiatry 158:197–200

Harvey NS, Peet M (1991) Lithium maintenance: 2. Effects of personality and attitude on health information acquisition and compliance. Br J Psychiatry 158:200–204

Dogan S, Sabanciogullari S (2003) The effects of patient education in lithium therapy on quality of life and compliance. Arch Psychiatr Nurs 17(6):270–275

Perry A, Tarrier N, Morriss R, McCarthy E, Limb K (1999) Randomised controlled trial of efficacy of teaching patients with bipolar disorder to identify early symptoms of relapse and obtain treatment. BMJ 318(7177):149–153

Colom F, Vieta E, Sanchez-Moreno J, Palomino-Otiniano R, Reinares M, Goikolea JM et al (2009) Group psychoeducation for stabilised bipolar disorders: 5-year outcome of a randomised clinical trial. Br J Psychiatry 194(3):260–265

Colom F, Vieta E, Martinez-Aran A, Reinares M, Goikolea JM, Benabarre A et al (2003) A randomized trial on the efficacy of group psychoeducation in the prophylaxis of recurrences in bipolar patients whose disease is in remission. Arch Gen Psychiatry 60(4):402–407

Colom F, Vieta E, Reinares M, Martinez-Aran A, Torrent C, Goikolea JM et al (2003) Psychoeducation efficacy in bipolar disorders: beyond compliance enhancement. J Clin Psychiatry 64(9):1101–1105

Lobban F, Taylor L, Chandler C, Tyler E, Kinderman P, Kolamunnage-Dona R et al (2010) Enhanced relapse prevention for bipolar disorder by community mental health teams: cluster feasibility randomised trial. Br J Psychiatry 196(1):59–63

Colom F, Reinares M, Pacchiarotti I, Popovic D, Mazzarini L, Martinez AA et al (2010) Has number of previous episodes any effect on response to group psychoeducation in bipolar patients? Acta Neuropsychiatrica 22:50–53

Javadpour A, Hedayati A, Dehbozorgi GR, Azizi A (2013) The impact of a simple individual psycho-education program on quality of life, rate of relapse and medication adherence in bipolar disorder patients. Asian J Psychiatry 6(3):208–213

Kurdal E, Tanriverdi D, Savas HA (2014) The effect of psychoeducation on the functioning level of patients with bipolar disorder. West J Nurs Res 36(3):312–328

Scott J, Colom F, Popova E, Benabarre A, Cruz N, Valenti M et al (2009) Long-term mental health resource utilization and cost of care following group psychoeducation or unstructured group support for bipolar disorders: a cost–benefit analysis. J Clin Psychiatry 70(3):378–386

Parikh SV, Zaretsky A, Beaulieu S, Yatham LN, Young LT, Patelis-Siotis I et al (2012) A randomized controlled trial of psychoeducation or cognitive-behavioral therapy in bipolar disorder: a Canadian Network for Mood and Anxiety treatments (CANMAT) study [CME]. J Clin Psychiatry 73(6):803–810

Smith DJ, Griffiths E, Poole R, di Florio A, Barnes E, Kelly MJ et al (2011) Beating bipolar: exploratory trial of a novel Internet-based psychoeducational treatment for bipolar disorder. Bipolar Disord 13(5–6):571–577

Proudfoot J, Parker G, Manicavasagar V, Hadzi-Pavlovic D, Whitton A, Nicholas J et al (2012) Effects of adjunctive peer support on perceptions of illness control and understanding in an online psychoeducation program for bipolar disorder: a randomised controlled trial. J Affect Disord 142(1–3):98–105

Castle D, White C, Chamberlain J, Berk M, Berk L, Lauder S et al (2010) Group-based psychosocial intervention for bipolar disorder: randomised controlled trial. Br J Psychiatry 196(5):383–388

van der Voort TY, van Meijel B, Goossens PJ, Hoogendoorn AW, Draisma S, Beekman A et al (2015) Collaborative care for patients with bipolar disorder: randomised controlled trial. Br J Psychiatry 206(5):393–400

Fiorillo A, Del Vecchio V, Luciano M, Sampogna G, De Rosa C, Malangone C et al (2014) Efficacy of psychoeducational family intervention for bipolar I disorder: a controlled, multicentric, real-world study. J Affect Disord 172C:291–299

Bauer MS, McBride L, Williford WO, Glick H, Kinosian B, Altshuler L et al (2006) Collaborative care for bipolar disorder: part II. Impact on clinical outcome, function, and costs. Psychiatr Serv 57(7):937–945

Simon GE, Ludman EJ, Bauer MS, Unutzer J, Operskalski B (2006) Long-term effectiveness and cost of a systematic care program for bipolar disorder. Arch Gen Psychiatry 63(5):500–508

Eker F, Harkin S (2012) Effectiveness of six-week psychoeducation program on adherence of patients with bipolar affective disorder. J Affect Disord 138(3):409–416

Faria AD, de Mattos Souza LD, de Azevedo Cardoso T, Pinheiro KA, Pinheiro RT, da Silva RA et al (2014) The influence of psychoeducation on regulating biological rhythm in a sample of patients with bipolar II disorder: a randomized clinical trial. Psychol Res Behav Manag 7:167–174

de Cardoso TA, de Farias CA, Mondin TC, da Silva GDG, Souza LD, da Silva RA et al (2014) Brief psychoeducation for bipolar disorder: impact on quality of life in young adults in a 6-month follow-up of a randomized controlled trial. Psychiatry Res 220(3):896–902

Cuhadar D, Cam MO (2014) Effectiveness of psychoeducation in reducing internalized stigmatization in patients with bipolar disorder. Arch Psychiatr Nurs 28(1):62–66

Todd NJ, Jones SH, Hart A, Lobban FA (2014) A web-based self-management intervention for bipolar disorder ‘living with bipolar’: a feasibility randomised controlled trial. J Affect Disord 169:21–29

Barnes CW, Hadzi-Pavlovic D, Wilhelm K, Mitchell PB (2015) A web-based preventive intervention program for bipolar disorder: outcome of a 12-months randomized controlled trial. J Affect Disord 174:485–492

Depp CA, Ceglowski J, Wang VC, Yaghouti F, Mausbach BT, Thompson WK et al (2015) Augmenting psychoeducation with a mobile intervention for bipolar disorder: a randomized controlled trial. J Affect Disord 174:23–30

Bond K, Anderson IM (2015) Psychoeducation for relapse prevention in bipolar disorder: a systematic review of efficacy in randomized controlled trials. Bipolar Disord 17(4):349–362

Frank E, Kupfer DJ, Thase ME, Mallinger AG, Swartz HA, Fagiolini AM et al (2005) Two-year outcomes for interpersonal and social rhythm therapy in individuals with bipolar I disorder. Arch Gen Psychiatry 62(9):996–1004

Frank E, Soreca I, Swartz HA, Fagiolini AM, Mallinger AG, Thase ME et al (2008) The role of interpersonal and social rhythm therapy in improving occupational functioning in patients with bipolar I disorder. Am J Psychiatry 165(12):1559–1565

Swartz HA, Frank E, Cheng Y (2012) A randomized pilot study of psychotherapy and quetiapine for the acute treatment of bipolar II depression. Bipolar Disord 14(2):211–216

Inder ML, Crowe MT, Luty SE, Carter JD, Moor S, Frampton CM et al (2015) Randomized, controlled trial of Interpersonal and Social Rhythm Therapy for young people with bipolar disorder. Bipolar Disord 17(2):128–138

van Gent EM, Zwart FM (1991) Psychoeducation of partners of bipolar-manic patients. J Affect Disord 21(1):15–18

Miklowitz DJ, Simoneau TL, George EL, Richards JA, Kalbag A, Sachs-Ericsson N et al (2000) Family-focused treatment of bipolar disorder: 1-year effects of a psychoeducational program in conjunction with pharmacotherapy. Biol Psychiatry 48(6):582–592

Miklowitz DJ, George EL, Richards JA, Simoneau TL, Suddath RL (2003) A randomized study of family-focused psychoeducation and pharmacotherapy in the outpatient management of bipolar disorder. Arch Gen Psychiatry 60(9):904–912

Rea MM, Tompson MC, Miklowitz DJ, Goldstein MJ, Hwang S, Mintz J (2003) Family-focused treatment versus individual treatment for bipolar disorder: results of a randomized clinical trial. J Consult Clin Psychol 71(3):482–492

Scott J, Colom F, Pope M, Reinares M, Vieta E (2012) The prognostic role of perceived criticism, medication adherence and family knowledge in bipolar disorders. J Affect Disord 142(1–3):72–76

Clarkin JF, Carpenter D, Hull J, Wilner P, Glick I (1998) Effects of psychoeducational intervention for married patients with bipolar disorder and their spouses. Psychiatr Serv 49(4):531–533

Miller IW, Keitner GI, Ryan CE, Uebelacker LA, Johnson SL, Solomon DA (2008) Family treatment for bipolar disorder: family impairment by treatment interactions. J Clin Psychiatry 69(5):732–740

Solomon DA, Keitner GI, Ryan CE, Kelley J, Miller IW (2008) Preventing recurrence of bipolar I mood episodes and hospitalizations: family psychotherapy plus pharmacotherapy versus pharmacotherapy alone. Bipolar Disord 10(7):798–805

Reinares M, Colom F, Sanchez-Moreno J, Torrent C, Martinez-Aran A, Comes M et al (2008) Impact of caregiver group psychoeducation on the course and outcome of bipolar patients in remission: a randomized controlled trial. Bipolar Disord 10(4):511–519

Reinares M, Vieta E, Colom F, Martinez-Aran A, Torrent C, Comes M et al (2004) Impact of a psychoeducational family intervention on caregivers of stabilized bipolar patients. Psychother Psychosom 73(5):312–319

Madigan K, Egan P, Brennan D, Hill S, Maguire B, Horgan F et al (2012) A randomised controlled trial of carer-focussed multi-family group psychoeducation in bipolar disorder. Eur Psychiatry 27(4):281–284

Perlick DA, Miklowitz DJ, Lopez N, Chou J, Kalvin C, Adzhiashvili V et al (2010) Family-focused treatment for caregivers of patients with bipolar disorder. Bipolar Disord 12(6):627–637

D’Souza R, Piskulic D, Sundram S (2010) A brief dyadic group based psychoeducation program improves relapse rates in recently remitted bipolar disorder: a pilot randomised controlled trial. J Affect Disord 120(1–3):272–276

Fredman SJ, Baucom DH, Boeding SE, Miklowitz DJ (2015) Relatives’ emotional involvement moderates the effects of family therapy for bipolar disorder. J Consult Clin Psychol 83(1):81–91

Miklowitz DJ, Otto MW, Frank E, Reilly-Harrington NA, Wisniewski SR, Kogan JN et al (2007) Psychosocial treatments for bipolar depression: a 1-year randomized trial from the Systematic Treatment Enhancement Program. Arch Gen Psychiatry 64(4):419–426

Miklowitz DJ, Otto MW, Frank E, Reilly-Harrington NA, Kogan JN, Sachs GS et al (2007) Intensive psychosocial intervention enhances functioning in patients with bipolar depression: results from a 9-month randomized controlled trial. Am J Psychiatry 164(9):1340–1347

Deckersbach T, Nierenberg AA, Kessler R, Lund HG, Ametrano RM, Sachs G et al (2010) RESEARCH: cognitive rehabilitation for bipolar disorder: an open trial for employed patients with residual depressive symptoms. CNS Neurosci Ther 16(5):298–307

Martinez-Aran A, Torrent C, Sole B, Bonnin CM, Rosa AR, Sanchez-Moreno J et al (2011) Functional remediation for bipolar disorder. Clin Pract Epidemiol Ment Health 7:112–116

Torrent C, Bonnin CM, Martinez-Aran A, Valle J, Amann BL, Gonzalez-Pinto A et al (2013) Efficacy of functional remediation in bipolar disorder: a multicenter randomized controlled study. Am J Psychiatry 170(8):852–859

Lahera G, Benito A, Montes JM, Fernandez-Liria A, Olbert CM, Penn DL (2013) Social cognition and interaction training (SCIT) for outpatients with bipolar disorder. J Affect Disord 146(1):132–136

Sole B, Bonnin CM, Mayoral M, Amann BL, Torres I, Gonzalez-Pinto A et al (2015) Functional remediation for patients with bipolar II disorder: improvement of functioning and subsyndromal symptoms. Eur Neuropsychopharmacol 25(2):257–264

Williams JM, Alatiq Y, Crane C, Barnhofer T, Fennell MJ, Duggan DS et al (2008) Mindfulness-based cognitive therapy (MBCT) in bipolar disorder: preliminary evaluation of immediate effects on between-episode functioning. J Affect Disord 107(1–3):275–279

Ives-Deliperi VL, Howells F, Stein DJ, Meintjes EM, Horn N (2013) The effects of mindfulness-based cognitive therapy in patients with bipolar disorder: a controlled functional MRI investigation. J Affect Disord 150(3):1152–1157

Perich T, Manicavasagar V, Mitchell PB, Ball JR, Hadzi-Pavlovic D (2013) A randomized controlled trial of mindfulness-based cognitive therapy for bipolar disorder. Acta Psychiatr Scand 127(5):333–343

Perich T, Manicavasagar V, Mitchell PB, Ball JR (2013) The association between meditation practice and treatment outcome in mindfulness-based cognitive therapy for bipolar disorder. Behav Res Ther 51(7):338–343

Howells FM, Ives-Deliperi VL, Horn NR, Stein DJ (2012) Mindfulness based cognitive therapy improves frontal control in bipolar disorder: a pilot EEG study. BMC Psychiatry 12:15

Stange JP, Eisner LR, Holzel BK, Peckham AD, Dougherty DD, Rauch SL et al (2011) Mindfulness-based cognitive therapy for bipolar disorder: effects on cognitive functioning. J Psychiatr Pract 17(6):410–419

Van DS, Jeffrey J, Katz MR (2013) A randomized, controlled, pilot study of dialectical behavior therapy skills in a psychoeducational group for individuals with bipolar disorder. J Affect Disord 145(3):386–393

Bos EH, Merea R, van den Brink E, Sanderman R, Bartels-Velthuis AA (2014) Mindfulness training in a heterogeneous psychiatric sample: outcome evaluation and comparison of different diagnostic groups. J Clin Psychol 70(1):60–71

Colom F, Vieta E, Sanchez-Moreno J, Martinez-Aran A, Reinares M, Goikolea JM et al (2005) Stabilizing the stabilizer: group psychoeducation enhances the stability of serum lithium levels. Bipolar Disord 7(Suppl 5):32–36

Simoneau B, Lavallee P, Anderson PC, Bailey M, Bantle G, Berthiaume S et al (1999) Discovery of non-peptidic P2-P3 butanediamide renin inhibitors with high oral efficacy. Bioorg Med Chem 7(3):489–508

Scott J, Colom F, Vieta E (2007) A meta-analysis of relapse rates with adjunctive psychological therapies compared to usual psychiatric treatment for bipolar disorders. Int J Neuropsychopharmacol 10(1):123–129

Reinares M, Colom F, Rosa AR, Bonnin CM, Franco C, Sole B et al (2010) The impact of staging bipolar disorder on treatment outcome of family psychoeducation. J Affect Disord 123(1–3):81–86

Lam DH, Burbeck R, Wright K, Pilling S (2009) Psychological therapies in bipolar disorder: the effect of illness history on relapse prevention—a systematic review. Bipolar Disord 11(5):474–482

Kapczinski F, Dias VV, Kauer-Sant’Anna M, Frey BN, Grassi-Oliveira R, Colom F et al (2009) Clinical implications of a staging model for bipolar disorders. Expert Rev Neurother 9(7):957–966

Berk M, Conus P, Lucas N, Hallam K, Malhi GS, Dodd S et al (2007) Setting the stage: from prodrome to treatment resistance in bipolar disorder. Bipolar Disord 9(7):671–678

Miklowitz DJ, Axelson DA, George EL, Taylor DO, Schneck CD, Sullivan AE et al (2009) Expressed emotion moderates the effects of family-focused treatment for bipolar adolescents. J Am Acad Child Adolesc Psychiatry 48(6):643–651

Vieta E (2010) Individualizing treatment for patients with schizoaffective disorder. J Clin Psychiatry 71(10):e26

Murru A, Pacchiarotti I, Nivoli AM, Colom F, Vieta E (2012) Is schizoaffective disorder still a neglected condition in the scientific literature? Psychother Psychosom 81(6):389–390

Fountoulakis KN, Gonda X, Siamouli M, Rihmer Z (2009) Psychotherapeutic intervention and suicide risk reduction in bipolar disorder: a review of the evidence. J Affect Disord 113(1–2):21–29

Fountoulakis KN, Siamouli M (2009) Re: how well do psychosocial interventions work in bipolar disorder? Can J Psychiatry 54(8):578

Weiss RD, Griffin ML, Kolodziej ME, Greenfield SF, Najavits LM, Daley DC et al (2007) A randomized trial of integrated group therapy versus group drug counseling for patients with bipolar disorder and substance dependence. Am J Psychiatry 164(1):100–107

Weiss RD, Griffin ML, Jaffee WB, Bender RE, Graff FS, Gallop RJ et al (2009) A “community-friendly” version of integrated group therapy for patients with bipolar disorder and substance dependence: a randomized controlled trial. Drug Alcohol Depend 104(3):212–219

Gonzalez-Isasi A, Echeburua E, Mosquera F, Ibanez B, Aizpuru F, Gonzalez-Pinto A (2010) Long-term efficacy of a psychological intervention program for patients with refractory bipolar disorder: a pilot study. Psychiatry Res 176(2–3):161–165

Lam D, Donaldson C, Brown Y, Malliaris Y (2005) Burden and marital and sexual satisfaction in the partners of bipolar patients. Bipolar Disord 7(5):431–440

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